TissGeneSummary for PRDX1 |
Gene summary |
Basic gene information | Gene symbol | PRDX1 |
Gene name | peroxiredoxin 1 | |
Synonyms | MSP23|NKEF-A|NKEFA|PAG|PAGA|PAGB|PRX1|PRXI|TDPX2 | |
Cytomap | UCSC genome browser: 1p34.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001202431.1, NM_002574.3,NM_181696.2,NM_181697.2, | |
Description | natural killer cell-enhancing factor Anatural killer-enhancing factor Aperoxiredoxin-1proliferation-associated gene Aproliferation-associated gene proteinthioredoxin peroxidase 2thioredoxin-dependent peroxide reductase 2 | |
Modification date | 20141222 | |
dbXrefs | MIM : 176763 | |
HGNC : HGNC | ||
Ensembl : ENSG00000117450 | ||
HPRD : 01458 | ||
Vega : OTTHUMG00000007738 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRDX1 | |
BioGPS: 5052 | ||
Pathway | NCI Pathway Interaction Database: PRDX1 | |
KEGG: PRDX1 | ||
REACTOME: PRDX1 | ||
Pathway Commons: PRDX1 | ||
Context | iHOP: PRDX1 | |
ligand binding site mutation search in PubMed: PRDX1 | ||
UCL Cancer Institute: PRDX1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCATHCA | |
Reference showing the relevant tissue of PRDX1 | ||
Description by TissGene annotations | TissgsLTS Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0042744 | hydrogen peroxide catabolic process | 11986303 | GO:0042744 | hydrogen peroxide catabolic process | 11986303 |
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TissGeneExp for PRDX1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.205678684 | 1.020389316 | -1.226068 | 2.28E-15 | 5.03E-14 |
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TissGene-miRNA for PRDX1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PRDX1 |
TissGeneSNV for PRDX1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.F42L | BLCA | 2 |
p.I184M | BLCA | 1 |
p.S106* | BLCA | 1 |
p.F15L | KIRC | 1 |
p.G129D | ESCA | 1 |
p.H84P | LUAD | 1 |
p.Q161* | SKCM | 1 |
p.R140W | SKCM | 1 |
p.R62T | LUSC | 1 |
p.A63T | COAD | 1 |
p.E193* | STAD | 1 |
p.D33G | THCA | 1 |
p.K185N | PAAD | 1 |
p.I184M | LUAD | 1 |
p.E65X | READ | 1 |
p.F195L | LIHC | 1 |
p.I184F | THYM | 1 |
p.P45L | LUAD | 1 |
p.I184M | CESC | 1 |
p.P108S | SKCM | 1 |
p.K92N | PRAD | 1 |
p.K67R | LUAD | 1 |
p.Q161X | SKCM | 1 |
p.S191R | ESCA | 1 |
p.I56S | UCEC | 1 |
p.E193X | STAD | 1 |
p.D182N | BLCA | 1 |
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TissGeneCNV for PRDX1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PRDX1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CD742959 | PRDX1-TNFAIP3 | chr1:45976963 | chr6:138203259 | |
Chimerdb3.0 | ChiTaRs | NA | CN369906 | SNRNP40-PRDX1 | chr1:31769566 | chr1:45981406 | |
Chimerdb3.0 | ChiTaRs | NA | CN267646 | PRDX1-PRDX1 | chr1:45980245 | chr1:45981369 | |
Chimerdb3.0 | ChiTaRs | NA | BF763254 | PRDX1-WDR59 | chr1:45977225 | chr16:74985356 | |
Chimerdb3.0 | ChiTaRs | NA | AI084599 | USP16-PRDX1 | chr21:30415890 | chr1:45976942 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-A2-A0YE-01A | HS2ST1-PRDX1 | CDS-5'UTR | chr1:87380843 | chr1:45984726 |
Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-LN-A5U5-01A3 | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976750 | chr1:45976722 |
Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-LN-A5U5-01A3 | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976751 | chr1:45976722 |
Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-LN-A5U5-01A3 | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976759 | chr1:45976735 |
Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-LN-A5U5-01A3 | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976814 | chr1:45976726 |
Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-LN-A5U5-01A3 | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976928 | chr1:45976722 |
Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-LN-A5U5-01A3 | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976929 | chr1:45976716 |
Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-LN-A5U5-01A3 | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976931 | chr1:45976722 |
Chimerdb3.0 | TopHat-Fusion | OV | TCGA-10-0931-01A | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976750 | chr1:45976722 |
Chimerdb3.0 | TopHat-Fusion | OV | TCGA-10-0931-01A | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976751 | chr1:45976722 |
Chimerdb3.0 | TopHat-Fusion | OV | TCGA-10-0931-01A | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976814 | chr1:45976726 |
Chimerdb3.0 | TopHat-Fusion | OV | TCGA-10-0931-01A | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976929 | chr1:45976722 |
Chimerdb3.0 | TopHat-Fusion | OV | TCGA-10-0931-01A | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976931 | chr1:45976722 |
Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-CG-4477-01A | PRDX1-MMACHC | 3'UTR-3'UTR | chr1:45976751 | chr1:45976722 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0YE-01A | HS2ST1-PRDX1 | CDS-5UTR | Chr1:87380843 | Chr1:45984726 |
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TissGeneNet for PRDX1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PRDX1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PRDX1 |
TissGeneDrug for PRDX1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PRDX1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0684249 | Carcinoma of lung | 8 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 7 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
umls:C0017638 | Glioma | 4 | BeFree |
umls:C0596263 | Carcinogenesis | 4 | BeFree |
umls:C0678222 | Breast Carcinoma | 4 | BeFree |
umls:C2239176 | Liver carcinoma | 4 | BeFree |
umls:C0024121 | Lung Neoplasms | 3 | BeFree,LHGDN |
umls:C0279626 | Squamous cell carcinoma of esophagus | 3 | BeFree,CTD_human |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0002395 | Alzheimer's Disease | 2 | BeFree,LHGDN |
umls:C0003130 | Anoxia | 2 | LHGDN |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree,CTD_human |
umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,LHGDN |
umls:C0013080 | Down Syndrome | 2 | BeFree,LHGDN |
umls:C0014859 | Esophageal Neoplasms | 2 | BeFree,LHGDN |
umls:C0017636 | Glioblastoma | 2 | BeFree |
umls:C0239946 | Fibrosis, Liver | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0003486 | Aortic Aneurysm | 1 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0007113 | Rectal Carcinoma | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
umls:C0009375 | Colonic Neoplasms | 1 | LHGDN |
umls:C0014544 | Epilepsy | 1 | BeFree |
umls:C0014556 | Epilepsy, Temporal Lobe | 1 | BeFree |
umls:C0015230 | Exanthema | 1 | BeFree |
umls:C0022548 | Keloid | 1 | CTD_human |
umls:C0026277 | Mixed Salivary Gland Tumor | 1 | LHGDN |
umls:C0027022 | Myeloproliferative disease | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0029928 | Ovarian Diseases | 1 | BeFree |
umls:C0036323 | Schistosomiasis | 1 | CTD_human |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
umls:C0153452 | Malignant neoplasm of gallbladder | 1 | BeFree |
umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | BeFree |
umls:C0206623 | Adenosquamous carcinoma | 1 | BeFree |
umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0278504 | Non-small cell lung cancer stage I | 1 | BeFree |
umls:C0279651 | Gallbladder adenocarcinoma | 1 | BeFree |
umls:C0334579 | Anaplastic astrocytoma | 1 | BeFree |
umls:C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | BeFree |
umls:C0346627 | Intestinal Cancer | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0746102 | Chronic lung disease | 1 | BeFree |
umls:C0848332 | Spots on skin | 1 | BeFree |
umls:C1335110 | Oligodendroglial Neoplasm | 1 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
umls:C1504404 | Hippocampal sclerosis | 1 | BeFree |
umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
umls:C1520166 | Xenograft Model | 1 | BeFree |
umls:C3828416 | Radiation Damage | 1 | BeFree |