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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for DRG1
check button Gene summary
Basic gene informationGene symbolDRG1
Gene namedevelopmentally regulated GTP binding protein 1
SynonymsNEDD3
CytomapUCSC genome browser: 22q12.2
Type of geneprotein-coding
RefGenesNM_004147.3,
DescriptionDRG-1NEDD-3developmentally regulated GTP-binding protein 1developmentally-regulated GTP-binding protein 1neural precursor cell expressed developmentally down-regulated protein 3neural precursor cell expressed, developmentally down-regulated 3
Modification date20141207
dbXrefs MIM : 603952
HGNC : HGNC
Ensembl : ENSG00000185721
HPRD : 16034
Vega : OTTHUMG00000030792
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DRG1
BioGPS: 4733
PathwayNCI Pathway Interaction Database: DRG1
KEGG: DRG1
REACTOME: DRG1
Pathway Commons: DRG1
ContextiHOP: DRG1
ligand binding site mutation search in PubMed: DRG1
UCL Cancer Institute: DRG1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)CervixTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)CESCTGCT
Reference showing the relevant tissue of DRG1
Description by TissGene annotationsCancer gene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for DRG1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for DRG1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for DRG1
TissGeneSNV for DRG1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R34CBLCA1
p.L289VBLCA1
p.Q114RKIRP1
p.A336DHNSC1
p.I244MBRCA1
p.R66QUCEC1
p.M15ILGG1
p.G300VTHYM1
p.D228NCESC1
p.K213NBRCA1
p.V361AUCS1
p.Q348ELUSC1
p.E359DPRAD1
p.I244MBLCA1
p.V234AUCEC1
p.A60VCOAD1
p.S174NTHYM1
p.E319XTHYM1
p.L152MUCEC1
p.G156ECOAD1
p.K158NUCEC1
p.V75MREAD1
p.R222HPAAD1
p.A202VUCEC1
p.S307FCESC1
p.R275HCOAD1
p.T316ISTAD1
p.R140QUCEC1
p.A137VUCEC1
p.I161VUVM1
p.A60SLIHC1
p.R40*LGG1
p.L84MCOAD1
p.I106MBLCA1


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TissGeneCNV for DRG1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for DRG1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABF813460TMEM214-DRG1chr2:27263240chr22:31830006
Chimerdb3.0ChiTaRsNABM150997DRG1-DEPDC5chr22:31830172chr22:32270371
Chimerdb3.0FusionScanPRADTCGA-YL-A8SO-01BDRG1-DEPDC5Out-of-Framechr22:31796729chr22:32266575
Chimerdb3.0TopHat-FusionLUSCTCGA-33-4532-01ADRG1-MYO18BIn-Framechr22:31799189chr22:26317223
TCGAfusionPortalPRADALUSCTCGA-33-4532-01ADRG1-MYO18BIn-frameChr22:31799190Chr22:26317224


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TissGeneNet for DRG1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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COAD (tumor)COAD (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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HNSC (tumor)HNSC (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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KICH (tumor)KICH (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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KIRC (tumor)KIRC (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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KIRP (tumor)KIRP (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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LIHC (tumor)LIHC (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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LUAD (tumor)LUAD (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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LUSC (tumor)LUSC (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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PRAD (tumor)PRAD (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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STAD (tumor)STAD (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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THCA (tumor)THCA (normal)
DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (tumor)DRG1, CUL2, UBC, YWHAZ, SUMO2, KIAA0101, HLA-B, LYL1, HSPA4, SUMO1, HDGF, UBE2I, MCC, CLDN1, FTSJ1, TAL1, BCL2L11, CAPNS1, ZC3H15, RWDD1 (normal)
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TissGeneProg for DRG1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for DRG1
TissGeneDrug for DRG1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for DRG1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0027627Neoplasm Metastasis6BeFree,LHGDN
umls:C0699790Colon Carcinoma6BeFree
umls:C0007102Malignant tumor of colon5BeFree
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C0033578Prostatic Neoplasms2BeFree,LHGDN
umls:C0178874Tumor Progression2BeFree
umls:C0001418Adenocarcinoma1BeFree
umls:C0001430Adenoma1BeFree
umls:C0005695Bladder Neoplasm1BeFree
umls:C0025202melanoma1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0278484Malignant neoplasm of colon stage IV1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0282612Prostatic Intraepithelial Neoplasias1BeFree
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C1458155Mammary Neoplasms1LHGDN
umls:C1519670Tumor Angiogenesis1BeFree