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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for GHRL
check button Gene summary
Basic gene informationGene symbolGHRL
Gene nameghrelin/obestatin prepropeptide
SynonymsMTLRP
CytomapUCSC genome browser: 3p26-p25
Type of geneprotein-coding
RefGenesNM_001134941.2,
NM_001134944.1,NM_001134945.1,NM_001134946.1,NM_001302821.1,
NM_001302822.1,NM_001302823.1,NM_001302824.1,NM_001302825.1,
NM_016362.4,NR_024132.1,NR_024133.1,NR_024134.1,
NR_024135.1,NR_024136.1,NR_024137.1,NR_024138.1,
NR_126505.1,
Descriptionappetite-regulating hormoneghrelin, growth hormone secretagogue receptor ligandghrelin/obestatin preprohormonegrowth hormone-releasing peptidemotilin-related peptideprepro-appetite regulatory hormone
Modification date20141207
dbXrefs MIM : 605353
HGNC : HGNC
Ensembl : ENSG00000157017
HPRD : 05638
Vega : OTTHUMG00000155360
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GHRL
BioGPS: 51738
PathwayNCI Pathway Interaction Database: GHRL
KEGG: GHRL
REACTOME: GHRL
Pathway Commons: GHRL
ContextiHOP: GHRL
ligand binding site mutation search in PubMed: GHRL
UCL Cancer Institute: GHRL
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Stomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)STAD
Reference showing the relevant tissue of GHRL
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0001937negative regulation of endothelial cell proliferation15572208
GO:0008154actin polymerization or depolymerization15232612
GO:0009725response to hormone15232612
GO:0016358dendrite development16491079
GO:0032691negative regulation of interleukin-1 beta production15232612
GO:0042127regulation of cell proliferation15564328
GO:0042322negative regulation of circadian sleep/wake cycle, REM sleep18329818
GO:0042536negative regulation of tumor necrosis factor biosynthetic process15232612
GO:0043066negative regulation of apoptotic process15158140
GO:0043627response to estrogen15292338
GO:0045409negative regulation of interleukin-6 biosynthetic process15232612
GO:0046010positive regulation of circadian sleep/wake cycle, non-REM sleep18329818
GO:0046697decidualization17494105
GO:0050728negative regulation of inflammatory response15232612
GO:0051461positive regulation of corticotropin secretion12566947
GO:0051464positive regulation of cortisol secretion12566947
GO:0051965positive regulation of synapse assembly16491079
GO:0060124positive regulation of growth hormone secretion12566947
GO:0001937negative regulation of endothelial cell proliferation15572208
GO:0008154actin polymerization or depolymerization15232612
GO:0009725response to hormone15232612
GO:0016358dendrite development16491079
GO:0032691negative regulation of interleukin-1 beta production15232612
GO:0042127regulation of cell proliferation15564328
GO:0042322negative regulation of circadian sleep/wake cycle, REM sleep18329818
GO:0042536negative regulation of tumor necrosis factor biosynthetic process15232612
GO:0043066negative regulation of apoptotic process15158140
GO:0043627response to estrogen15292338
GO:0045409negative regulation of interleukin-6 biosynthetic process15232612
GO:0046010positive regulation of circadian sleep/wake cycle, non-REM sleep18329818
GO:0046697decidualization17494105
GO:0050728negative regulation of inflammatory response15232612
GO:0051461positive regulation of corticotropin secretion12566947
GO:0051464positive regulation of cortisol secretion12566947
GO:0051965positive regulation of synapse assembly16491079
GO:0060124positive regulation of growth hormone secretion12566947


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TissGeneExp for GHRL

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-0.9098158020.48023714-1.3900529412.11E-086.43E-08
ESCA-0.6023919165.310289902-5.9126818180.004150.035093536


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TissGene-miRNA for GHRL

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for GHRL
TissGeneSNV for GHRL

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.L57HHNSC1
p.D81HBLCA1
p.L102IUCEC1
p.D61NSTAD1
p.E71KSKCM1
p.Q89LCOAD1
p.G14SESCA1
p.E66KBRCA1
p.L10IUCEC1
p.R51QSKCM1
p.G54CCOAD1
p.G63SBRCA1
p.R51QDLBC1


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TissGeneCNV for GHRL

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for GHRL

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0TopHat-FusionUCECTCGA-PG-A915-01AGHRL-SEC13Out-of-Framechr3:10328387chr3:10343057


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TissGeneNet for GHRL

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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COAD (tumor)COAD (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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HNSC (tumor)HNSC (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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KICH (tumor)KICH (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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KIRC (tumor)KIRC (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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KIRP (tumor)KIRP (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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LIHC (tumor)LIHC (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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LUAD (tumor)LUAD (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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LUSC (tumor)LUSC (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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PRAD (tumor)PRAD (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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STAD (tumor)STAD (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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THCA (tumor)THCA (normal)
GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (tumor)GHRL, MLNR, NPY, AGRP, GHRHR, ACE2, LEP, GHSR (normal)
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TissGeneProg for GHRL

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for GHRL
TissGeneDrug for GHRL

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for GHRL

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0028754Obesity24BeFree,CTD_human,GAD
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent12BeFree,GAD,LHGDN
umls:C0003125Anorexia Nervosa8BeFree,GAD,LHGDN
umls:C0032460Polycystic Ovary Syndrome8BeFree,LHGDN
umls:C3714514Infection7LHGDN
umls:C0032897Prader-Willi Syndrome6LHGDN
umls:C0524620Metabolic Syndrome X6BeFree,GAD
umls:C0006142Malignant neoplasm of breast5BeFree,GAD
umls:C0011849Diabetes Mellitus5BeFree,LHGDN
umls:C2267227Bulimia Nervosa5BeFree,LHGDN
umls:C0003123Anorexia4BeFree,LHGDN
umls:C0011847Diabetes4BeFree
umls:C0013473Eating Disorders4BeFree,GAD
umls:C0032000Pituitary Adenoma4BeFree
umls:C0001430Adenoma3BeFree,LHGDN
umls:C0004153Atherosclerosis3BeFree,LHGDN
umls:C0006370Bulimia3GAD,LHGDN
umls:C0006625Cachexia3BeFree,CTD_human,LHGDN
umls:C0018801Heart failure3BeFree,CTD_human
umls:C0018802Congestive heart failure3BeFree
umls:C0020538Hypertensive disease3BeFree,GAD,LHGDN
umls:C0021368Inflammation3GAD,LHGDN
umls:C0032002Pituitary Diseases3BeFree
umls:C0238462Medullary carcinoma of thyroid3BeFree
umls:C0271650Impaired glucose tolerance3BeFree
umls:C1956346Coronary Artery Disease3BeFree
umls:C0001973Alcoholic Intoxication, Chronic2GAD
umls:C0003873Rheumatoid Arthritis2BeFree,LHGDN
umls:C0009375Colonic Neoplasms2GAD,LHGDN
umls:C0010054Coronary Arteriosclerosis2BeFree
umls:C0010068Coronary heart disease2BeFree,GAD
umls:C0010481Cushing Syndrome2LHGDN
umls:C0011881Diabetic Nephropathy2BeFree,GAD,LHGDN
umls:C0013336Dwarfism2BeFree
umls:C0018799Heart Diseases2LHGDN
umls:C0020459Hyperinsulinism2LHGDN
umls:C0024305Lymphoma, Non-Hodgkin2GAD
umls:C0029928Ovarian Diseases2BeFree
umls:C0031511Pheochromocytoma2BeFree,LHGDN
umls:C0036341Schizophrenia2BeFree,GAD
umls:C0038356Stomach Neoplasms2LHGDN
umls:C0038358Gastric ulcer2CTD_human
umls:C0162429Malnutrition2LHGDN
umls:C0206754Neuroendocrine Tumors2BeFree,LHGDN
umls:C0221406Pituitary-dependent Cushing's disease2LHGDN
umls:C0279628Adenocarcinoma Of Esophagus2BeFree
umls:C0518010body mass2GAD
umls:C0600139Prostate carcinoma2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C0001206Acromegaly1LHGDN
umls:C0001418Adenocarcinoma1CTD_human
umls:C0004096Asthma1BeFree,GAD,LHGDN
umls:C0007222Cardiovascular Diseases1GAD
umls:C0007570Celiac Disease1LHGDN
umls:C0008728Churg-Strauss Syndrome1GAD
umls:C0009319Colitis1CTD_human
umls:C0009324Ulcerative Colitis1CTD_human
umls:C0010346Crohn Disease1LHGDN
umls:C0011570Mental Depression1GAD
umls:C0011581Depressive disorder1CTD_human
umls:C0014859Esophageal Neoplasms1CTD_human
umls:C0015695Fatty Liver1LHGDN
umls:C0017152Gastritis1LHGDN
umls:C0017154Gastritis, Atrophic1LHGDN
umls:C0020179Huntington Disease1LHGDN
umls:C0020649Hypotension1LHGDN
umls:C0021296Infant, Small for Gestational Age1BeFree
umls:C0021655Insulin Resistance1GAD
umls:C0022661Kidney Failure, Chronic1LHGDN
umls:C0023890Liver Cirrhosis1LHGDN
umls:C0023892Biliary cirrhosis1LHGDN
umls:C0024121Lung Neoplasms1LHGDN
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0027051Myocardial Infarction1BeFree,LHGDN
umls:C0027746Nerve Degeneration1CTD_human
umls:C0027794Neural Tube Defects1CTD_human
umls:C0028756Obesity, Morbid1GAD
umls:C0030305Pancreatitis1BeFree
umls:C0033578Prostatic Neoplasms1LHGDN
umls:C0035078Kidney Failure1GAD
umls:C0035126Reperfusion Injury1CTD_human
umls:C0036572Seizures1CTD_human
umls:C0040336Tobacco Use Disorder1GAD
umls:C0041948Uremia1LHGDN
umls:C0043094Weight Gain1CTD_human
umls:C0085207Gestational Diabetes1GAD
umls:C0236736Cocaine-Related Disorders1CTD_human
umls:C0238198Gastrointestinal Stromal Tumors1LHGDN
umls:C0264716Chronic heart failure1BeFree
umls:C0334299Carcinoid tumor no ICD-O subtype1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0497406Overweight1BeFree
umls:C0546837Malignant neoplasm of esophagus1GAD
umls:C0549473Thyroid carcinoma1BeFree
umls:C0687132heavy drinking1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0740392Infarction, Middle Cerebral Artery1RGD
umls:C0850666Helicobacter pylori infection1BeFree
umls:C0920269Microsatellite Instability1GAD
umls:C1306214ACTH-Secreting Pituitary Adenoma1BeFree
umls:C1458155Mammary Neoplasms1LHGDN
umls:C1527249Colorectal Cancer1GAD
umls:C1533217Methamphetamine dependence1GAD
umls:C3495801Granulomatosis with polyangiitis1GAD