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| TissGeneSummary for ZMYND10 |
 Gene summary |
| Basic gene information | Gene symbol | ZMYND10 |
| Gene name | zinc finger, MYND-type containing 10 | |
| Synonyms | BLU|CILD22|FLU | |
| Cytomap | UCSC genome browser: 3p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_015896.2, | |
| Description | protein BLuzinc finger MYND domain-containing protein 10zinc finger, MYND domain containing 10 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607070 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000004838 | ||
| HPRD : 06145 | ||
| Vega : OTTHUMG00000156874 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZMYND10 | |
| BioGPS: 51364 | ||
| Pathway | NCI Pathway Interaction Database: ZMYND10 | |
| KEGG: ZMYND10 | ||
| REACTOME: ZMYND10 | ||
| Pathway Commons: ZMYND10 | ||
| Context | iHOP: ZMYND10 | |
| ligand binding site mutation search in PubMed: ZMYND10 | ||
| UCL Cancer Institute: ZMYND10 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ZMYND10 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZMYND10 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 1.336135735 | -0.663151108 | 1.999286842 | 1.94E-14 | 9.76E-14 |
| LIHC | -2.322587494 | -3.644245494 | 1.321658 | 7.57E-08 | 5.44E-07 |
| KICH | -2.823553494 | 0.760826506 | -3.58438 | 4.11E-13 | 5.24E-12 |
| LUSC | -1.542164317 | 2.498547448 | -4.040711765 | 3.27E-15 | 2.09E-14 |
| LUAD | 0.041491058 | 2.695439334 | -2.653948276 | 3.86E-09 | 1.84E-08 |
| HNSC | -3.045952005 | -1.977168284 | -1.068783721 | 0.0165 | 0.03815519 |
| PRAD | -1.081767032 | -2.099457417 | 1.017690385 | 0.000366 | 0.00133802 |
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| TissGene-miRNA for ZMYND10 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZMYND10 |
| TissGeneSNV for ZMYND10 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G156A | STAD | 1 |
| p.E182Q | CESC | 1 |
| p.L145R | LAML | 1 |
| p.R393H | LGG | 1 |
| p.H355N | THYM | 1 |
| p.P87H | LGG | 1 |
| p.L201P | LIHC | 1 |
| p.L296I | UCEC | 1 |
| p.R373P | SKCM | 1 |
| p.D165H | HNSC | 1 |
| p.R391W | PCPG | 1 |
| p.R293W | UCEC | 1 |
| p.A399T | UCEC | 1 |
| p.R288W | UCEC | 1 |
| p.R293W | PAAD | 1 |
| p.E93K | SKCM | 1 |
| p.R391W | UCEC | 1 |
| p.H36R | OV | 1 |
| p.A77T | STAD | 1 |
| p.W412* | KIRP | 1 |
| p.D139H | CESC | 1 |
| p.R192C | COAD | 1 |
| p.S398T | BRCA | 1 |
| p.R404C | UCEC | 1 |
| p.K254E | CESC | 1 |
| p.E60K | ESCA | 1 |
| p.Q303R | LUAD | 1 |
| p.E161K | CESC | 1 |
| p.R288W | STAD | 1 |
| p.S362C | ACC | 1 |
| p.D437Y | KIRC | 1 |
| p.A187T | UCEC | 1 |
| p.R369W | DLBC | 1 |
| p.R340G | STAD | 1 |
| p.W412X | KIRP | 1 |
| p.E159K | LUAD | 1 |
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| TissGeneCNV for ZMYND10 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZMYND10 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ZMYND10 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| COAD (tumor) | COAD (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| KICH (tumor) | KICH (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| STAD (tumor) | STAD (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| THCA (tumor) | THCA (normal) |
| ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (tumor) | ZMYND10, E2F1, NR0B2, CTCF, TSC22D4, RNF181, SERINC1 (normal) |
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| TissGeneProg for ZMYND10 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZMYND10 |
| TissGeneDrug for ZMYND10 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZMYND10 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2931822 | Nasopharyngeal carcinoma | 6 | BeFree |
| umls:C0596263 | Carcinogenesis | 5 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 4 | BeFree |
| umls:C0684249 | Carcinoma of lung | 4 | BeFree |
| umls:C0021400 | Influenza | 3 | BeFree |
| umls:C0042769 | Virus Diseases | 3 | BeFree |
| umls:C0521839 | Influenza-like illness | 3 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0008780 | Ciliary Motility Disorders | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0022521 | Kartagener Syndrome | 2 | BeFree,CLINVAR |
| umls:C0024121 | Lung Neoplasms | 2 | BeFree,LHGDN |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0392171 | Influenza-like symptoms | 2 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 2 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
| umls:C3809543 | CILIARY DYSKINESIA, PRIMARY, 22 | 2 | CLINVAR,UNIPROT |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0010200 | Coughing | 1 | BeFree |
| umls:C0022679 | Cystic kidney | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | LHGDN |
| umls:C0033027 | Preleukemia | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
| umls:C0235782 | Gallbladder Carcinoma | 1 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C1096184 | West Nile viral infection | 1 | BeFree |
| umls:C1302773 | Low Grade Squamous Intraepithelial Neoplasia | 1 | BeFree |
| umls:C1335177 | Ovarian Serous Adenocarcinoma | 1 | BeFree |
| umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3463824 | MYELODYSPLASTIC SYNDROME | 1 | BeFree |
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