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| TissGeneSummary for DRG1 |
 Gene summary |
| Basic gene information | Gene symbol | DRG1 |
| Gene name | developmentally regulated GTP binding protein 1 | |
| Synonyms | NEDD3 | |
| Cytomap | UCSC genome browser: 22q12.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004147.3, | |
| Description | DRG-1NEDD-3developmentally regulated GTP-binding protein 1developmentally-regulated GTP-binding protein 1neural precursor cell expressed developmentally down-regulated protein 3neural precursor cell expressed, developmentally down-regulated 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603952 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000185721 | ||
| HPRD : 16034 | ||
| Vega : OTTHUMG00000030792 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DRG1 | |
| BioGPS: 4733 | ||
| Pathway | NCI Pathway Interaction Database: DRG1 | |
| KEGG: DRG1 | ||
| REACTOME: DRG1 | ||
| Pathway Commons: DRG1 | ||
| Context | iHOP: DRG1 | |
| ligand binding site mutation search in PubMed: DRG1 | ||
| UCL Cancer Institute: DRG1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
| Reference showing the relevant tissue of DRG1 | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for DRG1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for DRG1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for DRG1 |
| TissGeneSNV for DRG1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R34C | BLCA | 1 |
| p.L289V | BLCA | 1 |
| p.Q114R | KIRP | 1 |
| p.A336D | HNSC | 1 |
| p.I244M | BRCA | 1 |
| p.R66Q | UCEC | 1 |
| p.M15I | LGG | 1 |
| p.G300V | THYM | 1 |
| p.D228N | CESC | 1 |
| p.K213N | BRCA | 1 |
| p.V361A | UCS | 1 |
| p.Q348E | LUSC | 1 |
| p.E359D | PRAD | 1 |
| p.I244M | BLCA | 1 |
| p.V234A | UCEC | 1 |
| p.A60V | COAD | 1 |
| p.S174N | THYM | 1 |
| p.E319X | THYM | 1 |
| p.L152M | UCEC | 1 |
| p.G156E | COAD | 1 |
| p.K158N | UCEC | 1 |
| p.V75M | READ | 1 |
| p.R222H | PAAD | 1 |
| p.A202V | UCEC | 1 |
| p.S307F | CESC | 1 |
| p.R275H | COAD | 1 |
| p.T316I | STAD | 1 |
| p.R140Q | UCEC | 1 |
| p.A137V | UCEC | 1 |
| p.I161V | UVM | 1 |
| p.A60S | LIHC | 1 |
| p.R40* | LGG | 1 |
| p.L84M | COAD | 1 |
| p.I106M | BLCA | 1 |
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| TissGeneCNV for DRG1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DRG1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF813460 | TMEM214-DRG1 | chr2:27263240 | chr22:31830006 | |
| Chimerdb3.0 | ChiTaRs | NA | BM150997 | DRG1-DEPDC5 | chr22:31830172 | chr22:32270371 | |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-YL-A8SO-01B | DRG1-DEPDC5 | Out-of-Frame | chr22:31796729 | chr22:32266575 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-33-4532-01A | DRG1-MYO18B | In-Frame | chr22:31799189 | chr22:26317223 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-33-4532-01A | DRG1-MYO18B | In-frame | Chr22:31799190 | Chr22:26317224 |
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| TissGeneNet for DRG1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| COAD (tumor) | COAD (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| KICH (tumor) | KICH (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| STAD (tumor) | STAD (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| THCA (tumor) | THCA (normal) |
| DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor) | DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal) |
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| TissGeneProg for DRG1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DRG1 |
| TissGeneDrug for DRG1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DRG1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027627 | Neoplasm Metastasis | 6 | BeFree,LHGDN |
| umls:C0699790 | Colon Carcinoma | 6 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
| umls:C0600139 | Prostate carcinoma | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 2 | BeFree,LHGDN |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0005695 | Bladder Neoplasm | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0278484 | Malignant neoplasm of colon stage IV | 1 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0282612 | Prostatic Intraepithelial Neoplasias | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
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