TissGeneSummary for RNF138 |
Gene summary |
Basic gene information | Gene symbol | RNF138 |
Gene name | ring finger protein 138, E3 ubiquitin protein ligase | |
Synonyms | HSD-4|NARF|STRIN|hNARF | |
Cytomap | UCSC genome browser: 18q12.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001191324.1, NM_016271.4,NM_198128.2, | |
Description | E3 ubiquitin-protein ligase RNF138NLK-associated RING finger proteinNemo-like kinase-associated RING finger proteinnemo-like kinase associated ring finger protein | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000134758 | ||
HPRD : 11508 | ||
Vega : OTTHUMG00000132265 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RNF138 | |
BioGPS: 51444 | ||
Pathway | NCI Pathway Interaction Database: RNF138 | |
KEGG: RNF138 | ||
REACTOME: RNF138 | ||
Pathway Commons: RNF138 | ||
Context | iHOP: RNF138 | |
ligand binding site mutation search in PubMed: RNF138 | ||
UCL Cancer Institute: RNF138 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of RNF138 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA TissgsLTS Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for RNF138 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for RNF138 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-495-3p | MIMAT0002817 | 0.0092 | -0.34 | 60 |
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TissGeneMut for RNF138 |
TissGeneSNV for RNF138 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H36Q | LUAD | 1 |
p.V37F | CHOL | 1 |
p.Q183* | BLCA | 1 |
p.S151Y | UCEC | 1 |
p.R99K | COAD | 1 |
p.G198V | LUAD | 1 |
p.Y219C | COAD | 1 |
p.V208I | PRAD | 1 |
p.K81T | COAD | 1 |
p.S115F | BLCA | 1 |
p.H101N | STAD | 1 |
p.P190T | LUAD | 1 |
p.S141C | LUSC | 1 |
p.T179A | LUSC | 1 |
p.P190S | HNSC | 1 |
p.A236V | OV | 1 |
p.G84D | LGG | 1 |
p.V185I | LUAD | 1 |
p.S240C | LUAD | 1 |
p.S116F | STAD | 1 |
p.I78T | LGG | 1 |
p.Q269K | KIRP | 1 |
p.S115C | BLCA | 1 |
p.R58H | BRCA | 1 |
p.Q232K | SARC | 1 |
p.A52T | UCEC | 1 |
p.Y108H | STAD | 1 |
p.E239* | UCEC | 1 |
p.R214I | READ | 1 |
p.R171C | UCEC | 1 |
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TissGeneCNV for RNF138 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RNF138 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A1L3-01A | RNF138-RAP1B | Out-of-Frame | chr18:29672849 | chr12:69050085 |
TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A1HN-01A | RNF138-RNF125 | Out-of-frame | Chr18:29672849 | Chr18:29648261 |
TCGAfusionPortal | PRADA | LUAD | TCGA-86-8673-01A | RNF138-RNF125 | Out-of-frame | Chr18:29672849 | Chr18:29645865 |
TCGAfusionPortal | PRADA | THCA | TCGA-CE-A484-01A | RNF138-RNF125 | Out-of-frame | Chr18:29672849 | Chr18:29648261 |
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TissGeneNet for RNF138 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RNF138 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RNF138 |
TissGeneDrug for RNF138 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RNF138 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |