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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MT1H
check button Gene summary
Basic gene informationGene symbolMT1H
Gene namemetallothionein 1H
SynonymsMT-0|MT-1H|MT-IH|MT1
CytomapUCSC genome browser: 16q13
Type of geneprotein-coding
RefGenesNM_005951.2,
Descriptionmetallothionein-0metallothionein-1Hmetallothionein-IH
Modification date20141207
dbXrefs MIM : 156354
HGNC : HGNC
Ensembl : ENSG00000205358
HPRD : 01128
Vega : OTTHUMG00000133283
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MT1H
BioGPS: 4496
PathwayNCI Pathway Interaction Database: MT1H
KEGG: MT1H
REACTOME: MT1H
Pathway Commons: MT1H
ContextiHOP: MT1H
ligand binding site mutation search in PubMed: MT1H
UCL Cancer Institute: MT1H
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LiverEye
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHCUVM
Reference showing the relevant tissue of MT1H
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for MT1H

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUAD-1.152489176-2.7959771071.6434879311.45E-075.54E-07
LIHC-1.0237577286.961830272-7.9855882.40E-255.33E-23
LUSC-0.899746512-2.4672563161.5675098041.86E-054.13E-05
KIRC-1.4173148944.369319828-5.7866347224.01E-234.08E-22
KICH-2.7510817284.700514272-7.4515962.29E-143.80E-13
KIRP-2.4248763535.370420522-7.7952968753.98E-202.62E-18
THCA0.6580142724.842719357-4.1847050852.62E-122.15E-11
COAD0.2457950424.406733503-4.1609384621.30E-091.42E-08
BLCA-1.746238359-3.4033699381.6571315790.000860.006230098


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TissGene-miRNA for MT1H

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for MT1H
TissGeneSNV for MT1H

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E8KBLCA2
p.K23RKIRC1
p.K31EESCA1
p.S28FSKCM1
p.A14TCESC1
p.P3LSKCM1
p.C13RHNSC1
p.A53GLUAD1
p.S32RPAAD1
p.C48FKIRC1
p.G11VCESC1
p.S32CLUAD1
p.P38TCESC1


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TissGeneCNV for MT1H

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for MT1H

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for MT1H

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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COAD (tumor)COAD (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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HNSC (tumor)HNSC (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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KICH (tumor)KICH (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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KIRC (tumor)KIRC (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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KIRP (tumor)KIRP (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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LIHC (tumor)LIHC (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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LUAD (tumor)LUAD (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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LUSC (tumor)LUSC (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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PRAD (tumor)PRAD (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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STAD (tumor)STAD (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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THCA (tumor)THCA (normal)
MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (tumor)MT1H, HNF4A, NFYA, HNF1A, DNAJC1, SPINK7 (normal)
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TissGeneProg for MT1H

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for MT1H
TissGeneDrug for MT1H

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for MT1H

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0678222Breast Carcinoma5BeFree
umls:C0339573Glaucoma, Primary Open Angle4BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C0005684Malignant neoplasm of urinary bladder1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0022336Creutzfeldt-Jakob disease1BeFree
umls:C0041848Unspecified idiopathic peripheral neuropathy1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma1BeFree
umls:C0345904Malignant neoplasm of liver1BeFree
umls:C0410702Adolescent idiopathic scoliosis1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C1862939AMYOTROPHIC LATERAL SCLEROSIS 11BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C3714542Lymphoma, Diffuse1BeFree