 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for OPCML |
 Gene summary |
| Basic gene information | Gene symbol | OPCML |
| Gene name | opioid binding protein/cell adhesion molecule-like | |
| Synonyms | IGLON1|OBCAM|OPCM | |
| Cytomap | UCSC genome browser: 11q25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001012393.1, NM_002545.3, | |
| Description | IgLON family member 1opioid binding protein/cell adhesion molecule-like preproteinopioid-binding protein/cell adhesion molecule | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 600632 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000183715 | ||
| HPRD : 07198 | ||
| Vega : OTTHUMG00000163658 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OPCML | |
| BioGPS: 4978 | ||
| Pathway | NCI Pathway Interaction Database: OPCML | |
| KEGG: OPCML | ||
| REACTOME: OPCML | ||
| Pathway Commons: OPCML | ||
| Context | iHOP: OPCML | |
| ligand binding site mutation search in PubMed: OPCML | ||
| UCL Cancer Institute: OPCML | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of OPCML | ||
| Description by TissGene annotations | Protective TissGene in OS Cancer gene Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for OPCML |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | -1.460663377 | 0.843683498 | -2.304346875 | 7.61E-08 | 2.17E-06 |
| KICH | -1.039990377 | 2.445713623 | -3.485704 | 1.57E-12 | 1.80E-11 |
| KIRP | -2.262132127 | 2.562774123 | -4.82490625 | 1.15E-25 | 1.61E-23 |
| PRAD | -2.338601838 | -0.681059531 | -1.657542308 | 1.07E-07 | 1.00E-06 |
| ESCA | -1.69566565 | 0.394752532 | -2.090418182 | 0.00374 | 0.033138486 |
| THCA | 0.071648064 | -1.401614648 | 1.473262712 | 0.000119 | 0.000323668 |
| BLCA | -2.405564693 | -0.803038377 | -1.602526316 | 5.11E-06 | 0.000115019 |
| LUAD | -1.093559067 | -2.17020217 | 1.076643103 | 4.22E-05 | 0.000112953 |
| Top |
| TissGene-miRNA for OPCML |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-372-3p | MIMAT0000724 | 0.025 | -0.26 | 78 |
| ACC | hsa-miR-489-3p | MIMAT0002805 | 0.024 | -0.26 | 78 |
| ACC | hsa-miR-372-3p | MIMAT0000724 | 0.025 | -0.26 | 78 |
| ACC | hsa-miR-489-3p | MIMAT0002805 | 0.024 | -0.26 | 78 |
| UVM | hsa-miR-204-5p | MIMAT0000265 | 0.015 | -0.27 | 80 |
| UCS | hsa-miR-224-5p | MIMAT0000281 | 0.011 | -0.34 | 56 |
| Top |
| TissGeneMut for OPCML |
| TissGeneSNV for OPCML |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P112L | SKCM | 2 |
| p.S203R | LUAD | 2 |
| p.T58N | BLCA | 1 |
| p.P211L | PAAD | 1 |
| p.A53T | CESC | 1 |
| p.E201K | SKCM | 1 |
| p.W332C | HNSC | 1 |
| p.R271M | READ | 1 |
| p.X346R | THYM | 1 |
| p.L205V | LUAD | 1 |
| p.T58K | BLCA | 1 |
| p.D106N | SKCM | 1 |
| p.M251V | STAD | 1 |
| p.T39M | COAD | 1 |
| p.R32L | BLCA | 1 |
| p.R71C | STAD | 1 |
| p.R277C | UCS | 1 |
| p.T94S | GBM | 1 |
| p.S143* | BLCA | 1 |
| p.T14S | STAD | 1 |
| p.Q97H | LUSC | 1 |
| p.E110K | SKCM | 1 |
| p.T232I | LUAD | 1 |
| p.G269E | HNSC | 1 |
| p.M1V | BRCA | 1 |
| p.D106H | HNSC | 1 |
| p.A210G | THYM | 1 |
| p.C4Y | ESCA | 1 |
| p.X346R | STAD | 1 |
| p.G143E | SKCM | 1 |
| p.N44S | PAAD | 1 |
| p.R71C | UCEC | 1 |
| p.V45L | LUSC | 1 |
| p.R127W | HNSC | 1 |
| p.F254S | LUAD | 1 |
| p.G50R | LIHC | 1 |
| p.R170K | LUSC | 1 |
| p.N121Y | LIHC | 1 |
| p.E201Q | LUSC | 1 |
| p.H3Q | STAD | 1 |
| p.A36D | LUAD | 1 |
| p.G266C | READ | 1 |
| p.N322I | BLCA | 1 |
| p.T96N | OV | 1 |
| p.A12E | COAD | 1 |
| p.I343S | STAD | 1 |
| p.Y98C | STAD | 1 |
| p.S142P | BLCA | 1 |
| p.E260* | SARC | 1 |
| p.V297M | MESO | 1 |
| p.A339V | SKCM | 1 |
| p.R25C | COAD | 1 |
| p.T73N | UCEC | 1 |
| p.P105L | SKCM | 1 |
| p.R87C | HNSC | 1 |
| p.G43E | SKCM | 1 |
| p.R194Q | UCEC | 1 |
| p.P223S | BLCA | 1 |
| p.S247T | LUAD | 1 |
| p.F342S | ESCA | 1 |
| p.I84V | STAD | 1 |
| p.R271K | BLCA | 1 |
| p.E51G | THCA | 1 |
| p.V107L | ESCA | 1 |
| p.C157W | BLCA | 1 |
| p.L331H | OV | 1 |
| p.G150V | CESC | 1 |
| p.V105A | STAD | 1 |
| p.E288K | SKCM | 1 |
| p.D102A | READ | 1 |
| p.T114S | HNSC | 1 |
| p.P95L | KIRC | 1 |
| p.R170I | PRAD | 1 |
| p.R277P | LUAD | 1 |
| p.T46M | UCEC | 1 |
| p.E149K | SKCM | 1 |
| p.S235L | SKCM | 1 |
| p.L242M | PRAD | 1 |
| p.G50E | SKCM | 1 |
| p.K239T | ESCA | 1 |
| p.T66N | COAD | 1 |
| p.G150E | SKCM | 1 |
| p.A204V | STAD | 1 |
| p.D212N | SARC | 1 |
| p.S203R | HNSC | 1 |
| p.S52R | STAD | 1 |
| p.A210G | LUAD | 1 |
| p.H3R | LIHC | 1 |
| p.G335R | SKCM | 1 |
| p.Q97K | THYM | 1 |
| p.I84M | LGG | 1 |
| p.T282S | PCPG | 1 |
| p.R214P | LUAD | 1 |
| p.N44K | LIHC | 1 |
| p.K168N | COAD | 1 |
| p.D99N | SKCM | 1 |
| p.P314S | SKCM | 1 |
| p.E142K | SKCM | 1 |
| p.N199K | COAD | 1 |
| p.N306K | PRAD | 1 |
| p.E194K | SKCM | 1 |
| p.A210V | STAD | 1 |
| p.R214Q | BLCA | 1 |
| p.D290V | LUAD | 1 |
| p.D207E | LUSC | 1 |
| p.P307S | SKCM | 1 |
| p.H349P | UCEC | 1 |
| p.E51K | LUAD | 1 |
| p.S18Y | UCEC | 1 |
| p.H171Q | LUAD | 1 |
| p.E245* | BLCA | 1 |
| Top |
| TissGeneCNV for OPCML |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for OPCML |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DA569674 | GABPA-OPCML | chr21:27143516 | chr11:132285875 | |
| Chimerdb3.0 | ChiTaRs | NA | BF856072 | OPCML-MIR5095 | chr11:132542973 | chr20:55948608 | |
| Chimerdb3.0 | ChiTaRs | NA | AI471650 | OPCML-SMARCD2 | chr11:132777864 | chr17:61909445 | |
| Chimerdb3.0 | ChiTaRs | NA | DB056744 | OPCML-NRD1 | chr11:132383306 | chr1:52280372 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-R6-A6KZ-01A | APLP2-OPCML | Out-of-Frame | chr11:129939977 | chr11:132307253 |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-64-1679-01A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-55-6986-11A | NTM-OPCML | In-Frame | chr11:131240782 | chr11:132812904 |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-55-6986-11A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-91-6848-01A | OPCML-NTM | In-Frame | chr11:132812820 | chr11:132016175 |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-50-8459-01A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-BH-A1ES-06A | NTM-OPCML | Out-of-Frame | chr11:131781538 | chr11:132527216 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AC-A23E-01A | OPCML-NTM | In-Frame | chr11:132812820 | chr11:132016175 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E9-A1NG-01A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-22-4604-01A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-56-7222-11A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-43-6647-01A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-56-6545-01A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-51-4079-11A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-22-5472-11A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-34-5928-01A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-43-6771-11A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-77-8008-01A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-92-7340-11A | OPCML-NTM | In-Frame | chr11:132812820 | chr11:132016175 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-34-5239-01A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-77-7337-11A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-85-6175-01A | OPCML-NTM | Out-of-Frame | chr11:132812824 | chr11:132016171 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A14N-01A | SHANK2-OPCML | Out-of-frame | Chr11:70505933 | Chr11:132399080 |
| Top |
| TissGeneNet for OPCML |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| OPCML, PRNP (tumor) | OPCML, PRNP (normal) |
 |  |
| Top |
| TissGeneProg for OPCML |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for OPCML |
| TissGeneDrug for OPCML |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for OPCML |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0029925 | Ovarian Carcinoma | 6 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 5 | BeFree,UNIPROT |
| umls:C0677886 | Epithelial ovarian cancer | 4 | BeFree |
| umls:C0919267 | ovarian neoplasm | 3 | BeFree,CLINVAR,CTD_human,LHGDN |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C1271104 | Blood pressure finding | 2 | GAD,GWASCAT |
| umls:C1272641 | Systemic arterial pressure | 2 | GAD,GWASCAT |
| umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | GWASCAT |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0006118 | Brain Neoplasms | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0019829 | Hodgkin Disease | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | LHGDN |
| umls:C0036341 | Schizophrenia | 1 | BeFree,GAD |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
| umls:C0279680 | Transitional cell carcinoma of bladder | 1 | BeFree |
| umls:C0567312 | Menopause present (finding) | 1 | GAD |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
| umls:C2676676 | BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 | 0 | CTD_human |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |