TissGeneSummary for PCK1 |
Gene summary |
Basic gene information | Gene symbol | PCK1 |
Gene name | phosphoenolpyruvate carboxykinase 1 (soluble) | |
Synonyms | PEPCK-C|PEPCK1|PEPCKC | |
Cytomap | UCSC genome browser: 20q13.31 | |
Type of gene | protein-coding | |
RefGenes | NM_002591.3, | |
Description | PEP carboxykinasephosphoenolpyruvate carboxykinase, cytosolicphosphoenolpyruvate carboxykinase, cytosolic [GTP]phosphoenolpyruvate carboxylasephosphopyruvate carboxylase | |
Modification date | 20141207 | |
dbXrefs | MIM : 614168 | |
HGNC : HGNC | ||
HPRD : 02028 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PCK1 | |
BioGPS: 5105 | ||
Pathway | NCI Pathway Interaction Database: PCK1 | |
KEGG: PCK1 | ||
REACTOME: PCK1 | ||
Pathway Commons: PCK1 | ||
Context | iHOP: PCK1 | |
ligand binding site mutation search in PubMed: PCK1 | ||
UCL Cancer Institute: PCK1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of PCK1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006475 | internal protein amino acid acetylation | 20167786 | GO:0032868 | response to insulin | 14764811 | GO:0006475 | internal protein amino acid acetylation | 20167786 | GO:0032868 | response to insulin | 14764811 |
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TissGeneExp for PCK1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -2.640701973 | -0.103962438 | -2.536739535 | 1.01E-07 | 9.88E-07 |
KIRP | 4.012926298 | 9.153648173 | -5.140721875 | 7.72E-11 | 9.18E-10 |
COAD | 4.420052499 | 7.468567884 | -3.048515385 | 7.47E-09 | 6.85E-08 |
BRCA | -1.055973209 | 4.275707493 | -5.331680702 | 4.29E-33 | 6.81E-32 |
KIRC | 5.437498867 | 8.5169697 | -3.079470833 | 1.63E-10 | 5.60E-10 |
THCA | -3.570225662 | -2.457957866 | -1.112267797 | 1.28E-07 | 5.49E-07 |
KICH | 2.297987423 | 7.762639423 | -5.464652 | 7.81E-09 | 4.25E-08 |
LIHC | 8.179437423 | 11.72315342 | -3.543716 | 5.99E-13 | 1.27E-11 |
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TissGene-miRNA for PCK1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PCK1 |
TissGeneSNV for PCK1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E302K | SKCM | 3 |
p.E62K | SKCM | 3 |
p.M296I | SKCM | 2 |
p.D186N | SKCM | 2 |
p.E89K | SKCM | 2 |
p.A319T | STAD | 2 |
p.A418V | SKCM | 1 |
p.P24T | LUAD | 1 |
p.K510N | LUAD | 1 |
p.F433L | LUAD | 1 |
p.D374H | BLCA | 1 |
p.P402S | SKCM | 1 |
p.M60I | SKCM | 1 |
p.F357S | SKCM | 1 |
p.G546R | SKCM | 1 |
p.D545N | SKCM | 1 |
p.G236S | LIHC | 1 |
p.R55W | UCEC | 1 |
p.F126L | READ | 1 |
p.A336T | GBM | 1 |
p.F333L | LUSC | 1 |
p.G430S | LUAD | 1 |
p.M173I | SKCM | 1 |
p.D374N | LIHC | 1 |
p.G157S | UCEC | 1 |
p.R100G | LUAD | 1 |
p.L79V | SKCM | 1 |
p.P143S | SKCM | 1 |
p.P605H | LUSC | 1 |
p.A495T | LGG | 1 |
p.E362K | STAD | 1 |
p.E362K | UCEC | 1 |
p.E215K | SKCM | 1 |
p.E52K | BLCA | 1 |
p.M296I | TGCT | 1 |
p.S230F | SKCM | 1 |
p.S404L | LUAD | 1 |
p.S12L | BLCA | 1 |
p.S12L | STAD | 1 |
p.A325T | LGG | 1 |
p.P376S | ESCA | 1 |
p.S239L | SKCM | 1 |
p.R543W | UCEC | 1 |
p.A283T | UCS | 1 |
p.R137H | LUAD | 1 |
p.C288R | KIRP | 1 |
p.R293M | LUAD | 1 |
p.S195Y | LUAD | 1 |
p.V166M | UCS | 1 |
p.E469* | UCEC | 1 |
p.V95I | STAD | 1 |
p.R68W | BLCA | 1 |
p.T102I | KIRP | 1 |
p.P438L | LIHC | 1 |
p.L66F | SKCM | 1 |
p.H322N | STAD | 1 |
p.R28T | ACC | 1 |
p.E607K | SKCM | 1 |
p.A287S | LUAD | 1 |
p.H312Y | LUAD | 1 |
p.A319T | LGG | 1 |
p.D374Y | LUAD | 1 |
p.A282D | LUAD | 1 |
p.A281V | STAD | 1 |
p.P427S | SKCM | 1 |
p.K304M | UCEC | 1 |
p.G453A | BLCA | 1 |
p.S404L | BLCA | 1 |
p.W303* | SKCM | 1 |
p.P285L | ESCA | 1 |
p.P273H | LUAD | 1 |
p.G289W | LUSC | 1 |
p.G259E | SKCM | 1 |
p.Y165C | COAD | 1 |
p.D162N | SKCM | 1 |
p.H477N | LUAD | 1 |
p.I228F | PCPG | 1 |
p.T217A | UCEC | 1 |
p.S392I | PAAD | 1 |
p.I228S | KIRC | 1 |
p.E375D | LUAD | 1 |
p.S195F | BRCA | 1 |
p.P104L | SKCM | 1 |
p.K567T | GBM | 1 |
p.L11F | SKCM | 1 |
p.G331S | SKCM | 1 |
p.P199L | SKCM | 1 |
p.P398L | PAAD | 1 |
p.V166M | GBM | 1 |
p.T217K | BRCA | 1 |
p.K587* | LUAD | 1 |
p.A325S | ESCA | 1 |
p.A287T | STAD | 1 |
p.T217K | LUAD | 1 |
p.V381I | UCEC | 1 |
p.V180I | BLCA | 1 |
p.A281T | UCEC | 1 |
p.N388S | KIRP | 1 |
p.G289R | SKCM | 1 |
p.E52D | LUAD | 1 |
p.E120K | SKCM | 1 |
p.A319T | BLCA | 1 |
p.D311N | LUAD | 1 |
p.E375K | LIHC | 1 |
p.P148L | SKCM | 1 |
p.T161M | COAD | 1 |
p.D478N | SKCM | 1 |
p.S340L | SKCM | 1 |
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TissGeneCNV for PCK1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PCK1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BJ994441 | PCK1-AMY2B | chr20:56136259 | chr1:104108055 | |
Chimerdb3.0 | ChiTaRs | NA | AA484533 | PCK1-PCK1 | chr20:56141455 | chr20:56141152 | |
Chimerdb3.0 | ChiTaRs | NA | AW195637 | PCK1-PAPPA2 | chr20:56141510 | chr1:176802967 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AR-A24R-01A | AURKA-PCK1 | CDS-5'UTR | chr20:54963211 | chr20:56136427 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L7-A6VZ-01A | PCK1-PCK2 | In-Frame | chr20:56138271 | chr14:24568766 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-R6-A6DQ-01B | PCK1-PCK2 | In-Frame | chr20:56138271 | chr14:24568766 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OQ-01A | PCK2-PCK1 | In-Frame | chr14:24568445 | chr20:56138620 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A24R-01A | AURKA-PCK1 | CDS-5UTR | Chr20:54963212 | Chr20:56136428 |
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TissGeneNet for PCK1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PCK1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PCK1 |
TissGeneDrug for PCK1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PCK1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 14 | BeFree,GAD,LHGDN,RGD |
umls:C0011849 | Diabetes Mellitus | 6 | BeFree,GAD |
umls:C0011847 | Diabetes | 5 | BeFree |
umls:C0002395 | Alzheimer's Disease | 4 | BeFree,GAD,LHGDN |
umls:C0028754 | Obesity | 3 | BeFree,CTD_human |
umls:C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human,RGD |
umls:C0524620 | Metabolic Syndrome X | 2 | BeFree,GAD |
umls:C0004153 | Atherosclerosis | 1 | GAD |
umls:C0015934 | Fetal Growth Retardation | 1 | RGD |
umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
umls:C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
umls:C0036341 | Schizophrenia | 1 | BeFree,GAD |
umls:C0342276 | Maturity onset diabetes mellitus in young | 1 | BeFree |
umls:C0376618 | Endotoxemia | 1 | RGD |
umls:C2239176 | Liver carcinoma | 1 | CTD_human |
umls:C0268194 | Phosphoenolpyruvate carboxykinase deficiency | 0 | CTD_human,ORPHANET |