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| TissGeneSummary for NTSR1 |
 Gene summary |
| Basic gene information | Gene symbol | NTSR1 |
| Gene name | neurotensin receptor 1 (high affinity) | |
| Synonyms | NTR | |
| Cytomap | UCSC genome browser: 20q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002531.2, | |
| Description | NT-R-1NTR1NTRHhigh-affinity levocabastine-insensitive neurotensin receptorneurotensin receptor type 1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 162651 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000101188 | ||
| HPRD : 01218 | ||
| Vega : OTTHUMG00000032932 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NTSR1 | |
| BioGPS: 4923 | ||
| Pathway | NCI Pathway Interaction Database: NTSR1 | |
| KEGG: NTSR1 | ||
| REACTOME: NTSR1 | ||
| Pathway Commons: NTSR1 | ||
| Context | iHOP: NTSR1 | |
| ligand binding site mutation search in PubMed: NTSR1 | ||
| UCL Cancer Institute: NTSR1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonPancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADPAAD | |
| Reference showing the relevant tissue of NTSR1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0007218 | neuropeptide signaling pathway | 21725197 | GO:0007218 | neuropeptide signaling pathway | 21725197 |
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| TissGeneExp for NTSR1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -2.031502015 | -3.032399384 | 1.000897368 | 7.38E-07 | 2.03E-06 |
| HNSC | -0.804631942 | -2.002866825 | 1.198234884 | 0.00709 | 0.018315155 |
| KICH | 0.830572616 | -0.183459384 | 1.014032 | 0.00649 | 0.012142581 |
| LUAD | -1.615432142 | -2.623394211 | 1.007962069 | 0.00226 | 0.00470676 |
| KIRP | -1.483605634 | 0.184619366 | -1.668225 | 0.000114 | 0.000381475 |
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| TissGene-miRNA for NTSR1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for NTSR1 |
| TissGeneSNV for NTSR1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R303C | STAD | 2 |
| p.C383R | COAD | 1 |
| p.R299Q | LUSC | 1 |
| p.F353L | HNSC | 1 |
| p.A139T | STAD | 1 |
| p.F146L | SARC | 1 |
| p.S253L | SKCM | 1 |
| p.P11S | PRAD | 1 |
| p.M325V | READ | 1 |
| p.V76M | SKCM | 1 |
| p.V385L | LUAD | 1 |
| p.R414C | SKCM | 1 |
| p.R142H | GBM | 1 |
| p.G25E | SKCM | 1 |
| p.C381W | STAD | 1 |
| p.G143S | GBM | 1 |
| p.A150T | UCS | 1 |
| p.T100M | PRAD | 1 |
| p.G137S | READ | 1 |
| p.L198M | GBM | 1 |
| p.T84M | READ | 1 |
| p.D400N | CESC | 1 |
| p.G301C | LUAD | 1 |
| p.V302L | LUAD | 1 |
| p.C151* | LUSC | 1 |
| p.R268S | LUSC | 1 |
| p.S93L | UCEC | 1 |
| p.F188L | UCS | 1 |
| p.A260T | UCEC | 1 |
| p.M347L | SKCM | 1 |
| p.T100M | LUAD | 1 |
| p.G77V | LUAD | 1 |
| p.S181P | UCEC | 1 |
| p.R322Q | PRAD | 1 |
| p.G143S | LGG | 1 |
| p.E272K | LUAD | 1 |
| p.A197V | SKCM | 1 |
| p.A311T | KIRP | 1 |
| p.R372H | PRAD | 1 |
| p.N365S | LGG | 1 |
| p.A200S | SARC | 1 |
| p.R388C | STAD | 1 |
| p.R372L | UCEC | 1 |
| p.G140C | SARC | 1 |
| p.R414H | COAD | 1 |
| p.R268C | HNSC | 1 |
| p.S39L | SKCM | 1 |
| p.R142C | SKCM | 1 |
| p.V304I | COAD | 1 |
| p.E282K | SARC | 1 |
| p.Y344* | LUAD | 1 |
| p.A219S | LUAD | 1 |
| p.A195T | LUAD | 1 |
| p.T155M | UCEC | 1 |
| p.P361L | LGG | 1 |
| p.E209K | STAD | 1 |
| p.V295I | HNSC | 1 |
| p.P292L | SKCM | 1 |
| p.G220D | STAD | 1 |
| p.A150T | STAD | 1 |
| p.R182Q | BLCA | 1 |
| p.R303H | STAD | 1 |
| p.G221S | BLCA | 1 |
| p.A150T | READ | 1 |
| p.A195T | KIRC | 1 |
| p.R390T | SKCM | 1 |
| p.W193C | ESCA | 1 |
| p.S356T | LUAD | 1 |
| p.R148C | COAD | 1 |
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| TissGeneCNV for NTSR1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for NTSR1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A0H7-01A | RBFOX2-NTSR1 | In-Frame | chr22:36424287 | chr20:61386036 |
| Chimerdb3.0 | TopHat-Fusion | UCS | TCGA-N8-A4PM-01A | LAMA5-NTSR1 | Out-of-Frame | chr20:60893509 | chr20:61347961 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A0H7-01A | RBFOX2-NTSR1 | In-frame | Chr22:36424288 | Chr20:61386037 |
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| TissGeneNet for NTSR1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| COAD (tumor) | COAD (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| HNSC (tumor) | HNSC (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| KICH (tumor) | KICH (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| KIRC (tumor) | KIRC (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| KIRP (tumor) | KIRP (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| LIHC (tumor) | LIHC (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| LUAD (tumor) | LUAD (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| LUSC (tumor) | LUSC (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| PRAD (tumor) | PRAD (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| STAD (tumor) | STAD (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| THCA (tumor) | THCA (normal) |
| NTSR1, ARRB2, NTS (tumor) | NTSR1, ARRB2, NTS (normal) |
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| TissGeneProg for NTSR1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for NTSR1 |
| TissGeneDrug for NTSR1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for NTSR1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0178874 | Tumor Progression | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0019159 | Hepatitis A | 4 | BeFree |
| umls:C0036341 | Schizophrenia | 4 | BeFree,CTD_human,GAD |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
| umls:C0267797 | Acute hepatitis | 3 | BeFree |
| umls:C0699790 | Colon Carcinoma | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree,LHGDN |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0024121 | Lung Neoplasms | 2 | BeFree,LHGDN |
| umls:C0033578 | Prostatic Neoplasms | 2 | BeFree,LHGDN |
| umls:C0041696 | Unipolar Depression | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
| umls:C0302809 | Fulminant hepatitis | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C1269683 | Major Depressive Disorder | 2 | BeFree |
| umls:C1270972 | Mild cognitive disorder | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0004936 | Mental disorders | 1 | GAD |
| umls:C0008074 | Child Development Disorders, Pervasive | 1 | CTD_human |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0011615 | Dermatitis, Atopic | 1 | BeFree |
| umls:C0013595 | Eczema | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0020429 | Hyperalgesia | 1 | RGD |
| umls:C0020503 | Hyperparathyroidism, Secondary | 1 | GAD |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0025500 | Mesothelioma | 1 | BeFree |
| umls:C0027659 | Neoplasms, Experimental | 1 | BeFree |
| umls:C0030193 | Pain | 1 | CTD_human |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0042111 | Urticaria Pigmentosa | 1 | BeFree |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | LHGDN |
| umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
| umls:C0149931 | Migraine Disorders | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | BeFree |
| umls:C0263338 | Chronic urticaria | 1 | BeFree |
| umls:C0278504 | Non-small cell lung cancer stage I | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0525045 | Mood Disorders | 1 | BeFree |
| umls:C0555198 | Malignant Glioma | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
| umls:C0854985 | Adenocarcinoma of lung, stage I | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
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