TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MT1G
check button Gene summary
Basic gene informationGene symbolMT1G
Gene namemetallothionein 1G
SynonymsMT1|MT1K
CytomapUCSC genome browser: 16q13
Type of geneprotein-coding
RefGenesNM_001301267.1,
NM_005950.2,
DescriptionMT-1GMT-1KMT-IGmetallothionein 1Kmetallothionein-1Gmetallothionein-1Kmetallothionein-IG
Modification date20141207
dbXrefs MIM : 156353
HGNC : HGNC
Ensembl : ENSG00000125144
HPRD : 11827
Vega : OTTHUMG00000133275
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MT1G
BioGPS: 4495
PathwayNCI Pathway Interaction Database: MT1G
KEGG: MT1G
REACTOME: MT1G
Pathway Commons: MT1G
ContextiHOP: MT1G
ligand binding site mutation search in PubMed: MT1G
UCL Cancer Institute: MT1G
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of MT1G
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0045926negative regulation of growth18332874
GO:0071294cellular response to zinc ion7559655
GO:0045926negative regulation of growth18332874
GO:0071294cellular response to zinc ion7559655


Top
TissGeneExp for MT1G

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRP-2.2403650745.507006801-7.7473718751.00E-217.73E-20
LIHC0.4956279267.639159926-7.1435329.01E-226.90E-20
KIRC-0.671558134.502876593-5.1744347228.03E-216.82E-20
THCA1.4755234855.647020095-4.171496615.16E-124.08E-11
KICH-2.6857060744.754065926-7.4397721.35E-153.10E-14
COAD1.3165022344.853263772-3.5367615381.12E-091.24E-08
ESCA0.5008826534.039982653-3.53910.003610.032373548
HNSC-1.22695519-0.213594725-1.0133604650.003250.0093991


Top
TissGene-miRNA for MT1G

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for MT1G
TissGeneSNV for MT1G

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.V39LCESC2
p.E23KCESC2
p.K56RKIRC1
p.S17GCESC1
p.A9TESCA1
p.A16SLUAD1
p.A16TSTAD1
p.S54LSTAD1
p.A42VTHYM1
p.K22RTHYM1


Top
TissGeneCNV for MT1G

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for MT1G

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAX13227MT1G-DAOchr16:56701975chr12:109273885
Chimerdb3.0FusionScanUCECTCGA-BK-A4ZD-01AMT1G-MT3In-Framechr16:56701877chr16:56624751


Top
TissGeneNet for MT1G

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
MT1G, SHBG, SPINK7 (tumor)MT1G, SHBG, SPINK7 (normal)
bullet pointbullet point


Top
TissGeneProg for MT1G

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for MT1G
TissGeneDrug for MT1G

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for MT1G

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C2239176Liver carcinoma6BeFree
umls:C0007134Renal Cell Carcinoma4BeFree,LHGDN
umls:C0339573Glaucoma, Primary Open Angle4BeFree
umls:C0376358Malignant neoplasm of prostate4BeFree
umls:C0596263Carcinogenesis4BeFree
umls:C0600139Prostate carcinoma4BeFree
umls:C0238463Papillary thyroid carcinoma3BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0206624Hepatoblastoma2BeFree
umls:C0242379Malignant neoplasm of lung2BeFree
umls:C0684249Carcinoma of lung2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C0007115Malignant neoplasm of thyroid1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0014859Esophageal Neoplasms1CTD_human
umls:C0022336Creutzfeldt-Jakob disease1BeFree
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0023487Acute Promyelocytic Leukemia1BeFree
umls:C0029456Osteoporosis1BeFree
umls:C0040136Thyroid Neoplasm1LHGDN
umls:C0410702Adolescent idiopathic scoliosis1BeFree
umls:C0549473Thyroid carcinoma1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C1862939AMYOTROPHIC LATERAL SCLEROSIS 11BeFree
umls:C3714542Lymphoma, Diffuse1BeFree