TissGeneSummary for SLC22A18AS |
Gene summary |
Basic gene information | Gene symbol | SLC22A18AS |
Gene name | solute carrier family 22 (organic cation transporter), member 18 antisense | |
Synonyms | BWR1B|BWSCR1B|ORCTL2S|SLC22A1LS|p27-BWR1B | |
Cytomap | UCSC genome browser: 11p15.5 | |
Type of gene | protein-coding | |
RefGenes | NM_001302862.1, NM_007105.3, | |
Description | Beckwith-Wiedemann region 1BBeckwith-Wiedemann syndrome chromosome region 1, candidate bbeckwith-Wiedemann syndrome chromosomal region 1 candidate gene B proteinorganic cation transporter-like 2 antisenseorganic cation transporter-like protein 2 antis | |
Modification date | 20141207 | |
dbXrefs | MIM : 603240 | |
HGNC : HGNC | ||
Ensembl : ENSG00000254827 | ||
HPRD : 09127 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC22A18AS | |
BioGPS: 5003 | ||
Pathway | NCI Pathway Interaction Database: SLC22A18AS | |
KEGG: SLC22A18AS | ||
REACTOME: SLC22A18AS | ||
Pathway Commons: SLC22A18AS | ||
Context | iHOP: SLC22A18AS | |
ligand binding site mutation search in PubMed: SLC22A18AS | ||
UCL Cancer Institute: SLC22A18AS | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Colon | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COAD | |
Reference showing the relevant tissue of SLC22A18AS | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC22A18AS |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.520043793 | -1.934486166 | 1.414442373 | 1.59E-09 | 8.93E-09 |
LUAD | 1.457995132 | -1.333870386 | 2.791865517 | 3.15E-21 | 7.52E-20 |
COAD | 2.198287041 | 4.849790887 | -2.651503846 | 1.68E-12 | 3.96E-11 |
KICH | -1.54724542 | 0.73567858 | -2.282924 | 3.43E-06 | 1.17E-05 |
KIRP | 0.68766108 | 1.76742358 | -1.0797625 | 0.0217 | 0.043672711 |
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TissGene-miRNA for SLC22A18AS |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC22A18AS |
TissGeneSNV for SLC22A18AS |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R36S | LIHC | 1 |
p.R105W | CESC | 1 |
p.P222L | DLBC | 1 |
p.F229L | SARC | 1 |
p.A122T | ESCA | 1 |
p.G74A | LIHC | 1 |
p.T200I | DLBC | 1 |
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TissGeneCNV for SLC22A18AS |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC22A18AS |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OF-01A | CARS-SLC22A18AS | Out-of-Frame | chr11:3028108 | chr11:2909865 |
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TissGeneNet for SLC22A18AS |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC22A18AS |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC22A18AS |
TissGeneDrug for SLC22A18AS |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC22A18AS |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004903 | Beckwith-Wiedemann Syndrome | 1 | BeFree |