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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PRDX1
check button Gene summary
Basic gene informationGene symbolPRDX1
Gene nameperoxiredoxin 1
SynonymsMSP23|NKEF-A|NKEFA|PAG|PAGA|PAGB|PRX1|PRXI|TDPX2
CytomapUCSC genome browser: 1p34.1
Type of geneprotein-coding
RefGenesNM_001202431.1,
NM_002574.3,NM_181696.2,NM_181697.2,
Descriptionnatural killer cell-enhancing factor Anatural killer-enhancing factor Aperoxiredoxin-1proliferation-associated gene Aproliferation-associated gene proteinthioredoxin peroxidase 2thioredoxin-dependent peroxide reductase 2
Modification date20141222
dbXrefs MIM : 176763
HGNC : HGNC
Ensembl : ENSG00000117450
HPRD : 01458
Vega : OTTHUMG00000007738
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRDX1
BioGPS: 5052
PathwayNCI Pathway Interaction Database: PRDX1
KEGG: PRDX1
REACTOME: PRDX1
Pathway Commons: PRDX1
ContextiHOP: PRDX1
ligand binding site mutation search in PubMed: PRDX1
UCL Cancer Institute: PRDX1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BladderThyroid gland
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BLCATHCA
Reference showing the relevant tissue of PRDX1
Description by TissGene annotationsTissgsLTS
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0042744hydrogen peroxide catabolic process11986303
GO:0042744hydrogen peroxide catabolic process11986303


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TissGeneExp for PRDX1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-0.2056786841.020389316-1.2260682.28E-155.03E-14


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TissGene-miRNA for PRDX1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for PRDX1
TissGeneSNV for PRDX1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.F42LBLCA2
p.I184MBLCA1
p.S106*BLCA1
p.F15LKIRC1
p.G129DESCA1
p.H84PLUAD1
p.Q161*SKCM1
p.R140WSKCM1
p.R62TLUSC1
p.A63TCOAD1
p.E193*STAD1
p.D33GTHCA1
p.K185NPAAD1
p.I184MLUAD1
p.E65XREAD1
p.F195LLIHC1
p.I184FTHYM1
p.P45LLUAD1
p.I184MCESC1
p.P108SSKCM1
p.K92NPRAD1
p.K67RLUAD1
p.Q161XSKCM1
p.S191RESCA1
p.I56SUCEC1
p.E193XSTAD1
p.D182NBLCA1


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TissGeneCNV for PRDX1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for PRDX1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNACD742959PRDX1-TNFAIP3chr1:45976963chr6:138203259
Chimerdb3.0ChiTaRsNACN369906SNRNP40-PRDX1chr1:31769566chr1:45981406
Chimerdb3.0ChiTaRsNACN267646PRDX1-PRDX1chr1:45980245chr1:45981369
Chimerdb3.0ChiTaRsNABF763254PRDX1-WDR59chr1:45977225chr16:74985356
Chimerdb3.0ChiTaRsNAAI084599USP16-PRDX1chr21:30415890chr1:45976942
Chimerdb3.0FusionScanBRCATCGA-A2-A0YE-01AHS2ST1-PRDX1CDS-5'UTRchr1:87380843chr1:45984726
Chimerdb3.0TopHat-FusionSTADTCGA-LN-A5U5-01A3PRDX1-MMACHC3'UTR-3'UTRchr1:45976750chr1:45976722
Chimerdb3.0TopHat-FusionSTADTCGA-LN-A5U5-01A3PRDX1-MMACHC3'UTR-3'UTRchr1:45976751chr1:45976722
Chimerdb3.0TopHat-FusionSTADTCGA-LN-A5U5-01A3PRDX1-MMACHC3'UTR-3'UTRchr1:45976759chr1:45976735
Chimerdb3.0TopHat-FusionSTADTCGA-LN-A5U5-01A3PRDX1-MMACHC3'UTR-3'UTRchr1:45976814chr1:45976726
Chimerdb3.0TopHat-FusionSTADTCGA-LN-A5U5-01A3PRDX1-MMACHC3'UTR-3'UTRchr1:45976928chr1:45976722
Chimerdb3.0TopHat-FusionSTADTCGA-LN-A5U5-01A3PRDX1-MMACHC3'UTR-3'UTRchr1:45976929chr1:45976716
Chimerdb3.0TopHat-FusionSTADTCGA-LN-A5U5-01A3PRDX1-MMACHC3'UTR-3'UTRchr1:45976931chr1:45976722
Chimerdb3.0TopHat-FusionOVTCGA-10-0931-01APRDX1-MMACHC3'UTR-3'UTRchr1:45976750chr1:45976722
Chimerdb3.0TopHat-FusionOVTCGA-10-0931-01APRDX1-MMACHC3'UTR-3'UTRchr1:45976751chr1:45976722
Chimerdb3.0TopHat-FusionOVTCGA-10-0931-01APRDX1-MMACHC3'UTR-3'UTRchr1:45976814chr1:45976726
Chimerdb3.0TopHat-FusionOVTCGA-10-0931-01APRDX1-MMACHC3'UTR-3'UTRchr1:45976929chr1:45976722
Chimerdb3.0TopHat-FusionOVTCGA-10-0931-01APRDX1-MMACHC3'UTR-3'UTRchr1:45976931chr1:45976722
Chimerdb3.0TopHat-FusionSTADTCGA-CG-4477-01APRDX1-MMACHC3'UTR-3'UTRchr1:45976751chr1:45976722
TCGAfusionPortalPRADABRCATCGA-A2-A0YE-01AHS2ST1-PRDX1CDS-5UTRChr1:87380843Chr1:45984726


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TissGeneNet for PRDX1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
PRDX1, PRDX4, YWHAQ, GAPDH, PTEN, IKBKAP, AR, PPP2R1A, EGFR, ADRM1, ABL1, UCHL5, UBE3A, PXN, PPP2R1B, IRF3, TXN, RAD52, MYD88, SH2D1B, ADH5 (tumor)PRDX1, UBC, YWHAZ, PRDX4, YWHAQ, GAPDH, PTEN, IKBKAP, BTRC, CALM1, AR, RIPK3, PPP2R1A, ADRM1, ABL1, UCHL5, UBE3A, IRF3, TXN, RAD52, SESN1 (normal)
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COAD (tumor)COAD (normal)
PRDX1, UBC, YWHAZ, YWHAQ, GAPDH, MYC, IKBKAP, BTRC, CALM1, RIPK3, EGFR, ADRM1, SESN2, ABL1, UCHL5, UBE3A, PPP2R1B, RAD52, MYD88, SH2D1B, ADH5 (tumor)PRDX1, YWHAZ, PRDX4, YWHAQ, GAPDH, MYC, PTEN, IKBKAP, BTRC, CALM1, AR, PPP2R1A, EGFR, ADRM1, ABL1, UCHL5, UBE3A, IRF3, TXN, CLEC4G, ADH5 (normal)
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HNSC (tumor)HNSC (normal)
PRDX1, UBC, YWHAZ, YWHAQ, GAPDH, MYC, CALM1, AR, RIPK3, PPP2R1A, ADRM1, SESN2, ABL1, UCHL5, PXN, PPP2R1B, IRF3, TXN, LUC7L, MYD88, SH2D1B (tumor)PRDX1, UBC, PRDX4, GAPDH, PTEN, BTRC, CALM1, AR, RIPK3, PPP2R1A, EGFR, ADRM1, ABL1, SMARCD1, UBE3A, IRF3, TXN, CLEC4G, LUC7L, MYD88, ADH5 (normal)
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KICH (tumor)KICH (normal)
PRDX1, YWHAZ, PRDX4, YWHAQ, GAPDH, PTEN, IKBKAP, BTRC, CALM1, AR, PPP2R1A, EGFR, ABL1, UCHL5, SMARCD1, UBE3A, PXN, PPP2R1B, TXN, SH2D1B, ADH5 (tumor)PRDX1, YWHAZ, PRDX4, YWHAQ, GAPDH, IKBKAP, BTRC, AR, PPP2R1A, ADRM1, UCHL5, UBE3A, PXN, PPP2R1B, IRF3, TXN, CLEC4G, RAD52, LUC7L, MYD88, SESN1 (normal)
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KIRC (tumor)KIRC (normal)
PRDX1, UBC, YWHAZ, PRDX4, YWHAQ, GAPDH, MYC, BTRC, CALM1, AR, PPP2R1A, EGFR, ABL1, UCHL5, UBE3A, PXN, PPP2R1B, IRF3, MYD88, ADH5, SESN1 (tumor)PRDX1, UBC, YWHAZ, PRDX4, GAPDH, PTEN, IKBKAP, BTRC, CALM1, AR, PPP2R1A, EGFR, ADRM1, SESN2, ABL1, SMARCD1, UBE3A, PPP2R1B, IRF3, TXN, SESN1 (normal)
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KIRP (tumor)KIRP (normal)
PRDX1, UBC, PRDX4, YWHAQ, GAPDH, CALM1, AR, RIPK3, SESN2, ABL1, UCHL5, SMARCD1, PXN, PPP2R1B, IRF3, TXN, RAD52, LUC7L, MYD88, ADH5, SESN1 (tumor)PRDX1, UBC, YWHAZ, PRDX4, GAPDH, MYC, PTEN, IKBKAP, BTRC, CALM1, AR, PPP2R1A, EGFR, ADRM1, SESN2, ABL1, UBE3A, PXN, TXN, RAD52, ADH5 (normal)
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LIHC (tumor)LIHC (normal)
PRDX1, YWHAZ, PRDX4, YWHAQ, GAPDH, PTEN, AR, PPP2R1A, EGFR, ADRM1, SESN2, ABL1, UCHL5, UBE3A, PPP2R1B, IRF3, TXN, RAD52, MYD88, SH2D1B, ADH5 (tumor)PRDX1, UBC, YWHAZ, PRDX4, YWHAQ, GAPDH, PTEN, IKBKAP, BTRC, PPP2R1A, EGFR, ADRM1, ABL1, UBE3A, PXN, PPP2R1B, IRF3, TXN, RAD52, MYD88, SESN1 (normal)
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LUAD (tumor)LUAD (normal)
PRDX1, YWHAZ, PRDX4, YWHAQ, GAPDH, MYC, IKBKAP, BTRC, AR, RIPK3, PPP2R1A, EGFR, ADRM1, ABL1, UCHL5, SMARCD1, PXN, TXN, LUC7L, MYD88, ADH5 (tumor)PRDX1, UBC, YWHAZ, PRDX4, YWHAQ, GAPDH, MYC, BTRC, RIPK3, PPP2R1A, EGFR, ADRM1, SESN2, ABL1, UCHL5, PPP2R1B, TXN, CLEC4G, LUC7L, MYD88, ADH5 (normal)
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LUSC (tumor)LUSC (normal)
PRDX1, UBC, YWHAZ, PRDX4, YWHAQ, GAPDH, MYC, IKBKAP, BTRC, AR, RIPK3, PPP2R1A, EGFR, ABL1, UCHL5, SMARCD1, PXN, PPP2R1B, TXN, ADH5, SESN1 (tumor)PRDX1, UBC, YWHAZ, YWHAQ, GAPDH, MYC, PTEN, BTRC, AR, RIPK3, EGFR, ABL1, UCHL5, PXN, TXN, CLEC4G, RAD52, LUC7L, MYD88, ADH5, SESN1 (normal)
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PRAD (tumor)PRAD (normal)
PRDX1, UBC, PRDX4, GAPDH, MYC, PTEN, IKBKAP, BTRC, CALM1, AR, PPP2R1A, EGFR, ADRM1, ABL1, UBE3A, IRF3, TXN, LUC7L, MYD88, SH2D1B, SESN1 (tumor)PRDX1, UBC, PRDX4, GAPDH, IKBKAP, BTRC, AR, PPP2R1A, EGFR, ADRM1, SESN2, ABL1, UCHL5, SMARCD1, UBE3A, PPP2R1B, IRF3, TXN, RAD52, LUC7L, MYD88 (normal)
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STAD (tumor)STAD (normal)
PRDX1, YWHAZ, PRDX4, GAPDH, PTEN, IKBKAP, CALM1, AR, RIPK3, ADRM1, ABL1, UCHL5, UBE3A, PPP2R1B, IRF3, TXN, RAD52, LUC7L, MYD88, SH2D1B, ADH5 (tumor)PRDX1, YWHAZ, PRDX4, GAPDH, PTEN, BTRC, CALM1, AR, RIPK3, EGFR, ADRM1, ABL1, UCHL5, PXN, PPP2R1B, IRF3, TXN, CLEC4G, RAD52, SH2D1B, SESN1 (normal)
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THCA (tumor)THCA (normal)
PRDX1, PRDX4, GAPDH, MYC, PTEN, IKBKAP, BTRC, CALM1, AR, RIPK3, PPP2R1A, EGFR, ADRM1, ABL1, UCHL5, SMARCD1, UBE3A, PPP2R1B, TXN, RAD52, MYD88 (tumor)PRDX1, UBC, PRDX4, YWHAQ, GAPDH, MYC, PTEN, IKBKAP, CALM1, RIPK3, PPP2R1A, EGFR, ADRM1, SESN2, ABL1, UBE3A, PXN, TXN, RAD52, MYD88, ADH5 (normal)
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TissGeneProg for PRDX1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for PRDX1
TissGeneDrug for PRDX1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for PRDX1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0684249Carcinoma of lung8BeFree
umls:C0242379Malignant neoplasm of lung7BeFree
umls:C0006142Malignant neoplasm of breast4BeFree
umls:C0017638Glioma4BeFree
umls:C0596263Carcinogenesis4BeFree
umls:C0678222Breast Carcinoma4BeFree
umls:C2239176Liver carcinoma4BeFree
umls:C0024121Lung Neoplasms3BeFree,LHGDN
umls:C0279626Squamous cell carcinoma of esophagus3BeFree,CTD_human
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C0002395Alzheimer's Disease2BeFree,LHGDN
umls:C0003130Anoxia2LHGDN
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree,CTD_human
umls:C0007137Squamous cell carcinoma2BeFree,LHGDN
umls:C0013080Down Syndrome2BeFree,LHGDN
umls:C0014859Esophageal Neoplasms2BeFree,LHGDN
umls:C0017636Glioblastoma2BeFree
umls:C0239946Fibrosis, Liver2BeFree
umls:C0001418Adenocarcinoma1BeFree
umls:C0003486Aortic Aneurysm1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007113Rectal Carcinoma1BeFree
umls:C0007222Cardiovascular Diseases1BeFree
umls:C0009375Colonic Neoplasms1LHGDN
umls:C0014544Epilepsy1BeFree
umls:C0014556Epilepsy, Temporal Lobe1BeFree
umls:C0015230Exanthema1BeFree
umls:C0022548Keloid1CTD_human
umls:C0026277Mixed Salivary Gland Tumor1LHGDN
umls:C0027022Myeloproliferative disease1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0029928Ovarian Diseases1BeFree
umls:C0036323Schistosomiasis1CTD_human
umls:C0152013Adenocarcinoma of lung (disorder)1BeFree
umls:C0152018Esophageal carcinoma1BeFree
umls:C0153381Malignant neoplasm of mouth1BeFree
umls:C0153452Malignant neoplasm of gallbladder1BeFree
umls:C0162871Aortic Aneurysm, Abdominal1BeFree
umls:C0206623Adenosquamous carcinoma1BeFree
umls:C0220641Lip and Oral Cavity Carcinoma1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0278504Non-small cell lung cancer stage I1BeFree
umls:C0279651Gallbladder adenocarcinoma1BeFree
umls:C0334579Anaplastic astrocytoma1BeFree
umls:C0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1BeFree
umls:C0346627Intestinal Cancer1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0546837Malignant neoplasm of esophagus1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0746102Chronic lung disease1BeFree
umls:C0848332Spots on skin1BeFree
umls:C1335110Oligodendroglial Neoplasm1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1504404Hippocampal sclerosis1BeFree
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1520166Xenograft Model1BeFree
umls:C3828416Radiation Damage1BeFree