TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for AKR1B15
check button Gene summary
Basic gene informationGene symbolAKR1B15
Gene namealdo-keto reductase family 1, member B15
SynonymsAKR1B10L, AK1R1B7
CytomapUCSC genome browser: 7q33
Type of geneprotein-coding
RefGenesNM_001080538.2,
Descriptionaldo-keto reductase family 1 member B15putative aldo-keto reductase family 1 member B15
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000227471
Vega : OTTHUMG00000155376
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AKR1B15
BioGPS: 441282
PathwayNCI Pathway Interaction Database: AKR1B15
KEGG: AKR1B15
REACTOME: AKR1B15
Pathway Commons: AKR1B15
ContextiHOP: AKR1B15
ligand binding site mutation search in PubMed: AKR1B15
UCL Cancer Institute: AKR1B15
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BreastStomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BRCASTAD
Reference showing the relevant tissue of AKR1B15
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


Top
TissGeneExp for AKR1B15

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA0.1365392171.727240094-1.5907008773.30E-068.56E-06
LUAD0.89498347-1.8832579092.7782413794.05E-102.25E-09
LIHC2.452393884-0.7195221163.1719161.74E-071.15E-06
LUSC2.64602157-1.8417705874.4877921571.42E-161.07E-15
HNSC4.9445198373.8459989071.098520930.009620.0239701
KIRP0.273180884-1.6597534911.9329343750.001790.004602271
COAD-1.513351809-0.054659501-1.4586923080.0007060.00210742


Top
TissGene-miRNA for AKR1B15

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for AKR1B15
TissGeneSNV for AKR1B15

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G162ESKCM2
p.G143ESKCM2
p.R69CSKCM1
p.D259YLUAD1
p.A2TPRAD1
p.M293VBLCA1
p.E82QSKCM1
p.P202SUCEC1
p.E113DBLCA1
p.E179KOV1
p.K145ELUAD1
p.S202FBRCA1
p.A74DLUAD1
p.P260TCOAD1
p.E58XCOAD1
p.I265VBLCA1
p.Y68CACC1
p.A184TSKCM1
p.Q212HLUAD1
p.R69HPAAD1
p.L241MLUAD1
p.A274DHNSC1
p.Q92KLUSC1
p.P202HSTAD1
p.K270RKIRC1
p.F111VSKCM1
p.P260STHYM1
p.T220MDLBC1
p.C73SLUAD1
p.S239ILUAD1
p.F320LHNSC1
p.T316NLIHC1
p.F190VCOAD1
p.H269QLUAD1
p.E264QSKCM1
p.W108*STAD1
p.S264YUCEC1
p.D155NSKCM1
p.D148HHNSC1
p.G143RGBM1
p.A74TCOAD1
p.V56GSTAD1
p.D148ELGG1
p.R246KBLCA1
p.G84RSTAD1
p.V235ILUAD1
p.R98LLUAD1
p.K119QKIRC1
p.N285KKIRC1
p.K291NCOAD1
p.P174SUCEC1
p.M13KSKCM1
p.L199FKIRP1
p.K207NDLBC1
p.E258KLGG1
p.D134EHNSC1
p.R114IBLCA1
p.P240TLUAD1
p.W108XSTAD1
p.T273ADLBC1
p.S105ILUSC1
p.Q88LLUAD1


Top
TissGeneCNV for AKR1B15

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for AKR1B15

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADAHNSCTCGA-CV-7407-01ACALD1-AKR1B155UTR-5UTRChr7:134528722Chr7:134249350


Top
TissGeneNet for AKR1B15

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


Top
TissGeneProg for AKR1B15

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for AKR1B15
TissGeneDrug for AKR1B15

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for AKR1B15

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource