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| TissGeneSummary for RHCG |
 Gene summary |
| Basic gene information | Gene symbol | RHCG |
| Gene name | Rh family, C glycoprotein | |
| Synonyms | C15orf6|PDRC2|RHGK|SLC42A3 | |
| Cytomap | UCSC genome browser: 15q25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_016321.2, NR_110261.1, | |
| Description | Rh type C glycoproteinRhesus blood group, C glycoproteinammonium transporter Rh type Crh family type C glycoproteinrh glycoprotein kidneyrhesus blood group family type C glycoproteintumor-related protein DRC2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605381 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000140519 | ||
| HPRD : 16102 | ||
| Vega : OTTHUMG00000149647 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RHCG | |
| BioGPS: 51458 | ||
| Pathway | NCI Pathway Interaction Database: RHCG | |
| KEGG: RHCG | ||
| REACTOME: RHCG | ||
| Pathway Commons: RHCG | ||
| Context | iHOP: RHCG | |
| ligand binding site mutation search in PubMed: RHCG | ||
| UCL Cancer Institute: RHCG | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
| Reference showing the relevant tissue of RHCG | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006873 | cellular ion homeostasis | 14761968 | GO:0015696 | ammonium transport | 14761968 | GO:0070634 | transepithelial ammonium transport | 18032481 | GO:0072488 | ammonium transmembrane transport | 14761968 | GO:0006873 | cellular ion homeostasis | 14761968 | GO:0015696 | ammonium transport | 14761968 | GO:0070634 | transepithelial ammonium transport | 18032481 | GO:0072488 | ammonium transmembrane transport | 14761968 |
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| TissGeneExp for RHCG |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -2.382346319 | 6.292759931 | -8.67510625 | 1.58E-16 | 6.00E-15 |
| COAD | -1.111979011 | -3.218775165 | 2.106796154 | 1.22E-05 | 5.48E-05 |
| LUSC | 2.366378681 | -3.48062328 | 5.847001961 | 8.02E-15 | 4.79E-14 |
| KIRC | -3.615531041 | 5.919684237 | -9.535215278 | 5.24E-50 | 4.70E-48 |
| HNSC | 5.482443798 | 9.146678681 | -3.664234884 | 2.31E-07 | 2.05E-06 |
| KICH | 8.938230681 | 6.251234681 | 2.686996 | 4.71E-06 | 1.58E-05 |
| BRCA | -3.024301143 | -1.654455529 | -1.369845614 | 3.94E-06 | 1.02E-05 |
| LUAD | -3.155840284 | -4.300279939 | 1.144439655 | 1.00E-04 | 0.000253733 |
| PRAD | -2.784507857 | -0.891144396 | -1.893363462 | 5.22E-05 | 0.000237737 |
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| TissGene-miRNA for RHCG |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for RHCG |
| TissGeneSNV for RHCG |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S217X | LIHC | 2 |
| p.K47N | UCEC | 2 |
| p.W436R | LUAD | 1 |
| p.G85D | SKCM | 1 |
| p.T295I | SKCM | 1 |
| p.H333Q | LUAD | 1 |
| p.Q390H | LUAD | 1 |
| p.C429S | LUAD | 1 |
| p.L398F | SKCM | 1 |
| p.L414F | SARC | 1 |
| p.Y117C | LUSC | 1 |
| p.V132M | LUAD | 1 |
| p.S207I | STAD | 1 |
| p.I340F | BLCA | 1 |
| p.A433E | HNSC | 1 |
| p.E35K | UCS | 1 |
| p.V66M | BLCA | 1 |
| p.S462* | BRCA | 1 |
| p.A387T | COAD | 1 |
| p.L204Q | LUAD | 1 |
| p.V164M | UCS | 1 |
| p.A88V | KIRP | 1 |
| p.S207N | UCEC | 1 |
| p.F167S | STAD | 1 |
| p.Q379E | BLCA | 1 |
| p.F378L | BRCA | 1 |
| p.I153V | ESCA | 1 |
| p.R83H | PRAD | 1 |
| p.E166* | UCEC | 1 |
| p.K454N | READ | 1 |
| p.G368E | SKCM | 1 |
| p.S213P | OV | 1 |
| p.A189T | SARC | 1 |
| p.D426Y | UCEC | 1 |
| p.V195A | LIHC | 1 |
| p.V466L | PRAD | 1 |
| p.M182I | SKCM | 1 |
| p.L307P | UCEC | 1 |
| p.G391E | UCEC | 1 |
| p.R197L | LUAD | 1 |
| p.N165D | KIRP | 1 |
| p.A288T | KIRC | 1 |
| p.F34V | COAD | 1 |
| p.F235L | BLCA | 1 |
| p.R197Q | UCS | 1 |
| p.A250T | COAD | 1 |
| p.E440Q | CESC | 1 |
| p.V30M | COAD | 1 |
| p.S217* | LIHC | 1 |
| p.R197Q | UCEC | 1 |
| p.A38T | STAD | 1 |
| p.A292T | ESCA | 1 |
| p.M182V | SKCM | 1 |
| p.F453L | CESC | 1 |
| p.V30A | HNSC | 1 |
| p.Q107H | LUAD | 1 |
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| TissGeneCNV for RHCG |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for RHCG |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI141812 | RHCG-ITGA6 | chr15:90014889 | chr2:173341156 | |
| Chimerdb3.0 | ChiTaRs | NA | BQ351152 | RHCG-TULP4 | chr15:90016359 | chr6:158915672 |
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| TissGeneNet for RHCG |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for RHCG |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for RHCG |
| TissGeneDrug for RHCG |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for RHCG |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011570 | Mental Depression | 1 | GAD |
| umls:C0020595 | Hypoaldosteronism | 1 | RGD |
| umls:C0020621 | Hypokalemia | 1 | RGD |
| umls:C1565489 | Renal Insufficiency | 1 | RGD |
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