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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PLA2G1B
check button Gene summary
Basic gene informationGene symbolPLA2G1B
Gene namephospholipase A2, group IB (pancreas)
SynonymsPLA2|PLA2A|PPLA2
CytomapUCSC genome browser: 12q24.31
Type of geneprotein-coding
RefGenesNM_000928.2,
Descriptionphosphatidylcholine 2-acylhydrolase 1Bphospholipase A2
Modification date20141207
dbXrefs MIM : 172410
HGNC : HGNC
Ensembl : ENSG00000170890
HPRD : 01396
Vega : OTTHUMG00000169343
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PLA2G1B
BioGPS: 5319
PathwayNCI Pathway Interaction Database: PLA2G1B
KEGG: PLA2G1B
REACTOME: PLA2G1B
Pathway Commons: PLA2G1B
ContextiHOP: PLA2G1B
ligand binding site mutation search in PubMed: PLA2G1B
UCL Cancer Institute: PLA2G1B
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Pancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAAD
Reference showing the relevant tissue of PLA2G1B
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0002227innate immune response in mucosa12860195
GO:0006633fatty acid biosynthetic process1918029
GO:0019731antibacterial humoral response12860195
GO:0044240multicellular organismal lipid catabolic process7060561
GO:0045740positive regulation of DNA replication1918029
GO:0046470phosphatidylcholine metabolic process7060561
GO:0050830defense response to Gram-positive bacterium12860195
GO:0002227innate immune response in mucosa12860195
GO:0006633fatty acid biosynthetic process1918029
GO:0019731antibacterial humoral response12860195
GO:0044240multicellular organismal lipid catabolic process7060561
GO:0045740positive regulation of DNA replication1918029
GO:0046470phosphatidylcholine metabolic process7060561
GO:0050830defense response to Gram-positive bacterium12860195


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TissGeneExp for PLA2G1B

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC-0.67751873-1.7045840081.0270652783.36E-068.21E-06
KICH-2.622417286-1.452245286-1.1701721.79E-066.49E-06
LUSC-1.0918865415.223307577-6.3151941183.40E-311.82E-29
LUAD0.8130162315.441512783-4.6284965526.09E-221.57E-20
ESCA-2.5659765590.402032532-2.9680090910.005040.039764806


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TissGene-miRNA for PLA2G1B

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for PLA2G1B
TissGeneSNV for PLA2G1B

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.D141NSKCM1
p.C113YBLCA1
p.S82GUCEC1
p.A7DCHOL1
p.K84TUCS1
p.G18DLIHC1
p.L42FSKCM1
p.L4ILUAD1
p.N123KBLCA1
p.D16NHNSC1
p.Q147KLUAD1


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TissGeneCNV for PLA2G1B

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for PLA2G1B

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABP323855TUBGCP3-PLA2G1Bchr13:113159210chr12:120763707
Chimerdb3.0ChiTaRsNABM926419PLA2G1B-TIPINchr12:120763976chr15:66641655
Chimerdb3.0FusionScanESCATCGA-L5-A891-01APXN-PLA2G1BIn-Framechr12:120703419chr12:120763823


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TissGeneNet for PLA2G1B

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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COAD (tumor)COAD (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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HNSC (tumor)HNSC (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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KICH (tumor)KICH (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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KIRC (tumor)KIRC (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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KIRP (tumor)KIRP (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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LIHC (tumor)LIHC (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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LUAD (tumor)LUAD (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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LUSC (tumor)LUSC (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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PRAD (tumor)PRAD (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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STAD (tumor)STAD (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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THCA (tumor)THCA (normal)
PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (tumor)PLA2G1B, SOCS2, CSF3R, BGN, PLA2G2A, PLAA (normal)
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TissGeneProg for PLA2G1B

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for PLA2G1B
TissGeneDrug for PLA2G1B

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00795SulfasalazineAntagonistSmall moleculeApproved
DB02659Cholic AcidSmall moleculeApproved


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TissGeneDisease for PLA2G1B

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0027051Myocardial Infarction18BeFree
umls:C0010054Coronary Arteriosclerosis14BeFree
umls:C0010068Coronary heart disease14BeFree
umls:C1956346Coronary Artery Disease12BeFree
umls:C0003850Arteriosclerosis11BeFree
umls:C0004153Atherosclerosis10BeFree
umls:C0036341Schizophrenia10BeFree,GAD
umls:C0086445Idiopathic Membranous Glomerulonephritis10BeFree
umls:C0600139Prostate carcinoma9BeFree
umls:C0017665Membranous glomerulonephritis8BeFree
umls:C0376358Malignant neoplasm of prostate8BeFree
umls:C0270724Infantile Neuroaxonal Dystrophy7BeFree
umls:C0007222Cardiovascular Diseases6BeFree
umls:C0009402Colorectal Carcinoma6BeFree
umls:C0032580Adenomatous Polyposis Coli6BeFree
umls:C0596263Carcinogenesis6BeFree
umls:C0003873Rheumatoid Arthritis5BeFree
umls:C0005586Bipolar Disorder5BeFree
umls:C0027819Neuroblastoma5BeFree
umls:C0038454Cerebrovascular accident5BeFree
umls:C2239176Liver carcinoma5BeFree
umls:C0010072Coronary Thrombosis4BeFree
umls:C0010346Crohn Disease4BeFree
umls:C0027627Neoplasm Metastasis4BeFree
umls:C0151942Arterial thrombosis4BeFree
umls:C0268575Isovaleryl-CoA dehydrogenase deficiency4BeFree
umls:C0700095Central neuroblastoma4BeFree
umls:C1527249Colorectal Cancer4BeFree
umls:C2931845Neurodegeneration with brain iron accumulation (NBIA)4BeFree
umls:C0003864Arthritis3BeFree
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0009324Ulcerative Colitis3BeFree
umls:C0018523Hallervorden-Spatz Syndrome3BeFree
umls:C0021390Inflammatory Bowel Diseases3BeFree
umls:C0023903Liver neoplasms3BeFree
umls:C0242379Malignant neoplasm of lung3BeFree
umls:C0243026Sepsis3BeFree
umls:C0524851Neurodegenerative Disorders3BeFree
umls:C0677886Epithelial ovarian cancer3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C0684249Carcinoma of lung3BeFree
umls:C0948089Acute Coronary Syndrome3BeFree
umls:C0002395Alzheimer's Disease2BeFree
umls:C0004364Autoimmune Diseases2BeFree
umls:C0009319Colitis2BeFree
umls:C0009375Colonic Neoplasms2BeFree
umls:C0011847Diabetes2BeFree
umls:C0011849Diabetes Mellitus2BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2BeFree
umls:C0013537Eclampsia2BeFree
umls:C0014836Escherichia coli Infections2BeFree
umls:C0020456Hyperglycemia2BeFree
umls:C0022116Ischemia2BeFree
umls:C0024115Lung diseases2BeFree
umls:C0026946Mycoses2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0033578Prostatic Neoplasms2BeFree
umls:C0036572Seizures2BeFree
umls:C0036690Septicemia2BeFree
umls:C0040038Thromboembolism2BeFree
umls:C0042373Vascular Diseases2BeFree
umls:C0149871Deep Vein Thrombosis2BeFree
umls:C0155626Acute myocardial infarction2BeFree
umls:C0271650Impaired glucose tolerance2BeFree
umls:C0333186Restenosis2BeFree
umls:C0525045Mood Disorders2BeFree
umls:C0948008Ischemic stroke2BeFree
umls:C3539909Allergic disposition2BeFree
umls:C0003175Anthrax disease1BeFree
umls:C0004096Asthma1BeFree
umls:C0007758Cerebellar Ataxia1BeFree
umls:C0008031Chest Pain1BeFree
umls:C0008370Cholestasis1BeFree
umls:C0010692Cystitis1BeFree
umls:C0014072Experimental Autoimmune Encephalomyelitis1BeFree
umls:C0014544Epilepsy1BeFree
umls:C0014868Esophagitis1BeFree
umls:C0018021Goiter1BeFree
umls:C0018213Graves Disease1BeFree
umls:C0018621Hay fever1BeFree
umls:C0018799Heart Diseases1BeFree
umls:C0018915Hemangioendothelioma1BeFree
umls:C0020443Hypercholesterolemia1BeFree
umls:C0020538Hypertensive disease1BeFree
umls:C0020877Ileitis1BeFree
umls:C0021846Intestinal Polyps1BeFree
umls:C0022661Kidney Failure, Chronic1BeFree
umls:C0023520Leukodystrophy1BeFree
umls:C0023521Globoid cell leukodystrophy1BeFree
umls:C0023890Liver Cirrhosis1BeFree
umls:C0024117Chronic Obstructive Airway Disease1BeFree
umls:C0024141Lupus Erythematosus, Systemic1BeFree
umls:C0026769Multiple Sclerosis1BeFree
umls:C0027430Nasal Polyps1BeFree
umls:C0027765nervous system disorder1BeFree
umls:C0028754Obesity1BeFree
umls:C0029134Optic Neuritis1BeFree
umls:C0032285Pneumonia1BeFree
umls:C0032584polyps1BeFree
umls:C0035220Respiratory Distress Syndrome, Newborn1BeFree
umls:C0035222Respiratory Distress Syndrome, Adult1BeFree
umls:C0038525Subarachnoid Hemorrhage1BeFree
umls:C0039483Giant Cell Arteritis1BeFree
umls:C0040015Thrombasthenia1BeFree
umls:C0041341Tuberous Sclerosis1BeFree
umls:C0042133Uterine Fibroids1BeFree
umls:C0085409Polyendocrinopathies, Autoimmune1BeFree
umls:C0087012Ataxia, Spinocerebellar1BeFree
umls:C0149516Chronic sinusitis1BeFree
umls:C0151281Genital ulceration1BeFree
umls:C0151449Primary Sj�gren's syndrome1BeFree
umls:C0151950Deep thrombophlebitis1BeFree
umls:C0155877Allergic asthma1BeFree
umls:C0238463Papillary thyroid carcinoma1BeFree
umls:C0241961Angiomyolipoma of kidney1BeFree
umls:C0242231Coronary Stenosis1BeFree
umls:C0262929Myxoma of the Endocardium1BeFree
umls:C0263641Epithelial hyperplasia of skin1BeFree
umls:C0272285Heparin-induced thrombocytopenia1BeFree
umls:C0276275Disease due to Parvoviridae1BeFree
umls:C0278701Gastric Adenocarcinoma1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0280220stage, ovarian epithelial cancer1BeFree
umls:C0311361Adenomatous goiter1BeFree
umls:C0338106Adenocarcinoma of colon1BeFree
umls:C0341439Chronic liver disease1BeFree
umls:C0342895Fish-Eye Disease1BeFree
umls:C0349649Pulmonary lymphangioleiomyomatosis1BeFree
umls:C0398623Thrombophilia1BeFree
umls:C0577631Carotid Atherosclerosis1BeFree
umls:C0596321Chemical Carcinogenesis1BeFree
umls:C0685938Malignant neoplasm of gastrointestinal tract1BeFree
umls:C0751674Lymphangioleiomyomatosis1BeFree
umls:C0836924Thrombocytosis1BeFree
umls:C0856727Cholesterol gallstones1BeFree
umls:C0877008Enzyme inhibition disorder1BeFree
umls:C1260881Allergic bronchitis1BeFree
umls:C1264031Alloimmune thrombocytopenia1BeFree
umls:C1302401Adenoma of large intestine1BeFree
umls:C1318973Staphylococcus aureus infection1BeFree
umls:C1328577Empty follicle syndrome1BeFree
umls:C1623038Cirrhosis1BeFree
umls:C1654637androgen independent prostate cancer1BeFree
umls:C1709246Non-Neoplastic Disorder1BeFree
umls:C1839780FRAGILE X TREMOR/ATAXIA SYNDROME1BeFree
umls:C1853578Neuroferritinopathy1BeFree
umls:C1868001Polyposis Of Gastric Fundus Without Polyposis Coli1BeFree
umls:C1868251Neonatal alloimmune thrombocytopenia (NAIT)1BeFree
umls:C1959635Parvovirus B19 (disease)1BeFree
umls:C2316810Chronic kidney disease stage 51BeFree
umls:C2349404Heparin induced thrombocytopenia (HIT)1BeFree
umls:C2674616FAMILIAL ADENOMATOUS POLYPOSIS, ATTENUATED (disorder)1BeFree