TissGeneSummary for THEG |
Gene summary |
Basic gene information | Gene symbol | THEG |
Gene name | theg spermatid protein | |
Synonyms | CT56|THEG1 | |
Cytomap | UCSC genome browser: 19p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_016585.4, NM_199202.2, | |
Description | Theg homologcancer/testis antigen 56testicular haploid expressed gene proteintestis-specific | |
Modification date | 20141207 | |
dbXrefs | MIM : 609503 | |
HGNC : HGNC | ||
Ensembl : ENSG00000105549 | ||
HPRD : 15503 | ||
Vega : OTTHUMG00000165491 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_THEG | |
BioGPS: 51298 | ||
Pathway | NCI Pathway Interaction Database: THEG | |
KEGG: THEG | ||
REACTOME: THEG | ||
Pathway Commons: THEG | ||
Context | iHOP: THEG | |
ligand binding site mutation search in PubMed: THEG | ||
UCL Cancer Institute: THEG | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of THEG | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for THEG |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | 1.921244912 | 0.788408373 | 1.132836538 | 8.87E-08 | 8.49E-07 |
LUSC | 0.914141367 | -0.351829221 | 1.265970588 | 2.07E-05 | 4.58E-05 |
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TissGene-miRNA for THEG |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for THEG |
TissGeneSNV for THEG |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D287N | SKCM | 1 |
p.A228V | UCEC | 1 |
p.G146E | SKCM | 1 |
p.C165S | LAML | 1 |
p.P356S | SKCM | 1 |
p.P164L | SKCM | 1 |
p.G10R | SKCM | 1 |
p.R20S | LIHC | 1 |
p.M360I | CESC | 1 |
p.D44N | UCEC | 1 |
p.V263M | COAD | 1 |
p.E196D | LUSC | 1 |
p.R6* | STAD | 1 |
p.P215L | SKCM | 1 |
p.L362M | LUAD | 1 |
p.R321C | COAD | 1 |
p.A258E | PRAD | 1 |
p.R41W | GBM | 1 |
p.P65L | LUAD | 1 |
p.L280F | ESCA | 1 |
p.R320C | LUAD | 1 |
p.R23M | CESC | 1 |
p.G149D | BLCA | 1 |
p.R30C | UCEC | 1 |
p.R299H | UCEC | 1 |
p.E225K | PAAD | 1 |
p.M249I | THCA | 1 |
p.L205P | UCEC | 1 |
p.R299H | LGG | 1 |
p.R41W | UCEC | 1 |
p.S266W | LUAD | 1 |
p.P75L | SKCM | 1 |
p.S34N | KIRC | 1 |
p.R30C | STAD | 1 |
p.A367T | STAD | 1 |
p.M225I | THCA | 1 |
p.R147C | COAD | 1 |
p.D318V | KIRC | 1 |
p.A237T | UCEC | 1 |
p.E282K | SKCM | 1 |
p.D311N | SKCM | 1 |
p.E67K | SKCM | 1 |
p.R267W | LIHC | 1 |
p.R217C | SKCM | 1 |
p.E68D | SKCM | 1 |
p.H273Y | COAD | 1 |
p.R6X | STAD | 1 |
p.P264H | LUAD | 1 |
p.R207C | SKCM | 1 |
p.V42I | KIRC | 1 |
p.R231C | SKCM | 1 |
p.R317Q | GBM | 1 |
p.G2R | HNSC | 1 |
p.D373N | SKCM | 1 |
p.P191L | SKCM | 1 |
p.W168X | DLBC | 1 |
p.L271S | BLCA | 1 |
p.R320C | SKCM | 1 |
p.S359C | BLCA | 1 |
p.G146* | SKCM | 1 |
p.D373H | BRCA | 1 |
p.P286T | STAD | 1 |
p.F244L | UCS | 1 |
p.A258E | CHOL | 1 |
p.F244L | HNSC | 1 |
p.R355C | ESCA | 1 |
p.R47C | HNSC | 1 |
p.G27S | LUAD | 1 |
p.S359F | HNSC | 1 |
p.P60S | LGG | 1 |
p.L339P | STAD | 1 |
p.P188L | SKCM | 1 |
p.S4N | SKCM | 1 |
p.R241C | SKCM | 1 |
p.R355H | UCEC | 1 |
p.A358T | LUSC | 1 |
p.R192H | PAAD | 1 |
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TissGeneCNV for THEG |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for THEG |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for THEG |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for THEG |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for THEG |
TissGeneDrug for THEG |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for THEG |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0021364 | Male infertility | 9 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 4 | BeFree |
umls:C0006118 | Brain Neoplasms | 2 | BeFree |
umls:C0004509 | Azoospermia | 1 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0020619 | Hypogonadism | 1 | BeFree |
umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0032897 | Prader-Willi Syndrome | 1 | BeFree |
umls:C0085669 | Acute leukemia | 1 | BeFree |
umls:C0206661 | Gonadoblastoma | 1 | BeFree |
umls:C0242596 | Neoplasm, Residual | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1262296 | Testicular infection | 1 | BeFree |
umls:C1847540 | Azoospermia, Nonobstructive | 1 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |