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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MST1
check button Gene summary
Basic gene informationGene symbolMST1
Gene namemacrophage stimulating 1 (hepatocyte growth factor-like)
SynonymsD3F15S2|DNF15S2|HGFL|MSP|NF15S2
CytomapUCSC genome browser: 3p21
Type of geneprotein-coding
RefGenesNM_020998.3,
Descriptionhepatocyte growth factor-like proteinhepatocyte growth factor-like protein homologmacrophage-stimulating protein
Modification date20141207
dbXrefs MIM : 142408
HGNC : HGNC
Ensembl : ENSG00000173531
HPRD : 00798
Vega : OTTHUMG00000155918
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MST1
BioGPS: 4485
PathwayNCI Pathway Interaction Database: MST1
KEGG: MST1
REACTOME: MST1
Pathway Commons: MST1
ContextiHOP: MST1
ligand binding site mutation search in PubMed: MST1
UCL Cancer Institute: MST1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of MST1
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for MST1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD-0.845822239-2.3901683931.5443461541.34E-067.38E-06
KICH-0.4598370081.720826992-2.1806643.39E-123.56E-11
LIHC5.2064569926.754418992-1.5479622.22E-071.42E-06


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TissGene-miRNA for MST1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for MST1
TissGeneSNV for MST1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P349LPAAD6
p.P349LSARC4
p.R347WPAAD4
p.R347WUCEC4
p.A367GPAAD4
p.W264XPAAD4
p.R347WSARC3
p.P349LUCEC3
p.R347WTGCT3
p.R374CPAAD2
p.R535GLUAD2
p.G673SPAAD2
p.P678LPAAD2
p.P349LLGG2
p.A366VHNSC2
p.D472NLIHC2
p.M364TPAAD2
p.T546MPCPG2
p.A366VPAAD2
p.P349LACC2
p.P349LTGCT1
p.R289HUCEC1
p.E68DUCEC1
p.N164KBLCA1
p.A367GTHCA1
p.W264*UCEC1
p.R347WLGG1
p.S131*BRCA1
p.T546MTHYM1
p.A670VLIHC1
p.P416LDLBC1
p.G58RKIRP1
p.P76LPAAD1
p.A204TSTAD1
p.S565GCESC1
p.P349LPRAD1
p.R347WACC1
p.R535GHNSC1
p.M364TLGG1
p.I197MBRCA1
p.G547VKIRC1
p.C74GPAAD1
p.R400CHNSC1
p.W264*PAAD1
p.T332RHNSC1
p.E623KBLCA1
p.R597CSTAD1
p.R493CLIHC1
p.P76LCHOL1
p.R342WBLCA1
p.C660RSTAD1
p.A367GLGG1
p.Q328*BLCA1
p.R347WBLCA1
p.G45VSKCM1
p.Y184HGBM1
p.T683IHNSC1
p.R373WLGG1
p.R655WESCA1
p.G547VLUAD1
p.C112YBLCA1
p.R81WKIRC1
p.S88NCOAD1
p.D175YLUSC1
p.Q26LKIRP1
p.A619TCOAD1
p.R651QLGG1
p.E411*LUAD1
p.G210STHYM1
p.Q193HBLCA1
p.H90DMESO1
p.W551*SKCM1
p.G547VPCPG1
p.R655QESCA1
p.R597HUCEC1
p.G553SSTAD1
p.Q287HPAAD1
p.A366VLGG1
p.A367GTHYM1
p.P416LPCPG1
p.G242RTHCA1
p.G652*UCEC1
p.S88RTHYM1
p.D472ALIHC1
p.R107WSTAD1
p.Q371KLUAD1
p.R347WHNSC1
p.P57LLGG1
p.E261DUVM1
p.F331LLUAD1
p.M364TKIRP1
p.R461HHNSC1
p.G196SESCA1
p.T104KLUAD1
p.T161IHNSC1
p.R365CSTAD1
p.T546MUVM1
p.V640AKIRC1
p.R434QLIHC1
p.D251NBLCA1
p.R347WPRAD1
p.T546MBRCA1
p.Y253HLIHC1
p.T627KPRAD1
p.S591YBLCA1
p.E261DUCEC1
p.D246HBLCA1
p.R374CCHOL1
p.V87MUCEC1
p.R365CUCS1
p.A367GCESC1
p.R81WLIHC1
p.A137VREAD1
p.R289CUCS1
p.R374CLUSC1
p.R374CKIRP1
p.R374CGBM1


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TissGeneCNV for MST1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for MST1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADABRCATCGA-A2-A0D2-01AMST1-SRRDOut-of-frameChr3:49721747Chr22:26883995


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TissGeneNet for MST1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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COAD (tumor)COAD (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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HNSC (tumor)HNSC (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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KICH (tumor)KICH (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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KIRC (tumor)KIRC (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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KIRP (tumor)KIRP (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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LIHC (tumor)LIHC (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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LUAD (tumor)LUAD (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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LUSC (tumor)LUSC (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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PRAD (tumor)PRAD (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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STAD (tumor)STAD (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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THCA (tumor)THCA (normal)
MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (tumor)MST1, HNF4A, NFYA, SERPINA3, MST1R, KLKB1 (normal)
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TissGeneProg for MST1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for MST1
TissGeneDrug for MST1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for MST1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0024530Malaria45BeFree
umls:C0009324Ulcerative Colitis13BeFree,CTD_human,GAD,GWASCAT,LHGDN
umls:C0010346Crohn Disease12BeFree,CTD_human,GAD,GWASCAT
umls:C0021390Inflammatory Bowel Diseases8BeFree,GAD,GWASCAT
umls:C0596263Carcinogenesis8BeFree
umls:C0027627Neoplasm Metastasis6BeFree
umls:C0600139Prostate carcinoma6BeFree
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0007134Renal Cell Carcinoma5BeFree
umls:C0009402Colorectal Carcinoma5BeFree
umls:C0024623Malignant neoplasm of stomach5BeFree
umls:C0302592Cervix carcinoma5BeFree
umls:C0376358Malignant neoplasm of prostate5BeFree
umls:C0678222Breast Carcinoma5BeFree
umls:C0699791Stomach Carcinoma5BeFree
umls:C1527249Colorectal Cancer5BeFree
umls:C2239176Liver carcinoma5BeFree
umls:C0007847Malignant tumor of cervix4BeFree
umls:C0024535Malaria, Falciparum4BeFree
umls:C0149925Small cell carcinoma of lung4BeFree
umls:C0242379Malignant neoplasm of lung4BeFree
umls:C0275524Coinfection4BeFree
umls:C0566602Primary sclerosing cholangitis4BeFree,GWASCAT,ORPHANET
umls:C0684249Carcinoma of lung4BeFree
umls:C0002736Amyotrophic Lateral Sclerosis3BeFree
umls:C0008313Cholangitis, Sclerosing3BeFree,CTD_human,GAD
umls:C0017636Glioblastoma3BeFree
umls:C0017638Glioma3BeFree
umls:C0025202melanoma3BeFree
umls:C0346647Malignant neoplasm of pancreas3BeFree
umls:C0001418Adenocarcinoma2BeFree
umls:C0002312alpha-Thalassemia2BeFree
umls:C0007124Noninfiltrating Intraductal Carcinoma2BeFree
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree
umls:C0007137Squamous cell carcinoma2BeFree
umls:C0026769Multiple Sclerosis2BeFree
umls:C0033578Prostatic Neoplasms2BeFree
umls:C0085084Motor Neuron Disease2BeFree
umls:C0178874Tumor Progression2BeFree
umls:C0235974Pancreatic carcinoma2BeFree
umls:C0242723Parasitemia2BeFree
umls:C0949541Hurthle Cell Tumor2BeFree
umls:C1168401Squamous cell carcinoma of the head and neck2BeFree
umls:C1456873alpha^+^ Thalassemia2BeFree
umls:C1458155Mammary Neoplasms2BeFree,LHGDN
umls:C1862939AMYOTROPHIC LATERAL SCLEROSIS 12BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0004364Autoimmune Diseases1BeFree
umls:C0007095Carcinoid Tumor1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007103Malignant neoplasm of endometrium1BeFree
umls:C0007115Malignant neoplasm of thyroid1BeFree
umls:C0007193Cardiomyopathy, Dilated1BeFree
umls:C0011065Cessation of life1LHGDN
umls:C0014072Experimental Autoimmune Encephalomyelitis1BeFree
umls:C0014175Endometriosis1BeFree,LHGDN
umls:C0019360Herpes zoster disease1BeFree
umls:C0020455Hypergammaglobulinemia1BeFree
umls:C0021053Immune System Diseases1BeFree
umls:C0022104Irritable Bowel Syndrome1BeFree
umls:C0023267Fibroid Tumor1BeFree
umls:C0024121Lung Neoplasms1BeFree
umls:C0026265Diseases of mitral valve1BeFree
umls:C0026269Mitral Valve Stenosis1BeFree
umls:C0027051Myocardial Infarction1BeFree
umls:C0029463Osteosarcoma1BeFree
umls:C0030354Papilloma1BeFree
umls:C0031099Periodontitis1BeFree
umls:C0032897Prader-Willi Syndrome1BeFree
umls:C0034069Pulmonary Fibrosis1BeFree
umls:C0036202Sarcoidosis1BeFree
umls:C0036341Schizophrenia1BeFree
umls:C0037054Sickle Cell Trait1BeFree
umls:C0039483Giant Cell Arteritis1BeFree
umls:C0039614Tetanus1BeFree
umls:C0039984Thoracic Outlet Syndrome1BeFree
umls:C0040136Thyroid Neoplasm1BeFree
umls:C0042133Uterine Fibroids1BeFree
umls:C0042769Virus Diseases1BeFree
umls:C0042798Low Vision1BeFree
umls:C0042961Intestinal Volvulus1BeFree
umls:C0149782Squamous cell carcinoma of lung1BeFree
umls:C0162557Liver Failure, Acute1BeFree
umls:C0162565Acute intermittent porphyria1BeFree
umls:C0162635Angelman Syndrome1BeFree
umls:C0206062Lung Diseases, Interstitial1BeFree
umls:C0206623Adenosquamous carcinoma1BeFree
umls:C0206698Cholangiocarcinoma1BeFree
umls:C0206754Neuroendocrine Tumors1BeFree
umls:C0238463Papillary thyroid carcinoma1BeFree
umls:C0275522Asymptomatic Infections1BeFree
umls:C0278488Carcinoma breast stage IV1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0398686Primary immune deficiency disorder1BeFree
umls:C0472762Alpha trait thalassemia1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0483368Human anaplasmosis due to Anaplasma phagocytophilum1BeFree
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0549473Thyroid carcinoma1BeFree
umls:C0585362Squamous cell carcinoma of mouth1BeFree
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0677948Stage II Colorectal Cancer1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0740380Varicella zoster1BeFree
umls:C0878544Cardiomyopathies1BeFree
umls:C1261473Sarcoma1BeFree
umls:C1378050Oncocytic Neoplasm1BeFree
umls:C1510502Oxyphilic Adenoma1BeFree
umls:C1562061Microspherophakia1BeFree
umls:C1621958Glioblastoma Multiforme1BeFree
umls:C1800706Idiopathic Pulmonary Fibrosis1BeFree
umls:C1840264IMMUNE SUPPRESSION1BeFree
umls:C1883486Uterine Corpus Cancer1BeFree
umls:C2609129Autoimmune pancreatitis1BeFree
umls:C2939465Deficiency of glucose-6-phosphate dehydrogenase1BeFree
umls:C3146252Stage II Colorectal Cancer AJCC v71BeFree
umls:C3826128Infection in children1BeFree