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| TissGeneSummary for CPA4 |
 Gene summary |
| Basic gene information | Gene symbol | CPA4 |
| Gene name | carboxypeptidase A4 | |
| Synonyms | CPA3 | |
| Cytomap | UCSC genome browser: 7q32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001163446.1, NM_016352.3, | |
| Description | carboxypeptidase A3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607635 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000128510 | ||
| HPRD : 07405 | ||
| Vega : OTTHUMG00000157825 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CPA4 | |
| BioGPS: 51200 | ||
| Pathway | NCI Pathway Interaction Database: CPA4 | |
| KEGG: CPA4 | ||
| REACTOME: CPA4 | ||
| Pathway Commons: CPA4 | ||
| Context | iHOP: CPA4 | |
| ligand binding site mutation search in PubMed: CPA4 | ||
| UCL Cancer Institute: CPA4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of CPA4 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CPA4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -2.601822649 | -4.247818803 | 1.645996154 | 1.06E-08 | 9.25E-08 |
| LUSC | 0.656588135 | -2.460584414 | 3.117172549 | 2.09E-09 | 6.95E-09 |
| BLCA | 0.636537877 | -2.271472649 | 2.908010526 | 0.00477 | 0.025686392 |
| KIRC | -0.92210876 | -2.068414316 | 1.146305556 | 0.00395 | 0.006970039 |
| KICH | -3.404320649 | -1.898760649 | -1.50556 | 0.00235 | 0.004764857 |
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| TissGene-miRNA for CPA4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-455-5p | MIMAT0003150 | 0.022 | -0.31 | 56 |
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| TissGeneMut for CPA4 |
| TissGeneSNV for CPA4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E297K | SKCM | 2 |
| p.E330K | SKCM | 2 |
| p.E381K | SKCM | 1 |
| p.A282T | STAD | 1 |
| p.E414K | SKCM | 1 |
| p.D205N | SKCM | 1 |
| p.R113W | UCEC | 1 |
| p.E287Q | UCS | 1 |
| p.D103Y | THYM | 1 |
| p.R32K | LUAD | 1 |
| p.A302V | COAD | 1 |
| p.G110V | LUAD | 1 |
| p.Y360N | LIHC | 1 |
| p.R204K | SKCM | 1 |
| p.T194K | LUAD | 1 |
| p.R236X | STAD | 1 |
| p.S152W | SKCM | 1 |
| p.A282P | LUSC | 1 |
| p.A173T | UCEC | 1 |
| p.D201H | LUAD | 1 |
| p.V44G | LUAD | 1 |
| p.G319W | LUAD | 1 |
| p.Y87H | UCEC | 1 |
| p.G166E | SKCM | 1 |
| p.S152L | CESC | 1 |
| p.Q312L | LUAD | 1 |
| p.K333M | LIHC | 1 |
| p.R145S | BLCA | 1 |
| p.G270C | COAD | 1 |
| p.Q296K | OV | 1 |
| p.E36Q | BLCA | 1 |
| p.E154Q | BLCA | 1 |
| p.T348I | LUAD | 1 |
| p.A338V | LUAD | 1 |
| p.E19* | UCEC | 1 |
| p.D216N | SKCM | 1 |
| p.E329D | STAD | 1 |
| p.D372N | SKCM | 1 |
| p.L420F | SKCM | 1 |
| p.Q74* | BRCA | 1 |
| p.I367M | LUAD | 1 |
| p.W3* | SKCM | 1 |
| p.D93Y | LUAD | 1 |
| p.E382K | BLCA | 1 |
| p.K240T | HNSC | 1 |
| p.P255T | LUAD | 1 |
| p.G133E | SKCM | 1 |
| p.Y421F | LIHC | 1 |
| p.E414K | BLCA | 1 |
| p.R236* | STAD | 1 |
| p.A138S | SARC | 1 |
| p.R171K | SKCM | 1 |
| p.N419I | LUAD | 1 |
| p.W259G | PCPG | 1 |
| p.R417W | KIRP | 1 |
| p.Y230C | STAD | 1 |
| p.S284L | BLCA | 1 |
| p.L387F | SKCM | 1 |
| p.R236L | HNSC | 1 |
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| TissGeneCNV for CPA4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CPA4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF738633 | CPA4-CPA4 | chr7:129946369 | chr7:129962403 |
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| TissGeneNet for CPA4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| COAD (tumor) | COAD (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| KICH (tumor) | KICH (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| STAD (tumor) | STAD (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| THCA (tumor) | THCA (normal) |
| CPA4, LXN (tumor) | CPA4, LXN (normal) |
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| TissGeneProg for CPA4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CPA4 |
| TissGeneDrug for CPA4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CPA4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004096 | Asthma | 3 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree,GAD |
| umls:C0600139 | Prostate carcinoma | 3 | BeFree |
| umls:C0175693 | Russell-Silver syndrome | 2 | BeFree |
| umls:C0341106 | Eosinophilic esophagitis | 2 | BeFree |
| umls:C1853195 | Prostate Cancer, Hereditary, 7 | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree,GAD |
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