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| TissGeneSummary for REG3A |
 Gene summary |
| Basic gene information | Gene symbol | REG3A |
| Gene name | regenerating islet-derived 3 alpha | |
| Synonyms | HIP|HIP/PAP|INGAP|PAP|PAP-H|PAP1|PBCGF|REG-III|REG3 | |
| Cytomap | UCSC genome browser: 2p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002580.2, NM_138937.2,NM_138938.2, | |
| Description | PAP homologous proteinREG-3-alphahepatocarcinoma-intestine-pancreashepatointestinal pancreatic proteinhuman proislet peptidepancreatic beta cell growth factorpancreatitis-associated protein 1proliferation-inducing protein 34proliferation-inducing | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 167805 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000172016 | ||
| HPRD : 01342 | ||
| Vega : OTTHUMG00000130017 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_REG3A | |
| BioGPS: 5068 | ||
| Pathway | NCI Pathway Interaction Database: REG3A | |
| KEGG: REG3A | ||
| REACTOME: REG3A | ||
| Pathway Commons: REG3A | ||
| Context | iHOP: REG3A | |
| ligand binding site mutation search in PubMed: REG3A | ||
| UCL Cancer Institute: REG3A | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADSTAD | |
| Reference showing the relevant tissue of REG3A | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for REG3A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 3.264205907 | 0.529390522 | 2.734815385 | 0.00664 | 0.015346245 |
| KIRP | -1.389160199 | -2.536963324 | 1.147803125 | 0.000818 | 0.002309768 |
| LIHC | 1.318118676 | -1.687059324 | 3.005178 | 0.000189 | 0.000610129 |
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| TissGene-miRNA for REG3A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for REG3A |
| TissGeneSNV for REG3A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V102I | PAAD | 6 |
| p.S142R | LUAD | 2 |
| p.W158C | HNSC | 2 |
| p.S150L | LUAD | 2 |
| p.S138Y | LUAD | 1 |
| p.W120S | LUAD | 1 |
| p.P4S | CESC | 1 |
| p.S11Y | LUAD | 1 |
| p.S78F | COAD | 1 |
| p.H107D | ACC | 1 |
| p.R157M | ESCA | 1 |
| p.G48V | LUAD | 1 |
| p.G144S | LUAD | 1 |
| p.G105V | LUAD | 1 |
| p.G43V | BLCA | 1 |
| p.S124I | LUAD | 1 |
| p.V24F | STAD | 1 |
| p.A6D | LUAD | 1 |
| p.A46D | LUAD | 1 |
| p.H50Q | ACC | 1 |
| p.P29S | SKCM | 1 |
| p.Q111K | LUAD | 1 |
| p.Q23L | LUAD | 1 |
| p.A83P | HNSC | 1 |
| p.P109R | LUAD | 1 |
| p.N136Y | BRCA | 1 |
| p.R166T | BRCA | 1 |
| p.W133* | SKCM | 1 |
| p.P34R | LUSC | 1 |
| p.G85R | LUAD | 1 |
| p.S152N | PAAD | 1 |
| p.V102I | STAD | 1 |
| p.M128I | SKCM | 1 |
| p.G82V | LUSC | 1 |
| p.W158* | SKCM | 1 |
| p.C40F | LUSC | 1 |
| p.P8T | HNSC | 1 |
| p.W158X | SKCM | 1 |
| p.G96A | LUAD | 1 |
| p.H50Q | LUAD | 1 |
| p.L2P | LUAD | 1 |
| p.E118K | LUAD | 1 |
| p.Q69R | LUSC | 1 |
| p.V127L | LUSC | 1 |
| p.R37Q | UCEC | 1 |
| p.H50D | LUAD | 1 |
| p.A64V | LUAD | 1 |
| p.Y130C | HNSC | 1 |
| p.S60Y | LUAD | 1 |
| p.P109T | LUSC | 1 |
| p.F55Y | HNSC | 1 |
| p.G96S | THYM | 1 |
| p.G82W | LUAD | 1 |
| p.C51S | THCA | 1 |
| p.S60F | SARC | 1 |
| p.L7M | HNSC | 1 |
| p.H50P | COAD | 1 |
| p.Q30E | LUSC | 1 |
| p.T62I | COAD | 1 |
| p.L2P | CESC | 1 |
| p.R151K | LUSC | 1 |
| p.T62I | CESC | 1 |
| p.W133L | LUSC | 1 |
| p.P72H | LUSC | 1 |
| p.S81I | LUAD | 1 |
| p.W133X | SKCM | 1 |
| p.E114K | UCEC | 1 |
| p.K45N | LUSC | 1 |
| p.S125C | LUAD | 1 |
| p.K45N | UCEC | 1 |
| p.S125I | LUAD | 1 |
| p.R135K | SKCM | 1 |
| p.G85* | LUSC | 1 |
| p.N97K | LUSC | 1 |
| p.H50N | LUSC | 1 |
| p.H107Y | LUAD | 1 |
| p.A46T | SKCM | 1 |
| p.P137S | SKCM | 1 |
| p.V102I | COAD | 1 |
| p.P109S | SKCM | 1 |
| p.W120C | LUAD | 1 |
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| TissGeneCNV for REG3A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for REG3A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AA494454 | NDE1-REG3A | chr16:15797411 | chr2:79385830 |
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| TissGeneNet for REG3A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| COAD (tumor) | COAD (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| KICH (tumor) | KICH (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| STAD (tumor) | STAD (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| THCA (tumor) | THCA (normal) |
| REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (tumor) | REG3A, FN1, SDC2, ANXA3, TRHDE, REG1A (normal) |
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| TissGeneProg for REG3A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for REG3A |
| TissGeneDrug for REG3A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for REG3A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2239176 | Liver carcinoma | 11 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 6 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 5 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 5 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 5 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 5 | BeFree |
| umls:C0001339 | Acute pancreatitis | 4 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 4 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 4 | BeFree,RGD |
| umls:C0023903 | Liver neoplasms | 4 | BeFree |
| umls:C0149521 | Pancreatitis, Chronic | 4 | BeFree,RGD |
| umls:C1527249 | Colorectal Cancer | 4 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
| umls:C0011847 | Diabetes | 3 | BeFree |
| umls:C0034186 | Pyelonephritis | 3 | BeFree |
| umls:C0206708 | Cervical Intraepithelial Neoplasia | 3 | BeFree |
| umls:C0343401 | MRSA - Methicillin resistant Staphylococcus aureus infection | 3 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0699790 | Colon Carcinoma | 3 | BeFree |
| umls:C0001430 | Adenoma | 2 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 2 | GAD |
| umls:C0007847 | Malignant tumor of cervix | 2 | BeFree |
| umls:C0019693 | HIV Infections | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0030286 | Pancreatic Diseases | 2 | BeFree |
| umls:C0034050 | Pulmonary Alveolar Proteinosis | 2 | BeFree |
| umls:C0302592 | Cervix carcinoma | 2 | BeFree |
| umls:C0339525 | Autosomal dominant retinitis pigmentosa | 2 | BeFree |
| umls:C0520575 | Acute pyelonephritis | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0005586 | Bipolar Disorder | 1 | GAD |
| umls:C0007114 | Malignant neoplasm of skin | 1 | BeFree |
| umls:C0007868 | Cervical dysplasia | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0015230 | Exanthema | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0018801 | Heart failure | 1 | BeFree |
| umls:C0018802 | Congestive heart failure | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023787 | Lipodystrophy | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0030305 | Pancreatitis | 1 | BeFree |
| umls:C0032000 | Pituitary Adenoma | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0032285 | Pneumonia | 1 | RGD |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0035078 | Kidney Failure | 1 | BeFree |
| umls:C0036572 | Seizures | 1 | RGD |
| umls:C0042341 | Varicocele | 1 | BeFree |
| umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
| umls:C0085605 | Liver Failure | 1 | LHGDN |
| umls:C0149940 | Sciatic Neuropathy | 1 | RGD |
| umls:C0206624 | Hepatoblastoma | 1 | BeFree |
| umls:C0220697 | POLYDACTYLY, POSTAXIAL | 1 | BeFree |
| umls:C0238339 | Hereditary pancreatitis | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0334276 | Adenocarcinoma in Situ | 1 | BeFree |
| umls:C0343641 | Human papilloma virus infection | 1 | BeFree |
| umls:C0376670 | Pancreatitis, Alcoholic | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0700138 | PANCREAS EXOCRINE | 1 | BeFree |
| umls:C0848332 | Spots on skin | 1 | BeFree |
| umls:C3714542 | Lymphoma, Diffuse | 1 | BeFree |
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