TissGeneSummary for PDHA2 |
Gene summary |
Basic gene information | Gene symbol | PDHA2 |
Gene name | pyruvate dehydrogenase (lipoamide) alpha 2 | |
Synonyms | PDHAL | |
Cytomap | UCSC genome browser: 4q22-q23 | |
Type of gene | protein-coding | |
RefGenes | NM_005390.4, | |
Description | PDHE1-A type IIpyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrialpyruvate dehydrogenase, E1-alpha polypeptide, testis specific | |
Modification date | 20141207 | |
dbXrefs | MIM : 179061 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163114 | ||
HPRD : 01531 | ||
Vega : OTTHUMG00000130990 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PDHA2 | |
BioGPS: 5161 | ||
Pathway | NCI Pathway Interaction Database: PDHA2 | |
KEGG: PDHA2 | ||
REACTOME: PDHA2 | ||
Pathway Commons: PDHA2 | ||
Context | iHOP: PDHA2 | |
ligand binding site mutation search in PubMed: PDHA2 | ||
UCL Cancer Institute: PDHA2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PDHA2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006090 | pyruvate metabolic process | 16436377 | GO:0006090 | pyruvate metabolic process | 16436377 |
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TissGeneExp for PDHA2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for PDHA2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PDHA2 |
TissGeneSNV for PDHA2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D185N | SKCM | 4 |
p.E335K | SKCM | 2 |
p.R300C | SKCM | 2 |
p.A57V | STAD | 1 |
p.H111Y | SKCM | 1 |
p.V387A | LGG | 1 |
p.K311N | LUAD | 1 |
p.S293T | LUSC | 1 |
p.K156T | STAD | 1 |
p.D239V | CESC | 1 |
p.P355S | SKCM | 1 |
p.G146E | SKCM | 1 |
p.A203S | LUAD | 1 |
p.S109L | SKCM | 1 |
p.S29L | LUAD | 1 |
p.R71H | THCA | 1 |
p.M292I | UCEC | 1 |
p.R300L | LUAD | 1 |
p.R86C | GBM | 1 |
p.D40N | SKCM | 1 |
p.E135Q | HNSC | 1 |
p.S109L | THYM | 1 |
p.A196T | COAD | 1 |
p.R376C | UCEC | 1 |
p.R261H | PAAD | 1 |
p.T137M | LUSC | 1 |
p.M292I | HNSC | 1 |
p.Y159* | STAD | 1 |
p.R321I | UCEC | 1 |
p.T51N | LUSC | 1 |
p.R321G | SKCM | 1 |
p.R261H | BRCA | 1 |
p.Y123C | HNSC | 1 |
p.R376C | READ | 1 |
p.R130* | LGG | 1 |
p.V9M | GBM | 1 |
p.I106V | READ | 1 |
p.R243M | LUAD | 1 |
p.W212* | SKCM | 1 |
p.Y225H | COAD | 1 |
p.R376C | STAD | 1 |
p.K275T | LUSC | 1 |
p.S298C | LUAD | 1 |
p.E204K | COAD | 1 |
p.A173V | BLCA | 1 |
p.T137M | LGG | 1 |
p.L250I | ESCA | 1 |
p.G148* | UCEC | 1 |
p.D185N | COAD | 1 |
p.R302X | PRAD | 1 |
p.Y225F | COAD | 1 |
p.V308I | HNSC | 1 |
p.R233K | SKCM | 1 |
p.K251N | LUAD | 1 |
p.E232V | LUAD | 1 |
p.E186Q | CESC | 1 |
p.M65I | HNSC | 1 |
p.Y181C | COAD | 1 |
p.R26S | LUAD | 1 |
p.E232K | LUAD | 1 |
p.V323L | ESCA | 1 |
p.G174S | HNSC | 1 |
p.D110N | SKCM | 1 |
p.S371L | SKCM | 1 |
p.W381C | LUAD | 1 |
p.G226R | SKCM | 1 |
p.K213Q | UCEC | 1 |
p.L60R | STAD | 1 |
p.H364Y | SKCM | 1 |
p.R11M | LUAD | 1 |
p.E58* | LUAD | 1 |
p.G193E | BLCA | 1 |
p.R26S | BLCA | 1 |
p.A267E | LUAD | 1 |
p.M280I | SKCM | 1 |
p.D320Y | LUAD | 1 |
p.S28Y | LUAD | 1 |
p.F84L | LUAD | 1 |
p.V9M | COAD | 1 |
p.M255I | PAAD | 1 |
p.Q168R | LUAD | 1 |
p.D320Y | CESC | 1 |
p.G87C | HNSC | 1 |
p.Y42D | ESCA | 1 |
p.G146E | UCEC | 1 |
p.R70C | UCEC | 1 |
p.A18T | SKCM | 1 |
p.I175V | STAD | 1 |
p.G166S | TGCT | 1 |
p.K334N | STAD | 1 |
p.R71H | LUAD | 1 |
p.L22M | LUAD | 1 |
p.R70S | BLCA | 1 |
p.M66K | BLCA | 1 |
p.D31E | LUSC | 1 |
p.G166S | LIHC | 1 |
p.A57T | COAD | 1 |
p.K156N | HNSC | 1 |
p.L102R | STAD | 1 |
p.A196S | LUAD | 1 |
p.G160V | SARC | 1 |
p.R302* | PRAD | 1 |
p.E221G | DLBC | 1 |
p.S325I | LUSC | 1 |
p.Y285H | COAD | 1 |
p.D320N | HNSC | 1 |
p.T353A | UCEC | 1 |
p.E335K | SARC | 1 |
p.V165I | KICH | 1 |
p.Q82H | UCEC | 1 |
p.F246L | SKCM | 1 |
p.V257I | LUAD | 1 |
p.R140K | BLCA | 1 |
p.Y159X | STAD | 1 |
p.E186K | SKCM | 1 |
p.E186D | HNSC | 1 |
p.E221D | STAD | 1 |
p.A205D | LUAD | 1 |
p.V165I | LUAD | 1 |
p.E186* | CESC | 1 |
p.R86C | UCEC | 1 |
p.G149E | SKCM | 1 |
p.E332X | READ | 1 |
p.E45D | ESCA | 1 |
p.R70S | LUAD | 1 |
p.G138E | SKCM | 1 |
p.D313Y | LUSC | 1 |
p.Y240* | LUAD | 1 |
p.D253N | LIHC | 1 |
p.P49L | SKCM | 1 |
p.G47V | LIHC | 1 |
p.R86C | READ | 1 |
p.S368I | UCEC | 1 |
p.R12X | STAD | 1 |
p.P108S | SKCM | 1 |
p.A4T | LUSC | 1 |
p.D185N | STAD | 1 |
p.R300S | LIHC | 1 |
p.P277L | SKCM | 1 |
p.L318V | HNSC | 1 |
p.R26C | READ | 1 |
p.V308G | STAD | 1 |
p.R302* | GBM | 1 |
p.S109X | SKCM | 1 |
p.G228V | BRCA | 1 |
p.A173P | LUAD | 1 |
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TissGeneCNV for PDHA2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PDHA2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI393336 | CIAPIN1-PDHA2 | chr16:57462595 | chr4:96761617 |
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TissGeneNet for PDHA2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PDHA2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PDHA2 |
TissGeneDrug for PDHA2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PDHA2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1561955 | Fibrinogen Adverse Event | 1 | GAD |