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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SERPINA1
check button Gene summary
Basic gene informationGene symbolSERPINA1
Gene nameserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SynonymsA1A|A1AT|AAT|PI|PI1|PRO2275|alpha1AT
CytomapUCSC genome browser: 14q32.1
Type of geneprotein-coding
RefGenesNM_000295.4,
NM_001002235.2,NM_001002236.2,NM_001127700.1,NM_001127701.1,
NM_001127702.1,NM_001127703.1,NM_001127704.1,NM_001127705.1,
NM_001127706.1,NM_001127707.1,
Descriptionalpha-1 protease inhibitoralpha-1-antiproteinasealpha-1-antitrypsinalpha-1-antitrypsin nullprotease inhibitor 1 (anti-elastase), alpha-1-antitrypsinserine (or cysteine) proteinase inhibitor, clade A, member 1serpin A1
Modification date20141222
dbXrefs MIM : 107400
HGNC : HGNC
Ensembl : ENSG00000197249
HPRD : 02463
Vega : OTTHUMG00000150355
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SERPINA1
BioGPS: 5265
PathwayNCI Pathway Interaction Database: SERPINA1
KEGG: SERPINA1
REACTOME: SERPINA1
Pathway Commons: SERPINA1
ContextiHOP: SERPINA1
ligand binding site mutation search in PubMed: SERPINA1
UCL Cancer Institute: SERPINA1
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTExHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of SERPINA1
Description by TissGene annotationsCancer gene
Fused withOncogene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SERPINA1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-1.4161435552.652724445-4.0688686.53E-137.95E-12
LIHC8.3870224459.758056445-1.3710346.07E-073.41E-06
LUAD2.9956904454.236740445-1.241056.86E-062.05E-05
KIRC4.4417848892.7561196111.6856652784.03E-141.91E-13
THCA3.824065869-0.0490256573.8730915259.96E-171.76E-15
LUSC1.1034973084.454262013-3.3507647061.79E-171.50E-16
STAD2.215252945-0.063887682.2791406250.004180.016847348


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TissGene-miRNA for SERPINA1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SERPINA1
TissGeneSNV for SERPINA1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G410RSKCM2
p.P393HESCA1
p.S164*GBM1
p.S89FSKCM1
p.G119DUCEC1
p.Q285*THCA1
p.G91RSKCM1
p.Y184*BRCA1
p.P2ABRCA1
p.T51IUCEC1
p.G91VLUAD1
p.S358LSKCM1
p.G282RSARC1
p.V237ACOAD1
p.E228KSTAD1
p.G344RBRCA1
p.S6LGBM1
p.G319VLUSC1
p.S383YKIRC1
p.D183NBLCA1
p.G319ESKCM1
p.K160NPRAD1
p.Q417RSKCM1
p.V357MSTAD1
p.F299VHNSC1
p.L407VKIRC1
p.D304NHNSC1
p.Q121PKIRP1
p.G191ESKCM1
p.E400DCOAD1
p.A166VHNSC1
p.V361ASTAD1
p.V185AUCEC1
p.V326IUCEC1
p.Y268CPAAD1
p.R63CUCEC1
p.S22FHNSC1
p.G339ESKCM1
p.H311NHNSC1
p.A207SLUAD1
p.Q254HESCA1
p.M244ISKCM1
p.R247HCOAD1
p.G188DLUAD1
p.E387KSKCM1


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TissGeneCNV for SERPINA1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SERPINA1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABG566103LAP3-SERPINA1chr4:17585220chr14:94844710
Chimerdb3.0ChiTaRsNAAA969777MCL1-SERPINA1chr1:150547317chr14:94849277
Chimerdb3.0ChiTaRsNAAF130068AGAP9-SERPINA1chr10:48236381chr14:94844710
Chimerdb3.0ChiTaRsNAAF121182SERPINA1-AGXT2chr14:94849230chr5:35013072
Chimerdb3.0ChiTaRsNABF733145SERPINA1-TMEM123chr14:94849090chr11:102267280
Chimerdb3.0ChiTaRsNABX500960SERPINA1-MOB2chr14:94845837chr11:1756031
Chimerdb3.0ChiTaRsNABX500961SERPINA1-MOB2chr14:94845837chr11:1756030
Chimerdb3.0ChiTaRsNACB138512SERPINA1-RPL23chr14:94844909chr17:37006649
Chimerdb3.0ChiTaRsNACB147232GAPDH-SERPINA1chr12:6647311chr14:94849493
Chimerdb3.0ChiTaRsNAAF075367SERPINA1-PSMD2chr14:94854926chr3:184026505
Chimerdb3.0ChiTaRsNACB134886SERPINA1-RPL23chr14:94844909chr17:37006350
Chimerdb3.0ChiTaRsNAAF113676AKAP13-SERPINA1chr15:86078482chr14:94844698
Chimerdb3.0ChiTaRsNAAI803294SERPINA1-KREMEN1chr14:94845857chr22:29538266
Chimerdb3.0ChiTaRsNACB147374SERPINA1-RPL23chr14:94844909chr17:37006381
Chimerdb3.0ChiTaRsNABQ181873MYH9-SERPINA1chr22:36677537chr14:94847271
Chimerdb3.0ChiTaRsNAAI133003SERPINA1-ALDOBchr14:94849463chr9:104188898
Chimerdb3.0TopHat-FusionLUADTCGA-97-8175-01AGAPDH-SERPINA13'UTR-CDSchr12:6647470chr14:94844936


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TissGeneNet for SERPINA1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SERPINA1, RAP2A, PRTN3, GSDMB, TCF3, SDC2, PRSS3, PITX3, HNF1A, CANX, ECHS1, LRP1, MMP7, KLK3, MMP11, DERL1, PRSS1, DERL3, KLK13, GZMM, KLK5 (tumor)SERPINA1, UBC, RAP2A, VCP, GSDMB, TCF3, SDC2, LGALS3, ELANE, SMAD4, OS9, CANX, ECHS1, ATP5C1, ERLEC1, DERL1, CELA1, DERL2, DERL3, MMP26, GZMM (normal)
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COAD (tumor)COAD (normal)
SERPINA1, HNF4A, PRTN3, GSDMB, SDC2, LGALS3, SMAD4, PRSS3, OS9, HNF1A, CANX, RCHY1, KLK3, ERLEC1, CTSG, DERL1, DERL2, PRSS1, DERL3, KLK13, GZMM (tumor)SERPINA1, HNF4A, GSDMB, TCF3, SMAD4, OS9, HNF1A, CANX, MMP7, KLK3, ERLEC1, MIS12, CTSG, MMP11, SSR1, DERL2, PRSS1, DERL3, KLK13, MMP26, GZMM (normal)
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HNSC (tumor)HNSC (normal)
SERPINA1, UBC, RAP2A, TCF3, SDC2, LGALS3, PRSS3, OS9, ADAMTS4, ATP5C1, MMP7, ERLEC1, CTSG, MMP11, DERL1, UGGT1, DERL2, PRSS1, DERL3, KLK13, GZMM (tumor)SERPINA1, PRTN3, GSDMB, TCF3, SDC2, ELANE, PRSS3, OS9, CANX, ADAMTS4, LRP1, MMP7, ERLEC1, MIS12, CTSG, MMP11, SSR1, DERL1, DERL3, KLK13, GZMM (normal)
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KICH (tumor)KICH (normal)
SERPINA1, HNF4A, UBC, RAP2A, GSDMB, TCF3, SDC2, ELANE, SMAD4, PITX3, HNF1A, LRP1, ATP5C1, KLK3, MIS12, CTSG, DERL1, DERL3, MMP26, GZMM, KLK5 (tumor)SERPINA1, RAP2A, PRTN3, TCF3, SDC2, ELANE, SMAD4, PRSS3, PITX3, OS9, HNF1A, CANX, ADAMTS4, MMP7, CTSG, MMP11, SSR1, CELA1, DERL3, KLK13, GZMM (normal)
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KIRC (tumor)KIRC (normal)
SERPINA1, HNF4A, UBC, RAP2A, PRTN3, GSDMB, TCF3, SDC2, SMAD4, PITX3, OS9, HNF1A, ECHS1, KLK3, ERLEC1, SSR1, DERL1, UGGT1, DERL2, KLK13, KLK5 (tumor)SERPINA1, HNF4A, UBC, RAP2A, TCF3, SMAD4, OS9, HNF1A, CANX, ADAMTS4, RCHY1, LRP1, ATP5C1, MMP7, KLK3, MMP11, DERL1, DERL3, KLK13, MMP26, GZMM (normal)
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KIRP (tumor)KIRP (normal)
SERPINA1, HNF4A, TCF3, SDC2, LGALS3, ELANE, SMAD4, PITX3, ECHS1, RCHY1, KLK3, ERLEC1, CTSG, SSR1, DERL1, CELA1, UGGT1, PRSS1, DERL3, KLK13, MMP26 (tumor)SERPINA1, HNF4A, UBC, RAP2A, TCF3, LGALS3, ELANE, SMAD4, OS9, HNF1A, ADAMTS4, LRP1, MMP7, CTSG, CELA1, DERL2, PRSS1, DERL3, KLK13, GZMM, KLK5 (normal)
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LIHC (tumor)LIHC (normal)
SERPINA1, UBC, RAP2A, TCF3, LGALS3, ELANE, SMAD4, PRSS3, PITX3, OS9, RCHY1, LRP1, MMP7, KLK3, SSR1, CELA1, DERL2, KLK13, MMP26, GZMM, KLK5 (tumor)SERPINA1, HNF4A, RAP2A, GSDMB, TCF3, SDC2, SMAD4, PRSS3, OS9, HNF1A, ECHS1, RCHY1, LRP1, MMP7, ERLEC1, DERL1, CELA1, DERL2, PRSS1, KLK13, GZMM (normal)
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LUAD (tumor)LUAD (normal)
SERPINA1, HNF4A, UBC, PRTN3, VCP, GSDMB, LGALS3, ELANE, SMAD4, PRSS3, OS9, HNF1A, ADAMTS4, ECHS1, RCHY1, KLK3, MIS12, DERL1, DERL2, KLK13, KLK5 (tumor)SERPINA1, HNF4A, UBC, RAP2A, PRTN3, GSDMB, TCF3, SDC2, LGALS3, ELANE, SMAD4, PRSS3, PITX3, OS9, CANX, ADAMTS4, RCHY1, MMP7, MIS12, CTSG, PRSS1 (normal)
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LUSC (tumor)LUSC (normal)
SERPINA1, HNF4A, UBC, RAP2A, VCP, LGALS3, ELANE, SMAD4, PRSS3, OS9, ADAMTS4, ECHS1, RCHY1, ATP5C1, MMP7, ERLEC1, CTSG, MMP11, DERL1, DERL2, KLK13 (tumor)SERPINA1, HNF4A, RAP2A, PRTN3, TCF3, LGALS3, ELANE, PRSS3, OS9, CANX, ADAMTS4, RCHY1, LRP1, MMP7, ERLEC1, CTSG, DERL1, PRSS1, DERL3, GZMM, KLK5 (normal)
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PRAD (tumor)PRAD (normal)
SERPINA1, VCP, SDC2, ELANE, SMAD4, PRSS3, HNF1A, CANX, ECHS1, RCHY1, KLK3, MIS12, MMP11, SSR1, DERL1, UGGT1, PRSS1, DERL3, KLK13, MMP26, GZMM (tumor)SERPINA1, HNF4A, SDC2, LGALS3, ELANE, PRSS3, OS9, HNF1A, ADAMTS4, LRP1, MMP7, KLK3, CTSG, MMP11, CELA1, UGGT1, PRSS1, DERL3, KLK13, GZMM, KLK5 (normal)
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STAD (tumor)STAD (normal)
SERPINA1, HNF4A, RAP2A, GSDMB, TCF3, LGALS3, SMAD4, PRSS3, OS9, HNF1A, ECHS1, ATP5C1, MMP7, ERLEC1, DERL1, DERL2, PRSS1, DERL3, KLK13, GZMM, KLK5 (tumor)SERPINA1, HNF4A, UBC, TCF3, SMAD4, PRSS3, OS9, HNF1A, CANX, RCHY1, LRP1, MMP7, ERLEC1, SSR1, DERL1, UGGT1, DERL2, PRSS1, DERL3, KLK13, CTRB1 (normal)
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THCA (tumor)THCA (normal)
SERPINA1, RAP2A, PRTN3, VCP, GSDMB, TCF3, SDC2, LGALS3, SMAD4, CANX, ECHS1, RCHY1, LRP1, MMP7, ERLEC1, MMP11, DERL1, CELA1, PRSS1, DERL3, GZMM (tumor)SERPINA1, RAP2A, TCF3, LGALS3, ELANE, PRSS3, PITX3, HNF1A, CANX, ECHS1, LRP1, ATP5C1, MMP7, MIS12, MMP11, DERL1, DERL2, PRSS1, KLK13, GZMM, KLK5 (normal)
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TissGeneProg for SERPINA1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SERPINA1
TissGeneDrug for SERPINA1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SERPINA1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0221757alpha 1-Antitrypsin Deficiency127BeFree,CLINVAR,CTD_human,GAD,ORPHANET
umls:C0034067Pulmonary Emphysema116BeFree,CTD_human,GAD,LHGDN
umls:C0023895Liver diseases92BeFree,CTD_human,GAD,LHGDN
umls:C0024117Chronic Obstructive Airway Disease66BeFree,CTD_human,GAD,LHGDN
umls:C0024115Lung diseases46BeFree,CTD_human,GAD,LHGDN
umls:C3501835alpha-1-Antitrypsin Deficiency, Autosomal Recessive43BeFree
umls:C2239176Liver carcinoma36BeFree,CTD_human,GAD,LHGDN
umls:C0023890Liver Cirrhosis30BeFree,CTD_human,GAD,LHGDN
umls:C0004096Asthma20BeFree,GAD,LHGDN,RGD
umls:C0023903Liver neoplasms18BeFree,GAD
umls:C0010674Cystic Fibrosis16BeFree,GAD,LHGDN
umls:C0341439Chronic liver disease15BeFree
umls:C0003873Rheumatoid Arthritis14BeFree,GAD
umls:C1623038Cirrhosis13BeFree
umls:C0042384Vasculitis10BeFree,CTD_human
umls:C0006267Bronchiectasis9BeFree,CTD_human,GAD
umls:C0600260Lung Diseases, Obstructive9BeFree,GAD
umls:C0013295Duodenal Ulcer7BeFree
umls:C0242379Malignant neoplasm of lung7BeFree,GAD
umls:C0019693HIV Infections6BeFree,CTD_human,GAD
umls:C0264393Panacinar Emphysema6BeFree
umls:C0520463Chronic active hepatitis6BeFree
umls:C0684249Carcinoma of lung6BeFree
umls:C0002395Alzheimer's Disease5BeFree,GAD,LHGDN
umls:C0026769Multiple Sclerosis5BeFree
umls:C0162429Malnutrition5BeFree
umls:C0746102Chronic lung disease5BeFree
umls:C2717865Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis5BeFree
umls:C0001883Airway Obstruction4BeFree,GAD
umls:C0005779Blood Coagulation Disorders4BeFree
umls:C0008370Cholestasis4BeFree,CTD_human
umls:C0015230Exanthema4BeFree
umls:C0019158Hepatitis4BeFree,LHGDN
umls:C0019196Hepatitis C4BeFree,LHGDN
umls:C0024121Lung Neoplasms4BeFree,CTD_human,GAD,LHGDN
umls:C0027613Neonatal hepatitis4BeFree
umls:C0030305Pancreatitis4BeFree,RGD
umls:C0239946Fibrosis, Liver4BeFree
umls:C0521173Granulomatosis4BeFree
umls:C0596263Carcinogenesis4BeFree
umls:C0701807Acute anterior uveitis4BeFree
umls:C0848332Spots on skin4BeFree
umls:C1527249Colorectal Cancer4BeFree,GAD
umls:C0002940Aneurysm3BeFree
umls:C0004153Atherosclerosis3BeFree,GAD
umls:C0005586Bipolar Disorder3BeFree,CTD_human
umls:C0007131Non-Small Cell Lung Carcinoma3BeFree
umls:C0008677Bronchitis, Chronic3BeFree
umls:C0009324Ulcerative Colitis3BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0010346Crohn Disease3BeFree,LHGDN
umls:C0011854Diabetes Mellitus, Insulin-Dependent3BeFree
umls:C0013404Dyspnea3BeFree,GAD
umls:C0013990Pathological accumulation of air in tissues3CTD_human,GAD
umls:C0019159Hepatitis A3BeFree
umls:C0026269Mitral Valve Stenosis3BeFree
umls:C0027627Neoplasm Metastasis3BeFree,CTD_human
umls:C0030326Panniculitis3BeFree
umls:C0030328Panniculitis, Nodular Nonsuppurative3BeFree,CTD_human
umls:C0033860Psoriasis3BeFree,GAD
umls:C0034069Pulmonary Fibrosis3BeFree,CTD_human
umls:C0036341Schizophrenia3BeFree
umls:C0037090Signs and Symptoms, Respiratory3BeFree
umls:C0149521Pancreatitis, Chronic3BeFree,GAD
umls:C0392514Hereditary hemochromatosis3BeFree
umls:C0497327Dementia3BeFree,LHGDN
umls:C1112213Cholestasis in newborn3BeFree
umls:C0003469Anxiety Disorders2BeFree,CTD_human
umls:C0003850Arteriosclerosis2BeFree,CTD_human
umls:C0003864Arthritis2BeFree
umls:C0003949Asbestosis2BeFree,CTD_human,GAD,LHGDN
umls:C0006542Byssinosis2BeFree
umls:C0007222Cardiovascular Diseases2GAD
umls:C0007570Celiac Disease2BeFree
umls:C0007766Intracranial Aneurysm2BeFree
umls:C0009447Common Variable Immunodeficiency2BeFree,GAD
umls:C0010200Coughing2BeFree,GAD
umls:C0011265Presenile dementia2BeFree
umls:C0011849Diabetes Mellitus2BeFree,LHGDN
umls:C0013080Down Syndrome2BeFree
umls:C0014458Eosinophilia, Tropical2BeFree
umls:C0015695Fatty Liver2GAD,LHGDN
umls:C0018995Hemochromatosis2BeFree
umls:C0019163Hepatitis B2BeFree
umls:C0020541Hypertension, Portal2BeFree,GAD
umls:C0022104Irritable Bowel Syndrome2BeFree
umls:C0023891Liver Cirrhosis, Alcoholic2BeFree,GAD
umls:C0024299Lymphoma2BeFree
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0025521Inborn Errors of Metabolism2BeFree
umls:C0027051Myocardial Infarction2GAD
umls:C0032285Pneumonia2BeFree
umls:C0033578Prostatic Neoplasms2LHGDN
umls:C0035222Respiratory Distress Syndrome, Adult2BeFree
umls:C0035242Respiratory Tract Diseases2BeFree
umls:C0035435Rheumatism2BeFree
umls:C0035455Rhinitis2BeFree,GAD
umls:C0038013Ankylosing spondylitis2BeFree
umls:C0039730Thalassemia2BeFree
umls:C0040336Tobacco Use Disorder2GAD
umls:C0041296Tuberculosis2BeFree,GAD
umls:C0042769Virus Diseases2BeFree
umls:C0085605Liver Failure2BeFree
umls:C0206180Ki-1+ Anaplastic Large Cell Lymphoma2BeFree,LHGDN
umls:C0235974Pancreatic carcinoma2BeFree
umls:C0238339Hereditary pancreatitis2BeFree
umls:C0267809Cirrhosis, Cryptogenic2BeFree
umls:C0282577Congenital Disorders of Glycosylation2BeFree
umls:C0346647Malignant neoplasm of pancreas2BeFree
umls:C0376670Pancreatitis, Alcoholic2BeFree,GAD
umls:C0398625Protein C Deficiency2BeFree
umls:C0432306Ichthyosis Bullosa of Siemens2BeFree
umls:C0699791Stomach Carcinoma2BeFree
umls:C0740304COPD exacerbation2BeFree
umls:C0742343Acute Chest Syndrome2BeFree
umls:C0971858Arthritis, Collagen-Induced2BeFree
umls:C1709246Non-Neoplastic Disorder2BeFree
umls:C3495801Granulomatosis with polyangiitis2BeFree,LHGDN
umls:C3714514Infection2LHGDN
umls:C0001418Adenocarcinoma1CTD_human
umls:C0002793Anaplasia1BeFree
umls:C0002895Anemia, Sickle Cell1BeFree
umls:C0003486Aortic Aneurysm1BeFree
umls:C0003499Supravalvular aortic stenosis1GAD
umls:C0004943Behcet Syndrome1BeFree
umls:C0005411Biliary Atresia1BeFree
umls:C0005859Bloom Syndrome1BeFree
umls:C0005940Bone Diseases1BeFree
umls:C0006277Bronchitis1GAD
umls:C0007133Carcinoma, Papillary1BeFree
umls:C0007682CNS disorder1BeFree
umls:C0008312Primary biliary cirrhosis1BeFree
umls:C0008372Intrahepatic Cholestasis1BeFree
umls:C0009088Cluster Headache1BeFree
umls:C0010054Coronary Arteriosclerosis1GAD
umls:C0010495Cutis Laxa1BeFree
umls:C0011847Diabetes1BeFree
umls:C0012691Dislocations1GAD
umls:C0014522Epidermodysplasia Verruciformis1BeFree
umls:C0014836Escherichia coli Infections1LHGDN
umls:C0014849Esophageal and Gastric Varices1LHGDN
umls:C0016052Fibromuscular Dysplasia1BeFree
umls:C0017154Gastritis, Atrophic1BeFree
umls:C0017205Gaucher Disease1BeFree
umls:C0017662Glomerulonephritis, Membranoproliferative1BeFree
umls:C0017665Membranous glomerulonephritis1GAD
umls:C0018023Nodular Goiter1BeFree
umls:C0018133Graft-vs-Host Disease1BeFree
umls:C0018203Chronic granulomatous disease1BeFree
umls:C0019080Hemorrhage1CTD_human
umls:C0019189Hepatitis, Chronic1BeFree
umls:C0019829Hodgkin Disease1BeFree
umls:C0020428Hyperaldosteronism1RGD
umls:C0020456Hyperglycemia1BeFree
umls:C0020538Hypertensive disease1BeFree
umls:C0020542Pulmonary Hypertension1RGD
umls:C0020615Hypoglycemia1CTD_human
umls:C0021051Immunologic Deficiency Syndromes1GAD
umls:C0021368Inflammation1LHGDN
umls:C0021670insulinoma1BeFree,LHGDN
umls:C0022660Kidney Failure, Acute1BeFree
umls:C0022661Kidney Failure, Chronic1BeFree
umls:C0022735Klinefelter Syndrome1BeFree
umls:C0023267Fibroid Tumor1BeFree
umls:C0023452Leukemia, Lymphocytic, Acute, L11BeFree
umls:C0023473Myeloid Leukemia, Chronic1BeFree
umls:C0023904Liver Neoplasms, Experimental1RGD
umls:C0024031Low Back Pain1BeFree
umls:C0024437Macular degeneration1BeFree
umls:C0025517Metabolic Diseases1BeFree
umls:C0026691Mucocutaneous Lymph Node Syndrome1BeFree
umls:C0027430Nasal Polyps1GAD
umls:C0028754Obesity1BeFree
umls:C0028797Occupational Diseases1GAD
umls:C0029408Degenerative polyarthritis1RGD
umls:C0030848Peyronie Disease1GAD
umls:C0031036Polyarteritis Nodosa1BeFree
umls:C0031090Periodontal Diseases1GAD
umls:C0031099Periodontitis1GAD
umls:C0031106Periodontitis, Juvenile1BeFree
umls:C0033687Proteinuria1RGD
umls:C0034065Pulmonary Embolism1BeFree
umls:C0035204Respiration Disorders1BeFree
umls:C0035220Respiratory Distress Syndrome, Newborn1BeFree
umls:C0036421Systemic Scleroderma1BeFree
umls:C0036439Scoliosis, unspecified1BeFree,GAD
umls:C0037199Sinusitis1GAD
umls:C0037274Dermatologic disorders1BeFree
umls:C0038356Stomach Neoplasms1CTD_human
umls:C0038580Substance Dependence1BeFree
umls:C0039263Takayasu Arteritis1BeFree
umls:C0039841Thiamine Deficiency1CTD_human
umls:C0042133Uterine Fibroids1BeFree
umls:C0042164Uveitis1BeFree,LHGDN
umls:C0042165Anterior uveitis1BeFree
umls:C0085096Peripheral Vascular Diseases1GAD
umls:C0149725Lower respiratory tract infection1BeFree
umls:C0151744Myocardial Ischemia1GAD
umls:C0162532Variegate Porphyria1BeFree
umls:C0162871Aortic Aneurysm, Abdominal1BeFree
umls:C0175702Williams Syndrome1BeFree,GAD
umls:C0205734Diabetes, Autoimmune1BeFree
umls:C0206307Canavan Disease1BeFree
umls:C0220656Malignant ascites1BeFree
umls:C0238463Papillary thyroid carcinoma1BeFree
umls:C0240035Interstitial fibrosis1BeFree
umls:C0241876Obstructive emphysema1BeFree
umls:C0242383Age related macular degeneration1BeFree
umls:C0242656Disease Progression1LHGDN
umls:C0264220Chronic disease of respiratory system1BeFree
umls:C0267812Micronodular cirrhosis1BeFree
umls:C0276623Chronic viral hepatitis1BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma1BeFree
umls:C0282193Iron Overload1GAD
umls:C0302592Cervix carcinoma1BeFree
umls:C0333983Hyperplastic Polyp1BeFree
umls:C0334357Papillary cystic tumor1BeFree
umls:C0334489Pancreatoblastoma1BeFree
umls:C0340613Arterial aneurysm1BeFree
umls:C0340643Dissection of aorta1BeFree
umls:C0343192Microscopic Polyangiitis1BeFree
umls:C0345904Malignant neoplasm of liver1BeFree
umls:C0345967Malignant mesothelioma1BeFree
umls:C0346976Secondary malignant neoplasm of pancreas1BeFree
umls:C0375023Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0392164Pulmonary Cystic Fibrosis1BeFree
umls:C0432474Klinefelter's syndrome - male with more than two X chromosomes1BeFree
umls:C0524851Neurodegenerative Disorders1CTD_human
umls:C0524910Hepatitis C, Chronic1GAD
umls:C0525045Mood Disorders1BeFree
umls:C0559260Congenital scoliosis1BeFree
umls:C0687675Pregnancy loss1GAD
umls:C0700208Acquired scoliosis1BeFree
umls:C0729233Dissecting aneurysm of the thoracic aorta1BeFree
umls:C0745744End Stage Liver Disease1BeFree
umls:C0751071Familial Dementia1BeFree
umls:C0751651Mitochondrial Diseases1BeFree
umls:C0751753Carbamoyl-Phosphate Synthase I Deficiency Disease1BeFree
umls:C0752347Lewy Body Disease1BeFree
umls:C0796126AICARDI-GOUTIERES SYNDROME 11BeFree
umls:C0860207Drug-Induced Liver Injury1RGD
umls:C0867389Chronic graft-versus-host disease1BeFree
umls:C0877015Pelvic Organ Prolapse1BeFree
umls:C0948008Ischemic stroke1GAD
umls:C1271104Blood pressure finding1GAD
umls:C1272641Systemic arterial pressure1GAD
umls:C1318500Non-toxic nodular goiter1BeFree
umls:C1333990Hereditary Nonpolyposis Colorectal Cancer1BeFree
umls:C1458155Mammary Neoplasms1LHGDN
umls:C1704321Nephrotic Syndrome, Minimal Change1BeFree
umls:C1840264IMMUNE SUPPRESSION1BeFree
umls:C1858680Familial encephalopathy with neuroserpin inclusion bodies1BeFree
umls:C1956346Coronary Artery Disease1GAD
umls:C2316810Chronic kidney disease stage 51BeFree
umls:C2718001Protein Misfolding Disorders1BeFree
umls:C2936349Plaque, Amyloid1BeFree
umls:C3273033Well Differentiated Hepatocellular Carcinoma1BeFree
umls:C0751157FRAXE Syndrome0CLINVAR