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| TissGeneSummary for NNMT |
 Gene summary |
| Basic gene information | Gene symbol | NNMT |
| Gene name | nicotinamide N-methyltransferase | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 11q23.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006169.2, | |
| Description | - | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600008 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166741 | ||
| HPRD : 02478 | ||
| Vega : OTTHUMG00000168245 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NNMT | |
| BioGPS: 4837 | ||
| Pathway | NCI Pathway Interaction Database: NNMT | |
| KEGG: NNMT | ||
| REACTOME: NNMT | ||
| Pathway Commons: NNMT | ||
| Context | iHOP: NNMT | |
| ligand binding site mutation search in PubMed: NNMT | ||
| UCL Cancer Institute: NNMT | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of NNMT | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for NNMT |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 3.794429305 | -0.890219306 | 4.684648611 | 2.61E-36 | 7.60E-35 |
| LUSC | 0.58833004 | 2.228582982 | -1.640252941 | 4.10E-11 | 1.61E-10 |
| LIHC | 2.116247139 | 5.766593139 | -3.650346 | 4.56E-13 | 1.01E-11 |
| KICH | -2.543216861 | -0.808692861 | -1.734524 | 0.000636 | 0.001424537 |
| KIRP | 1.429493889 | -1.004902986 | 2.434396875 | 0.000177 | 0.000569346 |
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| TissGene-miRNA for NNMT |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for NNMT |
| TissGeneSNV for NNMT |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E233K | UCEC | 3 |
| p.E233K | READ | 2 |
| p.E250K | SKCM | 2 |
| p.R258T | ESCA | 1 |
| p.G119E | SKCM | 1 |
| p.G65D | BLCA | 1 |
| p.S29C | OV | 1 |
| p.G63D | SKCM | 1 |
| p.D19N | SKCM | 1 |
| p.I206L | COAD | 1 |
| p.R18W | CESC | 1 |
| p.L173P | SARC | 1 |
| p.K26R | LUAD | 1 |
| p.Q92X | STAD | 1 |
| p.E128X | SKCM | 1 |
| p.G150R | LGG | 1 |
| p.G150E | SKCM | 1 |
| p.L45I | UCEC | 1 |
| p.E128* | SKCM | 1 |
| p.E22X | READ | 1 |
| p.E80K | SKCM | 1 |
| p.S77F | SKCM | 1 |
| p.P189S | SKCM | 1 |
| p.Y11C | LUAD | 1 |
| p.G217V | LUAD | 1 |
| p.E233K | SKCM | 1 |
| p.L91Q | HNSC | 1 |
| p.P125T | HNSC | 1 |
| p.W97L | LUAD | 1 |
| p.A33T | THYM | 1 |
| p.A257V | PRAD | 1 |
| p.P156L | HNSC | 1 |
| p.G191D | SKCM | 1 |
| p.D85G | SKCM | 1 |
| p.P153S | LUAD | 1 |
| p.R121G | ESCA | 1 |
| p.L139P | UCEC | 1 |
| p.D158H | BLCA | 1 |
| p.W107* | SKCM | 1 |
| p.A247T | COAD | 1 |
| p.D61N | BLCA | 1 |
| p.A198V | UCEC | 1 |
| p.P155L | SKCM | 1 |
| p.Q92* | STAD | 1 |
| p.A198V | STAD | 1 |
| p.G191S | SKCM | 1 |
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| TissGeneCNV for NNMT |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for NNMT |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF913499 | TERF2-NNMT | chr16:69419618 | chr11:114182954 | |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A0B5-11A | ZBTB16-NNMT | In-Frame | chr11:114057760 | chr11:114168672 |
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| TissGeneNet for NNMT |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| COAD (tumor) | COAD (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| HNSC (tumor) | HNSC (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| KICH (tumor) | KICH (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| KIRC (tumor) | KIRC (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| KIRP (tumor) | KIRP (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| LIHC (tumor) | LIHC (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| LUAD (tumor) | LUAD (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| LUSC (tumor) | LUSC (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| PRAD (tumor) | PRAD (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| STAD (tumor) | STAD (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| THCA (tumor) | THCA (normal) |
| NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (tumor) | NNMT, HDAC6, HNF1A, BMF, ATF6, HNF1B (normal) |
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| TissGeneProg for NNMT |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for NNMT |
| TissGeneDrug for NNMT |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00627 | Niacin | Binder | Small molecule | Approved|Investigational|Nutraceutical |
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| TissGeneDisease for NNMT |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0598608 | Hyperhomocysteinemia | 3 | BeFree,GAD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree |
| umls:C0005695 | Bladder Neoplasm | 2 | BeFree,LHGDN |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0018798 | Congenital Heart Defects | 2 | BeFree,GAD |
| umls:C0023449 | Acute lymphocytic leukemia | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0030567 | Parkinson Disease | 2 | BeFree,GAD |
| umls:C0036341 | Schizophrenia | 2 | BeFree |
| umls:C0040136 | Thyroid Neoplasm | 2 | LHGDN |
| umls:C0080178 | Spina Bifida | 2 | BeFree,GAD,LHGDN |
| umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
| umls:C0238463 | Papillary thyroid carcinoma | 2 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 2 | BeFree |
| umls:C0003838 | Arterial Occlusive Diseases | 1 | BeFree |
| umls:C0004096 | Asthma | 1 | GAD |
| umls:C0006111 | Brain Diseases | 1 | GAD |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
| umls:C0007133 | Carcinoma, Papillary | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0030297 | Pancreatic Neoplasm | 1 | BeFree |
| umls:C0030421 | Paraganglioma | 1 | BeFree |
| umls:C0033054 | Prenatal Exposure Delayed Effects | 1 | GAD |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
| umls:C0149931 | Migraine Disorders | 1 | GAD |
| umls:C0151546 | Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0153392 | Malignant neoplasm of nasopharynx | 1 | BeFree |
| umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | GAD |
| umls:C0206682 | Follicular thyroid carcinoma | 1 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0238301 | Cancer of Nasopharynx | 1 | BeFree |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0585362 | Squamous cell carcinoma of mouth | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree,GAD |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
| umls:C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | BeFree |
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