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| TissGeneSummary for MLXIPL |
 Gene summary |
| Basic gene information | Gene symbol | MLXIPL |
| Gene name | MLX interacting protein-like | |
| Synonyms | CHREBP|MIO|MONDOB|WBSCR14|WS-bHLH|bHLHd14 | |
| Cytomap | UCSC genome browser: 7q11.23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032951.2, NM_032952.2,NM_032953.2,NM_032954.2,NM_032994.2, | |
| Description | MLX-interacting protein-likeMlx interactorWS basic-helix-loop-helix leucine zipper proteinWilliams Beuren syndrome chromosome region 14Williams-Beuren syndrome chromosome region 14 protein 1Williams-Beuren syndrome chromosome region 14 protein 2carb | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605678 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000009950 | ||
| HPRD : 12033 | ||
| Vega : OTTHUMG00000129995 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MLXIPL | |
| BioGPS: 51085 | ||
| Pathway | NCI Pathway Interaction Database: MLXIPL | |
| KEGG: MLXIPL | ||
| REACTOME: MLXIPL | ||
| Pathway Commons: MLXIPL | ||
| Context | iHOP: MLXIPL | |
| ligand binding site mutation search in PubMed: MLXIPL | ||
| UCL Cancer Institute: MLXIPL | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADLIHC | |
| Reference showing the relevant tissue of MLXIPL | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MLXIPL |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -0.987123845 | 0.6739865 | -1.661110345 | 9.26E-10 | 4.92E-09 |
| THCA | 2.043910784 | 0.48469892 | 1.559211864 | 6.91E-09 | 3.51E-08 |
| BRCA | -1.003514952 | 2.943477153 | -3.946992105 | 6.85E-39 | 1.90E-37 |
| COAD | 3.787550028 | 0.88130772 | 2.906242308 | 1.58E-09 | 1.67E-08 |
| STAD | 2.068297384 | -0.009580741 | 2.077878125 | 0.000801 | 0.004448022 |
| LUSC | -0.449368977 | 0.601689847 | -1.051058824 | 0.001 | 0.001858086 |
| HNSC | -1.786410974 | 0.292842514 | -2.079253488 | 2.51E-05 | 0.000130127 |
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| TissGene-miRNA for MLXIPL |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MLXIPL |
| TissGeneSNV for MLXIPL |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q241H | PCPG | 3 |
| p.S619F | SKCM | 2 |
| p.S344F | SKCM | 2 |
| p.R173H | COAD | 2 |
| p.A810T | STAD | 2 |
| p.R761C | STAD | 1 |
| p.R639Q | COAD | 1 |
| p.T255A | LIHC | 1 |
| p.R761C | SKCM | 1 |
| p.A497T | LUAD | 1 |
| p.N360K | ESCA | 1 |
| p.Q241H | COAD | 1 |
| p.R707C | STAD | 1 |
| p.P400S | BRCA | 1 |
| p.Y786C | SKCM | 1 |
| p.Q241H | BRCA | 1 |
| p.P390L | SKCM | 1 |
| p.R662H | STAD | 1 |
| p.L545P | KIRC | 1 |
| p.S354N | SKCM | 1 |
| p.P393S | SKCM | 1 |
| p.R639W | STAD | 1 |
| p.R629P | PRAD | 1 |
| p.L808V | LUAD | 1 |
| p.F90S | LIHC | 1 |
| p.L336Q | SKCM | 1 |
| p.Q634K | BLCA | 1 |
| p.D285N | SKCM | 1 |
| p.P570S | UCEC | 1 |
| p.M281I | SKCM | 1 |
| p.K504I | BLCA | 1 |
| p.F257S | LIHC | 1 |
| p.G709S | SKCM | 1 |
| p.P311L | LIHC | 1 |
| p.R746C | CESC | 1 |
| p.R639W | UCEC | 1 |
| p.R355H | LGG | 1 |
| p.K194* | LUSC | 1 |
| p.A370T | LUAD | 1 |
| p.E712K | SKCM | 1 |
| p.A540T | STAD | 1 |
| p.F749V | SKCM | 1 |
| p.R661W | PRAD | 1 |
| p.L286R | LIHC | 1 |
| p.V546L | LGG | 1 |
| p.R579W | GBM | 1 |
| p.L816R | STAD | 1 |
| p.G765E | SKCM | 1 |
| p.L816P | PAAD | 1 |
| p.S807C | LIHC | 1 |
| p.P623S | SKCM | 1 |
| p.G690S | SKCM | 1 |
| p.D280H | CESC | 1 |
| p.R841P | LUAD | 1 |
| p.L679F | PAAD | 1 |
| p.N783K | ESCA | 1 |
| p.P596S | SKCM | 1 |
| p.L679R | HNSC | 1 |
| p.S818F | LUSC | 1 |
| p.E723K | DLBC | 1 |
| p.S680R | SKCM | 1 |
| p.N649D | SKCM | 1 |
| p.G784E | SKCM | 1 |
| p.F768V | SKCM | 1 |
| p.S140N | SKCM | 1 |
| p.S798* | BLCA | 1 |
| p.G608S | STAD | 1 |
| p.P342L | STAD | 1 |
| p.S345L | COAD | 1 |
| p.T529R | BLCA | 1 |
| p.N817D | STAD | 1 |
| p.E380K | SKCM | 1 |
| p.Y805C | SKCM | 1 |
| p.P414L | SKCM | 1 |
| p.P452H | ACC | 1 |
| p.G674V | LGG | 1 |
| p.A358V | COAD | 1 |
| p.E538D | LUAD | 1 |
| p.P365S | SKCM | 1 |
| p.S345L | CESC | 1 |
| p.P390S | SKCM | 1 |
| p.Q261R | PAAD | 1 |
| p.F302L | UCEC | 1 |
| p.K113N | LUAD | 1 |
| p.D244E | DLBC | 1 |
| p.A521T | STAD | 1 |
| p.S265L | COAD | 1 |
| p.R742C | SKCM | 1 |
| p.P571S | GBM | 1 |
| p.T439A | COAD | 1 |
| p.S602P | LIHC | 1 |
| p.E698Q | BLCA | 1 |
| p.D367N | PAAD | 1 |
| p.R43C | KIRP | 1 |
| p.P388S | HNSC | 1 |
| p.P342L | ESCA | 1 |
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| TissGeneCNV for MLXIPL |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MLXIPL |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI739073 | PUSL1-MLXIPL | chr1:1247203 | chr7:73014062 | |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A7B4-01A | NRF1-MLXIPL | 5'UTR-CDS | chr7:129251665 | chr7:73030507 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-KK-A7B4-01A | NRF1-MLXIPL | 5UTR-CDS | Chr7:129251665 | Chr7:73030507 |
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| TissGeneNet for MLXIPL |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| MLXIPL, GRB2, MLX, NIF3L1 (tumor) | MLXIPL, GRB2, MLX, NIF3L1 (normal) |
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| TissGeneProg for MLXIPL |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MLXIPL |
| TissGeneDrug for MLXIPL |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MLXIPL |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0028754 | Obesity | 6 | BeFree,GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 4 | BeFree,GAD |
| umls:C0015695 | Fatty Liver | 4 | BeFree |
| umls:C2711227 | Steatohepatitis | 4 | BeFree |
| umls:C0020456 | Hyperglycemia | 3 | BeFree |
| umls:C0175702 | Williams Syndrome | 3 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree,GAD |
| umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
| umls:C0010068 | Coronary heart disease | 2 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 2 | BeFree,GAD,GWASCAT |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 2 | BeFree,GAD |
| umls:C2239176 | Liver carcinoma | 2 | BeFree,CTD_human |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
| umls:C0017919 | Glycogen Storage Disease | 1 | BeFree |
| umls:C0020474 | Hyperlipidemia, Familial Combined | 1 | BeFree |
| umls:C0020557 | Hypertriglyceridemia | 1 | GAD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0154251 | Lipid Metabolism Disorders | 1 | GAD |
| umls:C0178664 | Glomerulosclerosis (disorder) | 1 | BeFree |
| umls:C0206669 | Hepatocellular Adenoma | 1 | BeFree |
| umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
| umls:C0346957 | Disseminated Malignant Neoplasm | 1 | BeFree |
| umls:C0362046 | Prediabetes syndrome | 1 | BeFree |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
| umls:C0497327 | Dementia | 1 | GAD |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1522137 | Hypertriglyceridemia result | 1 | GAD |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
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