TissGeneSummary for FAM47C |
Gene summary |
Basic gene information | Gene symbol | FAM47C |
Gene name | family with sequence similarity 47, member C | |
Synonyms | - | |
Cytomap | UCSC genome browser: Xp21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001013736.2, | |
Description | putative protein FAM47C | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000198173 | ||
HPRD : 18474 | ||
Vega : OTTHUMG00000024025 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM47C | |
BioGPS: 442444 | ||
Pathway | NCI Pathway Interaction Database: FAM47C | |
KEGG: FAM47C | ||
REACTOME: FAM47C | ||
Pathway Commons: FAM47C | ||
Context | iHOP: FAM47C | |
ligand binding site mutation search in PubMed: FAM47C | ||
UCL Cancer Institute: FAM47C | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM47C | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM47C |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FAM47C |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM47C |
TissGeneSNV for FAM47C |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.N648D | LGG | 6 |
p.N648D | BLCA | 6 |
p.N648D | PRAD | 4 |
p.Q225E | LUAD | 4 |
p.N648D | LUAD | 3 |
p.Q225E | BLCA | 3 |
p.H823N | LUAD | 2 |
p.S748F | SKCM | 2 |
p.E264K | SKCM | 2 |
p.N648D | SKCM | 2 |
p.E174K | SKCM | 2 |
p.E185K | SKCM | 2 |
p.Q225E | THCA | 2 |
p.Q225E | SKCM | 2 |
p.G948W | LUAD | 2 |
p.N648D | ACC | 2 |
p.E802K | SKCM | 2 |
p.A162P | LUAD | 2 |
p.E915K | SKCM | 2 |
p.L973I | UCEC | 2 |
p.R72C | LUSC | 1 |
p.I529T | ACC | 1 |
p.R458Q | PRAD | 1 |
p.E621D | LUAD | 1 |
p.S532Y | LUAD | 1 |
p.L402F | SKCM | 1 |
p.R451P | LUSC | 1 |
p.R506G | BLCA | 1 |
p.P344L | LUAD | 1 |
p.E717* | LUAD | 1 |
p.P668Q | LUAD | 1 |
p.P25L | LUAD | 1 |
p.P595L | LUAD | 1 |
p.P395S | SKCM | 1 |
p.P718S | BRCA | 1 |
p.R362S | LUAD | 1 |
p.S542R | ACC | 1 |
p.Y21H | HNSC | 1 |
p.C283F | HNSC | 1 |
p.R751C | COAD | 1 |
p.D971N | STAD | 1 |
p.G350E | SKCM | 1 |
p.M639V | UCEC | 1 |
p.E309K | SKCM | 1 |
p.E360* | STAD | 1 |
p.P584T | LUAD | 1 |
p.R410H | GBM | 1 |
p.R36K | LIHC | 1 |
p.H245N | LUAD | 1 |
p.S849L | SKCM | 1 |
p.K921N | SKCM | 1 |
p.R746W | ESCA | 1 |
p.Q883* | LUSC | 1 |
p.L778I | LUSC | 1 |
p.R362H | LUAD | 1 |
p.S736F | SKCM | 1 |
p.S628F | ESCA | 1 |
p.M993T | LGG | 1 |
p.E573G | SKCM | 1 |
p.E612* | UCEC | 1 |
p.R189W | UCEC | 1 |
p.S822F | SKCM | 1 |
p.R559C | COAD | 1 |
p.E837* | UCEC | 1 |
p.E516Q | ACC | 1 |
p.K99N | LUAD | 1 |
p.P491H | STAD | 1 |
p.V687L | LUAD | 1 |
p.R590Q | LUAD | 1 |
p.S515P | CESC | 1 |
p.P524Q | SKCM | 1 |
p.S328Y | ACC | 1 |
p.K946M | HNSC | 1 |
p.A716V | BRCA | 1 |
p.R451C | STAD | 1 |
p.S760C | DLBC | 1 |
p.H473Y | LIHC | 1 |
p.P644A | OV | 1 |
p.P274L | SKCM | 1 |
p.G939A | BLCA | 1 |
p.P401L | SKCM | 1 |
p.E955* | LUAD | 1 |
p.H725Y | SKCM | 1 |
p.M906I | LUSC | 1 |
p.R73S | LUAD | 1 |
p.D492N | STAD | 1 |
p.R746W | COAD | 1 |
p.R739C | ESCA | 1 |
p.R386C | SKCM | 1 |
p.R523H | UCEC | 1 |
p.T52M | BRCA | 1 |
p.R794L | KIRC | 1 |
p.V375E | BRCA | 1 |
p.G948W | COAD | 1 |
p.D492N | ESCA | 1 |
p.Q225E | COAD | 1 |
p.E185* | SARC | 1 |
p.E156D | ESCA | 1 |
p.P956T | STAD | 1 |
p.R9Q | ESCA | 1 |
p.L726V | CESC | 1 |
p.P512T | LUSC | 1 |
p.R487C | BRCA | 1 |
p.S208T | CESC | 1 |
p.L762F | SKCM | 1 |
p.R451C | SKCM | 1 |
p.S515P | BLCA | 1 |
p.E264D | PRAD | 1 |
p.K1012E | LUAD | 1 |
p.D140Y | UCEC | 1 |
p.P440S | STAD | 1 |
p.V387I | CESC | 1 |
p.V615I | PRAD | 1 |
p.G54V | BRCA | 1 |
p.E905K | SKCM | 1 |
p.L738V | LUAD | 1 |
p.A162T | LUAD | 1 |
p.P250L | SKCM | 1 |
p.R72C | READ | 1 |
p.R451H | PRAD | 1 |
p.S313* | LUAD | 1 |
p.E672Q | BLCA | 1 |
p.C655Y | STAD | 1 |
p.G302E | LUAD | 1 |
p.P395H | LUAD | 1 |
p.T565I | UCEC | 1 |
p.N648D | LIHC | 1 |
p.R211C | BLCA | 1 |
p.P431S | SARC | 1 |
p.G242E | SKCM | 1 |
p.P200Q | SKCM | 1 |
p.R247C | HNSC | 1 |
p.G494A | BLCA | 1 |
p.E348K | SKCM | 1 |
p.E789Q | CESC | 1 |
p.P803L | LUSC | 1 |
p.A88T | PAAD | 1 |
p.R800C | READ | 1 |
p.F186Y | LUAD | 1 |
p.P667S | SKCM | 1 |
p.R367C | SKCM | 1 |
p.A31T | SARC | 1 |
p.E122K | SKCM | 1 |
p.R9Q | STAD | 1 |
p.T385N | OV | 1 |
p.P275H | LGG | 1 |
p.V339L | HNSC | 1 |
p.E612D | STAD | 1 |
p.D974V | LUSC | 1 |
p.G276E | SKCM | 1 |
p.R631C | UCEC | 1 |
p.V207E | LUAD | 1 |
p.E477* | LUAD | 1 |
p.K636E | UCEC | 1 |
p.E741V | CHOL | 1 |
p.S797C | HNSC | 1 |
p.R72C | SKCM | 1 |
p.I529T | TGCT | 1 |
p.P407S | SKCM | 1 |
p.E645D | LUAD | 1 |
p.P595L | SKCM | 1 |
p.R638Q | LUAD | 1 |
p.P431L | STAD | 1 |
p.S484F | CESC | 1 |
p.A31T | LUAD | 1 |
p.R511H | LUAD | 1 |
p.E360X | STAD | 1 |
p.P212R | LUAD | 1 |
p.R59H | SARC | 1 |
p.R691C | LUSC | 1 |
p.T52M | UCEC | 1 |
p.R9W | UCEC | 1 |
p.P431S | SKCM | 1 |
p.T493P | LUAD | 1 |
p.P670L | HNSC | 1 |
p.S688F | SKCM | 1 |
p.R523C | GBM | 1 |
p.H35P | HNSC | 1 |
p.D1027E | LUSC | 1 |
p.K910I | SKCM | 1 |
p.P389L | LUAD | 1 |
p.R410L | LUSC | 1 |
p.S323Y | ESCA | 1 |
p.R614H | READ | 1 |
p.R319C | SKCM | 1 |
p.P551S | LGG | 1 |
p.R758H | STAD | 1 |
p.L107F | SKCM | 1 |
p.P706H | LUSC | 1 |
p.R434H | STAD | 1 |
p.R686H | STAD | 1 |
p.R631H | KICH | 1 |
p.D954N | SKCM | 1 |
p.C727R | STAD | 1 |
p.G1005R | SKCM | 1 |
p.S616F | SKCM | 1 |
p.D492N | COAD | 1 |
p.R73L | HNSC | 1 |
p.R739H | LUAD | 1 |
p.H331Y | SKCM | 1 |
p.H259Y | SKCM | 1 |
p.S436F | SKCM | 1 |
p.R619H | STAD | 1 |
p.E201* | HNSC | 1 |
p.R37C | HNSC | 1 |
p.R223C | BLCA | 1 |
p.G820V | LUAD | 1 |
p.P791A | LUAD | 1 |
p.T217S | SARC | 1 |
p.V687I | GBM | 1 |
p.P112S | KIRC | 1 |
p.P476A | LUAD | 1 |
p.R850K | BLCA | 1 |
p.R794G | LUAD | 1 |
p.F40S | STAD | 1 |
p.S313P | HNSC | 1 |
p.R367C | COAD | 1 |
p.R415C | SKCM | 1 |
p.G948E | SKCM | 1 |
p.S556T | STAD | 1 |
p.E965Q | CESC | 1 |
p.P392A | LUSC | 1 |
p.P752L | SKCM | 1 |
p.E756Q | STAD | 1 |
p.H221N | LUAD | 1 |
p.D305N | UCEC | 1 |
p.L702F | LUSC | 1 |
p.M55I | SKCM | 1 |
p.L145F | SKCM | 1 |
p.G975C | UCEC | 1 |
p.T172P | PCPG | 1 |
p.P644T | ESCA | 1 |
p.S894Y | LUAD | 1 |
p.R194Q | COAD | 1 |
p.S12Y | LUAD | 1 |
p.M639I | LUAD | 1 |
p.E1033K | SKCM | 1 |
p.R59L | LUSC | 1 |
p.P668L | KIRP | 1 |
p.L270F | SKCM | 1 |
p.V291I | SARC | 1 |
p.Q225E | PRAD | 1 |
p.L824I | SARC | 1 |
p.E657D | UCEC | 1 |
p.A31T | ACC | 1 |
p.Y568H | HNSC | 1 |
p.D305A | UCEC | 1 |
p.S988G | SKCM | 1 |
p.R795* | UCEC | 1 |
p.S12F | SKCM | 1 |
p.R691H | UCEC | 1 |
p.P611S | DLBC | 1 |
p.L786I | LUAD | 1 |
p.D873H | BLCA | 1 |
p.S628F | SKCM | 1 |
p.R211C | LGG | 1 |
p.S834I | LUSC | 1 |
p.R739C | LUAD | 1 |
p.P226H | UCEC | 1 |
p.R410H | UCEC | 1 |
p.P668R | SKCM | 1 |
p.S323F | LUSC | 1 |
p.R247C | BRCA | 1 |
p.T601A | OV | 1 |
p.S592F | SKCM | 1 |
p.L702F | HNSC | 1 |
p.R114Q | READ | 1 |
p.G14V | SARC | 1 |
p.H473Y | SKCM | 1 |
p.L366F | SKCM | 1 |
p.R800H | CESC | 1 |
p.S822C | LUSC | 1 |
p.A1002S | COAD | 1 |
p.R691S | LUAD | 1 |
p.A31T | STAD | 1 |
p.P742H | STAD | 1 |
p.L354F | SKCM | 1 |
p.Y882D | LUSC | 1 |
p.S833L | SKCM | 1 |
p.P876T | HNSC | 1 |
p.R367C | BRCA | 1 |
p.S196F | SKCM | 1 |
p.P876L | HNSC | 1 |
p.P404L | GBM | 1 |
p.P440S | SKCM | 1 |
p.R631H | BRCA | 1 |
p.Q225E | LGG | 1 |
p.N648D | THYM | 1 |
p.R434H | BLCA | 1 |
p.G820R | OV | 1 |
p.E657D | LUAD | 1 |
p.P667S | HNSC | 1 |
p.E600* | LUAD | 1 |
p.R451L | HNSC | 1 |
p.A981T | UCEC | 1 |
p.S187F | SKCM | 1 |
p.V483L | LUSC | 1 |
p.P776Q | LUAD | 1 |
p.P320L | HNSC | 1 |
p.R631C | STAD | 1 |
p.P25L | SKCM | 1 |
p.F76I | SKCM | 1 |
p.R845C | STAD | 1 |
p.L426F | LUAD | 1 |
p.H317Y | SKCM | 1 |
p.D576N | KIRC | 1 |
p.R590W | PRAD | 1 |
p.R614H | UCEC | 1 |
p.S713I | GBM | 1 |
p.R794C | UCEC | 1 |
p.E309Q | BRCA | 1 |
p.L654I | LUAD | 1 |
p.R114W | STAD | 1 |
p.K336N | LUAD | 1 |
p.P298S | PRAD | 1 |
p.L943F | SKCM | 1 |
p.P130L | SKCM | 1 |
p.R362C | SKCM | 1 |
p.P803T | LUAD | 1 |
p.R211C | STAD | 1 |
p.R439C | SKCM | 1 |
p.R223S | HNSC | 1 |
p.R845C | ESCA | 1 |
p.P956T | BRCA | 1 |
p.K886N | UCEC | 1 |
p.C727R | LUAD | 1 |
p.R763H | HNSC | 1 |
p.L774P | LIHC | 1 |
p.L246F | SKCM | 1 |
p.K336N | READ | 1 |
p.R59C | LUAD | 1 |
p.R853H | LGG | 1 |
p.H581N | LUAD | 1 |
p.L318F | CESC | 1 |
p.H331N | LUAD | 1 |
p.S376Y | BLCA | 1 |
p.E720Q | CESC | 1 |
p.P575H | LUAD | 1 |
p.P634L | LUAD | 1 |
p.R362H | STAD | 1 |
p.A716E | LUAD | 1 |
p.E174K | UCEC | 1 |
p.C197F | SARC | 1 |
p.C475Y | LUSC | 1 |
p.A116V | PRAD | 1 |
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TissGeneCNV for FAM47C |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM47C |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM47C |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM47C |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM47C |
TissGeneDrug for FAM47C |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM47C |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |