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| TissGeneSummary for DCDC2 |
 Gene summary |
| Basic gene information | Gene symbol | DCDC2 |
| Gene name | doublecortin domain containing 2 | |
| Synonyms | DCDC2A|RU2|RU2S | |
| Cytomap | UCSC genome browser: 6p22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001195610.1, NM_016356.4, | |
| Description | doublecortin domain-containing protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605755 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000146038 | ||
| HPRD : 09308 | ||
| Vega : OTTHUMG00000016275 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DCDC2 | |
| BioGPS: 51473 | ||
| Pathway | NCI Pathway Interaction Database: DCDC2 | |
| KEGG: DCDC2 | ||
| REACTOME: DCDC2 | ||
| Pathway Commons: DCDC2 | ||
| Context | iHOP: DCDC2 | |
| ligand binding site mutation search in PubMed: DCDC2 | ||
| UCL Cancer Institute: DCDC2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of DCDC2 | ||
| Description by TissGene annotations | Protective TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for DCDC2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 0.33324519 | 2.75771588 | -2.42447069 | 8.21E-13 | 6.48E-12 |
| BRCA | 0.26289277 | 2.25970242 | -1.996809649 | 7.76E-09 | 2.59E-08 |
| KICH | 0.585939121 | 5.264363121 | -4.678424 | 2.58E-10 | 1.85E-09 |
| KIRC | 3.850183121 | 5.68863451 | -1.838451389 | 3.61E-13 | 1.60E-12 |
| LUSC | -1.395834526 | 2.509959592 | -3.905794118 | 1.20E-19 | 1.35E-18 |
| STAD | -0.610716879 | -2.328479379 | 1.7177625 | 0.00581 | 0.021997795 |
| HNSC | -3.685891297 | -2.58682153 | -1.099069767 | 0.00169 | 0.005363188 |
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| TissGene-miRNA for DCDC2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for DCDC2 |
| TissGeneSNV for DCDC2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E430K | SKCM | 3 |
| p.P40S | SKCM | 3 |
| p.R400C | STAD | 2 |
| p.S247F | CESC | 1 |
| p.E415K | LUAD | 1 |
| p.Q48K | HNSC | 1 |
| p.S221N | SKCM | 1 |
| p.S250P | STAD | 1 |
| p.S221G | COAD | 1 |
| p.A474D | THYM | 1 |
| p.R400H | PRAD | 1 |
| p.P152A | COAD | 1 |
| p.N151H | DLBC | 1 |
| p.D428E | LUSC | 1 |
| p.S300P | COAD | 1 |
| p.V173A | SKCM | 1 |
| p.K217R | COAD | 1 |
| p.A402S | HNSC | 1 |
| p.I80M | LUSC | 1 |
| p.Q387H | STAD | 1 |
| p.R257H | COAD | 1 |
| p.K292I | LIHC | 1 |
| p.N126S | SKCM | 1 |
| p.A443D | STAD | 1 |
| p.Q81* | SKCM | 1 |
| p.Q91R | OV | 1 |
| p.P159L | SKCM | 1 |
| p.V127M | HNSC | 1 |
| p.S265F | SKCM | 1 |
| p.Q81H | LUAD | 1 |
| p.K106N | READ | 1 |
| p.D393N | SKCM | 1 |
| p.F59C | COAD | 1 |
| p.E422X | READ | 1 |
| p.T178N | ESCA | 1 |
| p.Q28* | SKCM | 1 |
| p.K176I | SKCM | 1 |
| p.H394D | LUAD | 1 |
| p.Q48K | BLCA | 1 |
| p.V127M | UCEC | 1 |
| p.D61N | BLCA | 1 |
| p.D332V | BLCA | 1 |
| p.K214T | STAD | 1 |
| p.N33T | LUAD | 1 |
| p.G353* | LUSC | 1 |
| p.D393Y | KIRC | 1 |
| p.A356S | LUAD | 1 |
| p.E375K | ESCA | 1 |
| p.E462K | SKCM | 1 |
| p.E411D | BLCA | 1 |
| p.E38K | THCA | 1 |
| p.G182R | SKCM | 1 |
| p.S221I | LIHC | 1 |
| p.G84C | LUAD | 1 |
| p.G192E | SKCM | 1 |
| p.Q81X | SKCM | 1 |
| p.M172I | SKCM | 1 |
| p.R400H | UCEC | 1 |
| p.K287T | READ | 1 |
| p.K313T | LIHC | 1 |
| p.S269L | SKCM | 1 |
| p.V87M | PRAD | 1 |
| p.R63K | STAD | 1 |
| p.Q448* | BLCA | 1 |
| p.K216N | UCEC | 1 |
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| TissGeneCNV for DCDC2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DCDC2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BG750306 | PCMTD1-DCDC2 | chr8:52773809 | chr6:24357883 | |
| Chimerdb3.0 | ChiTaRs | NA | BG751895 | PCMTD1-DCDC2 | chr8:52811574 | chr6:24357745 | |
| Chimerdb3.0 | ChiTaRs | NA | BC014954 | PCMTD1-DCDC2 | chr8:52811574 | chr6:24357394 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A081-01A | PC-DCDC2 | Out-of-frame | Chr11:66631245 | Chr6:24205330 |
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| TissGeneNet for DCDC2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for DCDC2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DCDC2 |
| TissGeneDrug for DCDC2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DCDC2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0476254 | Dyslexia | 20 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0920296 | Developmental reading disorder | 11 | BeFree |
| umls:C0871215 | Reading Disabilities | 8 | BeFree,GAD |
| umls:C0036341 | Schizophrenia | 3 | BeFree,GAD |
| umls:C0023015 | Language Disorders | 2 | BeFree |
| umls:C0751265 | Learning Disabilities | 2 | BeFree |
| umls:C0020255 | Hydrocephalus | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
| umls:C0037789 | Specific reading disorder | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0525041 | Neurobehavioral Manifestations | 1 | GAD |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 1 | BeFree,GAD |
| umls:C1837249 | Malformations of Cortical Development, Group II | 1 | BeFree |
| umls:C1857750 | DEAFNESS, AUTOSOMAL RECESSIVE 66 | 1 | CLINVAR,UNIPROT |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3711374 | Nonsyndromic Deafness | 0 | CLINVAR |
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