TissGeneSummary for MST1 |
Gene summary |
Basic gene information | Gene symbol | MST1 |
Gene name | macrophage stimulating 1 (hepatocyte growth factor-like) | |
Synonyms | D3F15S2|DNF15S2|HGFL|MSP|NF15S2 | |
Cytomap | UCSC genome browser: 3p21 | |
Type of gene | protein-coding | |
RefGenes | NM_020998.3, | |
Description | hepatocyte growth factor-like proteinhepatocyte growth factor-like protein homologmacrophage-stimulating protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 142408 | |
HGNC : HGNC | ||
Ensembl : ENSG00000173531 | ||
HPRD : 00798 | ||
Vega : OTTHUMG00000155918 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MST1 | |
BioGPS: 4485 | ||
Pathway | NCI Pathway Interaction Database: MST1 | |
KEGG: MST1 | ||
REACTOME: MST1 | ||
Pathway Commons: MST1 | ||
Context | iHOP: MST1 | |
ligand binding site mutation search in PubMed: MST1 | ||
UCL Cancer Institute: MST1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of MST1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MST1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -0.845822239 | -2.390168393 | 1.544346154 | 1.34E-06 | 7.38E-06 |
KICH | -0.459837008 | 1.720826992 | -2.180664 | 3.39E-12 | 3.56E-11 |
LIHC | 5.206456992 | 6.754418992 | -1.547962 | 2.22E-07 | 1.42E-06 |
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TissGene-miRNA for MST1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MST1 |
TissGeneSNV for MST1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P349L | PAAD | 6 |
p.P349L | SARC | 4 |
p.R347W | PAAD | 4 |
p.R347W | UCEC | 4 |
p.A367G | PAAD | 4 |
p.W264X | PAAD | 4 |
p.R347W | SARC | 3 |
p.P349L | UCEC | 3 |
p.R347W | TGCT | 3 |
p.R374C | PAAD | 2 |
p.R535G | LUAD | 2 |
p.G673S | PAAD | 2 |
p.P678L | PAAD | 2 |
p.P349L | LGG | 2 |
p.A366V | HNSC | 2 |
p.D472N | LIHC | 2 |
p.M364T | PAAD | 2 |
p.T546M | PCPG | 2 |
p.A366V | PAAD | 2 |
p.P349L | ACC | 2 |
p.P349L | TGCT | 1 |
p.R289H | UCEC | 1 |
p.E68D | UCEC | 1 |
p.N164K | BLCA | 1 |
p.A367G | THCA | 1 |
p.W264* | UCEC | 1 |
p.R347W | LGG | 1 |
p.S131* | BRCA | 1 |
p.T546M | THYM | 1 |
p.A670V | LIHC | 1 |
p.P416L | DLBC | 1 |
p.G58R | KIRP | 1 |
p.P76L | PAAD | 1 |
p.A204T | STAD | 1 |
p.S565G | CESC | 1 |
p.P349L | PRAD | 1 |
p.R347W | ACC | 1 |
p.R535G | HNSC | 1 |
p.M364T | LGG | 1 |
p.I197M | BRCA | 1 |
p.G547V | KIRC | 1 |
p.C74G | PAAD | 1 |
p.R400C | HNSC | 1 |
p.W264* | PAAD | 1 |
p.T332R | HNSC | 1 |
p.E623K | BLCA | 1 |
p.R597C | STAD | 1 |
p.R493C | LIHC | 1 |
p.P76L | CHOL | 1 |
p.R342W | BLCA | 1 |
p.C660R | STAD | 1 |
p.A367G | LGG | 1 |
p.Q328* | BLCA | 1 |
p.R347W | BLCA | 1 |
p.G45V | SKCM | 1 |
p.Y184H | GBM | 1 |
p.T683I | HNSC | 1 |
p.R373W | LGG | 1 |
p.R655W | ESCA | 1 |
p.G547V | LUAD | 1 |
p.C112Y | BLCA | 1 |
p.R81W | KIRC | 1 |
p.S88N | COAD | 1 |
p.D175Y | LUSC | 1 |
p.Q26L | KIRP | 1 |
p.A619T | COAD | 1 |
p.R651Q | LGG | 1 |
p.E411* | LUAD | 1 |
p.G210S | THYM | 1 |
p.Q193H | BLCA | 1 |
p.H90D | MESO | 1 |
p.W551* | SKCM | 1 |
p.G547V | PCPG | 1 |
p.R655Q | ESCA | 1 |
p.R597H | UCEC | 1 |
p.G553S | STAD | 1 |
p.Q287H | PAAD | 1 |
p.A366V | LGG | 1 |
p.A367G | THYM | 1 |
p.P416L | PCPG | 1 |
p.G242R | THCA | 1 |
p.G652* | UCEC | 1 |
p.S88R | THYM | 1 |
p.D472A | LIHC | 1 |
p.R107W | STAD | 1 |
p.Q371K | LUAD | 1 |
p.R347W | HNSC | 1 |
p.P57L | LGG | 1 |
p.E261D | UVM | 1 |
p.F331L | LUAD | 1 |
p.M364T | KIRP | 1 |
p.R461H | HNSC | 1 |
p.G196S | ESCA | 1 |
p.T104K | LUAD | 1 |
p.T161I | HNSC | 1 |
p.R365C | STAD | 1 |
p.T546M | UVM | 1 |
p.V640A | KIRC | 1 |
p.R434Q | LIHC | 1 |
p.D251N | BLCA | 1 |
p.R347W | PRAD | 1 |
p.T546M | BRCA | 1 |
p.Y253H | LIHC | 1 |
p.T627K | PRAD | 1 |
p.S591Y | BLCA | 1 |
p.E261D | UCEC | 1 |
p.D246H | BLCA | 1 |
p.R374C | CHOL | 1 |
p.V87M | UCEC | 1 |
p.R365C | UCS | 1 |
p.A367G | CESC | 1 |
p.R81W | LIHC | 1 |
p.A137V | READ | 1 |
p.R289C | UCS | 1 |
p.R374C | LUSC | 1 |
p.R374C | KIRP | 1 |
p.R374C | GBM | 1 |
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TissGeneCNV for MST1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MST1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0D2-01A | MST1-SRRD | Out-of-frame | Chr3:49721747 | Chr22:26883995 |
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TissGeneNet for MST1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MST1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MST1 |
TissGeneDrug for MST1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MST1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0024530 | Malaria | 45 | BeFree |
umls:C0009324 | Ulcerative Colitis | 13 | BeFree,CTD_human,GAD,GWASCAT,LHGDN |
umls:C0010346 | Crohn Disease | 12 | BeFree,CTD_human,GAD,GWASCAT |
umls:C0021390 | Inflammatory Bowel Diseases | 8 | BeFree,GAD,GWASCAT |
umls:C0596263 | Carcinogenesis | 8 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 6 | BeFree |
umls:C0600139 | Prostate carcinoma | 6 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 5 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 5 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 5 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 5 | BeFree |
umls:C0302592 | Cervix carcinoma | 5 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree |
umls:C0678222 | Breast Carcinoma | 5 | BeFree |
umls:C0699791 | Stomach Carcinoma | 5 | BeFree |
umls:C1527249 | Colorectal Cancer | 5 | BeFree |
umls:C2239176 | Liver carcinoma | 5 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 4 | BeFree |
umls:C0024535 | Malaria, Falciparum | 4 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 4 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 4 | BeFree |
umls:C0275524 | Coinfection | 4 | BeFree |
umls:C0566602 | Primary sclerosing cholangitis | 4 | BeFree,GWASCAT,ORPHANET |
umls:C0684249 | Carcinoma of lung | 4 | BeFree |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 3 | BeFree |
umls:C0008313 | Cholangitis, Sclerosing | 3 | BeFree,CTD_human,GAD |
umls:C0017636 | Glioblastoma | 3 | BeFree |
umls:C0017638 | Glioma | 3 | BeFree |
umls:C0025202 | melanoma | 3 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree |
umls:C0001418 | Adenocarcinoma | 2 | BeFree |
umls:C0002312 | alpha-Thalassemia | 2 | BeFree |
umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 2 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
umls:C0026769 | Multiple Sclerosis | 2 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 2 | BeFree |
umls:C0085084 | Motor Neuron Disease | 2 | BeFree |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
umls:C0242723 | Parasitemia | 2 | BeFree |
umls:C0949541 | Hurthle Cell Tumor | 2 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 2 | BeFree |
umls:C1456873 | alpha^+^ Thalassemia | 2 | BeFree |
umls:C1458155 | Mammary Neoplasms | 2 | BeFree,LHGDN |
umls:C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 2 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
umls:C0007095 | Carcinoid Tumor | 1 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
umls:C0007193 | Cardiomyopathy, Dilated | 1 | BeFree |
umls:C0011065 | Cessation of life | 1 | LHGDN |
umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | BeFree |
umls:C0014175 | Endometriosis | 1 | BeFree,LHGDN |
umls:C0019360 | Herpes zoster disease | 1 | BeFree |
umls:C0020455 | Hypergammaglobulinemia | 1 | BeFree |
umls:C0021053 | Immune System Diseases | 1 | BeFree |
umls:C0022104 | Irritable Bowel Syndrome | 1 | BeFree |
umls:C0023267 | Fibroid Tumor | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0026265 | Diseases of mitral valve | 1 | BeFree |
umls:C0026269 | Mitral Valve Stenosis | 1 | BeFree |
umls:C0027051 | Myocardial Infarction | 1 | BeFree |
umls:C0029463 | Osteosarcoma | 1 | BeFree |
umls:C0030354 | Papilloma | 1 | BeFree |
umls:C0031099 | Periodontitis | 1 | BeFree |
umls:C0032897 | Prader-Willi Syndrome | 1 | BeFree |
umls:C0034069 | Pulmonary Fibrosis | 1 | BeFree |
umls:C0036202 | Sarcoidosis | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | BeFree |
umls:C0037054 | Sickle Cell Trait | 1 | BeFree |
umls:C0039483 | Giant Cell Arteritis | 1 | BeFree |
umls:C0039614 | Tetanus | 1 | BeFree |
umls:C0039984 | Thoracic Outlet Syndrome | 1 | BeFree |
umls:C0040136 | Thyroid Neoplasm | 1 | BeFree |
umls:C0042133 | Uterine Fibroids | 1 | BeFree |
umls:C0042769 | Virus Diseases | 1 | BeFree |
umls:C0042798 | Low Vision | 1 | BeFree |
umls:C0042961 | Intestinal Volvulus | 1 | BeFree |
umls:C0149782 | Squamous cell carcinoma of lung | 1 | BeFree |
umls:C0162557 | Liver Failure, Acute | 1 | BeFree |
umls:C0162565 | Acute intermittent porphyria | 1 | BeFree |
umls:C0162635 | Angelman Syndrome | 1 | BeFree |
umls:C0206062 | Lung Diseases, Interstitial | 1 | BeFree |
umls:C0206623 | Adenosquamous carcinoma | 1 | BeFree |
umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
umls:C0206754 | Neuroendocrine Tumors | 1 | BeFree |
umls:C0238463 | Papillary thyroid carcinoma | 1 | BeFree |
umls:C0275522 | Asymptomatic Infections | 1 | BeFree |
umls:C0278488 | Carcinoma breast stage IV | 1 | BeFree |
umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
umls:C0398686 | Primary immune deficiency disorder | 1 | BeFree |
umls:C0472762 | Alpha trait thalassemia | 1 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
umls:C0483368 | Human anaplasmosis due to Anaplasma phagocytophilum | 1 | BeFree |
umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
umls:C0585362 | Squamous cell carcinoma of mouth | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
umls:C0677948 | Stage II Colorectal Cancer | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0740380 | Varicella zoster | 1 | BeFree |
umls:C0878544 | Cardiomyopathies | 1 | BeFree |
umls:C1261473 | Sarcoma | 1 | BeFree |
umls:C1378050 | Oncocytic Neoplasm | 1 | BeFree |
umls:C1510502 | Oxyphilic Adenoma | 1 | BeFree |
umls:C1562061 | Microspherophakia | 1 | BeFree |
umls:C1621958 | Glioblastoma Multiforme | 1 | BeFree |
umls:C1800706 | Idiopathic Pulmonary Fibrosis | 1 | BeFree |
umls:C1840264 | IMMUNE SUPPRESSION | 1 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
umls:C2609129 | Autoimmune pancreatitis | 1 | BeFree |
umls:C2939465 | Deficiency of glucose-6-phosphate dehydrogenase | 1 | BeFree |
umls:C3146252 | Stage II Colorectal Cancer AJCC v7 | 1 | BeFree |
umls:C3826128 | Infection in children | 1 | BeFree |