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| TissGeneSummary for AKR1B15 |
 Gene summary |
| Basic gene information | Gene symbol | AKR1B15 |
| Gene name | aldo-keto reductase family 1, member B15 | |
| Synonyms | AKR1B10L, AK1R1B7 | |
| Cytomap | UCSC genome browser: 7q33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001080538.2, | |
| Description | aldo-keto reductase family 1 member B15putative aldo-keto reductase family 1 member B15 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000227471 | ||
| Vega : OTTHUMG00000155376 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AKR1B15 | |
| BioGPS: 441282 | ||
| Pathway | NCI Pathway Interaction Database: AKR1B15 | |
| KEGG: AKR1B15 | ||
| REACTOME: AKR1B15 | ||
| Pathway Commons: AKR1B15 | ||
| Context | iHOP: AKR1B15 | |
| ligand binding site mutation search in PubMed: AKR1B15 | ||
| UCL Cancer Institute: AKR1B15 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCASTAD | |
| Reference showing the relevant tissue of AKR1B15 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for AKR1B15 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 0.136539217 | 1.727240094 | -1.590700877 | 3.30E-06 | 8.56E-06 |
| LUAD | 0.89498347 | -1.883257909 | 2.778241379 | 4.05E-10 | 2.25E-09 |
| LIHC | 2.452393884 | -0.719522116 | 3.171916 | 1.74E-07 | 1.15E-06 |
| LUSC | 2.64602157 | -1.841770587 | 4.487792157 | 1.42E-16 | 1.07E-15 |
| HNSC | 4.944519837 | 3.845998907 | 1.09852093 | 0.00962 | 0.0239701 |
| KIRP | 0.273180884 | -1.659753491 | 1.932934375 | 0.00179 | 0.004602271 |
| COAD | -1.513351809 | -0.054659501 | -1.458692308 | 0.000706 | 0.00210742 |
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| TissGene-miRNA for AKR1B15 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for AKR1B15 |
| TissGeneSNV for AKR1B15 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G162E | SKCM | 2 |
| p.G143E | SKCM | 2 |
| p.R69C | SKCM | 1 |
| p.D259Y | LUAD | 1 |
| p.A2T | PRAD | 1 |
| p.M293V | BLCA | 1 |
| p.E82Q | SKCM | 1 |
| p.P202S | UCEC | 1 |
| p.E113D | BLCA | 1 |
| p.E179K | OV | 1 |
| p.K145E | LUAD | 1 |
| p.S202F | BRCA | 1 |
| p.A74D | LUAD | 1 |
| p.P260T | COAD | 1 |
| p.E58X | COAD | 1 |
| p.I265V | BLCA | 1 |
| p.Y68C | ACC | 1 |
| p.A184T | SKCM | 1 |
| p.Q212H | LUAD | 1 |
| p.R69H | PAAD | 1 |
| p.L241M | LUAD | 1 |
| p.A274D | HNSC | 1 |
| p.Q92K | LUSC | 1 |
| p.P202H | STAD | 1 |
| p.K270R | KIRC | 1 |
| p.F111V | SKCM | 1 |
| p.P260S | THYM | 1 |
| p.T220M | DLBC | 1 |
| p.C73S | LUAD | 1 |
| p.S239I | LUAD | 1 |
| p.F320L | HNSC | 1 |
| p.T316N | LIHC | 1 |
| p.F190V | COAD | 1 |
| p.H269Q | LUAD | 1 |
| p.E264Q | SKCM | 1 |
| p.W108* | STAD | 1 |
| p.S264Y | UCEC | 1 |
| p.D155N | SKCM | 1 |
| p.D148H | HNSC | 1 |
| p.G143R | GBM | 1 |
| p.A74T | COAD | 1 |
| p.V56G | STAD | 1 |
| p.D148E | LGG | 1 |
| p.R246K | BLCA | 1 |
| p.G84R | STAD | 1 |
| p.V235I | LUAD | 1 |
| p.R98L | LUAD | 1 |
| p.K119Q | KIRC | 1 |
| p.N285K | KIRC | 1 |
| p.K291N | COAD | 1 |
| p.P174S | UCEC | 1 |
| p.M13K | SKCM | 1 |
| p.L199F | KIRP | 1 |
| p.K207N | DLBC | 1 |
| p.E258K | LGG | 1 |
| p.D134E | HNSC | 1 |
| p.R114I | BLCA | 1 |
| p.P240T | LUAD | 1 |
| p.W108X | STAD | 1 |
| p.T273A | DLBC | 1 |
| p.S105I | LUSC | 1 |
| p.Q88L | LUAD | 1 |
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| TissGeneCNV for AKR1B15 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for AKR1B15 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CV-7407-01A | CALD1-AKR1B15 | 5UTR-5UTR | Chr7:134528722 | Chr7:134249350 |
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| TissGeneNet for AKR1B15 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for AKR1B15 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for AKR1B15 |
| TissGeneDrug for AKR1B15 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for AKR1B15 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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