TissGeneSummary for OOEP |
Gene summary |
Basic gene information | Gene symbol | OOEP |
Gene name | oocyte expressed protein | |
Synonyms | C6orf156|FLOPED|HOEP19|KHDC2 | |
Cytomap | UCSC genome browser: 6q13 | |
Type of gene | protein-coding | |
RefGenes | NM_001080507.2, | |
Description | KH homology domain containing 2KH homology domain-containing protein 2oocyte and embryo protein 19oocyte expressed protein homolog (dog)oocyte- and embryo-specific protein 19oocyte-expressed protein homolog | |
Modification date | 20141207 | |
dbXrefs | MIM : 611689 | |
HGNC : HGNC | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OOEP | |
BioGPS: 441161 | ||
Pathway | NCI Pathway Interaction Database: OOEP | |
KEGG: OOEP | ||
REACTOME: OOEP | ||
Pathway Commons: OOEP | ||
Context | iHOP: OOEP | |
ligand binding site mutation search in PubMed: OOEP | ||
UCL Cancer Institute: OOEP | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of OOEP | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for OOEP |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.811119632 | -0.463179632 | -1.34794 | 1.01E-07 | 4.64E-07 |
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TissGene-miRNA for OOEP |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for OOEP |
TissGeneSNV for OOEP |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R101S | SKCM | 1 |
p.V51A | STAD | 1 |
p.R123X | COAD | 1 |
p.H19Y | SKCM | 1 |
p.L50S | SKCM | 1 |
p.E55* | UCEC | 1 |
p.R46C | LUAD | 1 |
p.R63Q | SKCM | 1 |
p.H117Y | CESC | 1 |
p.D85H | SARC | 1 |
p.S77R | LUSC | 1 |
p.P16S | SKCM | 1 |
p.V106A | STAD | 1 |
p.R68* | BLCA | 1 |
p.R121H | STAD | 1 |
p.D146E | HNSC | 1 |
p.R35H | BLCA | 1 |
p.R46P | LUAD | 1 |
p.R25H | BLCA | 1 |
p.E38K | SKCM | 1 |
p.E70K | HNSC | 1 |
p.G43R | STAD | 1 |
p.E61K | UCEC | 1 |
p.R46L | LUAD | 1 |
p.P49S | SKCM | 1 |
p.S10F | SKCM | 1 |
p.R37W | GBM | 1 |
p.D60N | SKCM | 1 |
p.D91E | HNSC | 1 |
p.P45A | LUAD | 1 |
p.D3N | SKCM | 1 |
p.G98R | STAD | 1 |
p.P71S | SKCM | 1 |
p.R105L | KIRP | 1 |
p.P100A | LUAD | 1 |
p.R101L | LUAD | 1 |
p.A7G | LUAD | 1 |
p.E64K | SKCM | 1 |
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TissGeneCNV for OOEP |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for OOEP |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE706163 | OOEP-EIF3A | chr6:74083034 | chr10:120810761 | |
Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-7210-01A | SENP6-OOEP | Out-of-Frame | chr6:76344526 | chr6:74079107 |
TCGAfusionPortal | PRADA | BRCA | TCGA-OL-A66P-01A | KHDC1-OOEP | Out-of-frame | Chr6:74001721 | Chr6:74079108 |
TCGAfusionPortal | PRADA | PRAD | TCGA-HC-7210-01A | SENP6-OOEP | Out-of-frame | Chr6:76344527 | Chr6:74079108 |
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TissGeneNet for OOEP |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for OOEP |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for OOEP |
TissGeneDrug for OOEP |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for OOEP |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |