TissGeneSummary for TCEB3B |
Gene summary |
Basic gene information | Gene symbol | TCEB3B |
Gene name | transcription elongation factor B polypeptide 3B (elongin A2) | |
Synonyms | ELOA2|HsT832|TCEB3L | |
Cytomap | UCSC genome browser: 18q21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_016427.2, | |
Description | RNA polymerase II transcription factor SIII subunit A2elongin-A2transcription elongation factor (SIII) elongin A2 elongin A2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609522 | |
HGNC : HGNC | ||
Ensembl : ENSG00000206181 | ||
HPRD : 18169 | ||
Vega : OTTHUMG00000132649 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TCEB3B | |
BioGPS: 51224 | ||
Pathway | NCI Pathway Interaction Database: TCEB3B | |
KEGG: TCEB3B | ||
REACTOME: TCEB3B | ||
Pathway Commons: TCEB3B | ||
Context | iHOP: TCEB3B | |
ligand binding site mutation search in PubMed: TCEB3B | ||
UCL Cancer Institute: TCEB3B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TCEB3B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TCEB3B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.196899187 | -1.349607187 | 1.152708 | 6.57E-07 | 2.53E-06 |
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TissGene-miRNA for TCEB3B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TCEB3B |
TissGeneSNV for TCEB3B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E583K | SKCM | 5 |
p.E600K | SKCM | 3 |
p.E233K | SKCM | 2 |
p.G400E | SKCM | 2 |
p.E435K | SKCM | 2 |
p.E107K | SKCM | 2 |
p.P236T | LUAD | 1 |
p.A543V | SKCM | 1 |
p.C254R | LIHC | 1 |
p.D546N | SKCM | 1 |
p.S165F | STAD | 1 |
p.L524R | LUAD | 1 |
p.P634S | SKCM | 1 |
p.G190R | COAD | 1 |
p.R231H | STAD | 1 |
p.G400E | THCA | 1 |
p.P712L | SKCM | 1 |
p.Q106R | BLCA | 1 |
p.W553S | STAD | 1 |
p.E719Q | CESC | 1 |
p.S311I | BLCA | 1 |
p.D105E | HNSC | 1 |
p.A116T | STAD | 1 |
p.G445S | HNSC | 1 |
p.K602N | SKCM | 1 |
p.T650M | PAAD | 1 |
p.P151H | LUSC | 1 |
p.V433D | LUSC | 1 |
p.E499G | LIHC | 1 |
p.G111S | SKCM | 1 |
p.Q104* | ACC | 1 |
p.S253* | BLCA | 1 |
p.A501S | BLCA | 1 |
p.Q106L | HNSC | 1 |
p.S646F | SKCM | 1 |
p.T453M | LUSC | 1 |
p.E28* | UCEC | 1 |
p.Q591H | LGG | 1 |
p.S363T | BLCA | 1 |
p.A373T | SKCM | 1 |
p.V361M | BRCA | 1 |
p.R620T | CESC | 1 |
p.N415S | STAD | 1 |
p.E251G | SKCM | 1 |
p.P184T | LUSC | 1 |
p.P136H | KICH | 1 |
p.P520T | LUSC | 1 |
p.A116V | UCEC | 1 |
p.S267F | SKCM | 1 |
p.H128N | SARC | 1 |
p.P119L | SKCM | 1 |
p.D425N | SKCM | 1 |
p.E375K | HNSC | 1 |
p.R169W | COAD | 1 |
p.A187T | LGG | 1 |
p.A271D | PAAD | 1 |
p.P266H | SKCM | 1 |
p.P541Q | OV | 1 |
p.S95Y | BLCA | 1 |
p.A296D | THYM | 1 |
p.P527L | UCEC | 1 |
p.R84W | THYM | 1 |
p.E671D | UCEC | 1 |
p.L544F | BLCA | 1 |
p.L714P | UCEC | 1 |
p.R585W | STAD | 1 |
p.G190W | LUSC | 1 |
p.D321G | STAD | 1 |
p.Q106R | GBM | 1 |
p.S698I | COAD | 1 |
p.G183D | SKCM | 1 |
p.S426L | SKCM | 1 |
p.E659G | OV | 1 |
p.Y389F | COAD | 1 |
p.R744Q | SKCM | 1 |
p.A710V | STAD | 1 |
p.L207M | KICH | 1 |
p.K429* | STAD | 1 |
p.G194R | COAD | 1 |
p.R84G | PAAD | 1 |
p.Q106R | CESC | 1 |
p.G194R | UCEC | 1 |
p.L320I | LUAD | 1 |
p.E154Q | CESC | 1 |
p.R235S | ESCA | 1 |
p.G4E | LUAD | 1 |
p.R412K | SKCM | 1 |
p.P263Q | LUAD | 1 |
p.R155K | SKCM | 1 |
p.A288T | LUAD | 1 |
p.Q106R | HNSC | 1 |
p.R753Q | SKCM | 1 |
p.D343E | LUAD | 1 |
p.P215H | HNSC | 1 |
p.P158R | ESCA | 1 |
p.Q15K | LUAD | 1 |
p.V554A | STAD | 1 |
p.E719G | CESC | 1 |
p.L76M | UCEC | 1 |
p.R506H | STAD | 1 |
p.E560K | SKCM | 1 |
p.G138R | SKCM | 1 |
p.G203S | SKCM | 1 |
p.P308S | STAD | 1 |
p.E260Q | HNSC | 1 |
p.D565N | BLCA | 1 |
p.M641I | HNSC | 1 |
p.R179P | COAD | 1 |
p.A10T | STAD | 1 |
p.A116E | STAD | 1 |
p.L69* | LUAD | 1 |
p.S545N | UCEC | 1 |
p.D390N | SKCM | 1 |
p.R130Q | SKCM | 1 |
p.S426L | UCEC | 1 |
p.L237X | LIHC | 1 |
p.W424* | SKCM | 1 |
p.R84G | THYM | 1 |
p.R618Q | SKCM | 1 |
p.S365C | BLCA | 1 |
p.T453M | STAD | 1 |
p.E668K | SKCM | 1 |
p.A187T | LAML | 1 |
p.S690R | LUAD | 1 |
p.S460L | SKCM | 1 |
p.Q599E | LUAD | 1 |
p.R570K | SKCM | 1 |
p.R538I | UCEC | 1 |
p.R709Q | HNSC | 1 |
p.A109T | SKCM | 1 |
p.D105E | GBM | 1 |
p.A576T | LUSC | 1 |
p.D582H | BLCA | 1 |
p.R393Q | STAD | 1 |
p.R130Q | ESCA | 1 |
p.D105E | CESC | 1 |
p.V370A | STAD | 1 |
p.R293H | PRAD | 1 |
p.R530H | STAD | 1 |
p.Q104X | ACC | 1 |
p.R167P | STAD | 1 |
p.R323W | COAD | 1 |
p.S456G | STAD | 1 |
p.G349E | SKCM | 1 |
p.P541S | SKCM | 1 |
p.E185K | SKCM | 1 |
p.A543T | OV | 1 |
p.G517S | SKCM | 1 |
p.G636D | STAD | 1 |
p.D371E | LIHC | 1 |
p.L611P | STAD | 1 |
p.G445S | STAD | 1 |
p.L364F | SKCM | 1 |
p.N415K | ESCA | 1 |
p.P137L | SKCM | 1 |
p.E500K | SKCM | 1 |
p.S460* | BLCA | 1 |
p.S229L | SKCM | 1 |
p.T7K | PRAD | 1 |
p.L248S | COAD | 1 |
p.E416K | SKCM | 1 |
p.M372I | SKCM | 1 |
p.A116T | PRAD | 1 |
p.N587K | CESC | 1 |
p.N711K | UCEC | 1 |
p.Y515H | BLCA | 1 |
p.P184L | SKCM | 1 |
p.S466T | LUAD | 1 |
p.D105E | BLCA | 1 |
p.R152I | STAD | 1 |
p.G680R | SKCM | 1 |
p.E384K | SKCM | 1 |
p.R96Q | SKCM | 1 |
p.M622I | LUAD | 1 |
p.G631E | SKCM | 1 |
p.A200E | LUSC | 1 |
p.K429X | STAD | 1 |
p.P476L | STAD | 1 |
p.K234N | LUSC | 1 |
p.A742V | PAAD | 1 |
p.M641I | SKCM | 1 |
p.E251K | TGCT | 1 |
p.D321E | LUAD | 1 |
p.D105E | THYM | 1 |
p.A491V | STAD | 1 |
p.G226R | SKCM | 1 |
p.I160T | LUAD | 1 |
p.T173M | HNSC | 1 |
p.H9R | LUAD | 1 |
p.R748K | UCEC | 1 |
p.V79M | COAD | 1 |
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TissGeneCNV for TCEB3B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TCEB3B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TCEB3B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TCEB3B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TCEB3B |
TissGeneDrug for TCEB3B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TCEB3B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |