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TissGeneSummary for TRMT6 |
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Basic gene information | Gene symbol | TRMT6 |
Gene name | tRNA methyltransferase 6 | |
Synonyms | GCD10|Gcd10p | |
Cytomap | UCSC genome browser: 20p12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001281467.1, NM_015939.4, | |
Description | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6tRNA methyltransferase 6 homologtRNA(m1A58)MTase subunit TRM6 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000089195 | ||
HPRD : 13027 | ||
Vega : OTTHUMG00000031816 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TRMT6 | |
BioGPS: 51605 | ||
Pathway | NCI Pathway Interaction Database: TRMT6 | |
KEGG: TRMT6 | ||
REACTOME: TRMT6 | ||
Pathway Commons: TRMT6 | ||
Context | iHOP: TRMT6 | |
ligand binding site mutation search in PubMed: TRMT6 | ||
UCL Cancer Institute: TRMT6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
Reference showing the relevant tissue of TRMT6 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for TRMT6 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.663714544 | 0.534814544 | 1.1289 | 2.18E-19 | 2.36E-18 |
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TissGene-miRNA for TRMT6 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TRMT6 |
TissGeneSNV for TRMT6 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G91C | LUAD | 1 |
p.T193M | COAD | 1 |
p.E287K | BLCA | 1 |
p.K151N | STAD | 1 |
p.R238L | SKCM | 1 |
p.R220Q | KIRC | 1 |
p.Q402H | LUAD | 1 |
p.T193M | UCEC | 1 |
p.I124L | BLCA | 1 |
p.G101W | SKCM | 1 |
p.G59V | UCEC | 1 |
p.V435G | UCS | 1 |
p.T323I | LUAD | 1 |
p.T133A | HNSC | 1 |
p.G418* | LUAD | 1 |
p.E299G | COAD | 1 |
p.R348S | LUAD | 1 |
p.R238W | BLCA | 1 |
p.Q347H | LUSC | 1 |
p.E122D | STAD | 1 |
p.M274V | TGCT | 1 |
p.A174S | BRCA | 1 |
p.L470F | LIHC | 1 |
p.E155* | BLCA | 1 |
p.M171K | STAD | 1 |
p.G59D | PAAD | 1 |
p.R348M | LGG | 1 |
p.K339R | BLCA | 1 |
p.N368K | ESCA | 1 |
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TissGeneCNV for TRMT6 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TRMT6 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TRMT6 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TRMT6 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TRMT6 |
TissGeneDrug for TRMT6 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TRMT6 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |