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| TissGeneSummary for RDH11 |
 Gene summary |
| Basic gene information | Gene symbol | RDH11 |
| Gene name | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | |
| Synonyms | ARSDR1|CGI82|HCBP12|MDT1|PSDR1|RALR1|RDJCSS|SCALD|SDR7C1 | |
| Cytomap | UCSC genome browser: 14q24.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001252650.1, NM_016026.3, | |
| Description | HCV core-binding protein HCBP12androgen-regulated short-chain dehydrogenase/reductase 1prostate short-chain dehydrogenase reductase 1prostate short-chain dehydrogenase/reductase 1retinal reductase 1retinol dehydrogenase 11short chain dehydrogenase/r | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607849 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000072042 | ||
| HPRD : 09707 | ||
| Vega : OTTHUMG00000171196 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RDH11 | |
| BioGPS: 51109 | ||
| Pathway | NCI Pathway Interaction Database: RDH11 | |
| KEGG: RDH11 | ||
| REACTOME: RDH11 | ||
| Pathway Commons: RDH11 | ||
| Context | iHOP: RDH11 | |
| ligand binding site mutation search in PubMed: RDH11 | ||
| UCL Cancer Institute: RDH11 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of RDH11 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0042574 | retinal metabolic process | 12807874 | GO:0042574 | retinal metabolic process | 12807874 |
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| TissGeneExp for RDH11 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -0.397039653 | 0.743175625 | -1.140215278 | 3.48E-35 | 9.51E-34 |
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| TissGene-miRNA for RDH11 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UVM | hsa-miR-34a-5p | MIMAT0000255 | 0.019 | -0.26 | 80 |
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| TissGeneMut for RDH11 |
| TissGeneSNV for RDH11 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R108X | READ | 1 |
| p.E143D | PAAD | 1 |
| p.K137R | LIHC | 1 |
| p.L17M | READ | 1 |
| p.R67Q | COAD | 1 |
| p.H231Q | THYM | 1 |
| p.V130M | BRCA | 1 |
| p.S29Y | STAD | 1 |
| p.K26T | KIRP | 1 |
| p.E238Q | LUAD | 1 |
| p.R247T | HNSC | 1 |
| p.I85L | PAAD | 1 |
| p.W248* | LUSC | 1 |
| p.Q214* | BRCA | 1 |
| p.R241Q | STAD | 1 |
| p.G31E | LUAD | 1 |
| p.A179S | LUAD | 1 |
| p.G54R | UCEC | 1 |
| p.L17V | LUAD | 1 |
| p.S254C | HNSC | 1 |
| p.F255L | KIRC | 1 |
| p.E238D | KIRC | 1 |
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| TissGeneCNV for RDH11 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for RDH11 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI928382 | CYCS-RDH11 | chr7:25162745 | chr14:68144286 | |
| Chimerdb3.0 | ChiTaRs | NA | AI160852 | HNRNPH3-RDH11 | chr10:70102028 | chr14:68145082 | |
| Chimerdb3.0 | ChiTaRs | NA | BM552700 | EPOR-RDH11 | chr19:11491888 | chr14:68156928 | |
| Chimerdb3.0 | ChiTaRs | NA | BF432108 | RDH11-PRSS23 | chr14:68144529 | chr11:86662375 | |
| Chimerdb3.0 | ChiTaRs | NA | BC017787 | RDH11-IPO7 | chr14:68162481 | chr11:9467536 | |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-E2-A1LL-01A | MPP5-RDH11 | 5'UTR-CDS | chr14:67708250 | chr14:68151921 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-A8Q7-01A | PLEK2-RDH11 | Out-of-Frame | chr14:67854940 | chr14:68159769 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A1LL-01A | MPP5-RDH11 | 5UTR-CDS | Chr14:67708250 | Chr14:68151921 |
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| TissGeneNet for RDH11 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| COAD (tumor) | COAD (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| KICH (tumor) | KICH (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| STAD (tumor) | STAD (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| THCA (tumor) | THCA (normal) |
| RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (tumor) | RDH11, HNF4A, UBC, NOD2, ISG15, ROBO2, CA12, BLOC1S2 (normal) |
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| TissGeneProg for RDH11 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for RDH11 |
| TissGeneDrug for RDH11 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for RDH11 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0024299 | Lymphoma | 1 | LHGDN |
| umls:C0035334 | Retinitis Pigmentosa | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | LHGDN |
| umls:C4015242 | RETINAL DYSTROPHY, JUVENILE CATARACTS, AND SHORT STATURE SYNDROME | 0 | ORPHANET |
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