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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PAEP
check button Gene summary
Basic gene informationGene symbolPAEP
Gene nameprogestagen-associated endometrial protein
SynonymsGD|GdA|GdF|GdS|PAEG|PEP|PP14
CytomapUCSC genome browser: 9q34
Type of geneprotein-coding
RefGenesNM_001018049.1,
NM_002571.2,
DescriptionPEGPP14 protein (placental protein 14)alpha uterine proteinglycodelinglycodelin-Aglycodelin-Fglycodelin-Splacental protein 14pregnancy-associated endometrial alpha-2 globulinpregnancy-associated endometrial alpha-2-globulinprogestagen-associated
Modification date20141207
dbXrefs MIM : 173310
HGNC : HGNC
Ensembl : ENSG00000122133
HPRD : 01411
Vega : OTTHUMG00000020914
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PAEP
BioGPS: 5047
PathwayNCI Pathway Interaction Database: PAEP
KEGG: PAEP
REACTOME: PAEP
Pathway Commons: PAEP
ContextiHOP: PAEP
ligand binding site mutation search in PubMed: PAEP
UCL Cancer Institute: PAEP
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)OvaryProstateUterus
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)OVPRADUCEC,UCS
Reference showing the relevant tissue of PAEP
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for PAEP

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
HNSC0.451082506-2.6806058663.1316883722.59E-128.21E-11
LUAD3.151898384-1.3794171334.5313155173.46E-112.22E-10
COAD-1.585378406-3.1278014831.5424230774.10E-062.04E-05
KIRC-1.132304154-3.0833166541.95101255.43E-061.30E-05
ESCA-0.317336098-3.0080451892.6907090910.005630.042734198
PRAD-2.868414944-0.647664944-2.220750.001320.0041085
STAD-1.761567348-2.8318298481.07026250.0006180.003572961
LUSC-0.813561589-2.1092615891.29570.0001030.000213195
LIHC-0.662438098-3.0937680982.431332.79E-050.000107207


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TissGene-miRNA for PAEP

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for PAEP
TissGeneSNV for PAEP

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.N96SUCEC1
p.P160HLIHC1
p.Q126KBRCA1
p.T36ISKCM1
p.V143FLUAD1
p.R179HCOAD1
p.Y117CUCEC1
p.R78KSKCM1
p.T67NLUAD1
p.D148NSKCM1
p.E69KSTAD1
p.T105MBRCA1
p.R78KHNSC1
p.R179HACC1
p.I61LPRAD1
p.P160SUCEC1
p.H164NSKCM1


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TissGeneCNV for PAEP

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for PAEP

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADAKIRCTCGA-B0-5706-01APAEP-FAR1NAChr9:138458622Chr11:13744912


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TissGeneNet for PAEP

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
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COAD (tumor)COAD (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
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HNSC (tumor)HNSC (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
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KICH (tumor)KICH (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
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KIRC (tumor)KIRC (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
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KIRP (tumor)KIRP (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
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LIHC (tumor)LIHC (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
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LUAD (tumor)LUAD (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
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LUSC (tumor)LUSC (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (tumor)PAEP, COPS6, SMAD3, IGSF21, PTPRC, RIF1, UBE2E1, A2M, EEF1A1, BANF1, XRCC6 (normal)
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TissGeneProg for PAEP

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for PAEP
TissGeneDrug for PAEP

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for PAEP

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0019196Hepatitis C113BeFree
umls:C0524910Hepatitis C, Chronic102BeFree
umls:C0019163Hepatitis B36BeFree
umls:C0524909Hepatitis B, Chronic26BeFree
umls:C0019693HIV Infections18BeFree
umls:C0002871Anemia11BeFree
umls:C0006142Malignant neoplasm of breast11BeFree
umls:C0678222Breast Carcinoma11BeFree
umls:C0023890Liver Cirrhosis8BeFree
umls:C0025202melanoma8BeFree
umls:C0019189Hepatitis, Chronic7BeFree
umls:C0023486Prolymphocytic Leukemia7BeFree
umls:C0029925Ovarian Carcinoma7BeFree
umls:C1623038Cirrhosis7BeFree
umls:C2239176Liver carcinoma7BeFree
umls:C0011570Mental Depression5BeFree
umls:C0011581Depressive disorder5BeFree
umls:C0014175Endometriosis5BeFree,LHGDN
umls:C1140680Malignant neoplasm of ovary5BeFree
umls:C0007103Malignant neoplasm of endometrium4BeFree
umls:C0011849Diabetes Mellitus4BeFree
umls:C0476089Endometrial Carcinoma4BeFree
umls:C1883486Uterine Corpus Cancer4BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0010346Crohn Disease3BeFree
umls:C0011847Diabetes3BeFree
umls:C0019158Hepatitis3BeFree
umls:C0019159Hepatitis A3BeFree
umls:C0023895Liver diseases3BeFree
umls:C0024623Malignant neoplasm of stomach3BeFree
umls:C0027627Neoplasm Metastasis3BeFree
umls:C0235974Pancreatic carcinoma3BeFree
umls:C0278883Metastatic melanoma3BeFree
umls:C0302592Cervix carcinoma3BeFree
umls:C0346647Malignant neoplasm of pancreas3BeFree
umls:C0699791Stomach Carcinoma3BeFree
umls:C1153706Endometrial adenocarcinoma3BeFree
umls:C1458155Mammary Neoplasms3BeFree,CTD_human,LHGDN
umls:C0003873Rheumatoid Arthritis2BeFree
umls:C0011226Hepatitis D Infection2BeFree
umls:C0015695Fatty Liver2BeFree
umls:C0017636Glioblastoma2BeFree
umls:C0017638Glioma2BeFree
umls:C0019348Herpes Simplex Infections2BeFree
umls:C0021367Mammary Ductal Carcinoma2BeFree
umls:C0023267Fibroid Tumor2BeFree,LHGDN
umls:C0024299Lymphoma2BeFree
umls:C0027819Neuroblastoma2BeFree
umls:C0038454Cerebrovascular accident2BeFree
umls:C0042769Virus Diseases2BeFree
umls:C0242379Malignant neoplasm of lung2BeFree
umls:C0275524Coinfection2BeFree
umls:C0280100Solid tumour2BeFree
umls:C0376358Malignant neoplasm of prostate2BeFree
umls:C0392607Severe combined immunodeficiency due to adenosine deaminase deficiency2BeFree
umls:C0400914Acute hepatitis C2BeFree
umls:C0600139Prostate carcinoma2BeFree
umls:C0677886Epithelial ovarian cancer2BeFree
umls:C0684249Carcinoma of lung2BeFree
umls:C0700095Central neuroblastoma2BeFree
umls:C0836924Thrombocytosis2BeFree
umls:C0858252Breast adenocarcinoma2BeFree
umls:C1336820Treatment-Induced Anemia2BeFree
umls:C1512409Hepatocarcinogenesis2BeFree
umls:C1520166Xenograft Model2BeFree
umls:C1527249Colorectal Cancer2BeFree
umls:C1863236SCID Due to ADA Deficiency, Early-Onset2BeFree
umls:C0000786Spontaneous abortion1CTD_human
umls:C0001418Adenocarcinoma1LHGDN
umls:C0001815Primary Myelofibrosis1BeFree
umls:C0002453Amenorrhea1BeFree
umls:C0002736Amyotrophic Lateral Sclerosis1BeFree
umls:C0003123Anorexia1BeFree
umls:C0006118Brain Neoplasms1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007570Celiac Disease1BeFree
umls:C0008497Choriocarcinoma1BeFree
umls:C0011603Dermatitis1BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree
umls:C0012833Dizziness1BeFree
umls:C0013949Embryopathies1BeFree
umls:C0017178Gastrointestinal Diseases1BeFree
umls:C0020538Hypertensive disease1BeFree
umls:C0020541Hypertension, Portal1BeFree
umls:C0020676Hypothyroidism1BeFree
umls:C0020875Ileal Diseases1BeFree
umls:C0021051Immunologic Deficiency Syndromes1BeFree
umls:C0023434Chronic Lymphocytic Leukemia1BeFree
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0023903Liver neoplasms1BeFree
umls:C0026987Myelofibrosis1BeFree
umls:C0029463Osteosarcoma1BeFree
umls:C0032460Polycystic Ovary Syndrome1LHGDN
umls:C0032463Polycythemia Vera1BeFree
umls:C0032584polyps1LHGDN
umls:C0038013Ankylosing spondylitis1BeFree
umls:C0039101synovial sarcoma1BeFree
umls:C0040028Thrombocythemia, Essential1BeFree
umls:C0042133Uterine Fibroids1BeFree
umls:C0042384Vasculitis1BeFree
umls:C0042571Vertigo1BeFree
umls:C0085110Severe Combined Immunodeficiency1BeFree
umls:C0086132Depressive Symptoms1BeFree
umls:C0152096Complete trisomy 18 syndrome1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0206709Cystadenoma, Serous1BeFree
umls:C0268124Adenosine deaminase deficiency1BeFree
umls:C0334337Endometrioid adenoma1BeFree
umls:C0334507Synovial sarcoma, biphasic1BeFree
umls:C0341439Chronic liver disease1BeFree
umls:C0341486Cystadenoma of pancreas1BeFree
umls:C0346957Disseminated Malignant Neoplasm1BeFree
umls:C0543697Mixed cryoglobulinemia1BeFree
umls:C0549379Recurrent Carcinoma1BeFree
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0747845early pregnancy1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C0948775High weight1BeFree
umls:C1264606Persistent infection1BeFree
umls:C1319315Adenocarcinoma of large intestine1BeFree
umls:C1527349Ductal Breast Carcinoma1BeFree
umls:C1839163THROMBOCYTOPENIA 1 (disorder)1BeFree
umls:C1861385SYMPHALANGISM, PROXIMAL1BeFree
umls:C1863239Partial adenosine deaminase deficiency1BeFree
umls:C2711227Steatohepatitis1BeFree
umls:C2955673Urate nephropathy1BeFree
umls:C3539878Triple Negative Breast Neoplasms1BeFree
umls:C3839044Compensated liver disease1BeFree