TissGeneSummary for TFDP3 |
Gene summary |
Basic gene information | Gene symbol | TFDP3 |
Gene name | transcription factor Dp family, member 3 | |
Synonyms | CT30|DP4|HCA661 | |
Cytomap | UCSC genome browser: Xq26.2 | |
Type of gene | protein-coding | |
RefGenes | NM_016521.2, | |
Description | E2F-like proteincancer/testis antigen 30hepatocellular carcinoma-associated antigen 661transcription factor Dp family member 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300772 | |
HGNC : HGNC | ||
Ensembl : ENSG00000183434 | ||
HPRD : 06623 | ||
Vega : OTTHUMG00000022433 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TFDP3 | |
BioGPS: 51270 | ||
Pathway | NCI Pathway Interaction Database: TFDP3 | |
KEGG: TFDP3 | ||
REACTOME: TFDP3 | ||
Pathway Commons: TFDP3 | ||
Context | iHOP: TFDP3 | |
ligand binding site mutation search in PubMed: TFDP3 | ||
UCL Cancer Institute: TFDP3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TFDP3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0000082 | G1/S transition of mitotic cell cycle | 17062573 | GO:0006974 | cellular response to DNA damage stimulus | 20559320 | GO:0000082 | G1/S transition of mitotic cell cycle | 17062573 | GO:0006974 | cellular response to DNA damage stimulus | 20559320 |
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TissGeneExp for TFDP3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -1.172583474 | -2.336331474 | 1.163748 | 0.000666 | 0.001884313 |
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TissGene-miRNA for TFDP3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TFDP3 |
TissGeneSNV for TFDP3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E20Q | DLBC | 2 |
p.G104* | UCEC | 1 |
p.E386D | COAD | 1 |
p.F280C | SKCM | 1 |
p.R163S | LUAD | 1 |
p.A148T | READ | 1 |
p.Y155H | SKCM | 1 |
p.A143P | OV | 1 |
p.P71S | SKCM | 1 |
p.L247Q | HNSC | 1 |
p.E331* | UCEC | 1 |
p.V133G | ACC | 1 |
p.G299D | PRAD | 1 |
p.S129F | SKCM | 1 |
p.E240* | LUAD | 1 |
p.D395N | UCEC | 1 |
p.W352C | STAD | 1 |
p.G377C | HNSC | 1 |
p.V266I | CESC | 1 |
p.R124S | LUSC | 1 |
p.Q56K | ACC | 1 |
p.ED403DY | BRCA | 1 |
p.Q56L | SARC | 1 |
p.V170L | LGG | 1 |
p.P383T | LUAD | 1 |
p.N349H | KIRC | 1 |
p.I70S | SKCM | 1 |
p.N101K | LUAD | 1 |
p.A333T | COAD | 1 |
p.S262N | UCEC | 1 |
p.P65S | KIRC | 1 |
p.P95L | SKCM | 1 |
p.G372E | SKCM | 1 |
p.V34M | LUAD | 1 |
p.P327L | UCEC | 1 |
p.Q195H | DLBC | 1 |
p.K214Q | UCS | 1 |
p.V29I | UCEC | 1 |
p.L111Q | LUAD | 1 |
p.D166N | SKCM | 1 |
p.M116T | STAD | 1 |
p.G377D | UCEC | 1 |
p.G104R | SKCM | 1 |
p.T121M | LGG | 1 |
p.G74E | SKCM | 1 |
p.A139V | PRAD | 1 |
p.E105K | SKCM | 1 |
p.R163C | UCEC | 1 |
p.E152K | SKCM | 1 |
p.K185R | LUAD | 1 |
p.N192S | UVM | 1 |
p.D273N | STAD | 1 |
p.E12K | UCEC | 1 |
p.V254M | UCEC | 1 |
p.K281T | UCEC | 1 |
p.R163C | ACC | 1 |
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TissGeneCNV for TFDP3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TFDP3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TFDP3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TFDP3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TFDP3 |
TissGeneDrug for TFDP3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TFDP3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |