TissGeneSummary for CD207 |
Gene summary |
Basic gene information | Gene symbol | CD207 |
Gene name | CD207 molecule, langerin | |
Synonyms | CLEC4K | |
Cytomap | UCSC genome browser: 2p13 | |
Type of gene | protein-coding | |
RefGenes | NM_015717.4, | |
Description | C-type lectin domain family 4 member KC-type lectin domain family 4, member KCD207 antigen, langerinLangerhans cell specific c-type lectin | |
Modification date | 20141222 | |
dbXrefs | MIM : 604862 | |
HGNC : HGNC | ||
Ensembl : ENSG00000116031 | ||
HPRD : 07278 | ||
Vega : OTTHUMG00000153176 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CD207 | |
BioGPS: 50489 | ||
Pathway | NCI Pathway Interaction Database: CD207 | |
KEGG: CD207 | ||
REACTOME: CD207 | ||
Pathway Commons: CD207 | ||
Context | iHOP: CD207 | |
ligand binding site mutation search in PubMed: CD207 | ||
UCL Cancer Institute: CD207 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of CD207 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0051607 | defense response to virus | 17334373 | GO:0051607 | defense response to virus | 17334373 |
Top |
TissGeneExp for CD207 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -2.3406701 | -0.604508561 | -1.736161538 | 1.04E-05 | 4.76E-05 |
LIHC | -2.643864407 | -0.986484407 | -1.65738 | 5.94E-07 | 3.36E-06 |
KIRC | -0.952220741 | -2.547752685 | 1.595531944 | 1.18E-07 | 3.28E-07 |
THCA | 0.303153694 | -2.368424272 | 2.671577966 | 3.90E-09 | 2.08E-08 |
KICH | -1.591496407 | -2.812812407 | 1.221316 | 0.0189 | 0.032067436 |
HNSC | 1.107027128 | 2.723710848 | -1.616683721 | 0.00156 | 0.005007133 |
Top |
TissGene-miRNA for CD207 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UVM | hsa-miR-22-3p | MIMAT0000077 | 0.0073 | -0.3 | 80 |
Top |
TissGeneMut for CD207 |
TissGeneSNV for CD207 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q79E | LUSC | 1 |
p.S99N | UCEC | 1 |
p.V267L | LUAD | 1 |
p.R24Q | THYM | 1 |
p.R172W | READ | 1 |
p.V147A | LIHC | 1 |
p.Y323D | READ | 1 |
p.R187Q | PAAD | 1 |
p.V194M | BLCA | 1 |
p.N288D | COAD | 1 |
p.F206L | BRCA | 1 |
p.P28S | SKCM | 1 |
p.P283S | SKCM | 1 |
p.E156* | LUSC | 1 |
p.M111I | HNSC | 1 |
p.D73N | SKCM | 1 |
p.A55T | PAAD | 1 |
p.E6D | PAAD | 1 |
p.D269G | PRAD | 1 |
p.E4Q | BLCA | 1 |
p.E285V | LIHC | 1 |
p.R84C | SKCM | 1 |
p.C223R | LUSC | 1 |
p.V57D | LUAD | 1 |
p.E131D | SKCM | 1 |
p.F241V | STAD | 1 |
p.Q138* | SKCM | 1 |
p.W266C | LUAD | 1 |
p.Y217H | UCEC | 1 |
p.R321* | PRAD | 1 |
p.S196Y | UCEC | 1 |
p.P28L | SKCM | 1 |
p.K299N | UCEC | 1 |
p.E114V | COAD | 1 |
p.P155S | SKCM | 1 |
p.S129N | COAD | 1 |
p.R172Q | LIHC | 1 |
p.Y118C | STAD | 1 |
p.N205I | SKCM | 1 |
p.W281* | SKCM | 1 |
p.A10V | UCEC | 1 |
p.A246V | COAD | 1 |
p.L184F | HNSC | 1 |
p.R172W | PAAD | 1 |
p.P36L | COAD | 1 |
p.P155Q | LUAD | 1 |
p.S89N | COAD | 1 |
p.Y251C | LUSC | 1 |
p.S228L | SKCM | 1 |
p.R172Q | GBM | 1 |
p.K183R | LUSC | 1 |
p.K313T | UCEC | 1 |
p.P28H | LUAD | 1 |
p.W216* | BLCA | 1 |
p.L211F | SKCM | 1 |
p.K313I | COAD | 1 |
p.F12S | SKCM | 1 |
Top |
TissGeneCNV for CD207 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CD207 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for CD207 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CD207 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CD207 |
TissGeneDrug for CD207 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CD207 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019621 | Histiocytosis, Langerhans-Cell | 6 | BeFree,LHGDN |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
umls:C0022602 | Actinic keratosis | 1 | BeFree |
umls:C0027022 | Myeloproliferative disease | 1 | BeFree |
umls:C0027430 | Nasal Polyps | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0032749 | Post-kala-azar dermal leishmaniasis | 1 | BeFree |
umls:C0751356 | Idiopathic Inflammatory Myopathies | 1 | BeFree |
umls:C1292778 | Chronic myeloproliferative disorder | 1 | BeFree |
umls:C3150657 | BIRBECK GRANULE DEFICIENCY | 1 | CLINVAR,UNIPROT |
umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 1 | BeFree |