TissGeneSummary for KPRP |
Gene summary |
Basic gene information | Gene symbol | KPRP |
Gene name | keratinocyte proline-rich protein | |
Synonyms | C1orf45 | |
Cytomap | UCSC genome browser: 1q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001025231.1, | |
Description | hKPRPkeratinocyte expressed, proline-rich protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 613260 | |
HGNC : HGNC | ||
Ensembl : ENSG00000203786 | ||
Vega : OTTHUMG00000012402 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KPRP | |
BioGPS: 448834 | ||
Pathway | NCI Pathway Interaction Database: KPRP | |
KEGG: KPRP | ||
REACTOME: KPRP | ||
Pathway Commons: KPRP | ||
Context | iHOP: KPRP | |
ligand binding site mutation search in PubMed: KPRP | ||
UCL Cancer Institute: KPRP | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of KPRP | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KPRP |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.745488353 | -1.433286156 | 3.17877451 | 2.28E-10 | 8.29E-10 |
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TissGene-miRNA for KPRP |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KPRP |
TissGeneSNV for KPRP |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S330F | SKCM | 3 |
p.P478T | ACC | 2 |
p.P384L | SKCM | 2 |
p.P344L | SKCM | 2 |
p.E134X | COAD | 1 |
p.P212S | LUSC | 1 |
p.R222L | LUAD | 1 |
p.W363* | LUAD | 1 |
p.V128D | STAD | 1 |
p.E123G | LGG | 1 |
p.R248C | GBM | 1 |
p.P229S | SKCM | 1 |
p.A99E | LUAD | 1 |
p.E42K | BLCA | 1 |
p.I350M | LUAD | 1 |
p.Q44K | LUAD | 1 |
p.G192D | BRCA | 1 |
p.G453W | PRAD | 1 |
p.P257L | HNSC | 1 |
p.R326Q | UCEC | 1 |
p.E553D | UCEC | 1 |
p.Q341H | LUAD | 1 |
p.G514C | STAD | 1 |
p.A63T | GBM | 1 |
p.P359S | OV | 1 |
p.F579V | BLCA | 1 |
p.R222Q | GBM | 1 |
p.P161S | SKCM | 1 |
p.A365T | PRAD | 1 |
p.V150G | LUAD | 1 |
p.T91I | SKCM | 1 |
p.A574T | LUAD | 1 |
p.E493K | SKCM | 1 |
p.Y153D | GBM | 1 |
p.R274C | UCEC | 1 |
p.P508T | UCS | 1 |
p.R261L | LUAD | 1 |
p.Q6R | SKCM | 1 |
p.R260Q | KIRP | 1 |
p.R425Q | SKCM | 1 |
p.G176E | SKCM | 1 |
p.P528S | SKCM | 1 |
p.V154A | UCEC | 1 |
p.Q160* | BLCA | 1 |
p.Q103* | LUAD | 1 |
p.E573G | STAD | 1 |
p.R554Q | OV | 1 |
p.C391R | LUAD | 1 |
p.G364V | STAD | 1 |
p.D562Y | OV | 1 |
p.P266S | PRAD | 1 |
p.R409H | READ | 1 |
p.S518C | SKCM | 1 |
p.S534I | GBM | 1 |
p.G192S | SKCM | 1 |
p.Q71H | READ | 1 |
p.R177K | SKCM | 1 |
p.Q209* | SKCM | 1 |
p.E42X | ESCA | 1 |
p.R386W | BLCA | 1 |
p.G358A | LUAD | 1 |
p.S125L | SKCM | 1 |
p.L283M | LUAD | 1 |
p.V374I | BRCA | 1 |
p.Q235X | DLBC | 1 |
p.T244N | HNSC | 1 |
p.R254K | SKCM | 1 |
p.S105P | BLCA | 1 |
p.C201W | BLCA | 1 |
p.R168H | COAD | 1 |
p.R261Q | SKCM | 1 |
p.R405C | STAD | 1 |
p.E471K | BLCA | 1 |
p.R308H | READ | 1 |
p.G572V | LUAD | 1 |
p.I457T | LUAD | 1 |
p.E328K | SKCM | 1 |
p.P257L | LUAD | 1 |
p.Q121H | LUAD | 1 |
p.R425* | UCS | 1 |
p.R352C | PRAD | 1 |
p.R405H | SARC | 1 |
p.C413S | COAD | 1 |
p.E526K | COAD | 1 |
p.R555K | TGCT | 1 |
p.Q397H | LGG | 1 |
p.E123K | HNSC | 1 |
p.G96C | LUSC | 1 |
p.S115F | SKCM | 1 |
p.P480S | SKCM | 1 |
p.R312C | DLBC | 1 |
p.R312C | UCEC | 1 |
p.A527G | DLBC | 1 |
p.C255* | KIRC | 1 |
p.R267C | LUAD | 1 |
p.E289* | SKCM | 1 |
p.R10H | PAAD | 1 |
p.S102Y | BLCA | 1 |
p.Q181K | LUAD | 1 |
p.Y282* | LUAD | 1 |
p.G544D | KIRP | 1 |
p.S576I | READ | 1 |
p.R312C | STAD | 1 |
p.Q185K | UCEC | 1 |
p.R321H | UCEC | 1 |
p.F579L | LAML | 1 |
p.R222W | COAD | 1 |
p.C148F | LUAD | 1 |
p.E517K | BLCA | 1 |
p.R475* | STAD | 1 |
p.A50V | UCEC | 1 |
p.282_283YL>*M | LUAD | 1 |
p.S497C | LUAD | 1 |
p.N152I | HNSC | 1 |
p.C113* | LUAD | 1 |
p.R496C | UCEC | 1 |
p.P29H | LIHC | 1 |
p.R267H | UCEC | 1 |
p.L513P | COAD | 1 |
p.P29L | HNSC | 1 |
p.A31T | OV | 1 |
p.P349S | SKCM | 1 |
p.A85V | UCEC | 1 |
p.A365T | LGG | 1 |
p.E540K | SKCM | 1 |
p.A574E | BRCA | 1 |
p.E540D | BLCA | 1 |
p.S576N | OV | 1 |
p.R445Q | PRAD | 1 |
p.R407H | COAD | 1 |
p.K95E | SKCM | 1 |
p.C255X | KIRC | 1 |
p.S105F | SKCM | 1 |
p.P462L | SKCM | 1 |
p.R496H | GBM | 1 |
p.R10C | OV | 1 |
p.E276D | LUSC | 1 |
p.C455S | HNSC | 1 |
p.R224Q | UCEC | 1 |
p.R312H | LGG | 1 |
p.R554P | LIHC | 1 |
p.R425X | UCS | 1 |
p.R387H | COAD | 1 |
p.Q75R | LIHC | 1 |
p.S213F | SKCM | 1 |
p.P349L | SKCM | 1 |
p.G20S | SKCM | 1 |
p.E116D | LUSC | 1 |
p.P40S | SKCM | 1 |
p.Q220* | HNSC | 1 |
p.R451L | LIHC | 1 |
p.R274C | UCS | 1 |
p.R475X | STAD | 1 |
p.S190G | ESCA | 1 |
p.P510Q | LUAD | 1 |
p.R445W | PAAD | 1 |
p.Q80L | LUAD | 1 |
p.D524G | ESCA | 1 |
p.Y240N | LIHC | 1 |
p.D389H | HNSC | 1 |
p.M1V | LUSC | 1 |
p.S366F | SKCM | 1 |
p.L388I | STAD | 1 |
p.Q62H | ESCA | 1 |
p.R387H | STAD | 1 |
p.Q14E | BLCA | 1 |
p.R250W | LIHC | 1 |
p.R326Q | SKCM | 1 |
p.C455Y | LUAD | 1 |
p.S105Y | UCEC | 1 |
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TissGeneCNV for KPRP |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KPRP |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KPRP |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KPRP |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KPRP |
TissGeneDrug for KPRP |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KPRP |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1832097 | EPIDERMAL DIFFERENTIATION COMPLEX | 1 | BeFree |