TissGeneSummary for NPR3 |
Gene summary |
Basic gene information | Gene symbol | NPR3 |
Gene name | natriuretic peptide receptor 3 | |
Synonyms | ANP-C|ANPR-C|ANPRC|C5orf23|GUCY2B|NPR-C|NPRC | |
Cytomap | UCSC genome browser: 5p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_000908.3, NM_001204375.1,NM_001204376.1,NM_024563.3, | |
Description | atrial natriuretic peptide clearance receptoratrial natriuretic peptide receptor 3atrial natriuretic peptide receptor type Catrionatriuretic peptide receptor Cguanylate cyclase Cnatriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic pep | |
Modification date | 20141207 | |
dbXrefs | MIM : 108962 | |
HGNC : HGNC | ||
Ensembl : ENSG00000113389 | ||
HPRD : 00167 | ||
Vega : OTTHUMG00000150316 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NPR3 | |
BioGPS: 4883 | ||
Pathway | NCI Pathway Interaction Database: NPR3 | |
KEGG: NPR3 | ||
REACTOME: NPR3 | ||
Pathway Commons: NPR3 | ||
Context | iHOP: NPR3 | |
ligand binding site mutation search in PubMed: NPR3 | ||
UCL Cancer Institute: NPR3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyBone marrow | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLAML | |
Reference showing the relevant tissue of NPR3 | ||
Description by TissGene annotations | Risk TissGene in OS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NPR3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 1.121242813 | 2.661750708 | -1.540507895 | 1.23E-08 | 4.01E-08 |
KIRP | 2.818526201 | 5.646410576 | -2.827884375 | 3.60E-08 | 2.42E-07 |
THCA | 0.954632822 | 3.229495534 | -2.274862712 | 3.63E-10 | 2.24E-09 |
LUAD | 2.029679111 | 3.732967042 | -1.703287931 | 3.95E-10 | 2.20E-09 |
STAD | -1.123689424 | 1.286663701 | -2.410353125 | 1.36E-06 | 2.12E-05 |
COAD | -1.070348077 | 0.195098076 | -1.265446154 | 0.0164 | 0.033898491 |
KICH | 3.803244076 | 4.870612076 | -1.067368 | 0.0111 | 0.019745278 |
LUSC | 2.647497096 | 3.771393175 | -1.123896078 | 0.00091 | 0.001697862 |
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TissGene-miRNA for NPR3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NPR3 |
TissGeneSNV for NPR3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Y138H | STAD | 3 |
p.R176C | STAD | 2 |
p.M271V | UCEC | 1 |
p.D299N | SKCM | 1 |
p.L372V | CESC | 1 |
p.Y353N | LIHC | 1 |
p.R81H | COAD | 1 |
p.E104K | BLCA | 1 |
p.Y138H | COAD | 1 |
p.R268Q | HNSC | 1 |
p.G278D | SARC | 1 |
p.H196Q | LUAD | 1 |
p.E374K | SKCM | 1 |
p.R530Q | BLCA | 1 |
p.R81H | STAD | 1 |
p.L93V | HNSC | 1 |
p.L33I | UCEC | 1 |
p.V489L | LUAD | 1 |
p.G347V | LUAD | 1 |
p.R395I | LUAD | 1 |
p.A75T | SKCM | 1 |
p.S336F | SKCM | 1 |
p.I247M | BRCA | 1 |
p.D299Y | LGG | 1 |
p.Q175K | ACC | 1 |
p.S148L | CESC | 1 |
p.D244N | READ | 1 |
p.D363N | STAD | 1 |
p.R51I | UCEC | 1 |
p.R176H | LIHC | 1 |
p.P451S | SKCM | 1 |
p.A262V | BRCA | 1 |
p.E290G | GBM | 1 |
p.F332S | LUAD | 1 |
p.D105N | HNSC | 1 |
p.G437E | BLCA | 1 |
p.I388S | UCEC | 1 |
p.Q391K | ACC | 1 |
p.D83N | SKCM | 1 |
p.Y171H | STAD | 1 |
p.L209P | UCEC | 1 |
p.F416L | LUAD | 1 |
p.D532N | UCS | 1 |
p.T206I | SKCM | 1 |
p.E311K | SKCM | 1 |
p.N305D | COAD | 1 |
p.Y234* | LUAD | 1 |
p.K127N | LUAD | 1 |
p.E359Q | LUAD | 1 |
p.E226D | THYM | 1 |
p.G410R | SARC | 1 |
p.S342L | SKCM | 1 |
p.Q390R | LUSC | 1 |
p.L152M | LUAD | 1 |
p.S148L | HNSC | 1 |
p.G87W | LUAD | 1 |
p.R211Q | ESCA | 1 |
p.W393C | LUSC | 1 |
p.R268Q | STAD | 1 |
p.E186K | SKCM | 1 |
p.D168N | SKCM | 1 |
p.E333D | PAAD | 1 |
p.Q225L | LGG | 1 |
p.R514M | LUAD | 1 |
p.V404E | LUAD | 1 |
p.R529P | BRCA | 1 |
p.V354F | HNSC | 1 |
p.G414R | BLCA | 1 |
p.A408V | KIRC | 1 |
p.T422I | SKCM | 1 |
p.E227* | LUAD | 1 |
p.R98C | BLCA | 1 |
p.M187I | BLCA | 1 |
p.N86S | HNSC | 1 |
p.R313W | COAD | 1 |
p.D237Y | LUAD | 1 |
p.R514S | THYM | 1 |
p.R211W | LUAD | 1 |
p.D363N | UCEC | 1 |
p.Q252* | SKCM | 1 |
p.E158K | SKCM | 1 |
p.R441H | HNSC | 1 |
p.A274V | LGG | 1 |
p.P94Q | STAD | 1 |
p.S205R | HNSC | 1 |
p.A426S | LUSC | 1 |
p.H275R | HNSC | 1 |
p.A426P | LUAD | 1 |
p.G360A | LUAD | 1 |
p.L58V | STAD | 1 |
p.Y204C | UCEC | 1 |
p.P235S | SKCM | 1 |
p.A159V | STAD | 1 |
p.R249H | STAD | 1 |
p.S126L | SKCM | 1 |
p.R463G | HNSC | 1 |
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TissGeneCNV for NPR3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NPR3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AR-A0TU-01A | MYO10-NPR3 | Out-of-Frame | chr5:16877717 | chr5:32724803 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CQ-7067-01A | C5orf42-NPR3 | In-frame | Chr5:37153842 | Chr5:32774814 |
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TissGeneNet for NPR3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NPR3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NPR3 |
TissGeneDrug for NPR3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NPR3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020538 | Hypertensive disease | 5 | BeFree,GAD |
umls:C0948008 | Ischemic stroke | 3 | BeFree,GAD |
umls:C0007222 | Cardiovascular Diseases | 2 | BeFree,GAD |
umls:C0018801 | Heart failure | 2 | BeFree,GAD |
umls:C0038454 | Cerebrovascular accident | 2 | BeFree |
umls:C0085580 | Essential Hypertension | 2 | BeFree |
umls:C3272363 | Ischemic Cerebrovascular Accident | 2 | BeFree |
umls:C0004096 | Asthma | 1 | BeFree |
umls:C0004936 | Mental disorders | 1 | GAD |
umls:C0009319 | Colitis | 1 | BeFree |
umls:C0010068 | Coronary heart disease | 1 | BeFree |
umls:C0011884 | Diabetic Retinopathy | 1 | RGD |
umls:C0018799 | Heart Diseases | 1 | BeFree |
umls:C0018802 | Congestive heart failure | 1 | BeFree |
umls:C0025149 | Medulloblastoma | 1 | BeFree |
umls:C0027051 | Myocardial Infarction | 1 | BeFree |
umls:C0027055 | Myocardial Reperfusion Injury | 1 | RGD |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0041956 | Ureteral obstruction | 1 | BeFree |
umls:C0043094 | Weight Gain | 1 | CTD_human |
umls:C0149939 | Obstructive nephropathy | 1 | BeFree |
umls:C0242973 | Ventricular Dysfunction | 1 | GAD |
umls:C1271104 | Blood pressure finding | 1 | GWASCAT |
umls:C1272641 | Systemic arterial pressure | 1 | GWASCAT |
umls:C1301700 | Cardiovascular morbidity | 1 | BeFree |
umls:C1397307 | Cardiac fibrosis | 1 | BeFree |