TissGeneSummary for NAT8 |
Gene summary |
Basic gene information | Gene symbol | NAT8 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NAT8 | |
BioGPS: 51471 | ||
Pathway | NCI Pathway Interaction Database: NAT8 | |
KEGG: NAT8 | ||
REACTOME: NAT8 | ||
Pathway Commons: NAT8 | ||
Context | iHOP: NAT8 | |
ligand binding site mutation search in PubMed: NAT8 | ||
UCL Cancer Institute: NAT8 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of NAT8 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NAT8 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.38138977 | 6.80770223 | -9.189092 | 1.08E-15 | 2.58E-14 |
COAD | -2.468659001 | -1.324424385 | -1.144234615 | 0.0061 | 0.014263714 |
KIRP | 6.041575855 | 8.434119605 | -2.39254375 | 0.00304 | 0.007514531 |
LIHC | 5.55374023 | 7.08859823 | -1.534858 | 0.00011 | 0.000377022 |
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TissGene-miRNA for NAT8 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NAT8 |
TissGeneSNV for NAT8 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M121K | OV | 1 |
p.V65M | STAD | 1 |
p.R41Q | ESCA | 1 |
p.G106D | COAD | 1 |
p.L142V | LUAD | 1 |
p.D167N | ESCA | 1 |
p.H5D | CESC | 1 |
p.A165T | UCEC | 1 |
p.R7C | HNSC | 1 |
p.Y101H | HNSC | 1 |
p.S221P | KIRC | 1 |
p.R136G | LUAD | 1 |
p.H28N | BRCA | 1 |
p.L39V | LGG | 1 |
p.Y101H | KIRP | 1 |
p.A2T | UCEC | 1 |
p.L74Q | LUAD | 1 |
p.P40T | LIHC | 1 |
p.R41Q | UCS | 1 |
p.E84G | THYM | 1 |
p.R7P | HNSC | 1 |
p.R23W | COAD | 1 |
p.K195N | STAD | 1 |
p.R150G | LUAD | 1 |
p.G24W | UCEC | 1 |
p.S183C | BLCA | 1 |
p.D167H | LUAD | 1 |
p.E104K | DLBC | 1 |
p.D13G | HNSC | 1 |
p.P3S | CESC | 1 |
p.L102P | KIRC | 1 |
p.P50L | HNSC | 1 |
p.T160I | UCEC | 1 |
p.R7S | HNSC | 1 |
p.T160N | LIHC | 1 |
p.A52T | LGG | 1 |
p.R41Q | UCEC | 1 |
p.A29V | COAD | 1 |
p.M191T | BLCA | 1 |
p.H218Y | ESCA | 1 |
p.M121V | KIRP | 1 |
p.G120D | STAD | 1 |
p.R166Q | STAD | 1 |
p.S183F | BLCA | 1 |
p.G58R | READ | 1 |
p.A124S | COAD | 1 |
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TissGeneCNV for NAT8 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NAT8 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NAT8 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NAT8 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NAT8 |
TissGeneDrug for NAT8 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NAT8 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002986 | Fabry Disease | 30 | BeFree |
umls:C0699885 | Carcinoma of bladder | 12 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 11 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 9 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 9 | BeFree |
umls:C0678222 | Breast Carcinoma | 9 | BeFree |
umls:C0041296 | Tuberculosis | 8 | BeFree |
umls:C1527249 | Colorectal Cancer | 8 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 5 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree |
umls:C0600139 | Prostate carcinoma | 5 | BeFree |
umls:C1827377 | Slow acetylator due to N-acetyltransferase enzyme variant | 5 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 4 | BeFree |
umls:C0014859 | Esophageal Neoplasms | 3 | BeFree |
umls:C0015230 | Exanthema | 3 | BeFree |
umls:C0021390 | Inflammatory Bowel Diseases | 3 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 3 | BeFree |
umls:C0038454 | Cerebrovascular accident | 3 | BeFree |
umls:C0152018 | Esophageal carcinoma | 3 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
umls:C0684249 | Carcinoma of lung | 3 | BeFree |
umls:C0848332 | Spots on skin | 3 | BeFree |
umls:C1262760 | Hepatitis, Drug-Induced | 3 | BeFree |
umls:C1561643 | Chronic Kidney Diseases | 3 | BeFree,GWASCAT |
umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
umls:C0010346 | Crohn Disease | 2 | BeFree |
umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
umls:C0020538 | Hypertensive disease | 2 | BeFree |
umls:C0022658 | Kidney Diseases | 2 | BeFree,GAD |
umls:C0022661 | Kidney Failure, Chronic | 2 | BeFree,GAD |
umls:C0403447 | Chronic Kidney Insufficiency | 2 | BeFree |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C0751688 | Malignant Squamous Cell Neoplasm | 2 | BeFree |
umls:C0948008 | Ischemic stroke | 2 | BeFree |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
umls:C0008925 | Cleft Palate | 1 | BeFree |
umls:C0017601 | Glaucoma | 1 | BeFree |
umls:C0019158 | Hepatitis | 1 | BeFree |
umls:C0019159 | Hepatitis A | 1 | BeFree |
umls:C0020544 | Renal hypertension | 1 | GAD |
umls:C0021364 | Male infertility | 1 | BeFree |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
umls:C0023891 | Liver Cirrhosis, Alcoholic | 1 | BeFree |
umls:C0023895 | Liver diseases | 1 | BeFree |
umls:C0033847 | Pseudoxanthoma Elasticum | 1 | BeFree |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0151945 | Thrombosis of cerebral veins | 1 | BeFree |
umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
umls:C0280324 | Laryngeal Squamous Cell Carcinoma | 1 | BeFree |
umls:C0333983 | Hyperplastic Polyp | 1 | BeFree |
umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |