TissGeneSummary for STYXL1 |
Gene summary |
Basic gene information | Gene symbol | STYXL1 |
Gene name | serine/threonine/tyrosine interacting-like 1 | |
Synonyms | DUSP24|MK-STYX | |
Cytomap | UCSC genome browser: 7q11.23 | |
Type of gene | protein-coding | |
RefGenes | NM_016086.2, | |
Description | dual specificity phosphatase 24 (putative)dual specificity phosphatase inhibitor MK-STYXdual specificity protein phosphatase 24map kinase phosphatase-like protein MK-STYXserine/threonine/tyrosine-interacting-like protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000127952 | ||
HPRD : 13256 | ||
Vega : OTTHUMG00000130459 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_STYXL1 | |
BioGPS: 51657 | ||
Pathway | NCI Pathway Interaction Database: STYXL1 | |
KEGG: STYXL1 | ||
REACTOME: STYXL1 | ||
Pathway Commons: STYXL1 | ||
Context | iHOP: STYXL1 | |
ligand binding site mutation search in PubMed: STYXL1 | ||
UCL Cancer Institute: STYXL1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVTGCT | |
Reference showing the relevant tissue of STYXL1 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for STYXL1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for STYXL1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for STYXL1 |
TissGeneSNV for STYXL1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D35N | LIHC | 1 |
p.A259S | PRAD | 1 |
p.R118H | COAD | 1 |
p.M309I | LUAD | 1 |
p.T247A | COAD | 1 |
p.Q107* | HNSC | 1 |
p.A256T | UCEC | 1 |
p.Y131C | STAD | 1 |
p.S97F | SKCM | 1 |
p.L185F | BRCA | 1 |
p.D184N | LUSC | 1 |
p.P311L | UCEC | 1 |
p.P217L | PRAD | 1 |
p.E280K | UCEC | 1 |
p.V76L | STAD | 1 |
p.F245Y | LUSC | 1 |
p.D310Y | LUAD | 1 |
p.S246Y | HNSC | 1 |
p.D103G | KIRP | 1 |
p.S240C | LUAD | 1 |
p.E44K | STAD | 1 |
p.L185F | CESC | 1 |
p.R226C | STAD | 1 |
p.R24G | UCEC | 1 |
p.D27N | LUAD | 1 |
p.T137A | SKCM | 1 |
p.K102I | TGCT | 1 |
p.V164M | STAD | 1 |
p.P2T | COAD | 1 |
p.V124I | UCEC | 1 |
p.R52Q | UCEC | 1 |
p.I232V | KIRP | 1 |
p.R133C | COAD | 1 |
p.G113D | LUAD | 1 |
p.S272A | SKCM | 1 |
p.E8X | READ | 1 |
p.S108* | CESC | 1 |
p.R226C | HNSC | 1 |
p.E297K | SKCM | 1 |
p.R37C | SKCM | 1 |
p.D178H | BLCA | 1 |
p.H227N | CESC | 1 |
p.N57D | LUSC | 1 |
p.H236R | LUAD | 1 |
p.V164M | HNSC | 1 |
p.H230Q | KIRC | 1 |
p.E266K | BRCA | 1 |
p.N172D | COAD | 1 |
p.D204N | UCEC | 1 |
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TissGeneCNV for STYXL1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for STYXL1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE717592 | STYXL1-PPIL2 | chr7:75634641 | chr22:22036785 | |
Chimerdb3.0 | ChiTaRs | NA | BF902200 | CKAP4-STYXL1 | chr12:106633861 | chr7:75662465 | |
TCGAfusionPortal | PRADA | GBM | TCGA-06-0130-01A | PION-STYXL1 | In-frame | Chr7:77006165 | Chr7:75634722 |
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TissGeneNet for STYXL1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for STYXL1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for STYXL1 |
TissGeneDrug for STYXL1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for STYXL1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0026351 | Moderate mental retardation (I.Q. 35-49) | 1 | BeFree |
umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |