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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for OXTR
check button Gene summary
Basic gene informationGene symbolOXTR
Gene nameoxytocin receptor
SynonymsOT-R
CytomapUCSC genome browser: 3p25
Type of geneprotein-coding
RefGenesNM_000916.3,
Description-
Modification date20141222
dbXrefs MIM : 167055
HGNC : HGNC
Ensembl : ENSG00000180914
HPRD : 01328
Vega : OTTHUMG00000090537
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_OXTR
BioGPS: 5021
PathwayNCI Pathway Interaction Database: OXTR
KEGG: OXTR
REACTOME: OXTR
Pathway Commons: OXTR
ContextiHOP: OXTR
ligand binding site mutation search in PubMed: OXTR
UCL Cancer Institute: OXTR
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BreastUterus
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BRCAUCEC,UCS
Reference showing the relevant tissue of OXTR
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for OXTR

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
THCA-1.569668638-2.6719635541.1022949159.33E-105.45E-09
KICH-2.558712164-0.742580164-1.8161328.20E-073.11E-06
BRCA0.8901222925.132971415-4.2428491231.89E-292.39E-28
COAD-0.659837087-3.0471332412.3872961544.50E-131.33E-11
LIHC-1.524396164-2.6192281641.0948320.002570.006370502
STAD-0.555625789-2.3690570391.813431251.58E-050.000167883


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TissGene-miRNA for OXTR

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for OXTR
TissGeneSNV for OXTR

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G107RSKCM1
p.S176FSKCM1
p.R376CSKCM1
p.P326LSKCM1
p.A167SLUAD1
p.T289MLIHC1
p.P326SSKCM1
p.E339KSKCM1
p.D186NUCS1
p.A207VHNSC1
p.A243VSTAD1
p.R254LLUSC1
p.Q385KPRAD1
p.A167TBLCA1
p.R65CSTAD1
p.R40CSTAD1
p.T333MPAAD1
p.S368LSKCM1
p.D85EKICH1
p.A243SLUAD1
p.G196VLUAD1
p.S147LLUAD1
p.N367KUCEC1
p.V299IUCEC1
p.A304VUCEC1
p.C219YCESC1
p.T360MSARC1
p.L316FCESC1
p.V281MCESC1
p.S322RPAAD1
p.A256VSTAD1
p.G358ESKCM1
p.I328MHNSC1
p.M78TSTAD1
p.V314ISTAD1
p.R65HSTAD1
p.R343CSTAD1
p.A241TSKCM1
p.R376HUCEC1


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TissGeneCNV for OXTR

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for OXTR

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for OXTR

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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COAD (tumor)COAD (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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HNSC (tumor)HNSC (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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KICH (tumor)KICH (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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KIRC (tumor)KIRC (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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KIRP (tumor)KIRP (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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LIHC (tumor)LIHC (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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LUAD (tumor)LUAD (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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LUSC (tumor)LUSC (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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PRAD (tumor)PRAD (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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STAD (tumor)STAD (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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THCA (tumor)THCA (normal)
OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor)OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal)
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TissGeneProg for OXTR

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for OXTR
TissGeneDrug for OXTR

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB01282CarbetocinAgonistSmall moleculeApproved
DB00107OxytocinAgonistBiotechApproved|Vet_approved


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TissGeneDisease for OXTR

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0004352Autistic Disorder23BeFree,CTD_human,GAD
umls:C0018817Atrial Septal Defects9BeFree
umls:C1848140COGNITIVE FUNCTION 1, SOCIAL8BeFree
umls:C1510586Autism Spectrum Disorders7BeFree
umls:C0011570Mental Depression6BeFree,GAD
umls:C0011581Depressive disorder6BeFree
umls:C0678222Breast Carcinoma5BeFree
umls:C0003469Anxiety Disorders4BeFree
umls:C0006142Malignant neoplasm of breast4BeFree
umls:C0028754Obesity4BeFree
umls:C0036341Schizophrenia4BeFree,CTD_human
umls:C0003431Antisocial Personality Disorder2BeFree
umls:C0006012Borderline Personality Disorder2BeFree
umls:C0029463Osteosarcoma2BeFree
umls:C0033038Premature Ejaculation2BeFree
umls:C0038443Stress, Psychological2BeFree
umls:C0041696Unipolar Depression2BeFree
umls:C0086132Depressive Symptoms2BeFree
umls:C0585442Osteosarcoma of bone2BeFree
umls:C1269683Major Depressive Disorder2BeFree
umls:C1842981NEUROTICISM2BeFree
umls:C0001973Alcoholic Intoxication, Chronic1GAD
umls:C0002453Amenorrhea1BeFree
umls:C0003125Anorexia Nervosa1BeFree
umls:C0003130Anoxia1RGD
umls:C0004096Asthma1BeFree,GAD
umls:C0004936Mental disorders1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1CTD_human
umls:C0008074Child Development Disorders, Pervasive1CTD_human
umls:C0008495Chorioamnionitis1GAD
umls:C0009241Cognition Disorders1CTD_human
umls:C0013473Eating Disorders1BeFree
umls:C0015230Exanthema1BeFree
umls:C0015944Fetal Membranes, Premature Rupture1GAD
umls:C0020507Hyperplasia1LHGDN
umls:C0020538Hypertensive disease1RGD
umls:C0022104Irritable Bowel Syndrome1BeFree,GAD
umls:C0022876Premature Obstetric Labor1GAD
umls:C0023267Fibroid Tumor1BeFree
umls:C0024121Lung Neoplasms1BeFree
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0032914Pre-Eclampsia1GAD
umls:C0038358Gastric ulcer1RGD
umls:C0042133Uterine Fibroids1BeFree
umls:C0149925Small cell carcinoma of lung1BeFree
umls:C0151526Premature Birth1GAD
umls:C0206754Neuroendocrine Tumors1BeFree
umls:C0221074Depression, Postpartum1BeFree
umls:C0236792Asperger Syndrome1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0268318Cholestasis of pregnancy1BeFree
umls:C0338656Impaired cognition1BeFree
umls:C0338908Mixed anxiety and depressive disorder1BeFree
umls:C0338986Atypical autism1BeFree
umls:C0424166Social fear1BeFree
umls:C0429468Anovulatory1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0748073psychosocial stressor1BeFree
umls:C0795806Chromosome 3, monosomy 3p1BeFree
umls:C0848332Spots on skin1BeFree
umls:C0871189Psychotic symptom1BeFree
umls:C1263846Attention deficit hyperactivity disorder1BeFree
umls:C1563705Nephrogenic Diabetes Insipidus, Type I1BeFree
umls:C2267227Bulimia Nervosa1BeFree
umls:C2919032Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified1GAD
umls:C2931337Chromosome 3, monosomy 3p251CTD_human
umls:C2979982Vaginal Hemorrhage1BeFree
umls:C3163625vaginal bleeding during pregnancy1BeFree
umls:C3840214High-functioning autism1BeFree