TissGeneSummary for ORM2 |
Gene summary |
Basic gene information | Gene symbol | ORM2 |
Gene name | orosomucoid 2 | |
Synonyms | AGP-B|AGP-B'|AGP2 | |
Cytomap | UCSC genome browser: 9q32 | |
Type of gene | protein-coding | |
RefGenes | NM_000608.2, | |
Description | AGP 2OMD 2alpha-1-acid glycoprotein 2alpha-1-acid glycoprotein, type 2orosomucoid-2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 138610 | |
HGNC : HGNC | ||
Ensembl : ENSG00000228278 | ||
HPRD : 00725 | ||
Vega : OTTHUMG00000021014 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ORM2 | |
BioGPS: 5005 | ||
Pathway | NCI Pathway Interaction Database: ORM2 | |
KEGG: ORM2 | ||
REACTOME: ORM2 | ||
Pathway Commons: ORM2 | ||
Context | iHOP: ORM2 | |
ligand binding site mutation search in PubMed: ORM2 | ||
UCL Cancer Institute: ORM2 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of ORM2 | ||
Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ORM2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 11.78951351 | 13.86594751 | -2.076434 | 6.73E-08 | 4.97E-07 |
BRCA | 0.122676666 | -1.479092633 | 1.601769298 | 1.55E-06 | 4.16E-06 |
LUSC | -0.112117865 | 2.612697821 | -2.724815686 | 7.06E-11 | 2.71E-10 |
COAD | -1.315024954 | -2.3489788 | 1.033953846 | 0.000441 | 0.00138033 |
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TissGene-miRNA for ORM2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ORM2 |
TissGeneSNV for ORM2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M129T | UCEC | 1 |
p.R108T | HNSC | 1 |
p.Q63H | HNSC | 1 |
p.W178C | THYM | 1 |
p.R101Q | LIHC | 1 |
p.F144V | ESCA | 1 |
p.R113Q | DLBC | 1 |
p.W42* | CESC | 1 |
p.S143Y | COAD | 1 |
p.E158K | SKCM | 1 |
p.T74R | HNSC | 1 |
p.T77M | STAD | 1 |
p.R185H | PRAD | 1 |
p.R51Q | STAD | 1 |
p.D164N | DLBC | 1 |
p.R191Q | BLCA | 1 |
p.E75Q | BRCA | 1 |
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TissGeneCNV for ORM2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ORM2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ORM2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ORM2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ORM2 |
TissGeneDrug for ORM2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ORM2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023473 | Myeloid Leukemia, Chronic | 1 | GAD |
umls:C0037023 | Sialadenitis | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |
umls:C2608079 | WARFARIN SENSITIVITY (disorder) | 1 | GAD |