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| TissGeneSummary for SERPINA10 |
 Gene summary |
| Basic gene information | Gene symbol | SERPINA10 |
| Gene name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | |
| Synonyms | PZI|ZPI | |
| Cytomap | UCSC genome browser: 14q32.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001100607.2, NM_016186.2, | |
| Description | PZ-dependent protease inhibitorprotein Z-dependent protease inhibitorserine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10serpin A10 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605271 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000140093 | ||
| HPRD : 09245 | ||
| Vega : OTTHUMG00000171345 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SERPINA10 | |
| BioGPS: 51156 | ||
| Pathway | NCI Pathway Interaction Database: SERPINA10 | |
| KEGG: SERPINA10 | ||
| REACTOME: SERPINA10 | ||
| Pathway Commons: SERPINA10 | ||
| Context | iHOP: SERPINA10 | |
| ligand binding site mutation search in PubMed: SERPINA10 | ||
| UCL Cancer Institute: SERPINA10 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SERPINA10 | ||
| Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0060046 | regulation of acrosome reaction | 11751269 | GO:0060046 | regulation of acrosome reaction | 11751269 |
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| TissGeneExp for SERPINA10 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -2.234402916 | -0.968215416 | -1.2661875 | 1.55E-06 | 7.57E-06 |
| LIHC | 9.070885209 | 10.60380921 | -1.532924 | 8.38E-07 | 4.54E-06 |
| KICH | -2.446344791 | -1.389560791 | -1.056784 | 1.20E-05 | 3.75E-05 |
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| TissGene-miRNA for SERPINA10 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SERPINA10 |
| TissGeneSNV for SERPINA10 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G334E | SKCM | 4 |
| p.R324C | SKCM | 3 |
| p.E216K | SKCM | 2 |
| p.E176K | SKCM | 2 |
| p.E466K | SKCM | 2 |
| p.S68L | SKCM | 2 |
| p.G294E | SKCM | 2 |
| p.E334K | SKCM | 1 |
| p.M328I | SKCM | 1 |
| p.R236C | SKCM | 1 |
| p.S317Y | LUAD | 1 |
| p.Q75* | BLCA | 1 |
| p.T176N | LUAD | 1 |
| p.P258S | SKCM | 1 |
| p.S193F | SKCM | 1 |
| p.K125Q | COAD | 1 |
| p.D359N | SKCM | 1 |
| p.E392K | SKCM | 1 |
| p.N195K | LUAD | 1 |
| p.R284C | SKCM | 1 |
| p.R184K | SKCM | 1 |
| p.P441L | READ | 1 |
| p.M395I | SKCM | 1 |
| p.L181F | OV | 1 |
| p.M41I | SKCM | 1 |
| p.D287H | BLCA | 1 |
| p.E189Q | CESC | 1 |
| p.M410I | COAD | 1 |
| p.P119L | PAAD | 1 |
| p.E89* | HNSC | 1 |
| p.Q123X | SKCM | 1 |
| p.R154C | PRAD | 1 |
| p.P74S | SKCM | 1 |
| p.N194I | SKCM | 1 |
| p.R194C | PRAD | 1 |
| p.L232I | UCEC | 1 |
| p.D354N | SKCM | 1 |
| p.M193I | SKCM | 1 |
| p.F278L | LUAD | 1 |
| p.E161Q | HNSC | 1 |
| p.M355I | SKCM | 1 |
| p.N155K | LUAD | 1 |
| p.R254W | SKCM | 1 |
| p.R88Q | SKCM | 1 |
| p.M368I | SKCM | 1 |
| p.K125M | STAD | 1 |
| p.D171N | SKCM | 1 |
| p.D319N | SKCM | 1 |
| p.S68W | HNSC | 1 |
| p.G203R | SKCM | 1 |
| p.T482A | HNSC | 1 |
| p.N367I | SKCM | 1 |
| p.P218H | THYM | 1 |
| p.N155K | STAD | 1 |
| p.M233I | SKCM | 1 |
| p.D280H | CESC | 1 |
| p.M410R | DLBC | 1 |
| p.I236M | STAD | 1 |
| p.E374K | SKCM | 1 |
| p.G396E | SKCM | 1 |
| p.T386A | COAD | 1 |
| p.E87K | SKCM | 1 |
| p.N234I | SKCM | 1 |
| p.V231M | LUAD | 1 |
| p.L158M | LUAD | 1 |
| p.P142L | SKCM | 1 |
| p.P64S | SKCM | 1 |
| p.T255N | COAD | 1 |
| p.K281T | STAD | 1 |
| p.F140I | SKCM | 1 |
| p.L330M | LUAD | 1 |
| p.R437M | OV | 1 |
| p.D211N | SKCM | 1 |
| p.L232I | READ | 1 |
| p.N195K | STAD | 1 |
| p.H297Y | SKCM | 1 |
| p.R128Q | SKCM | 1 |
| p.R254P | LUAD | 1 |
| p.D314N | SKCM | 1 |
| p.G311D | SKCM | 1 |
| p.T213A | COAD | 1 |
| p.L484I | LUAD | 1 |
| p.S28L | SKCM | 1 |
| p.P218S | SKCM | 1 |
| p.R418W | HNSC | 1 |
| p.G163R | SKCM | 1 |
| p.N376H | LIHC | 1 |
| p.S141F | SKCM | 1 |
| p.Q163* | SKCM | 1 |
| p.R236C | LUAD | 1 |
| p.E432K | SKCM | 1 |
| p.P159L | PAAD | 1 |
| p.E197K | SKCM | 1 |
| p.V191M | GBM | 1 |
| p.S371X | ACC | 1 |
| p.R418W | STAD | 1 |
| p.E49* | HNSC | 1 |
| p.R224K | SKCM | 1 |
| p.S411* | ACC | 1 |
| p.D247H | BLCA | 1 |
| p.V231L | PCPG | 1 |
| p.L290M | LUAD | 1 |
| p.P72Q | SKCM | 1 |
| p.G271D | SKCM | 1 |
| p.G155R | SKCM | 1 |
| p.G356E | SKCM | 1 |
| p.K341N | ESCA | 1 |
| p.S33Y | LUAD | 1 |
| p.K274T | STAD | 1 |
| p.L198M | LUAD | 1 |
| p.S153F | SKCM | 1 |
| p.R196C | UCEC | 1 |
| p.M193I | CESC | 1 |
| p.S33F | SKCM | 1 |
| p.F404S | KIRC | 1 |
| p.M153K | LUAD | 1 |
| p.K186N | PRAD | 1 |
| p.M268I | BRCA | 1 |
| p.K216T | UCEC | 1 |
| p.E97K | BLCA | 1 |
| p.R196C | SKCM | 1 |
| p.F364S | KIRC | 1 |
| p.V321A | COAD | 1 |
| p.L433M | READ | 1 |
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| TissGeneCNV for SERPINA10 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SERPINA10 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SERPINA10 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
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| COAD (tumor) | COAD (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
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| KICH (tumor) | KICH (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
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| STAD (tumor) | STAD (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
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| THCA (tumor) | THCA (normal) |
| SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (tumor) | SERPINA10, HNF4A, PSMB7, HNF1A, F10, PIAS3 (normal) |
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| TissGeneProg for SERPINA10 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SERPINA10 |
| TissGeneDrug for SERPINA10 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SERPINA10 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0042487 | Venous Thrombosis | 2 | CTD_human,GAD,LHGDN |
| umls:C0027051 | Myocardial Infarction | 1 | GAD |
| umls:C0032962 | Pregnancy Complications | 1 | BeFree |
| umls:C0040038 | Thromboembolism | 1 | BeFree |
| umls:C0398623 | Thrombophilia | 1 | BeFree,CTD_human |
| umls:C1861172 | Venous Thromboembolism | 1 | GAD |
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