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| TissGeneSummary for PCSK2 |
 Gene summary |
| Basic gene information | Gene symbol | PCSK2 |
| Gene name | proprotein convertase subtilisin/kexin type 2 | |
| Synonyms | NEC 2|NEC-2|NEC2|PC2|SPC2 | |
| Cytomap | UCSC genome browser: 20p11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001201528.1, NM_001201529.2,NM_002594.4, | |
| Description | KEX2-like endoprotease 2neuroendocrine convertase 2prohormone convertase 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 162151 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000125851 | ||
| HPRD : 01202 | ||
| Vega : OTTHUMG00000031941 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PCSK2 | |
| BioGPS: 5126 | ||
| Pathway | NCI Pathway Interaction Database: PCSK2 | |
| KEGG: PCSK2 | ||
| REACTOME: PCSK2 | ||
| Pathway Commons: PCSK2 | ||
| Context | iHOP: PCSK2 | |
| ligand binding site mutation search in PubMed: PCSK2 | ||
| UCL Cancer Institute: PCSK2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADTHCA | |
| Reference showing the relevant tissue of PCSK2 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006508 | proteolysis | 7626024 | GO:0030070 | insulin processing | 7626024 | GO:0006508 | proteolysis | 7626024 | GO:0030070 | insulin processing | 7626024 |
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| TissGeneExp for PCSK2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BLCA | -2.22342761 | 2.897619759 | -5.121047368 | 9.65E-09 | 9.51E-07 |
| LUAD | 0.452144078 | 3.222418216 | -2.770274138 | 1.79E-06 | 5.76E-06 |
| LUSC | -1.015522656 | 3.350445971 | -4.365968627 | 5.21E-19 | 5.36E-18 |
| COAD | -2.369058177 | 2.970368746 | -5.339426923 | 1.13E-20 | 4.95E-18 |
| THCA | 7.719592997 | 4.768609946 | 2.950983051 | 6.85E-09 | 3.49E-08 |
| PRAD | -0.282646638 | 1.378041823 | -1.660688462 | 3.11E-07 | 2.53E-06 |
| KIRP | -3.013088465 | -0.49896034 | -2.514128125 | 1.83E-11 | 2.41E-10 |
| LIHC | -3.368407715 | -1.602845715 | -1.765562 | 1.48E-11 | 2.25E-10 |
| HNSC | -2.361885994 | 0.164076796 | -2.525962791 | 1.53E-08 | 1.78E-07 |
| KIRC | -3.081866937 | -0.914755826 | -2.167111111 | 1.72E-19 | 1.30E-18 |
| STAD | -1.36772909 | 2.94623341 | -4.3139625 | 9.70E-11 | 1.28E-08 |
| KICH | -2.549077715 | -1.051773715 | -1.497304 | 0.00121 | 0.002586654 |
| ESCA | -1.911469715 | 2.363721194 | -4.275190909 | 1.47E-05 | 0.001127338 |
| Top |
| TissGene-miRNA for PCSK2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-429 | MIMAT0001536 | 0.012 | -0.32 | 60 |
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| TissGeneMut for PCSK2 |
| TissGeneSNV for PCSK2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A597V | LIHC | 2 |
| p.P579S | SKCM | 2 |
| p.P175Q | LUAD | 1 |
| p.G358E | SKCM | 1 |
| p.D92Y | THYM | 1 |
| p.E90G | LIHC | 1 |
| p.S633G | KIRP | 1 |
| p.G321S | STAD | 1 |
| p.S472F | HNSC | 1 |
| p.G339E | SKCM | 1 |
| p.I511V | CHOL | 1 |
| p.D458H | LUAD | 1 |
| p.R106Q | BLCA | 1 |
| p.G280S | COAD | 1 |
| p.A220T | LGG | 1 |
| p.R419W | OV | 1 |
| p.R47C | SKCM | 1 |
| p.D291N | HNSC | 1 |
| p.M455I | LGG | 1 |
| p.R502C | STAD | 1 |
| p.R483C | COAD | 1 |
| p.A368T | PRAD | 1 |
| p.Y231C | LIHC | 1 |
| p.A509V | PRAD | 1 |
| p.R539H | STAD | 1 |
| p.K581N | HNSC | 1 |
| p.W587* | HNSC | 1 |
| p.G573E | SKCM | 1 |
| p.R539H | PRAD | 1 |
| p.R28C | SKCM | 1 |
| p.P579L | SKCM | 1 |
| p.S348F | SKCM | 1 |
| p.A201T | LGG | 1 |
| p.P480L | PAAD | 1 |
| p.A578T | SARC | 1 |
| p.K610N | LUAD | 1 |
| p.A267T | PAAD | 1 |
| p.G557S | READ | 1 |
| p.N274K | KIRC | 1 |
| p.E464D | BRCA | 1 |
| p.G496R | SKCM | 1 |
| p.L284F | KIRP | 1 |
| p.A138S | HNSC | 1 |
| p.S330F | SKCM | 1 |
| p.S217Y | UCEC | 1 |
| p.G226R | SKCM | 1 |
| p.L635I | UCEC | 1 |
| p.R502C | THYM | 1 |
| p.P344L | SKCM | 1 |
| p.R109* | UCEC | 1 |
| p.D544N | LUSC | 1 |
| p.A578G | ESCA | 1 |
| p.K108M | STAD | 1 |
| p.G403S | BLCA | 1 |
| p.N362K | OV | 1 |
| p.D168N | BLCA | 1 |
| p.P196S | BRCA | 1 |
| p.R81H | LGG | 1 |
| p.R81C | UCEC | 1 |
| p.G56* | BRCA | 1 |
| p.Y444C | LUAD | 1 |
| p.M97I | LUSC | 1 |
| p.M166T | LUSC | 1 |
| p.G366V | LUAD | 1 |
| p.M326V | UCEC | 1 |
| p.E586K | SARC | 1 |
| p.E26Q | LUSC | 1 |
| p.G339R | SKCM | 1 |
| p.L265F | KIRP | 1 |
| p.A307S | LUAD | 1 |
| p.S256I | KIRC | 1 |
| p.R58Q | ESCA | 1 |
| p.D544N | KIRC | 1 |
| p.F205C | BLCA | 1 |
| p.D316Y | ESCA | 1 |
| p.S305F | SKCM | 1 |
| p.E345D | CESC | 1 |
| p.D310G | STAD | 1 |
| p.V453M | HNSC | 1 |
| p.A390S | LUAD | 1 |
| p.A267T | SKCM | 1 |
| p.F500S | UCEC | 1 |
| p.L383M | READ | 1 |
| p.K546N | LUAD | 1 |
| p.D337N | BLCA | 1 |
| p.R80K | SKCM | 1 |
| p.Q88H | UCEC | 1 |
| p.V434I | HNSC | 1 |
| p.G207R | SKCM | 1 |
| p.K2E | COAD | 1 |
| p.R431H | GBM | 1 |
| p.R407W | MESO | 1 |
| p.R407W | GBM | 1 |
| p.P363L | SKCM | 1 |
| p.A51V | UCEC | 1 |
| p.A578S | COAD | 1 |
| p.G312V | THYM | 1 |
| p.E389D | LUAD | 1 |
| p.Q101H | CHOL | 1 |
| p.G358R | SKCM | 1 |
| p.A98T | BLCA | 1 |
| p.R109* | LGG | 1 |
| p.K2N | PRAD | 1 |
| p.F189V | ESCA | 1 |
| p.W568* | LGG | 1 |
| p.G136V | ACC | 1 |
| p.S356T | LUAD | 1 |
| p.E215D | STAD | 1 |
| p.K615R | LUAD | 1 |
| p.G554E | SKCM | 1 |
| p.G382V | HNSC | 1 |
| p.S324F | SKCM | 1 |
| p.T141N | LUAD | 1 |
| p.P124S | SKCM | 1 |
| p.T340I | OV | 1 |
| p.R431C | COAD | 1 |
| p.S329F | SKCM | 1 |
| p.D550H | HNSC | 1 |
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| TissGeneCNV for PCSK2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PCSK2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF825528 | PCSK2-SMAD4 | chr20:17256436 | chr18:48559252 |
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| TissGeneNet for PCSK2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| COAD (tumor) | COAD (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| KICH (tumor) | KICH (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| STAD (tumor) | STAD (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| THCA (tumor) | THCA (normal) |
| PCSK2, IAPP, SCG5, PMCH (tumor) | PCSK2, IAPP, SCG5, PMCH (normal) |
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| TissGeneProg for PCSK2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PCSK2 |
| TissGeneDrug for PCSK2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PCSK2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 6 | BeFree,CTD_human,GAD |
| umls:C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human,RGD |
| umls:C0028754 | Obesity | 2 | GAD,GWASCAT |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
| umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | RGD |
| umls:C0022658 | Kidney Diseases | 1 | GAD |
| umls:C0024299 | Lymphoma | 1 | LHGDN |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | LHGDN |
| umls:C0031511 | Pheochromocytoma | 1 | BeFree |
| umls:C0032000 | Pituitary Adenoma | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0038525 | Subarachnoid Hemorrhage | 1 | GAD |
| umls:C0040136 | Thyroid Neoplasm | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0151699 | Intracranial Hemorrhages | 1 | GAD |
| umls:C0206682 | Follicular thyroid carcinoma | 1 | BeFree |
| umls:C0376618 | Endotoxemia | 1 | RGD |
| umls:C0403447 | Chronic Kidney Insufficiency | 1 | RGD |
| umls:C1306214 | ACTH-Secreting Pituitary Adenoma | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1561955 | Fibrinogen Adverse Event | 1 | GAD |
| umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |
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