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| TissGeneSummary for BPIFA1 |
 Gene summary |
| Basic gene information | Gene symbol | BPIFA1 |
| Gene name | BPI fold containing family A, member 1 | |
| Synonyms | LUNX|NASG|PLUNC|SPLUNC1|SPURT|bA49G10.5 | |
| Cytomap | UCSC genome browser: 20q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001243193.1, NM_016583.3,NM_130852.2, | |
| Description | BPI fold-containing family A member 1ligand-binding protein RYA3lung-specific protein Xnasopharyngeal carcinoma-related proteinpalate lung and nasal epithelium clone proteinpalate, lung and nasal epithelium associatedprotein Pluncsecretory protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607412 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000198183 | ||
| HPRD : 07594 | ||
| Vega : OTTHUMG00000032243 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_BPIFA1 | |
| BioGPS: 51297 | ||
| Pathway | NCI Pathway Interaction Database: BPIFA1 | |
| KEGG: BPIFA1 | ||
| REACTOME: BPIFA1 | ||
| Pathway Commons: BPIFA1 | ||
| Context | iHOP: BPIFA1 | |
| ligand binding site mutation search in PubMed: BPIFA1 | ||
| UCL Cancer Institute: BPIFA1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC | |
| Reference showing the relevant tissue of BPIFA1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0019731 | antibacterial humoral response | 23499554 | GO:0045087 | innate immune response | 23499554 | GO:0050828 | regulation of liquid surface tension | 23499554 | GO:0050891 | multicellular organismal water homeostasis | 24124190 | GO:1902305 | regulation of sodium ion transmembrane transport | 24124190 | GO:0019731 | antibacterial humoral response | 23499554 | GO:0045087 | innate immune response | 23499554 | GO:0050828 | regulation of liquid surface tension | 23499554 | GO:0050891 | multicellular organismal water homeostasis | 24124190 | GO:1902305 | regulation of sodium ion transmembrane transport | 24124190 |
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| TissGeneExp for BPIFA1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for BPIFA1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for BPIFA1 |
| TissGeneSNV for BPIFA1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.I163M | LUAD | 1 |
| p.G90V | LUAD | 1 |
| p.G49E | KIRP | 1 |
| p.L218V | STAD | 1 |
| p.P216S | UCEC | 1 |
| p.P134A | TGCT | 1 |
| p.A39S | LUAD | 1 |
| p.G136S | COAD | 1 |
| p.E69Q | ESCA | 1 |
| p.G23S | SKCM | 1 |
| p.T96M | PCPG | 1 |
| p.L238Q | LIHC | 1 |
| p.I173M | HNSC | 1 |
| p.T17N | LUSC | 1 |
| p.R128S | LUSC | 1 |
| p.N70K | PAAD | 1 |
| p.G136S | LUAD | 1 |
| p.Q3* | SKCM | 1 |
| p.Q3X | SKCM | 1 |
| p.A148T | UCEC | 1 |
| p.A54S | CESC | 1 |
| p.D112G | LIHC | 1 |
| p.L191M | LUSC | 1 |
| p.E117K | SKCM | 1 |
| p.G12E | LIHC | 1 |
| p.L42* | LUAD | 1 |
| p.S56N | PRAD | 1 |
| p.L88H | HNSC | 1 |
| p.G196D | HNSC | 1 |
| p.L218F | LUAD | 1 |
| p.R172S | HNSC | 1 |
| p.L64M | LUAD | 1 |
| p.P72L | DLBC | 1 |
| p.S190Y | UCEC | 1 |
| p.S183F | SKCM | 1 |
| p.H182R | UCEC | 1 |
| p.Q251H | BLCA | 1 |
| p.P27L | SKCM | 1 |
| p.Q20* | LUSC | 1 |
| p.V110I | SKCM | 1 |
| p.G249R | BLCA | 1 |
| p.P134S | SKCM | 1 |
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| TissGeneCNV for BPIFA1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for BPIFA1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF155588 | RANBP10-BPIFA1 | chr16:67831179 | chr20:31828044 | |
| TCGAfusionPortal | PRADA | LUAD | TCGA-78-7159-01A | BPIFA1-CLDN7 | 3UTR-5UTR | Chr20:31831115 | Chr17:7166264 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-80-5608-01A | BPIFA1-CLDN7 | 3UTR-5UTR | Chr20:31831115 | Chr17:7166264 |
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| TissGeneNet for BPIFA1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for BPIFA1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for BPIFA1 |
| TissGeneDrug for BPIFA1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for BPIFA1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2931822 | Nasopharyngeal carcinoma | 8 | BeFree |
| umls:C0024115 | Lung diseases | 4 | BeFree |
| umls:C0027430 | Nasal Polyps | 4 | BeFree |
| umls:C1398301 | Short palate | 4 | BeFree |
| umls:C0004623 | Bacterial Infections | 3 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 3 | BeFree,LHGDN |
| umls:C0024121 | Lung Neoplasms | 3 | BeFree,LHGDN |
| umls:C0149516 | Chronic sinusitis | 3 | BeFree |
| umls:C2607914 | Allergic rhinitis (disorder) | 3 | BeFree,GAD |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,GAD |
| umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0010278 | Craniosynostosis | 1 | BeFree |
| umls:C0026936 | Mycoplasma Infections | 1 | BeFree |
| umls:C0027439 | Nasopharyngeal Neoplasms | 1 | GAD |
| umls:C0035243 | Respiratory Tract Infections | 1 | BeFree |
| umls:C0149678 | Epstein-Barr Virus Infections | 1 | BeFree |
| umls:C0206721 | Inverted Papilloma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0876973 | Infectious disease of lung | 1 | BeFree |
| umls:C1881254 | Inverted Squamous Cell Papilloma | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | LHGDN |
| umls:C2985290 | Fetal Alcohol Spectrum Disorders | 1 | CTD_human |
| umls:C3665444 | Neutrophilia (disorder) | 1 | BeFree |
| umls:C1833692 | OTITIS MEDIA, SUSCEPTIBILITY TO (finding) | 0 | MGD |
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