TissGeneSummary for CELA2B |
Gene summary |
Basic gene information | Gene symbol | CELA2B |
Gene name | chymotrypsin-like elastase family, member 2B | |
Synonyms | ELA2B | |
Cytomap | UCSC genome browser: 1p36.21 | |
Type of gene | protein-coding | |
RefGenes | NM_015849.2, | |
Description | RP11-265F14.2chymotrypsin-like elastase family member 2Belastase 2Belastase-2Bpancreatic elastase IIB (ELA2B) | |
Modification date | 20141207 | |
dbXrefs | MIM : 609444 | |
HGNC : HGNC | ||
Ensembl : ENSG00000215704 | ||
HPRD : 06496 | ||
Vega : OTTHUMG00000002259 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CELA2B | |
BioGPS: 51032 | ||
Pathway | NCI Pathway Interaction Database: CELA2B | |
KEGG: CELA2B | ||
REACTOME: CELA2B | ||
Pathway Commons: CELA2B | ||
Context | iHOP: CELA2B | |
ligand binding site mutation search in PubMed: CELA2B | ||
UCL Cancer Institute: CELA2B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of CELA2B | ||
Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CELA2B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.164814197 | 1.886879921 | -2.051694118 | 9.74E-14 | 5.08E-13 |
LUAD | -0.16730872 | 1.837082659 | -2.004391379 | 1.92E-14 | 1.87E-13 |
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TissGene-miRNA for CELA2B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CELA2B |
TissGeneSNV for CELA2B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S264L | UCEC | 2 |
p.P130H | LUAD | 2 |
p.E94K | SKCM | 1 |
p.L15P | LIHC | 1 |
p.H56Q | OV | 1 |
p.G79V | LUSC | 1 |
p.D260Y | UCEC | 1 |
p.C210R | UCS | 1 |
p.G242D | SKCM | 1 |
p.V131I | BLCA | 1 |
p.V116I | COAD | 1 |
p.G167R | HNSC | 1 |
p.T238M | PRAD | 1 |
p.G205S | SARC | 1 |
p.L69V | BLCA | 1 |
p.D260N | SKCM | 1 |
p.N213Y | BLCA | 1 |
p.L169P | BLCA | 1 |
p.N89S | STAD | 1 |
p.G217D | SKCM | 1 |
p.R98C | BRCA | 1 |
p.S20F | BRCA | 1 |
p.S77F | SKCM | 1 |
p.L62M | CESC | 1 |
p.G235D | HNSC | 1 |
p.V19D | STAD | 1 |
p.G59R | STAD | 1 |
p.V157I | UCEC | 1 |
p.T253M | PRAD | 1 |
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TissGeneCNV for CELA2B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CELA2B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CELA2B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CELA2B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CELA2B |
TissGeneDrug for CELA2B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CELA2B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |