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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MAGEC2
check button Gene summary
Basic gene informationGene symbolMAGEC2
Gene namemelanoma antigen family C, 2
SynonymsCT10|HCA587|MAGEE1
CytomapUCSC genome browser: Xq27
Type of geneprotein-coding
RefGenesNM_016249.3,
DescriptionMAGE-C2 antigenMAGE-E1 antigencancer/testis antigen 10hepatocellular cancer antigen 587hepatocellular carcinoma-associated antigen 587melanoma antigen, family E, 1, cancer/testis specificmelanoma-associated antigen C2
Modification date20141207
dbXrefs MIM : 300468
HGNC : HGNC
Ensembl : ENSG00000046774
HPRD : 06632
Vega : OTTHUMG00000022574
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAGEC2
BioGPS: 51438
PathwayNCI Pathway Interaction Database: MAGEC2
KEGG: MAGEC2
REACTOME: MAGEC2
Pathway Commons: MAGEC2
ContextiHOP: MAGEC2
ligand binding site mutation search in PubMed: MAGEC2
UCL Cancer Institute: MAGEC2
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)SkinTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)SKCMTGCT
Reference showing the relevant tissue of MAGEC2Cancer testis antigen expression in testicular germ cell tumorigenesis. Bode PK, Thielken A, Brandt S, Barghorn A, Lohe B, Knuth A, Moch H. Mod Pathol. 2014 Jun;27(6):899-905. doi: 10.1038/modpathol.2013.183. Epub 2013 Nov 15. (pmid:24232866)
go to article
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for MAGEC2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LIHC2.698948564-0.6629254363.3618747.07E-073.94E-06
HNSC0.355894843-0.9260935291.2819883720.001160.003838235
LUAD0.961823392-0.7750404011.7368637930.0002620.000619248
LUSC1.029727584-0.8686096711.8983372550.0001340.000273093


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TissGene-miRNA for MAGEC2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for MAGEC2
TissGeneSNV for MAGEC2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E157KSKCM3
p.S108LSKCM2
p.E269KSKCM2
p.R287WSKCM2
p.E272KSKCM2
p.S372FBLCA1
p.F55LGBM1
p.P270HSTAD1
p.S82IUCEC1
p.A346VSKCM1
p.C103FREAD1
p.D123NSKCM1
p.P295LLUAD1
p.A305TSKCM1
p.Y156HHNSC1
p.R343THNSC1
p.Y174*HNSC1
p.A336VSKCM1
p.D349NSKCM1
p.H306YSKCM1
p.S331YSKCM1
p.P303SSKCM1
p.E247DUCEC1
p.N11KGBM1
p.P131QLUAD1
p.A354VCESC1
p.H306QREAD1
p.L191FPRAD1
p.P95SSKCM1
p.E36DLGG1
p.E114DLUAD1
p.C103WUCS1
p.P295TLUAD1
p.S370FSKCM1
p.D216NCOAD1
p.R287QCESC1
p.G218CLUAD1
p.W278CLIHC1
p.W278*SKCM1
p.G94RLUAD1
p.S245FLUAD1
p.F9ISKCM1
p.V369IGBM1
p.M224ISTAD1
p.V49LUCS1
p.P31LSKCM1
p.E147KSKCM1
p.K183NBLCA1
p.D176YCOAD1
p.L79FSKCM1
p.E251KBLCA1
p.T350SLUAD1
p.R10CSKCM1
p.E35KSKCM1
p.S135FLIHC1
p.P131TLUAD1
p.G6CLUAD1
p.K276NCOAD1
p.K173TGBM1
p.E81KLUSC1
p.V344ICOAD1
p.W25CLUAD1
p.R186LLUSC1
p.A42PLUAD1
p.P72SCOAD1
p.G90CLUSC1
p.S106PSTAD1
p.S363ILUAD1
p.R343ILUAD1
p.G65CHNSC1
p.N14DLGG1
p.T32KLUAD1
p.F205LLUAD1
p.K173QCOAD1
p.D221HUCS1
p.R184KSKCM1
p.K276NESCA1
p.W25CUCEC1
p.S293FESCA1
p.P290ABRCA1
p.P294TLUAD1
p.G218SSKCM1
p.F238YGBM1
p.P202LSKCM1
p.W109CLUAD1
p.F205ILIHC1
p.E69KSKCM1
p.P17LUCEC1
p.P3SSKCM1
p.E247DBRCA1
p.P179SSKCM1
p.R262KSKCM1
p.P77SUCS1
p.P225HLUAD1
p.M365ILUSC1
p.P8SUCEC1
p.D176YUCEC1
p.E164KLUAD1
p.P161HCOAD1
p.L154FSKCM1
p.S102FSKCM1
p.S328FSKCM1
p.E34KHNSC1
p.W250*BLCA1
p.250_251WE>*KBLCA1
p.E288KSKCM1
p.D15NUCEC1
p.T324NLUAD1
p.V12IBRCA1
p.V180LLUAD1
p.T126SOV1
p.A336SSKCM1
p.G121RSKCM1
p.S85ILUAD1
p.P17LSKCM1
p.G257ESKCM1
p.S105FSKCM1
p.P3LSKCM1
p.P17TLUAD1
p.G74VLUSC1
p.G65RLUSC1
p.V7IUCEC1
p.I237TOV1
p.T215ISKCM1
p.S110GLIHC1
p.E143KSKCM1
p.E285DHNSC1
p.X374CLGG1
p.K144NHNSC1
p.S245PUCEC1
p.Q97LLUAD1
p.S292TUCS1
p.V200LLUAD1
p.C104SLUSC1


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TissGeneCNV for MAGEC2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for MAGEC2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for MAGEC2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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COAD (tumor)COAD (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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HNSC (tumor)HNSC (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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KICH (tumor)KICH (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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KIRC (tumor)KIRC (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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KIRP (tumor)KIRP (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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LIHC (tumor)LIHC (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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LUAD (tumor)LUAD (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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LUSC (tumor)LUSC (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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PRAD (tumor)PRAD (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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STAD (tumor)STAD (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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THCA (tumor)THCA (normal)
MAGEC2, TP53, TRIM28, UBE2H (tumor)MAGEC2, TP53, TRIM28, UBE2H (normal)
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TissGeneProg for MAGEC2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for MAGEC2
TissGeneDrug for MAGEC2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for MAGEC2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0025202melanoma8BeFree,GAD,LHGDN
umls:C0153594Malignant neoplasm of testis8BeFree
umls:C2239176Liver carcinoma5BeFree,LHGDN
umls:C0026764Multiple Myeloma2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C0001418Adenocarcinoma1LHGDN
umls:C0004565Melanoma, B161BeFree
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0007137Squamous cell carcinoma1LHGDN
umls:C0007222Cardiovascular Diseases1GAD
umls:C0009324Ulcerative Colitis1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0036631Seminoma1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0278883Metastatic melanoma1BeFree
umls:C0677944Sentinel node (disorder)1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C1261473Sarcoma1BeFree
umls:C1271104Blood pressure finding1GAD
umls:C1272641Systemic arterial pressure1GAD
umls:C1527249Colorectal Cancer1BeFree
umls:C1561955Fibrinogen Adverse Event1GAD