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| TissGeneSummary for OXTR |
 Gene summary |
| Basic gene information | Gene symbol | OXTR |
| Gene name | oxytocin receptor | |
| Synonyms | OT-R | |
| Cytomap | UCSC genome browser: 3p25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000916.3, | |
| Description | - | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 167055 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000180914 | ||
| HPRD : 01328 | ||
| Vega : OTTHUMG00000090537 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OXTR | |
| BioGPS: 5021 | ||
| Pathway | NCI Pathway Interaction Database: OXTR | |
| KEGG: OXTR | ||
| REACTOME: OXTR | ||
| Pathway Commons: OXTR | ||
| Context | iHOP: OXTR | |
| ligand binding site mutation search in PubMed: OXTR | ||
| UCL Cancer Institute: OXTR | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCAUCEC,UCS | |
| Reference showing the relevant tissue of OXTR | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for OXTR |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -1.569668638 | -2.671963554 | 1.102294915 | 9.33E-10 | 5.45E-09 |
| KICH | -2.558712164 | -0.742580164 | -1.816132 | 8.20E-07 | 3.11E-06 |
| BRCA | 0.890122292 | 5.132971415 | -4.242849123 | 1.89E-29 | 2.39E-28 |
| COAD | -0.659837087 | -3.047133241 | 2.387296154 | 4.50E-13 | 1.33E-11 |
| LIHC | -1.524396164 | -2.619228164 | 1.094832 | 0.00257 | 0.006370502 |
| STAD | -0.555625789 | -2.369057039 | 1.81343125 | 1.58E-05 | 0.000167883 |
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| TissGene-miRNA for OXTR |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for OXTR |
| TissGeneSNV for OXTR |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G107R | SKCM | 1 |
| p.S176F | SKCM | 1 |
| p.R376C | SKCM | 1 |
| p.P326L | SKCM | 1 |
| p.A167S | LUAD | 1 |
| p.T289M | LIHC | 1 |
| p.P326S | SKCM | 1 |
| p.E339K | SKCM | 1 |
| p.D186N | UCS | 1 |
| p.A207V | HNSC | 1 |
| p.A243V | STAD | 1 |
| p.R254L | LUSC | 1 |
| p.Q385K | PRAD | 1 |
| p.A167T | BLCA | 1 |
| p.R65C | STAD | 1 |
| p.R40C | STAD | 1 |
| p.T333M | PAAD | 1 |
| p.S368L | SKCM | 1 |
| p.D85E | KICH | 1 |
| p.A243S | LUAD | 1 |
| p.G196V | LUAD | 1 |
| p.S147L | LUAD | 1 |
| p.N367K | UCEC | 1 |
| p.V299I | UCEC | 1 |
| p.A304V | UCEC | 1 |
| p.C219Y | CESC | 1 |
| p.T360M | SARC | 1 |
| p.L316F | CESC | 1 |
| p.V281M | CESC | 1 |
| p.S322R | PAAD | 1 |
| p.A256V | STAD | 1 |
| p.G358E | SKCM | 1 |
| p.I328M | HNSC | 1 |
| p.M78T | STAD | 1 |
| p.V314I | STAD | 1 |
| p.R65H | STAD | 1 |
| p.R343C | STAD | 1 |
| p.A241T | SKCM | 1 |
| p.R376H | UCEC | 1 |
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| TissGeneCNV for OXTR |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for OXTR |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for OXTR |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
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| COAD (tumor) | COAD (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
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| HNSC (tumor) | HNSC (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
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| KICH (tumor) | KICH (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
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| KIRC (tumor) | KIRC (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
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| KIRP (tumor) | KIRP (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
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| LIHC (tumor) | LIHC (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
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| PRAD (tumor) | PRAD (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
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| STAD (tumor) | STAD (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
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| THCA (tumor) | THCA (normal) |
| OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (tumor) | OXTR, ARRB2, GABPA, GPRASP1, SNX1, OXT, GRK5, AVP (normal) |
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| TissGeneProg for OXTR |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for OXTR |
| TissGeneDrug for OXTR |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB01282 | Carbetocin | Agonist | Small molecule | Approved |
| DB00107 | Oxytocin | Agonist | Biotech | Approved|Vet_approved |
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| TissGeneDisease for OXTR |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004352 | Autistic Disorder | 23 | BeFree,CTD_human,GAD |
| umls:C0018817 | Atrial Septal Defects | 9 | BeFree |
| umls:C1848140 | COGNITIVE FUNCTION 1, SOCIAL | 8 | BeFree |
| umls:C1510586 | Autism Spectrum Disorders | 7 | BeFree |
| umls:C0011570 | Mental Depression | 6 | BeFree,GAD |
| umls:C0011581 | Depressive disorder | 6 | BeFree |
| umls:C0678222 | Breast Carcinoma | 5 | BeFree |
| umls:C0003469 | Anxiety Disorders | 4 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0028754 | Obesity | 4 | BeFree |
| umls:C0036341 | Schizophrenia | 4 | BeFree,CTD_human |
| umls:C0003431 | Antisocial Personality Disorder | 2 | BeFree |
| umls:C0006012 | Borderline Personality Disorder | 2 | BeFree |
| umls:C0029463 | Osteosarcoma | 2 | BeFree |
| umls:C0033038 | Premature Ejaculation | 2 | BeFree |
| umls:C0038443 | Stress, Psychological | 2 | BeFree |
| umls:C0041696 | Unipolar Depression | 2 | BeFree |
| umls:C0086132 | Depressive Symptoms | 2 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 2 | BeFree |
| umls:C1269683 | Major Depressive Disorder | 2 | BeFree |
| umls:C1842981 | NEUROTICISM | 2 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
| umls:C0002453 | Amenorrhea | 1 | BeFree |
| umls:C0003125 | Anorexia Nervosa | 1 | BeFree |
| umls:C0003130 | Anoxia | 1 | RGD |
| umls:C0004096 | Asthma | 1 | BeFree,GAD |
| umls:C0004936 | Mental disorders | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| umls:C0008074 | Child Development Disorders, Pervasive | 1 | CTD_human |
| umls:C0008495 | Chorioamnionitis | 1 | GAD |
| umls:C0009241 | Cognition Disorders | 1 | CTD_human |
| umls:C0013473 | Eating Disorders | 1 | BeFree |
| umls:C0015230 | Exanthema | 1 | BeFree |
| umls:C0015944 | Fetal Membranes, Premature Rupture | 1 | GAD |
| umls:C0020507 | Hyperplasia | 1 | LHGDN |
| umls:C0020538 | Hypertensive disease | 1 | RGD |
| umls:C0022104 | Irritable Bowel Syndrome | 1 | BeFree,GAD |
| umls:C0022876 | Premature Obstetric Labor | 1 | GAD |
| umls:C0023267 | Fibroid Tumor | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032914 | Pre-Eclampsia | 1 | GAD |
| umls:C0038358 | Gastric ulcer | 1 | RGD |
| umls:C0042133 | Uterine Fibroids | 1 | BeFree |
| umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
| umls:C0151526 | Premature Birth | 1 | GAD |
| umls:C0206754 | Neuroendocrine Tumors | 1 | BeFree |
| umls:C0221074 | Depression, Postpartum | 1 | BeFree |
| umls:C0236792 | Asperger Syndrome | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0268318 | Cholestasis of pregnancy | 1 | BeFree |
| umls:C0338656 | Impaired cognition | 1 | BeFree |
| umls:C0338908 | Mixed anxiety and depressive disorder | 1 | BeFree |
| umls:C0338986 | Atypical autism | 1 | BeFree |
| umls:C0424166 | Social fear | 1 | BeFree |
| umls:C0429468 | Anovulatory | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0748073 | psychosocial stressor | 1 | BeFree |
| umls:C0795806 | Chromosome 3, monosomy 3p | 1 | BeFree |
| umls:C0848332 | Spots on skin | 1 | BeFree |
| umls:C0871189 | Psychotic symptom | 1 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 1 | BeFree |
| umls:C1563705 | Nephrogenic Diabetes Insipidus, Type I | 1 | BeFree |
| umls:C2267227 | Bulimia Nervosa | 1 | BeFree |
| umls:C2919032 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 1 | GAD |
| umls:C2931337 | Chromosome 3, monosomy 3p25 | 1 | CTD_human |
| umls:C2979982 | Vaginal Hemorrhage | 1 | BeFree |
| umls:C3163625 | vaginal bleeding during pregnancy | 1 | BeFree |
| umls:C3840214 | High-functioning autism | 1 | BeFree |
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