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| TissGeneSummary for PDYN |
 Gene summary |
| Basic gene information | Gene symbol | PDYN |
| Gene name | prodynorphin | |
| Synonyms | ADCA|PENKB|SCA23 | |
| Cytomap | UCSC genome browser: 20p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001190892.1, NM_001190898.2,NM_001190899.2,NM_001190900.1,NM_024411.4, | |
| Description | beta-neoendorphin-dynorphinleu-enkephalinleumorphinneoendorphin-dynorphin-enkephalin prepropeptidepreprodynorphinpreproenkephalin Bproenkephalin-Brimorphin | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 131340 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000101327 | ||
| HPRD : 08838 | ||
| Vega : OTTHUMG00000031683 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PDYN | |
| BioGPS: 5173 | ||
| Pathway | NCI Pathway Interaction Database: PDYN | |
| KEGG: PDYN | ||
| REACTOME: PDYN | ||
| Pathway Commons: PDYN | ||
| Context | iHOP: PDYN | |
| ligand binding site mutation search in PubMed: PDYN | ||
| UCL Cancer Institute: PDYN | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of PDYN | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PDYN |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for PDYN |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PDYN |
| TissGeneSNV for PDYN |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R180H | PRAD | 2 |
| p.R215H | COAD | 2 |
| p.E80K | SKCM | 2 |
| p.G140R | SKCM | 2 |
| p.L82F | LUSC | 1 |
| p.R206C | GBM | 1 |
| p.K224N | LUSC | 1 |
| p.G195E | SKCM | 1 |
| p.K235N | OV | 1 |
| p.L211V | ESCA | 1 |
| p.K118N | LUAD | 1 |
| p.A190S | UCEC | 1 |
| p.Y207C | LUAD | 1 |
| p.R180C | UCEC | 1 |
| p.K118R | LIHC | 1 |
| p.G228S | STAD | 1 |
| p.R180H | PAAD | 1 |
| p.K85T | TGCT | 1 |
| p.R212W | GBM | 1 |
| p.R174H | LUSC | 1 |
| p.A141E | BRCA | 1 |
| p.A164T | ESCA | 1 |
| p.Y207F | STAD | 1 |
| p.G83W | LUSC | 1 |
| p.L12I | COAD | 1 |
| p.R213C | PAAD | 1 |
| p.F15L | LUAD | 1 |
| p.R232L | LUAD | 1 |
| p.K181R | STAD | 1 |
| p.F178L | SKCM | 1 |
| p.Y204* | ACC | 1 |
| p.G193R | SKCM | 1 |
| p.G195R | GBM | 1 |
| p.V237L | LUAD | 1 |
| p.K97T | SKCM | 1 |
| p.P216L | UCEC | 1 |
| p.R213C | LUSC | 1 |
| p.T18N | COAD | 1 |
| p.Y162N | LUSC | 1 |
| p.Y162S | HNSC | 1 |
| p.R215C | LUSC | 1 |
| p.A141E | LUAD | 1 |
| p.E119* | LUAD | 1 |
| p.D153N | STAD | 1 |
| p.R213C | MESO | 1 |
| p.G209V | UCEC | 1 |
| p.R174C | BLCA | 1 |
| p.D167N | SKCM | 1 |
| p.D202N | SKCM | 1 |
| p.L112I | UCEC | 1 |
| p.L126M | LUAD | 1 |
| p.E165X | COAD | 1 |
| p.A149S | LUAD | 1 |
| p.E170K | SARC | 1 |
| p.Y207X | KIRC | 1 |
| p.A164P | LUSC | 1 |
| p.A141T | SKCM | 1 |
| p.Y204X | ACC | 1 |
| p.E188Q | BRCA | 1 |
| p.V7I | SKCM | 1 |
| p.R180C | HNSC | 1 |
| p.I44M | COAD | 1 |
| p.R206C | OV | 1 |
| p.R180C | OV | 1 |
| p.M146I | LUAD | 1 |
| p.E119K | SKCM | 1 |
| p.D153N | SKCM | 1 |
| p.L163F | LUSC | 1 |
| p.G36D | THYM | 1 |
| p.R212W | HNSC | 1 |
| p.R212W | READ | 1 |
| p.D167E | LUAD | 1 |
| p.R25Q | SKCM | 1 |
| p.E107Q | BLCA | 1 |
| p.R206H | UCEC | 1 |
| p.G176E | LUSC | 1 |
| p.L230F | SKCM | 1 |
| p.R232C | STAD | 1 |
| p.F68L | SKCM | 1 |
| p.A164T | PAAD | 1 |
| p.R212Q | STAD | 1 |
| p.E192K | SKCM | 1 |
| p.E170K | SKCM | 1 |
| p.S17Y | BLCA | 1 |
| p.T19A | HNSC | 1 |
| p.Y207* | KIRC | 1 |
| p.P42L | SKCM | 1 |
| p.R212Q | LUAD | 1 |
| p.R180C | COAD | 1 |
| p.G176W | LUSC | 1 |
| p.D148N | SKCM | 1 |
| p.T18I | STAD | 1 |
| Top |
| TissGeneCNV for PDYN |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PDYN |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for PDYN |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| COAD (tumor) | COAD (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| KICH (tumor) | KICH (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| STAD (tumor) | STAD (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| THCA (tumor) | THCA (normal) |
| PDYN, NRD1 (tumor) | PDYN, NRD1 (normal) |
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| TissGeneProg for PDYN |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PDYN |
| TissGeneDrug for PDYN |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PDYN |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007758 | Cerebellar Ataxia | 11 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 9 | BeFree,CTD_human |
| umls:C0087012 | Ataxia, Spinocerebellar | 8 | BeFree |
| umls:C0004134 | Ataxia | 7 | BeFree |
| umls:C0018790 | Cardiac Arrest | 7 | BeFree |
| umls:C0013146 | Drug abuse | 6 | BeFree |
| umls:C0752124 | Spinocerebellar Ataxia Type 6 (disorder) | 6 | BeFree |
| umls:C0014556 | Epilepsy, Temporal Lobe | 5 | BeFree,GAD,LHGDN |
| umls:C0027819 | Neuroblastoma | 5 | BeFree |
| umls:C0600427 | Cocaine Dependence | 5 | BeFree,GAD |
| umls:C0700095 | Central neuroblastoma | 5 | BeFree |
| umls:C0752125 | Spinocerebellar Ataxia Type 7 | 5 | BeFree |
| umls:C0020649 | Hypotension | 4 | CTD_human |
| umls:C0236736 | Cocaine-Related Disorders | 4 | CTD_human,GAD |
| umls:C0752120 | Spinocerebellar Ataxia Type 1 | 4 | BeFree |
| umls:C1853250 | SPINOCEREBELLAR ATAXIA 23 | 4 | CTD_human,ORPHANET,UNIPROT |
| umls:C0011570 | Mental Depression | 3 | BeFree |
| umls:C0011581 | Depressive disorder | 3 | BeFree |
| umls:C0013384 | Dyskinetic syndrome | 3 | BeFree,CTD_human,LHGDN |
| umls:C0019337 | Heroin Dependence | 3 | BeFree,GAD |
| umls:C0027404 | Narcolepsy | 3 | BeFree |
| umls:C0036341 | Schizophrenia | 3 | BeFree,GAD |
| umls:C0036572 | Seizures | 3 | BeFree,CTD_human |
| umls:C0428977 | Bradycardia | 3 | CTD_human |
| umls:C0524662 | Opiate Addiction | 3 | BeFree,GAD |
| umls:C0524851 | Neurodegenerative Disorders | 3 | BeFree |
| umls:C0525045 | Mood Disorders | 3 | BeFree,LHGDN |
| umls:C0752121 | Spinocerebellar Ataxia Type 2 | 3 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 2 | BeFree |
| umls:C0004936 | Mental disorders | 2 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0007760 | Cerebellar Diseases | 2 | BeFree |
| umls:C0013386 | Dyskinesia, Drug-Induced | 2 | CTD_human |
| umls:C0014544 | Epilepsy | 2 | BeFree,GAD |
| umls:C0024408 | Machado-Joseph Disease | 2 | BeFree |
| umls:C0030193 | Pain | 2 | CTD_human |
| umls:C0041696 | Unipolar Depression | 2 | BeFree |
| umls:C0086025 | Codependency | 2 | BeFree |
| umls:C0242422 | Parkinsonian Disorders | 2 | BeFree,CTD_human |
| umls:C0740858 | Substance abuse problem | 2 | BeFree |
| umls:C0750937 | Ataxia, Appendicular | 2 | BeFree |
| umls:C0751781 | Dentatorubral-Pallidoluysian Atrophy | 2 | BeFree |
| umls:C1269683 | Major Depressive Disorder | 2 | BeFree |
| umls:C0002622 | Amnesia | 1 | CTD_human |
| umls:C0003130 | Anoxia | 1 | CTD_human |
| umls:C0004138 | Ataxias, Hereditary | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | GAD |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0008370 | Cholestasis | 1 | CTD_human |
| umls:C0011265 | Presenile dementia | 1 | BeFree |
| umls:C0011615 | Dermatitis, Atopic | 1 | BeFree,GAD |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0015644 | Muscular fasciculation | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0020429 | Hyperalgesia | 1 | CTD_human |
| umls:C0020440 | Hypercapnia | 1 | CTD_human |
| umls:C0020538 | Hypertensive disease | 1 | BeFree |
| umls:C0025261 | Memory Disorders | 1 | GAD |
| umls:C0026650 | Movement Disorders | 1 | CTD_human |
| umls:C0027765 | nervous system disorder | 1 | BeFree |
| umls:C0029095 | Opioid abuse | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0030200 | Pain, Intractable | 1 | BeFree |
| umls:C0030567 | Parkinson Disease | 1 | LHGDN |
| umls:C0033774 | Pruritus | 1 | BeFree,GAD |
| umls:C0035204 | Respiration Disorders | 1 | CTD_human |
| umls:C0035229 | Respiratory Insufficiency | 1 | CTD_human |
| umls:C0035304 | Retinal Degeneration | 1 | BeFree |
| umls:C0036659 | Sensation Disorders | 1 | CTD_human |
| umls:C0037952 | Spinocerebellar Degeneration | 1 | BeFree |
| umls:C0038580 | Substance Dependence | 1 | BeFree |
| umls:C0038587 | Substance Withdrawal Syndrome | 1 | BeFree |
| umls:C0085762 | Alcohol abuse | 1 | GAD |
| umls:C0086132 | Depressive Symptoms | 1 | BeFree |
| umls:C0150055 | Chronic pain | 1 | BeFree |
| umls:C0152128 | Drug withdrawal syndrome | 1 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
| umls:C0155552 | Hearing Loss, Mixed Conductive-Sensorineural | 1 | BeFree |
| umls:C0184567 | Acute onset pain | 1 | BeFree |
| umls:C0231218 | Malaise | 1 | BeFree |
| umls:C0233477 | Dysphoric mood | 1 | BeFree |
| umls:C0234215 | Sensory Discomfort | 1 | BeFree |
| umls:C0236664 | Alcohol-Related Disorders | 1 | GAD |
| umls:C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| umls:C0236969 | Substance-Related Disorders | 1 | GAD |
| umls:C0242510 | Drug usage | 1 | BeFree |
| umls:C0270712 | Late cortical cerebellar atrophy | 1 | BeFree |
| umls:C0271385 | Horizontal Nystagmus | 1 | BeFree |
| umls:C0278134 | Absence of sensation | 1 | BeFree |
| umls:C0333463 | Senile Plaques | 1 | BeFree |
| umls:C0338908 | Mixed anxiety and depressive disorder | 1 | BeFree |
| umls:C0376338 | Diagnosis, Psychiatric | 1 | BeFree |
| umls:C0393520 | Harding ataxia | 1 | BeFree |
| umls:C0497327 | Dementia | 1 | BeFree |
| umls:C0687132 | heavy drinking | 1 | BeFree |
| umls:C0730362 | Disorder of macula of retina | 1 | BeFree |
| umls:C0751354 | Myoclonus, Action | 1 | BeFree |
| umls:C0752122 | Spinocerebellar Ataxia Type 4 | 1 | BeFree |
| umls:C1533217 | Methamphetamine dependence | 1 | BeFree,GAD |
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