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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MUC1
check button Gene summary
Basic gene informationGene symbolMUC1
Gene namemucin 1, cell surface associated
SynonymsADMCKD|ADMCKD1|CA 15-3|CD227|EMA|H23AG|KL-6|MAM6|MCD|MCKD|MCKD1|MUC-1|MUC-1/SEC|MUC-1/X|MUC1/ZD|PEM|PEMT|PUM
CytomapUCSC genome browser: 1q21
Type of geneprotein-coding
RefGenesNM_001018016.2,
NM_001018017.2,NM_001044390.2,NM_001044391.2,NM_001044392.2,
NM_001044393.2,NM_001204285.1,NM_001204286.1,NM_001204287.1,
NM_001204288.1,NM_001204289.1,NM_001204290.1,NM_001204291.1,
NM_001204292.1,NM_001204293.1,NM_001204294.1,NM_001204295.1,
NM_001204296.1,NM_001204297.1,NM_002456.5,NM_001018021.1,
NM_182741.1,
DescriptionDF3 antigenH23 antigenMedullary cystic kidney disease, autosomal dominantbreast carcinoma-associated antigen DF3cancer antigen 15-3carcinoma-associated mucinepisialinkrebs von den Lungen-6mucin 1, transmembranemucin-1peanut-reactive urinary muci
Modification date20141222
dbXrefs MIM : 158340
HGNC : HGNC
Ensembl : ENSG00000185499
HPRD : 01152
Vega : OTTHUMG00000035681
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MUC1
BioGPS: 4582
PathwayNCI Pathway Interaction Database: MUC1
KEGG: MUC1
REACTOME: MUC1
Pathway Commons: MUC1
ContextiHOP: MUC1
ligand binding site mutation search in PubMed: MUC1
UCL Cancer Institute: MUC1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Stomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)STAD
Reference showing the relevant tissue of MUC1
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest15710329
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator15710329
GO:0010944negative regulation of transcription by competitive promoter binding15710329
GO:0036003positive regulation of transcription from RNA polymerase II promoter in response to stress15710329
GO:0043618regulation of transcription from RNA polymerase II promoter in response to stress15710329
GO:0090240positive regulation of histone H4 acetylation15710329
GO:1902166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator15710329
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest15710329
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator15710329
GO:0010944negative regulation of transcription by competitive promoter binding15710329
GO:0036003positive regulation of transcription from RNA polymerase II promoter in response to stress15710329
GO:0043618regulation of transcription from RNA polymerase II promoter in response to stress15710329
GO:0090240positive regulation of histone H4 acetylation15710329
GO:1902166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator15710329


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TissGeneExp for MUC1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC0.6255977343.417850511-2.7922527784.97E-224.51E-21
THCA1.522115695-0.3129588811.8350745769.61E-084.19E-07
LUSC1.7302154624.744882129-3.0146666674.19E-163.00E-15
KIRP0.6583890533.679814053-3.0214254.96E-062.18E-05
BRCA4.0277923971.2482897662.7795026321.59E-221.36E-21
HNSC0.8276337481.88402212-1.0563883720.01940.043303571
COAD1.5462508322.830289293-1.2840384620.002630.006779212


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TissGene-miRNA for MUC1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for MUC1
TissGeneSNV for MUC1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P143ATHYM3
p.T112PPAAD3
p.P418LSKCM2
p.T112PLGG2
p.V242ILIHC1
p.E167XREAD1
p.G95RSKCM1
p.N263HUCEC1
p.G67SLGG1
p.G314DSTAD1
p.S357*BLCA1
p.P418SSKCM1
p.T112PSTAD1
p.G42RSKCM1
p.V166ILGG1
p.L117PTHYM1
p.N69SBRCA1
p.P66LSKCM1
p.S88*BLCA1
p.D211YLUAD1
p.S126RSTAD1
p.G180DSTAD1
p.V193GLUAD1
p.P40QESCA1
p.P102SSKCM1
p.L118FSKCM1
p.F306IPAAD1
p.D336YLUAD1
p.T112PPRAD1
p.S149LDLBC1
p.F315IPAAD1
p.P102LSKCM1
p.P102LSTAD1
p.T112PBLCA1
p.T112PTGCT1
p.G34DCOAD1
p.P143ACHOL1
p.Q74ECESC1
p.S55NUCEC1
p.V359ILGG1
p.T31RCOAD1
p.L245VCESC1
p.A20DUCEC1
p.V157FBRCA1
p.C63YBLCA1
p.Q242KSARC1
p.S47RMESO1
p.G33RSKCM1
p.V251ILIHC1


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TissGeneCNV for MUC1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for MUC1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABF759082MUC1-MUC1chr1:155160832chr1:155160884
Chimerdb3.0ChiTaRsNAAW391727MUC1-LGALS4chr1:155162614chr19:39292986
Chimerdb3.0ChiTaRsNAAA847094MUC1-MUC1chr1:155160534chr1:155160771
Chimerdb3.0ChiTaRsNAAI675977HCN3-MUC1chr1:155259558chr1:155159684
Chimerdb3.0FusionScanUCSTCGA-N9-A4Q7-01ADPM3-MUC15'UTR-CDSchr1:155112966chr1:155158685
TCGAfusionPortalPRADALUADTCGA-44-6776-01AMUC1-SIAE3UTR-5UTRChr1:155158302Chr11:124543777
TCGAfusionPortalPRADALUADTCGA-91-A4BD-01AMUC1-PKLRIn-frameChr1:155161974Chr1:155263381


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TissGeneNet for MUC1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
MUC1, LCK, ZAP70, ERBB4, ERBB2, SCN9A, SRC, ESR1, IKBKB, CTNNB1, LYN, GATA3, GALNT10, CTNND1, SOS1, JUP, ERBB3, PRKCD, SIGLEC1, GALNT12, GALNT4 (tumor)MUC1, ERBB4, SP1, GRB2, ERBB2, TNFRSF1A, JUN, SRC, ESR1, STAT3, IKBKB, LGALS3, GATA3, GALNT10, EGFR, SOS1, JUP, ERBB3, PRKCD, GALNT4, GALNT2 (normal)
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COAD (tumor)COAD (normal)
MUC1, LCK, ZAP70, APC, SP1, JUN, SRC, ESR1, STAT3, LYN, STAT1, GATA3, GALNT10, CTNND1, EGFR, JUP, SIGLEC1, GALNT12, GALNT4, GALNT2, GALNT1 (tumor)MUC1, LCK, APC, SP1, IKBKG, TNFRSF1A, JUN, SCN9A, SRC, STAT3, IKBKB, CTNNB1, LYN, LGALS3, STAT1, GSK3B, SOS1, OSGEP, ERBB3, GALNT12, GALNT1 (normal)
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HNSC (tumor)HNSC (normal)
MUC1, ZAP70, SP1, ERBB2, SCN9A, SRC, CTNNB1, LYN, LGALS3, GATA3, GALNT10, CTNND1, EGFR, SOS1, OSGEP, ERBB3, PRKCD, GALNT12, GALNT4, GALNT2, GALNT1 (tumor)MUC1, LCK, ZAP70, ERBB2, SCN9A, SRC, STAT3, IKBKB, CTNNB1, LYN, LGALS3, STAT1, GALNT10, EGFR, ABL1, OSGEP, ERBB3, PRKCD, GALNT12, GALNT4, GALNT2 (normal)
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KICH (tumor)KICH (normal)
MUC1, ERBB4, APC, SP1, GRB2, ERBB2, IKBKG, JUN, SRC, STAT3, CTNNB1, STAT1, GSK3B, CTNND1, EGFR, ABL1, SOS1, JUP, OSGEP, PRKCD, GALNT4 (tumor)MUC1, ZAP70, APC, GRB2, ERBB2, TNFRSF1A, SCN9A, CTNNB1, LGALS3, STAT1, GATA3, GALNT10, CTNND1, SOS1, JUP, ERBB3, PRKCD, SIGLEC1, GALNT4, GALNT2, GALNT1 (normal)
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KIRC (tumor)KIRC (normal)
MUC1, LCK, ZAP70, APC, GRB2, ERBB2, SCN9A, SRC, ESR1, STAT3, IKBKB, LYN, STAT1, GATA3, GALNT10, SOS1, JUP, ERBB3, PRKCD, SIGLEC1, GALNT12 (tumor)MUC1, ERBB4, APC, IKBKG, TNFRSF1A, JUN, SCN9A, SRC, CTNNB1, LYN, LGALS3, GATA3, TNF, CTNND1, ABL1, SOS1, JUP, PRKCD, GALNT12, GALNT4, GALNT2 (normal)
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KIRP (tumor)KIRP (normal)
MUC1, LCK, APC, ERBB2, IKBKG, SCN9A, SRC, ESR1, STAT3, IKBKB, CTNNB1, LYN, LGALS3, STAT1, GATA3, CTNND1, SOS1, JUP, ERBB3, PRKCD, GALNT2 (tumor)MUC1, LCK, ZAP70, ERBB4, APC, SP1, GRB2, ERBB2, TNFRSF1A, JUN, SCN9A, ESR1, STAT3, LYN, LGALS3, GATA3, GALNT10, TNF, CTNND1, JUP, GALNT12 (normal)
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LIHC (tumor)LIHC (normal)
MUC1, ZAP70, ERBB4, APC, GRB2, ERBB2, TNFRSF1A, SRC, ESR1, LGALS3, GSK3B, GATA3, TNF, EGFR, ABL1, SOS1, JUP, PRKCD, SIGLEC1, GALNT12, GALNT4 (tumor)MUC1, LCK, ZAP70, ERBB4, SP1, SRC, ESR1, STAT3, IKBKB, CTNNB1, LYN, LGALS3, STAT1, GSK3B, GATA3, GALNT10, TNF, PRKCD, SIGLEC1, GALNT12, GALNT4 (normal)
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LUAD (tumor)LUAD (normal)
MUC1, ERBB4, GRB2, IKBKG, SCN9A, SRC, ESR1, STAT3, IKBKB, LYN, LGALS3, GSK3B, GATA3, GALNT10, CTNND1, ERBB3, PRKCD, SIGLEC1, GALNT12, GALNT2, GALNT1 (tumor)MUC1, LCK, ERBB4, ERBB2, TNFRSF1A, JUN, ESR1, STAT3, IKBKB, LGALS3, STAT1, GSK3B, GATA3, GALNT10, CTNND1, SOS1, JUP, ERBB3, PRKCD, GALNT12, GALNT2 (normal)
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LUSC (tumor)LUSC (normal)
MUC1, LCK, ZAP70, ERBB4, GRB2, ERBB2, JUN, SCN9A, SRC, STAT3, IKBKB, STAT1, GALNT10, EGFR, JUP, ERBB3, PRKCD, GALNT12, GALNT4, GALNT2, GALNT1 (tumor)MUC1, ZAP70, ERBB4, APC, ERBB2, TNFRSF1A, JUN, SCN9A, ESR1, STAT3, CTNNB1, LYN, LGALS3, GATA3, GALNT10, TNF, ERBB3, PRKCD, SIGLEC1, GALNT4, GALNT2 (normal)
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PRAD (tumor)PRAD (normal)
MUC1, ERBB4, APC, SP1, ERBB2, TNFRSF1A, JUN, SRC, ESR1, IKBKB, CTNNB1, LYN, LGALS3, GATA3, TNF, CTNND1, ABL1, JUP, SIGLEC1, GALNT12, GALNT2 (tumor)MUC1, LCK, ZAP70, GRB2, IKBKG, TNFRSF1A, SCN9A, ESR1, STAT3, IKBKB, LYN, LGALS3, STAT1, GATA3, TNF, ABL1, JUP, OSGEP, SIGLEC1, GALNT12, GALNT2 (normal)
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STAD (tumor)STAD (normal)
MUC1, LCK, ZAP70, APC, ERBB2, SCN9A, SRC, STAT3, CTNNB1, LYN, LGALS3, GSK3B, GATA3, EGFR, ABL1, SOS1, JUP, ERBB3, PRKCD, GALNT12, GALNT4 (tumor)MUC1, APC, SP1, ERBB2, TNFRSF1A, SCN9A, SRC, STAT3, IKBKB, CTNNB1, LYN, LGALS3, GALNT10, TNF, CTNND1, ABL1, SOS1, ERBB3, PRKCD, GALNT12, GALNT4 (normal)
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THCA (tumor)THCA (normal)
MUC1, LCK, ZAP70, ERBB4, APC, SP1, GRB2, IKBKG, TNFRSF1A, ESR1, LYN, LGALS3, STAT1, GSK3B, GALNT10, TNF, CTNND1, EGFR, ERBB3, SIGLEC1, GALNT12 (tumor)MUC1, LCK, ZAP70, ERBB4, APC, ERBB2, TNFRSF1A, SCN9A, SRC, STAT3, LYN, LGALS3, STAT1, GATA3, GALNT10, TNF, JUP, OSGEP, ERBB3, SIGLEC1, GALNT12 (normal)
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TissGeneProg for MUC1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for MUC1
TissGeneDrug for MUC1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for MUC1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0678222Breast Carcinoma132BeFree
umls:C0006142Malignant neoplasm of breast128BeFree,GAD
umls:C0027627Neoplasm Metastasis60BeFree,LHGDN
umls:C0001418Adenocarcinoma50BeFree,LHGDN
umls:C0699791Stomach Carcinoma42BeFree
umls:C1458155Mammary Neoplasms37BeFree,LHGDN
umls:C0024623Malignant neoplasm of stomach36BeFree,GWASCAT
umls:C0235974Pancreatic carcinoma35BeFree
umls:C0346647Malignant neoplasm of pancreas32BeFree
umls:C0029925Ovarian Carcinoma22BeFree
umls:C0596263Carcinogenesis21BeFree
umls:C0178874Tumor Progression20BeFree
umls:C1140680Malignant neoplasm of ovary18BeFree,GAD
umls:C0007131Non-Small Cell Lung Carcinoma17BeFree
umls:C0030297Pancreatic Neoplasm15BeFree,LHGDN
umls:C0376358Malignant neoplasm of prostate14BeFree,GAD
umls:C0600139Prostate carcinoma14BeFree
umls:C0699790Colon Carcinoma14BeFree
umls:C0686619Secondary malignant neoplasm of lymph node12BeFree
umls:C1368683Epithelioma12BeFree
umls:C0007137Squamous cell carcinoma11BeFree,LHGDN
umls:C0009402Colorectal Carcinoma11BeFree
umls:C0026764Multiple Myeloma11BeFree,CTD_human,LHGDN
umls:C0242379Malignant neoplasm of lung11BeFree,GAD
umls:C0677886Epithelial ovarian cancer10BeFree,GAD
umls:C0684249Carcinoma of lung10BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma10BeFree
umls:C0007134Renal Cell Carcinoma9BeFree,LHGDN
umls:C1519680Tumor Immunity8BeFree
umls:C1868139Medullary cystic kidney disease 18BeFree,CLINVAR,CTD_human
umls:C0001430Adenoma7BeFree,LHGDN
umls:C0038356Stomach Neoplasms7CTD_human,GAD,LHGDN
umls:C0152013Adenocarcinoma of lung (disorder)7BeFree
umls:C0238463Papillary thyroid carcinoma7BeFree
umls:C0281361Adenocarcinoma of pancreas7BeFree
umls:C0751912Paraneoplastic Encephalomyelitis7BeFree
umls:C0007102Malignant tumor of colon6BeFree
umls:C0022658Kidney Diseases6BeFree
umls:C0687120Nephronophthisis6BeFree
umls:C0699885Carcinoma of bladder6BeFree
umls:C0005684Malignant neoplasm of urinary bladder5BeFree
umls:C0009404Colorectal Neoplasms5BeFree,LHGDN
umls:C0033578Prostatic Neoplasms5BeFree,LHGDN
umls:C0149925Small cell carcinoma of lung5BeFree
umls:C0206698Cholangiocarcinoma5BeFree,LHGDN,RGD
umls:C0546837Malignant neoplasm of esophagus5BeFree,GWASCAT
umls:C0850666Helicobacter pylori infection5BeFree
umls:C0919267ovarian neoplasm5BeFree,LHGDN
umls:C1378703Renal carcinoma5BeFree
umls:C1527249Colorectal Cancer5BeFree
umls:C2239176Liver carcinoma5BeFree,LHGDN
umls:C0013238Dry Eye Syndromes4BeFree,GAD
umls:C0014175Endometriosis4BeFree
umls:C0014859Esophageal Neoplasms4BeFree,LHGDN
umls:C0017152Gastritis4BeFree,GAD,LHGDN
umls:C0020258Hydrocephalus, Normal Pressure4BeFree
umls:C0021390Inflammatory Bowel Diseases4BeFree
umls:C0024299Lymphoma4BeFree
umls:C0025202melanoma4BeFree
umls:C0079731B-Cell Lymphomas4BeFree
umls:C0152018Esophageal carcinoma4BeFree
umls:C0235782Gallbladder Carcinoma4BeFree
umls:C0302592Cervix carcinoma4BeFree
umls:C0345905Intrahepatic Cholangiocarcinoma4BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site4BeFree
umls:C0494165Secondary malignant neoplasm of liver4BeFree
umls:C0878500Intraepithelial Neoplasia4BeFree
umls:C0887833Carcinoma, Pancreatic Ductal4BeFree
umls:C1134719Invasive Ductal Breast Carcinoma4BeFree
umls:C0004096Asthma3BeFree,GAD
umls:C0007115Malignant neoplasm of thyroid3BeFree
umls:C0007124Noninfiltrating Intraductal Carcinoma3BeFree,LHGDN
umls:C0007130Mucinous Adenocarcinoma3BeFree
umls:C0007133Carcinoma, Papillary3BeFree
umls:C0007847Malignant tumor of cervix3BeFree
umls:C0009319Colitis3BeFree
umls:C0009375Colonic Neoplasms3BeFree,LHGDN
umls:C0010674Cystic Fibrosis3BeFree,LHGDN,RGD
umls:C0022661Kidney Failure, Chronic3BeFree
umls:C0023473Myeloid Leukemia, Chronic3BeFree,LHGDN
umls:C0024232Lymphatic Metastasis3BeFree,LHGDN
umls:C0032987Ectopic Pregnancy3BeFree,LHGDN
umls:C0039101synovial sarcoma3BeFree
umls:C0040136Thyroid Neoplasm3BeFree,LHGDN
umls:C0085695Chronic gastritis3BeFree
umls:C0153676Secondary malignant neoplasm of lung3BeFree
umls:C0268113Familial juvenile gout3BeFree
umls:C0314719Dryness of eye3BeFree
umls:C0375023Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site3BeFree
umls:C0549473Thyroid carcinoma3BeFree
umls:C0740277Bile duct carcinoma3BeFree
umls:C0751688Malignant Squamous Cell Neoplasm3BeFree
umls:C1176475Ductal Carcinoma3BeFree
umls:C1855681Nephronophthisis, familial juvenile3BeFree
umls:C2316810Chronic kidney disease stage 53BeFree
umls:C3714514Infection3LHGDN
umls:C0003873Rheumatoid Arthritis2BeFree
umls:C0004623Bacterial Infections2BeFree,LHGDN
umls:C0007107Malignant neoplasm of larynx2BeFree
umls:C0007120Bronchioloalveolar Adenocarcinoma2BeFree,LHGDN
umls:C0009324Ulcerative Colitis2BeFree
umls:C0010346Crohn Disease2BeFree
umls:C0014544Epilepsy2BeFree
umls:C0017154Gastritis, Atrophic2BeFree
umls:C0017168Gastroesophageal reflux disease2BeFree
umls:C0021051Immunologic Deficiency Syndromes2BeFree
umls:C0023418leukemia2BeFree
umls:C0023467Leukemia, Myelocytic, Acute2BeFree
umls:C0025500Mesothelioma2BeFree,CTD_human,LHGDN
umls:C0027721Lipoid nephrosis2BeFree
umls:C0032580Adenomatous Polyposis Coli2BeFree,LHGDN
umls:C0035078Kidney Failure2BeFree
umls:C0035204Respiration Disorders2BeFree
umls:C0035235Respiratory Syncytial Virus Infections2BeFree,GAD
umls:C0035242Respiratory Tract Diseases2BeFree
umls:C0036341Schizophrenia2BeFree
umls:C0079487Helicobacter Infections2BeFree,GAD
umls:C0079744Diffuse Large B-Cell Lymphoma2BeFree
umls:C0085110Severe Combined Immunodeficiency2BeFree
umls:C0151313Sensory neuropathy2BeFree
umls:C0206061Pneumonia, Interstitial2BeFree
umls:C0206062Lung Diseases, Interstitial2BeFree
umls:C0206692Carcinoma, Lobular2BeFree,LHGDN
umls:C0206694Mucoepidermoid Carcinoma2BeFree,LHGDN
umls:C0278488Carcinoma breast stage IV2BeFree
umls:C0278601Inflammatory Breast Carcinoma2BeFree
umls:C0278701Gastric Adenocarcinoma2BeFree
umls:C0279626Squamous cell carcinoma of esophagus2BeFree
umls:C0279628Adenocarcinoma Of Esophagus2BeFree
umls:C0334037Intestinal metaplasia2GAD
umls:C0376545Hematologic Neoplasms2BeFree
umls:C0476089Endometrial Carcinoma2BeFree,GAD
umls:C0524910Hepatitis C, Chronic2BeFree
umls:C0595989Carcinoma of larynx2BeFree
umls:C0677932Progressive Neoplastic Disease2BeFree
umls:C0740457Malignant neoplasm of kidney2BeFree
umls:C0812413Malignant Pleural Mesothelioma2BeFree
umls:C1135868Gestational Trophoblastic Neoplasms2BeFree
umls:C1266044Collecting Duct Carcinoma of the Kidney2BeFree
umls:C1301034Pancreatic intraepithelial neoplasia2BeFree
umls:C1319315Adenocarcinoma of large intestine2BeFree
umls:C1334811Mucinous Neoplasm2BeFree
umls:C1559271Non-Malignant Ascites Adverse Event2BeFree
umls:C1704320Glomerulonephritis, Minimal Change2BeFree
umls:C1800706Idiopathic Pulmonary Fibrosis2BeFree,LHGDN
umls:C2919861Medullary cystic kidney disease type 12BeFree
umls:C2939174Medullary cystic disease2BeFree
umls:C3539781Progressive cGVHD2BeFree
umls:C3669246Mammary adenocarcinoma2BeFree
umls:C0002793Anaplasia1BeFree
umls:C0003130Anoxia1LHGDN
umls:C0003850Arteriosclerosis1BeFree
umls:C0003864Arthritis1BeFree
umls:C0004114Astrocytoma1BeFree
umls:C0004153Atherosclerosis1BeFree
umls:C0004565Melanoma, B161BeFree
umls:C0005403Bile Reflux1BeFree
umls:C0005695Bladder Neoplasm1LHGDN
umls:C0006272Bronchiolitis Obliterans1LHGDN
umls:C0006274Bronchiolitis, Viral1GAD
umls:C0007117Basal cell carcinoma1LHGDN
umls:C0007621Neoplastic Cell Transformation1CTD_human
umls:C0008350Cholelithiasis1BeFree
umls:C0008412Choline Deficiency1BeFree
umls:C0009405Hereditary Nonpolyposis Colorectal Neoplasms1LHGDN
umls:C0010692Cystitis1LHGDN
umls:C0011065Cessation of life1LHGDN
umls:C0011570Mental Depression1BeFree
umls:C0011581Depressive disorder1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0011881Diabetic Nephropathy1BeFree
umls:C0012546Diphtheria1BeFree
umls:C0012739Disseminated Intravascular Coagulation1BeFree
umls:C0014145Yolk Sac Tumor1LHGDN
umls:C0015695Fatty Liver1BeFree
umls:C0015934Fetal Growth Retardation1RGD
umls:C0016629Fowlpox1BeFree
umls:C0017416Genital Neoplasms, Female1BeFree
umls:C0019196Hepatitis C1BeFree
umls:C0019348Herpes Simplex Infections1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0021368Inflammation1LHGDN
umls:C0021400Influenza1BeFree
umls:C0021831Intestinal Diseases1BeFree
umls:C0022660Kidney Failure, Acute1BeFree
umls:C0022665Kidney Neoplasm1BeFree
umls:C0023067Laryngitis1LHGDN
umls:C0023493Adult T-Cell Lymphoma/Leukemia1BeFree
umls:C0023903Liver neoplasms1BeFree
umls:C0024117Chronic Obstructive Airway Disease1RGD
umls:C0025521Inborn Errors of Metabolism1BeFree
umls:C0027070Myoepithelioma1BeFree
umls:C0027149Myxoma1BeFree
umls:C0027430Nasal Polyps1BeFree
umls:C0027707Nephritis, Interstitial1BeFree
umls:C0027719Nephrosclerosis1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0028754Obesity1BeFree
umls:C0029882Otitis Media1RGD
umls:C0030354Papilloma1BeFree
umls:C0032227Pleural effusion disorder1BeFree
umls:C0032460Polycystic Ovary Syndrome1BeFree
umls:C0032584polyps1BeFree
umls:C0032927Precancerous Conditions1BeFree
umls:C0034069Pulmonary Fibrosis1BeFree
umls:C0035126Reperfusion Injury1RGD
umls:C0035222Respiratory Distress Syndrome, Adult1BeFree
umls:C0036202Sarcoidosis1BeFree
umls:C0038013Ankylosing spondylitis1BeFree
umls:C0038048Sprains and Strains1LHGDN
umls:C0079773Lymphoma, T-Cell, Cutaneous1BeFree
umls:C0085584Encephalopathies1BeFree
umls:C0086448Ileoanal Pouches1BeFree
umls:C0149516Chronic sinusitis1BeFree
umls:C0149521Pancreatitis, Chronic1BeFree
umls:C0149678Epstein-Barr Virus Infections1BeFree
umls:C0153690Secondary malignant neoplasm of bone1BeFree
umls:C0155765Disease of capillaries1BeFree
umls:C0156344Endometriosis of ovary1BeFree
umls:C0206180Ki-1+ Anaplastic Large Cell Lymphoma1BeFree
umls:C0206663Neuroectodermal Tumor, Primitive1BeFree
umls:C0206696Carcinoma, Signet Ring Cell1BeFree
umls:C0206754Neuroendocrine Tumors1BeFree
umls:C0238461Anaplastic thyroid carcinoma1BeFree
umls:C0242656Disease Progression1LHGDN
umls:C0264490Acute respiratory failure1BeFree
umls:C0268731Renal glomerular disease1BeFree
umls:C0270246Meconium plug syndrome1BeFree
umls:C0278493Breast cancer recurrent1BeFree
umls:C0278883Metastatic melanoma1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0333983Hyperplastic Polyp1BeFree
umls:C0338106Adenocarcinoma of colon1BeFree
umls:C0342257Complications of Diabetes Mellitus1RGD
umls:C0342793Malonic aciduria1BeFree
umls:C0343378Helicobacter-associated gastritis1BeFree
umls:C0345967Malignant mesothelioma1BeFree
umls:C0392707Atopy1GAD
umls:C0400966Non-alcoholic Fatty Liver Disease1BeFree
umls:C0424605Developmental delay (disorder)1BeFree
umls:C0431718Multiple renal cysts1BeFree
umls:C0546982Cystic fibrosis with meconium ileus1BeFree
umls:C0598935Tumor Initiation1BeFree
umls:C0677944Sentinel node (disorder)1BeFree
umls:C0685938Malignant neoplasm of gastrointestinal tract1BeFree
umls:C0694571extranodal lymphoma1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0729233Dissecting aneurysm of the thoracic aorta1BeFree
umls:C0740394Hyperuricemia1BeFree
umls:C0744310gastritis h pylori1BeFree
umls:C0850572Adenomatous polyp of colon1BeFree
umls:C0854776Pancreatic carcinoma non-resectable1BeFree
umls:C0854985Adenocarcinoma of lung, stage I1BeFree
umls:C0936223Metastatic Prostate Carcinoma1BeFree
umls:C0947622Cholecystolithiasis1BeFree
umls:C1145670Respiratory Failure1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1266035Bronchiolo-alveolar carcinoma, mucinous1BeFree
umls:C1266071Intraductal papillary-mucinous adenoma1BeFree
umls:C1274788Atopic keratoconjunctivitis1BeFree
umls:C1290884Inflammatory disorder1BeFree
umls:C1301362Lymphoma, Primary Cutaneous Anaplastic Large Cell1BeFree
umls:C1321547T-cell/histiocyte rich large B-cell lymphoma1BeFree
umls:C1334425Low Grade Malignant Neoplasm1BeFree
umls:C1402294Primary Lesion1BeFree
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1512981Mammary Tumorigenesis1BeFree
umls:C1527336Sjogren's Syndrome1BeFree
umls:C1557335Ocular surface disease1BeFree
umls:C1561643Chronic Kidney Diseases1BeFree
umls:C1565489Renal Insufficiency1BeFree
umls:C1840311Laryngeal cleft1BeFree
umls:C1865349Ethylmalonic encephalopathy1BeFree
umls:C1881236Interstitial Disease1BeFree
umls:C2931618Gestational trophoblastic disease1BeFree
umls:C2939175Meconium ileus1BeFree
umls:C2987191Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type1BeFree
umls:C3241937Nonalcoholic Steatohepatitis1BeFree
umls:C3463897HYDATIDIFORM MOLE, RECURRENT, 11BeFree
umls:C3472608Micropapillary carcinoma1BeFree