TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for NPM1

Gene summary

Basic gene information	Gene symbol	NPM1
	Gene name	nucleophosmin (nucleolar phosphoprotein B23, numatrin)
	Synonyms	B23\|NPM
	Cytomap	UCSC genome browser: 5q35.1
	Type of gene	protein-coding
	RefGenes	NM_001037738.2, NM_002520.6,NM_199185.3,
	Description	nucleolar protein NO38nucleophosminnucleophosmin/nucleoplasmin family, member 1
	Modification date	20141222
dbXrefs	MIM : 164040
	HGNC : HGNC
	Ensembl : ENSG00000181163
	HPRD : 01246
	Vega : OTTHUMG00000130465
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_NPM1
	BioGPS: 4869
Pathway	NCI Pathway Interaction Database: NPM1
	KEGG: NPM1
	REACTOME: NPM1
	Pathway Commons: NPM1
Context	iHOP: NPM1
	ligand binding site mutation search in PubMed: NPM1
	UCL Cancer Institute: NPM1
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	BladderBone marrowOvary
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	BLCALAMLOV
Reference showing the relevant tissue of NPM1
Description by TissGene annotations	Cancer gene TissgsLTS Fused withOncogene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0006281	DNA repair	19188445
GO:0006334	nucleosome assembly	11602260
GO:0006913	nucleocytoplasmic transport	16041368
GO:0008104	protein localization	18420587
GO:0032071	regulation of endodeoxyribonuclease activity	19188445
GO:0043066	negative regulation of apoptotic process	12882984
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	12882984
GO:0045727	positive regulation of translation	12882984
GO:0051259	protein oligomerization	18809582
GO:0060699	regulation of endoribonuclease activity	19188445
GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA	12882984
GO:0006281	DNA repair	19188445
GO:0006334	nucleosome assembly	11602260
GO:0006913	nucleocytoplasmic transport	16041368
GO:0008104	protein localization	18420587
GO:0032071	regulation of endodeoxyribonuclease activity	19188445
GO:0043066	negative regulation of apoptotic process	12882984
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	12882984
GO:0045727	positive regulation of translation	12882984
GO:0051259	protein oligomerization	18809582
GO:0060699	regulation of endoribonuclease activity	19188445
GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA	12882984

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TissGeneExp for NPM1

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
COAD	2.050087496	1.029495189	1.020592308	1.74E-13	5.61E-12

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TissGene-miRNA for NPM1

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for NPM1

TissGeneSNV for NPM1

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.K27N	COAD	1
p.E185K	CESC	1
p.D213N	LUAD	1
p.V99A	UCEC	1
p.I196V	COAD	1
p.S106L	SKCM	1
p.Q281E	SKCM	1
p.I284V	LIHC	1
p.K257E	UCEC	1
p.W290X	THYM	1
p.G147V	CHOL	1
p.S4L	SKCM	1
p.K273N	LUAD	1
p.A53S	LUAD	1
p.K263R	LAML	1
p.G147D	LUAD	1
p.D34H	ESCA	1
p.I138V	LUAD	1
p.L12M	KIRP	1
p.K32E	LGG	1
p.K73Q	SKCM	1
p.P216S	SKCM	1
p.L136F	GBM	1
p.R197*	LGG	1
p.N203H	READ	1
p.D55N	HNSC	1
p.A258V	UCEC	1
p.P262T	ESCA	1

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TissGeneCNV for NPM1

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for NPM1

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	U04946	NPM1-ALK		chr5:170818803	chr2:29416090
Chimerdb3.0	ChiTaRs	NA	BG255268	NPM1-PTMA		chr5:170818771	chr2:232576618
Chimerdb3.0	ChiTaRs	NA	N88349	FERMT2-NPM1		chr14:53331543	chr5:170837756
Chimerdb3.0	ChiTaRs	NA	BC071891	INPPL1-NPM1		chr11:71949358	chr5:170814870
Chimerdb3.0	ChiTaRs	acute non lymphocytic leukemia	U41743	NPM1-RARA		chr5:170818803	chr17:38504565
Chimerdb3.0	ChiTaRs	anaplastic large cell lymphoma;Hodgkin disease;npn Hodgkin lymphoma	D45915	NPM1-ALK		chr5:170818803	chr2:29415642
TCGAfusionPortal	PRADA	BRCA	TCGA-D8-A1JL-01A	NPM1-RAB4A	In-frame	Chr5:170815010	Chr1:229422233
TCGAfusionPortal	PRADA	BRCA	TCGA-LL-A5YO-01A	BSPRY-NPM1	In-frame	Chr9:116123017	Chr5:170837531

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TissGeneNet for NPM1

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
NPM1, TP53, TFAP2A, HMGA1, SH3GL3, HDAC2, YWHAQ, HDAC1, NCL, CTCF, CDK2, HNRNPU, GRB7, EIF3E, CDT1, EPHA1, PA2G4, RRP1B, HABP4, CASKIN1, EPHB3 (tumor)	NPM1, YBX1, YWHAZ, CNBP, SH3GL3, SUMO2, LYAR, NCL, CDK1, TCERG1, HNRNPU, NOP56, CENPA, HJURP, EIF3E, NCAPG, HSPD1, EIF4B, PA2G4, UQCRH, NOP2 (normal)

COAD (tumor)	COAD (normal)
NPM1, YBX1, SUMO2, HDAC2, SHC1, RARA, LYAR, YWHAE, CDK2, NOP56, EP300, PINX1, NCOA6, DYRK2, DOT1L, EIF3E, SENP3, PC, RYK, PA2G4, UQCRH (tumor)	NPM1, YBX1, CNBP, SUMO2, LYAR, SUMO1, CDK1, HDAC5, TCERG1, CENPA, EP300, PINX1, HJURP, EIF3E, NCAPG, HSPD1, NUMA1, PA2G4, PPID, UQCRH, NOP2 (normal)

HNSC (tumor)	HNSC (normal)
NPM1, TFAP2A, YWHAZ, SUMO2, HDAC2, LYAR, YWHAQ, HDAC1, YWHAE, CDK1, CDK2, NOP56, CENPA, PSMC4, PINX1, SENP3, OTUB1, PTBP1, H2AFX, AFF1, PA2G4 (tumor)	NPM1, YBX1, SUMO2, LYAR, NCL, YWHAE, CDK1, TCERG1, NOP56, EP300, PINX1, EIF3E, NCAPG, CDT1, HSPD1, AFF1, CTNNBL1, NUMA1, PA2G4, PPID, UQCRH (normal)

KICH (tumor)	KICH (normal)
NPM1, SMARCA4, CNBP, PLCG1, YWHAQ, NCL, SUMO1, YWHAE, CTCF, HNRNPU, EP300, AKT1, PSMC4, NCOA6, EIF3E, PARP1, AFF1, ACACA, ABCC1, NUMA1, RRP1B (tumor)	NPM1, BRCA1, CNBP, MED9, YWHAE, CDK1, TCERG1, XPO1, GRB7, RPGR, AKT1, HJURP, EIF3E, NCAPG, HNRNPM, MED10, EIF4B, FANCC, CENPF, PA2G4, NSUN2 (normal)

KIRC (tumor)	KIRC (normal)
NPM1, SMARCA4, YWHAZ, CNBP, SUMO2, HDAC2, CDKN2A, YWHAQ, SUMO1, CDK1, CDK2, CENPA, MYL12A, DOT1L, HJURP, EIF3E, NCAPG, MED10, CENPF, NUMA1, PA2G4 (tumor)	NPM1, IKBKE, SMARCA4, YWHAZ, CNBP, SUMO2, HDAC2, YWHAQ, SUMO1, YWHAE, YY1, SIRT1, DOT1L, EIF3E, HSPD1, MED10, EIF4B, CTNNBL1, NUMA1, PA2G4, ZNF668 (normal)

KIRP (tumor)	KIRP (normal)
NPM1, CNBP, SUMO2, HDAC2, LYAR, YWHAQ, HDAC1, SUMO1, CDK2, XPO1, EP300, MYL12A, NCOA6, DOT1L, EIF3E, RYK, MED10, PTBP1, EIF4B, NUMA1, PA2G4 (tumor)	NPM1, YBX1, CNBP, LYAR, NCL, SUMO1, CDK1, CENPA, AKT1, DOT1L, HJURP, EIF3E, SENP3, PARP1, NCAPG, EPHA1, HSPD1, MED10, EIF4B, CENPF, PA2G4 (normal)

LIHC (tumor)	LIHC (normal)
NPM1, YBX1, CNBP, SUMO2, HDAC2, LYAR, HDAC1, YWHAE, MED19, NOP56, RPGR, AKT1, MYL12A, PINX1, EIF3E, EPHA1, CDC14A, RYK, MED10, PA2G4, HABP4 (tumor)	NPM1, YBX1, HMGA1, YWHAZ, HDAC2, ESR1, RARA, LYAR, NCL, TCERG1, PIK3R1, HNRNPU, NOP56, EIF3E, HNRNPM, HSPD1, MED10, GADD45A, EIF4B, PA2G4, NOP2 (normal)

LUAD (tumor)	LUAD (normal)
NPM1, YBX1, SMARCA4, ACY1, CNBP, SUMO2, PLCG1, YWHAQ, SUMO1, YWHAE, MED19, EP300, MYL12A, NCOA6, DOT1L, EIF3E, AFF1, ABCC1, NUMA1, PA2G4, UQCRH (tumor)	NPM1, YBX1, CNBP, SUMO2, PLCG1, LYAR, YWHAQ, SUMO1, YWHAE, EP300, PINX1, NCOA6, DOT1L, EIF3E, HSPD1, AFF1, EIF4B, NUMA1, PA2G4, PPID, UQCRH (normal)

LUSC (tumor)	LUSC (normal)
NPM1, YBX1, SMARCA4, CNBP, SUMO2, PLCG1, YWHAQ, SUMO1, YWHAE, HDAC5, MED19, EP300, NCOA6, IRS1, EIF3E, HSPD1, MED10, AFF1, ABCC1, NUMA1, UQCRH (tumor)	NPM1, CNBP, SUMO2, RARA, LYAR, YWHAQ, YWHAE, CDK1, TCERG1, NOP56, CENPA, EP300, AKT1, EIF3E, NCAPG, HSPD1, AFF1, EIF4B, NUMA1, PA2G4, UQCRH (normal)

PRAD (tumor)	PRAD (normal)
NPM1, YBX1, TP53, YWHAZ, CNBP, SUMO2, PLK1, LYAR, YWHAQ, SUMO1, YWHAE, YY1, NOP56, CENPA, HJURP, EIF3E, NCAPG, HSPD1, H2AFX, EIF4B, PA2G4 (tumor)	NPM1, YBX1, IKBKE, CNBP, SUMO2, LYAR, STAT3, NCL, YWHAE, NOP56, CENPA, MCC, GNAI2, EIF3E, NCAPG, HSPD1, EIF4B, PA2G4, PPID, UQCRH, NOP2 (normal)

STAD (tumor)	STAD (normal)
NPM1, YBX1, TRAF6, SUMO2, PLCG1, HDAC2, SHC1, LYAR, STAT3, SUMO1, MED19, NOP56, EP300, PINX1, NCOA6, DYRK2, EIF3E, MED10, NUMA1, PA2G4, UQCRH (tumor)	NPM1, YBX1, CNBP, SUMO2, LYAR, NCL, SUMO1, YWHAE, CDK1, HDAC5, TCERG1, NOP56, EIF3E, NCAPG, HSPD1, EIF4B, NUMA1, PA2G4, PPID, UQCRH, NOP2 (normal)

THCA (tumor)	THCA (normal)
NPM1, YBX1, HMGA1, CNBP, SUMO2, SHC1, NOP56, NCOA6, HIST1H4I, DOT1L, EIF3E, EPHA1, PC, MED10, AFF1, ACACA, EIF4B, FANCC, CTNNBL1, PA2G4, CASKIN1 (tumor)	NPM1, SMARCA4, TRAF6, HMGA1, CNBP, SUMO2, PLCG1, HDAC2, NCL, GRB7, MCC, MYL12A, IRS1, DOT1L, EIF3E, CDT1, PC, HSPD1, GADD45A, EIF4B, PA2G4 (normal)

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TissGeneProg for NPM1

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for NPM1

TissGeneDrug for NPM1

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for NPM1

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0023467	Leukemia, Myelocytic, Acute	298	BeFree,CLINVAR,CTD_human,GAD,LHGDN
umls:C0206180	Ki-1+ Anaplastic Large Cell Lymphoma	128	BeFree,LHGDN
umls:C0023418	leukemia	41	BeFree,GAD,LHGDN
umls:C0242596	Neoplasm, Residual	35	BeFree,GAD
umls:C3839868	Cytogenetically normal acute myeloid leukemia	33	BeFree
umls:C0024299	Lymphoma	32	BeFree,LHGDN
umls:C0596263	Carcinogenesis	25	BeFree
umls:C0598766	Leukemogenesis	25	BeFree
umls:C0023487	Acute Promyelocytic Leukemia	22	BeFree,CTD_human,ORPHANET
umls:C0023470	Myeloid Leukemia	17	BeFree,GAD
umls:C0033027	Preleukemia	17	BeFree,GAD
umls:C0220615	Adult Acute Myeloblastic Leukemia	17	BeFree
umls:C3463824	MYELODYSPLASTIC SYNDROME	16	BeFree,GAD,LHGDN
umls:C1332079	Anaplastic Large Cell Lymphoma, ALK-Positive	14	BeFree
umls:C0008626	Congenital chromosomal disease	12	BeFree
umls:C1840451	MULTICYSTIC RENAL DYSPLASIA, BILATERAL	10	BeFree
umls:C0220621	pediatric acute myeloblastic leukemia	9	BeFree
umls:C0376545	Hematologic Neoplasms	8	BeFree
umls:C0027708	Nephroblastoma	6	BeFree
umls:C0079772	T-Cell Lymphoma	6	BeFree,LHGDN
umls:C0022660	Kidney Failure, Acute	5	BeFree
umls:C0023480	Leukemia, Myelomonocytic, Chronic	5	BeFree,GAD
umls:C0026985	Myelodysplasia	5	BeFree
umls:C0264490	Acute respiratory failure	5	BeFree
umls:C2239176	Liver carcinoma	5	BeFree
umls:C0024623	Malignant neoplasm of stomach	4	BeFree
umls:C0027022	Myeloproliferative disease	4	BeFree,LHGDN
umls:C0027627	Neoplasm Metastasis	4	BeFree
umls:C0152276	Granulocytic Sarcoma	4	BeFree,LHGDN
umls:C1321546	Anaplastic large B-cell lymphoma	4	BeFree
umls:C0005684	Malignant neoplasm of urinary bladder	3	BeFree
umls:C0005699	Blast Phase	3	BeFree,GAD
umls:C0006142	Malignant neoplasm of breast	3	BeFree,GAD
umls:C0008625	Chromosome Aberrations	3	GAD
umls:C0015625	Fanconi Anemia	3	BeFree,LHGDN
umls:C0023473	Myeloid Leukemia, Chronic	3	BeFree
umls:C0033578	Prostatic Neoplasms	3	BeFree,LHGDN
umls:C0178874	Tumor Progression	3	BeFree
umls:C0280100	Solid tumour	3	BeFree
umls:C0280449	secondary acute myeloid leukemia	3	BeFree
umls:C0521158	Recurrent tumor	3	BeFree
umls:C0699791	Stomach Carcinoma	3	BeFree
umls:C0699885	Carcinoma of bladder	3	BeFree
umls:C2745900	Promyelocytic leukemia	3	BeFree
umls:C2826177	Acute myeloid leukemia with mutated NPM1	3	BeFree
umls:C3469521	FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	3	BeFree
umls:C0001430	Adenoma	2	BeFree
umls:C0001815	Primary Myelofibrosis	2	BeFree,LHGDN
umls:C0004114	Astrocytoma	2	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	2	BeFree
umls:C0009402	Colorectal Carcinoma	2	BeFree
umls:C0019693	HIV Infections	2	BeFree
umls:C0023449	Acute lymphocytic leukemia	2	BeFree
umls:C0026764	Multiple Myeloma	2	BeFree
umls:C0027819	Neuroblastoma	2	BeFree
umls:C0038356	Stomach Neoplasms	2	BeFree,CTD_human
umls:C0079731	B-Cell Lymphomas	2	BeFree
umls:C0085110	Severe Combined Immunodeficiency	2	BeFree
umls:C0085669	Acute leukemia	2	BeFree
umls:C0153381	Malignant neoplasm of mouth	2	BeFree
umls:C0206182	Lymphomatoid Papulosis	2	BeFree,ORPHANET
umls:C0220641	Lip and Oral Cavity Carcinoma	2	BeFree
umls:C0376358	Malignant neoplasm of prostate	2	BeFree
umls:C0600139	Prostate carcinoma	2	BeFree
umls:C0678222	Breast Carcinoma	2	BeFree
umls:C0700095	Central neuroblastoma	2	BeFree
umls:C1261473	Sarcoma	2	BeFree
umls:C1318544	M5b Acute differentiated monocytic leukemia	2	BeFree
umls:C1336548	Systemic Anaplastic Large Cell Lymphoma	2	BeFree
umls:C1336735	Treatment related acute myeloid leukaemia	2	BeFree
umls:C1709246	Non-Neoplastic Disorder	2	BeFree
umls:C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	BeFree
umls:C0007102	Malignant tumor of colon	1	BeFree
umls:C0007103	Malignant neoplasm of endometrium	1	BeFree
umls:C0007112	Adenocarcinoma of prostate	1	BeFree
umls:C0007134	Renal Cell Carcinoma	1	BeFree
umls:C0007137	Squamous cell carcinoma	1	BeFree
umls:C0007621	Neoplastic Cell Transformation	1	GAD
umls:C0014057	Japanese Encephalitis	1	LHGDN
umls:C0015230	Exanthema	1	BeFree
umls:C0017636	Glioblastoma	1	BeFree
umls:C0018133	Graft-vs-Host Disease	1	BeFree
umls:C0019163	Hepatitis B	1	BeFree
umls:C0019208	Hepatoma, Novikoff	1	BeFree
umls:C0019623	Malignant histiocytosis	1	BeFree
umls:C0019829	Hodgkin Disease	1	BeFree
umls:C0021051	Immunologic Deficiency Syndromes	1	BeFree
umls:C0021400	Influenza	1	BeFree
umls:C0021943	Chromosome inversion	1	GAD
umls:C0023434	Chronic Lymphocytic Leukemia	1	BeFree
umls:C0023465	Acute monocytic leukemia	1	BeFree
umls:C0023474	Leukemia, Myeloid, Chronic-Phase	1	BeFree
umls:C0023479	Acute myelomonocytic leukemia	1	BeFree
umls:C0023890	Liver Cirrhosis	1	BeFree
umls:C0023903	Liver neoplasms	1	BeFree
umls:C0024121	Lung Neoplasms	1	LHGDN
umls:C0024305	Lymphoma, Non-Hodgkin	1	BeFree
umls:C0024899	Mastocytosis	1	BeFree
umls:C0026499	Monosomy	1	BeFree
umls:C0029463	Osteosarcoma	1	LHGDN
umls:C0035335	Retinoblastoma	1	BeFree
umls:C0036220	Kaposi Sarcoma	1	BeFree
umls:C0037286	Skin Neoplasms	1	BeFree
umls:C0040715	Chromosomal translocation	1	GAD
umls:C0042111	Urticaria Pigmentosa	1	BeFree
umls:C0043346	Xeroderma Pigmentosum	1	BeFree
umls:C0043379	XYY Karyotype	1	GAD
umls:C0079744	Diffuse Large B-Cell Lymphoma	1	LHGDN
umls:C0079773	Lymphoma, T-Cell, Cutaneous	1	BeFree
umls:C0085702	Monocytosis	1	BeFree
umls:C0153886	Acute myeloid leukemia in remission	1	BeFree
umls:C0153888	Chronic myeloid leukemia in remission	1	BeFree
umls:C0235974	Pancreatic carcinoma	1	BeFree
umls:C0238246	Hemangioma of liver	1	BeFree
umls:C0242379	Malignant neoplasm of lung	1	BeFree
umls:C0275524	Coinfection	1	BeFree
umls:C0278484	Malignant neoplasm of colon stage IV	1	BeFree
umls:C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	1	BeFree
umls:C0333980	Focal Nodular Hyperplasia	1	BeFree
umls:C0334121	Inflammatory Myofibroblastic Tumor	1	BeFree
umls:C0334634	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	1	BeFree
umls:C0345904	Malignant neoplasm of liver	1	BeFree
umls:C0346647	Malignant neoplasm of pancreas	1	BeFree
umls:C0349667	Sarcoma of breast	1	BeFree
umls:C0476089	Endometrial Carcinoma	1	BeFree
umls:C0684249	Carcinoma of lung	1	BeFree
umls:C0686619	Secondary malignant neoplasm of lymph node	1	BeFree
umls:C0699790	Colon Carcinoma	1	BeFree
umls:C0795824	Chromosome 8, monosomy 8p	1	BeFree
umls:C0848332	Spots on skin	1	BeFree
umls:C0850572	Adenomatous polyp of colon	1	BeFree
umls:C0854917	Rhabdoid Tumor of the Kidney	1	BeFree
umls:C1292753	Primary Effusion Lymphoma	1	BeFree
umls:C1292773	Acute myeloid leukemia with multilineage dysplasia	1	BeFree
umls:C1292778	Chronic myeloproliferative disorder	1	BeFree
umls:C1292780	Therapy-related myelodysplastic syndrome	1	BeFree
umls:C1301362	Lymphoma, Primary Cutaneous Anaplastic Large Cell	1	BeFree,ORPHANET
umls:C1332078	Anaplastic large cell lymphoma, ALK negative	1	BeFree
umls:C1458155	Mammary Neoplasms	1	BeFree
umls:C1527249	Colorectal Cancer	1	BeFree
umls:C1621958	Glioblastoma Multiforme	1	BeFree
umls:C1856689	FRIEDREICH ATAXIA 1	1	BeFree
umls:C1883486	Uterine Corpus Cancer	1	BeFree
umls:C2613439	Extramedullary Hematopoiesis (disorder)	1	BeFree
umls:C2826178	Acute myeloid leukemia with mutated CEBPA	1	BeFree
umls:C2931822	Nasopharyngeal carcinoma	1	BeFree
umls:C2939461	Myeloid neoplasm	1	BeFree