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| TissGeneSummary for SERPINA4 |
 Gene summary |
| Basic gene information | Gene symbol | SERPINA4 |
| Gene name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 | |
| Synonyms | KAL|KLST|KST|PI-4|PI4|kallistatin | |
| Cytomap | UCSC genome browser: 14q32.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001289032.1, NM_001289033.1,NM_006215.3, | |
| Description | kallikrein inhibitorkallistatinpeptidase inhibitor 4protease inhibitor 4 (kallistatin)serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4serpin A4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 147935 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000100665 | ||
| HPRD : 01004 | ||
| Vega : OTTHUMG00000170859 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SERPINA4 | |
| BioGPS: 5267 | ||
| Pathway | NCI Pathway Interaction Database: SERPINA4 | |
| KEGG: SERPINA4 | ||
| REACTOME: SERPINA4 | ||
| Pathway Commons: SERPINA4 | ||
| Context | iHOP: SERPINA4 | |
| ligand binding site mutation search in PubMed: SERPINA4 | ||
| UCL Cancer Institute: SERPINA4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverPancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCPAAD | |
| Reference showing the relevant tissue of SERPINA4 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SERPINA4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -0.8380072 | 3.577808425 | -4.415815625 | 3.20E-14 | 7.27E-13 |
| COAD | -1.133200469 | -3.4644697 | 2.331269231 | 6.16E-09 | 5.84E-08 |
| KICH | -2.2810177 | 3.3202383 | -5.601256 | 2.90E-14 | 4.63E-13 |
| LUAD | -1.571345562 | -3.373361079 | 1.802015517 | 1.34E-06 | 4.41E-06 |
| LIHC | 7.8327643 | 10.1813823 | -2.348618 | 4.84E-07 | 2.82E-06 |
| KIRC | -0.824458588 | 3.297715023 | -4.122173611 | 1.09E-22 | 1.06E-21 |
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| TissGene-miRNA for SERPINA4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SERPINA4 |
| TissGeneSNV for SERPINA4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E136K | SKCM | 2 |
| p.R138G | LUAD | 2 |
| p.S90F | SKCM | 2 |
| p.R61C | CESC | 2 |
| p.A373D | LUAD | 1 |
| p.W301X | STAD | 1 |
| p.P71S | SKCM | 1 |
| p.D174H | COAD | 1 |
| p.Y327H | SARC | 1 |
| p.S324A | LUAD | 1 |
| p.F321L | COAD | 1 |
| p.E291K | SKCM | 1 |
| p.S81R | LUAD | 1 |
| p.V265A | LIHC | 1 |
| p.D116N | SKCM | 1 |
| p.L416F | SKCM | 1 |
| p.W301* | STAD | 1 |
| p.M334T | LUSC | 1 |
| p.I396N | OV | 1 |
| p.V162I | PRAD | 1 |
| p.L304M | SKCM | 1 |
| p.S78F | SKCM | 1 |
| p.V205I | HNSC | 1 |
| p.V205F | LUAD | 1 |
| p.L102F | SKCM | 1 |
| p.M299I | SKCM | 1 |
| p.P402L | SKCM | 1 |
| p.R267W | STAD | 1 |
| p.R259K | HNSC | 1 |
| p.R300M | LUAD | 1 |
| p.L40M | UCEC | 1 |
| p.D184N | BRCA | 1 |
| p.E315G | LIHC | 1 |
| p.S419R | LUSC | 1 |
| p.R306W | STAD | 1 |
| p.D347G | READ | 1 |
| p.L91M | SARC | 1 |
| p.L145M | UCEC | 1 |
| p.Q355P | READ | 1 |
| p.V370L | LUAD | 1 |
| p.R242Q | COAD | 1 |
| p.S264X | READ | 1 |
| p.V235D | ESCA | 1 |
| p.D153A | LUSC | 1 |
| p.R242Q | SKCM | 1 |
| p.K221N | LGG | 1 |
| p.F387L | COAD | 1 |
| p.P281S | SKCM | 1 |
| p.D5E | ESCA | 1 |
| p.S115F | SKCM | 1 |
| p.R306Q | ESCA | 1 |
| p.S409Y | LUAD | 1 |
| p.K187N | BLCA | 1 |
| p.T110N | ACC | 1 |
| p.L102V | SKCM | 1 |
| p.E376K | SKCM | 1 |
| p.T339A | UCEC | 1 |
| p.C263Y | HNSC | 1 |
| p.R394C | UCEC | 1 |
| p.M245I | SKCM | 1 |
| p.V162I | BRCA | 1 |
| p.G43S | SKCM | 1 |
| p.N33K | SKCM | 1 |
| p.S90F | LUAD | 1 |
| p.S46F | SKCM | 1 |
| p.W219* | SKCM | 1 |
| p.L261F | SARC | 1 |
| p.Q354H | HNSC | 1 |
| p.K308Q | LUSC | 1 |
| p.R335M | LUAD | 1 |
| p.S226* | HNSC | 1 |
| p.E358G | THYM | 1 |
| p.T107S | LUSC | 1 |
| p.F321L | READ | 1 |
| p.V243M | SKCM | 1 |
| p.H96N | HNSC | 1 |
| p.M88T | LUAD | 1 |
| p.R401Q | LGG | 1 |
| p.P47L | SKCM | 1 |
| p.G43D | LUAD | 1 |
| p.S264L | SKCM | 1 |
| p.A87V | STAD | 1 |
| p.E288D | BLCA | 1 |
| p.D286Y | LUSC | 1 |
| p.R61C | COAD | 1 |
| p.T159I | SKCM | 1 |
| p.E288K | SKCM | 1 |
| p.E274G | LUSC | 1 |
| p.Y173H | SKCM | 1 |
| p.P79T | LUAD | 1 |
| p.G72R | SKCM | 1 |
| p.P79T | SKCM | 1 |
| p.E296D | ESCA | 1 |
| p.E290K | SKCM | 1 |
| p.R394G | HNSC | 1 |
| p.P71Q | LUAD | 1 |
| p.V139M | ESCA | 1 |
| Top |
| TissGeneCNV for SERPINA4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SERPINA4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SERPINA4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| COAD (tumor) | COAD (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| KICH (tumor) | KICH (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| STAD (tumor) | STAD (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| THCA (tumor) | THCA (normal) |
| SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (tumor) | SERPINA4, HNF4A, TNFRSF14, ILK, CTSD, TNNT1, NR4A1, GADD45G, TAB1, RASA1, MAPK6, MAP4K2, KLK2, KLK1 (normal) |
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| Top |
| TissGeneProg for SERPINA4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for SERPINA4 |
| TissGeneDrug for SERPINA4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SERPINA4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0162809 | Kallmann Syndrome | 12 | BeFree |
| umls:C0019243 | Angioedemas, Hereditary | 4 | BeFree |
| umls:C0003126 | Anosmia | 3 | BeFree |
| umls:C0220766 | Congenital hypoplasia of adrenal gland | 3 | BeFree |
| umls:C0271623 | Hypogonadotropic hypogonadism | 3 | BeFree |
| umls:C0022735 | Klinefelter Syndrome | 2 | BeFree |
| umls:C0003864 | Arthritis | 1 | BeFree |
| umls:C0004936 | Mental disorders | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | LHGDN |
| umls:C0017168 | Gastroesophageal reflux disease | 1 | BeFree |
| umls:C0025362 | Mental Retardation | 1 | BeFree |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0042580 | Vesico-Ureteral Reflux | 1 | BeFree |
| umls:C0266294 | Unilateral agenesis of kidney | 1 | BeFree |
| umls:C0549463 | X-Linked Lymphoproliferative Disorder | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1619700 | RENAL ADYSPLASIA | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | CTD_human |
| umls:C2931498 | Mental Retardation, X-Linked 1 | 1 | BeFree |
| umls:C2945695 | Limb ischemia | 1 | BeFree |
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