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| TissGeneSummary for MAGEC2 |
 Gene summary |
| Basic gene information | Gene symbol | MAGEC2 |
| Gene name | melanoma antigen family C, 2 | |
| Synonyms | CT10|HCA587|MAGEE1 | |
| Cytomap | UCSC genome browser: Xq27 | |
| Type of gene | protein-coding | |
| RefGenes | NM_016249.3, | |
| Description | MAGE-C2 antigenMAGE-E1 antigencancer/testis antigen 10hepatocellular cancer antigen 587hepatocellular carcinoma-associated antigen 587melanoma antigen, family E, 1, cancer/testis specificmelanoma-associated antigen C2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300468 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000046774 | ||
| HPRD : 06632 | ||
| Vega : OTTHUMG00000022574 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MAGEC2 | |
| BioGPS: 51438 | ||
| Pathway | NCI Pathway Interaction Database: MAGEC2 | |
| KEGG: MAGEC2 | ||
| REACTOME: MAGEC2 | ||
| Pathway Commons: MAGEC2 | ||
| Context | iHOP: MAGEC2 | |
| ligand binding site mutation search in PubMed: MAGEC2 | ||
| UCL Cancer Institute: MAGEC2 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMTGCT | |
| Reference showing the relevant tissue of MAGEC2 | Cancer testis antigen expression in testicular germ cell tumorigenesis. Bode PK, Thielken A, Brandt S, Barghorn A, Lohe B, Knuth A, Moch H. Mod Pathol. 2014 Jun;27(6):899-905. doi: 10.1038/modpathol.2013.183. Epub 2013 Nov 15. (pmid:24232866) go to article | |
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MAGEC2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 2.698948564 | -0.662925436 | 3.361874 | 7.07E-07 | 3.94E-06 |
| HNSC | 0.355894843 | -0.926093529 | 1.281988372 | 0.00116 | 0.003838235 |
| LUAD | 0.961823392 | -0.775040401 | 1.736863793 | 0.000262 | 0.000619248 |
| LUSC | 1.029727584 | -0.868609671 | 1.898337255 | 0.000134 | 0.000273093 |
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| TissGene-miRNA for MAGEC2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MAGEC2 |
| TissGeneSNV for MAGEC2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E157K | SKCM | 3 |
| p.S108L | SKCM | 2 |
| p.E269K | SKCM | 2 |
| p.R287W | SKCM | 2 |
| p.E272K | SKCM | 2 |
| p.S372F | BLCA | 1 |
| p.F55L | GBM | 1 |
| p.P270H | STAD | 1 |
| p.S82I | UCEC | 1 |
| p.A346V | SKCM | 1 |
| p.C103F | READ | 1 |
| p.D123N | SKCM | 1 |
| p.P295L | LUAD | 1 |
| p.A305T | SKCM | 1 |
| p.Y156H | HNSC | 1 |
| p.R343T | HNSC | 1 |
| p.Y174* | HNSC | 1 |
| p.A336V | SKCM | 1 |
| p.D349N | SKCM | 1 |
| p.H306Y | SKCM | 1 |
| p.S331Y | SKCM | 1 |
| p.P303S | SKCM | 1 |
| p.E247D | UCEC | 1 |
| p.N11K | GBM | 1 |
| p.P131Q | LUAD | 1 |
| p.A354V | CESC | 1 |
| p.H306Q | READ | 1 |
| p.L191F | PRAD | 1 |
| p.P95S | SKCM | 1 |
| p.E36D | LGG | 1 |
| p.E114D | LUAD | 1 |
| p.C103W | UCS | 1 |
| p.P295T | LUAD | 1 |
| p.S370F | SKCM | 1 |
| p.D216N | COAD | 1 |
| p.R287Q | CESC | 1 |
| p.G218C | LUAD | 1 |
| p.W278C | LIHC | 1 |
| p.W278* | SKCM | 1 |
| p.G94R | LUAD | 1 |
| p.S245F | LUAD | 1 |
| p.F9I | SKCM | 1 |
| p.V369I | GBM | 1 |
| p.M224I | STAD | 1 |
| p.V49L | UCS | 1 |
| p.P31L | SKCM | 1 |
| p.E147K | SKCM | 1 |
| p.K183N | BLCA | 1 |
| p.D176Y | COAD | 1 |
| p.L79F | SKCM | 1 |
| p.E251K | BLCA | 1 |
| p.T350S | LUAD | 1 |
| p.R10C | SKCM | 1 |
| p.E35K | SKCM | 1 |
| p.S135F | LIHC | 1 |
| p.P131T | LUAD | 1 |
| p.G6C | LUAD | 1 |
| p.K276N | COAD | 1 |
| p.K173T | GBM | 1 |
| p.E81K | LUSC | 1 |
| p.V344I | COAD | 1 |
| p.W25C | LUAD | 1 |
| p.R186L | LUSC | 1 |
| p.A42P | LUAD | 1 |
| p.P72S | COAD | 1 |
| p.G90C | LUSC | 1 |
| p.S106P | STAD | 1 |
| p.S363I | LUAD | 1 |
| p.R343I | LUAD | 1 |
| p.G65C | HNSC | 1 |
| p.N14D | LGG | 1 |
| p.T32K | LUAD | 1 |
| p.F205L | LUAD | 1 |
| p.K173Q | COAD | 1 |
| p.D221H | UCS | 1 |
| p.R184K | SKCM | 1 |
| p.K276N | ESCA | 1 |
| p.W25C | UCEC | 1 |
| p.S293F | ESCA | 1 |
| p.P290A | BRCA | 1 |
| p.P294T | LUAD | 1 |
| p.G218S | SKCM | 1 |
| p.F238Y | GBM | 1 |
| p.P202L | SKCM | 1 |
| p.W109C | LUAD | 1 |
| p.F205I | LIHC | 1 |
| p.E69K | SKCM | 1 |
| p.P17L | UCEC | 1 |
| p.P3S | SKCM | 1 |
| p.E247D | BRCA | 1 |
| p.P179S | SKCM | 1 |
| p.R262K | SKCM | 1 |
| p.P77S | UCS | 1 |
| p.P225H | LUAD | 1 |
| p.M365I | LUSC | 1 |
| p.P8S | UCEC | 1 |
| p.D176Y | UCEC | 1 |
| p.E164K | LUAD | 1 |
| p.P161H | COAD | 1 |
| p.L154F | SKCM | 1 |
| p.S102F | SKCM | 1 |
| p.S328F | SKCM | 1 |
| p.E34K | HNSC | 1 |
| p.W250* | BLCA | 1 |
| p.250_251WE>*K | BLCA | 1 |
| p.E288K | SKCM | 1 |
| p.D15N | UCEC | 1 |
| p.T324N | LUAD | 1 |
| p.V12I | BRCA | 1 |
| p.V180L | LUAD | 1 |
| p.T126S | OV | 1 |
| p.A336S | SKCM | 1 |
| p.G121R | SKCM | 1 |
| p.S85I | LUAD | 1 |
| p.P17L | SKCM | 1 |
| p.G257E | SKCM | 1 |
| p.S105F | SKCM | 1 |
| p.P3L | SKCM | 1 |
| p.P17T | LUAD | 1 |
| p.G74V | LUSC | 1 |
| p.G65R | LUSC | 1 |
| p.V7I | UCEC | 1 |
| p.I237T | OV | 1 |
| p.T215I | SKCM | 1 |
| p.S110G | LIHC | 1 |
| p.E143K | SKCM | 1 |
| p.E285D | HNSC | 1 |
| p.X374C | LGG | 1 |
| p.K144N | HNSC | 1 |
| p.S245P | UCEC | 1 |
| p.Q97L | LUAD | 1 |
| p.S292T | UCS | 1 |
| p.V200L | LUAD | 1 |
| p.C104S | LUSC | 1 |
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| TissGeneCNV for MAGEC2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MAGEC2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for MAGEC2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| COAD (tumor) | COAD (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| HNSC (tumor) | HNSC (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| KICH (tumor) | KICH (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| KIRC (tumor) | KIRC (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| KIRP (tumor) | KIRP (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| LIHC (tumor) | LIHC (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| LUAD (tumor) | LUAD (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| LUSC (tumor) | LUSC (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| PRAD (tumor) | PRAD (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| STAD (tumor) | STAD (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| THCA (tumor) | THCA (normal) |
| MAGEC2, TP53, TRIM28, UBE2H (tumor) | MAGEC2, TP53, TRIM28, UBE2H (normal) |
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| TissGeneProg for MAGEC2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MAGEC2 |
| TissGeneDrug for MAGEC2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MAGEC2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0025202 | melanoma | 8 | BeFree,GAD,LHGDN |
| umls:C0153594 | Malignant neoplasm of testis | 8 | BeFree |
| umls:C2239176 | Liver carcinoma | 5 | BeFree,LHGDN |
| umls:C0026764 | Multiple Myeloma | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
| umls:C0004565 | Melanoma, B16 | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | LHGDN |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0036631 | Seminoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0278883 | Metastatic melanoma | 1 | BeFree |
| umls:C0677944 | Sentinel node (disorder) | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree |
| umls:C1271104 | Blood pressure finding | 1 | GAD |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1561955 | Fibrinogen Adverse Event | 1 | GAD |
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