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| TissGeneSummary for ATP4B |
 Gene summary |
| Basic gene information | Gene symbol | ATP4B |
| Gene name | ATPase, H+/K+ exchanging, beta polypeptide | |
| Synonyms | ATP6B | |
| Cytomap | UCSC genome browser: 13q34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000705.3, | |
| Description | ATPase, H+/K+ transporting, beta polypeptidegastric H(+)/K(+) ATPase subunit betagastric H+/K+ ATPase beta subunitgastric hydrogen-potassium ATPase, betapotassium-transporting ATPase beta chainpotassium-transporting ATPase subunit betaproton pump be | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 137217 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000186009 | ||
| HPRD : 00669 | ||
| Vega : OTTHUMG00000140234 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ATP4B | |
| BioGPS: 496 | ||
| Pathway | NCI Pathway Interaction Database: ATP4B | |
| KEGG: ATP4B | ||
| REACTOME: ATP4B | ||
| Pathway Commons: ATP4B | ||
| Context | iHOP: ATP4B | |
| ligand binding site mutation search in PubMed: ATP4B | ||
| UCL Cancer Institute: ATP4B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
| Reference showing the relevant tissue of ATP4B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ATP4B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -1.403010445 | 1.134750666 | -2.537761111 | 3.78E-33 | 8.92E-32 |
| KIRP | -1.19938614 | 1.47345136 | -2.6728375 | 1.64E-13 | 3.04E-12 |
| ESCA | -1.349612844 | 8.068414428 | -9.418027273 | 0.003 | 0.028979394 |
| STAD | 0.474398235 | 5.050779485 | -4.57638125 | 0.000396 | 0.002522958 |
| KICH | 0.26125261 | 1.50254861 | -1.241296 | 0.000194 | 0.000483137 |
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| TissGene-miRNA for ATP4B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ATP4B |
| TissGeneSNV for ATP4B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A56T | UCEC | 1 |
| p.D167N | SKCM | 1 |
| p.Y136C | HNSC | 1 |
| p.A144T | ESCA | 1 |
| p.P278S | SKCM | 1 |
| p.L59P | UCEC | 1 |
| p.E6V | LGG | 1 |
| p.A2V | UCEC | 1 |
| p.G234R | STAD | 1 |
| p.E280Q | BLCA | 1 |
| p.E6Q | BRCA | 1 |
| p.T155M | STAD | 1 |
| p.A2G | LUSC | 1 |
| p.V45M | BLCA | 1 |
| p.P221S | HNSC | 1 |
| p.T105A | LGG | 1 |
| p.G90R | COAD | 1 |
| p.P71L | STAD | 1 |
| p.V262M | BRCA | 1 |
| p.I253S | BRCA | 1 |
| p.A107T | SKCM | 1 |
| p.A248T | COAD | 1 |
| p.G194D | UCEC | 1 |
| p.E174* | LUSC | 1 |
| p.W39C | BRCA | 1 |
| p.G11D | STAD | 1 |
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| TissGeneCNV for ATP4B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ATP4B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-56-A4ZK-01A | PCID2-ATP4B | Out-of-Frame | chr13:113862912 | chr13:114309257 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-56-A4ZK-01A | PCID2-ATP4B | Out-of-Frame | chr13:113862912 | chr13:114307749 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-56-A4ZK-01A | PCID2-ATP4B | Out-of-Frame | chr13:113862912 | chr13:114309256 |
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| TissGeneNet for ATP4B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| COAD (tumor) | COAD (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| KICH (tumor) | KICH (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| STAD (tumor) | STAD (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| THCA (tumor) | THCA (normal) |
| ATP4B, STX1A, BPGM (tumor) | ATP4B, STX1A, BPGM (normal) |
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| TissGeneProg for ATP4B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ATP4B |
| TissGeneDrug for ATP4B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ATP4B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
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