TissGeneSummary for CAPN14 |
Gene summary |
Basic gene information | Gene symbol | CAPN14 |
Gene name | calpain 14 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2p23.1-p21 | |
Type of gene | protein-coding | |
RefGenes | NM_001145122.1, | |
Description | CANP 14calcium-activated neutral proteinase 14calpain-14 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610229 | |
HGNC : HGNC | ||
Ensembl : ENSG00000214711 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CAPN14 | |
BioGPS: 440854 | ||
Pathway | NCI Pathway Interaction Database: CAPN14 | |
KEGG: CAPN14 | ||
REACTOME: CAPN14 | ||
Pathway Commons: CAPN14 | ||
Context | iHOP: CAPN14 | |
ligand binding site mutation search in PubMed: CAPN14 | ||
UCL Cancer Institute: CAPN14 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
Reference showing the relevant tissue of CAPN14 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CAPN14 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.991507322 | -2.050771115 | 1.059263793 | 1.71E-05 | 4.87E-05 |
LUSC | 0.186917052 | -1.771375104 | 1.958292157 | 1.41E-09 | 4.75E-09 |
HNSC | 1.728682534 | 5.31194765 | -3.583265116 | 2.86E-06 | 1.91E-05 |
KICH | -3.462920908 | 0.179611092 | -3.642532 | 2.07E-09 | 1.22E-08 |
KIRP | -2.196191158 | -1.134409908 | -1.06178125 | 0.0136 | 0.028738172 |
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TissGene-miRNA for CAPN14 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CAPN14 |
TissGeneSNV for CAPN14 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.F316L | UCEC | 1 |
p.P475T | COAD | 1 |
p.C237F | CESC | 1 |
p.R444I | UCEC | 1 |
p.R68C | ESCA | 1 |
p.E227K | ESCA | 1 |
p.Q342* | SARC | 1 |
p.E227K | READ | 1 |
p.F526L | COAD | 1 |
p.W317X | ESCA | 1 |
p.A681T | UCEC | 1 |
p.V474M | BRCA | 1 |
p.E388K | LIHC | 1 |
p.E271G | THYM | 1 |
p.Q544H | ACC | 1 |
p.R136W | COAD | 1 |
p.G96R | COAD | 1 |
p.L370M | THYM | 1 |
p.N312S | DLBC | 1 |
p.K510N | COAD | 1 |
p.V487I | BRCA | 1 |
p.E654* | UCEC | 1 |
p.Q82K | UCEC | 1 |
p.P337Q | COAD | 1 |
p.G287V | UCEC | 1 |
p.L538I | MESO | 1 |
p.Q665K | ESCA | 1 |
p.C9X | THYM | 1 |
p.D520N | COAD | 1 |
p.A561V | CHOL | 1 |
p.S2Y | UCEC | 1 |
p.W11L | ACC | 1 |
p.S186Y | UCEC | 1 |
p.F173L | UCEC | 1 |
p.D666N | COAD | 1 |
p.V626I | COAD | 1 |
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TissGeneCNV for CAPN14 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CAPN14 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI908960 | CAPN14-HERC3 | chr2:31397364 | chr4:89629028 |
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TissGeneNet for CAPN14 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CAPN14 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CAPN14 |
TissGeneDrug for CAPN14 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CAPN14 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0341106 | Eosinophilic esophagitis | 2 | CTD_human,GWASCAT |
umls:C0029882 | Otitis Media | 1 | BeFree |
umls:C2827407 | Infectious Otitis Media | 1 | BeFree |
umls:C3662483 | Allergic sensitization | 1 | BeFree |