TissGeneSummary for PANK1 |
Gene summary |
Basic gene information | Gene symbol | PANK1 |
Gene name | pantothenate kinase 1 | |
Synonyms | PANK | |
Cytomap | UCSC genome browser: 10q23.31 | |
Type of gene | protein-coding | |
RefGenes | NM_138316.3, NM_148977.2,NM_148978.2, | |
Description | pantothenic acid kinase 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606160 | |
HGNC : HGNC | ||
Ensembl : ENSG00000152782 | ||
HPRD : 07549 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PANK1 | |
BioGPS: 53354 | ||
Pathway | NCI Pathway Interaction Database: PANK1 | |
KEGG: PANK1 | ||
REACTOME: PANK1 | ||
Pathway Commons: PANK1 | ||
Context | iHOP: PANK1 | |
ligand binding site mutation search in PubMed: PANK1 | ||
UCL Cancer Institute: PANK1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of PANK1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PANK1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 0.647908818 | 2.542124443 | -1.894215625 | 3.98E-12 | 5.83E-11 |
HNSC | -0.934710513 | 0.099024371 | -1.033734884 | 5.65E-07 | 4.57E-06 |
KIRC | 1.104813679 | 2.631927568 | -1.527113889 | 5.49E-16 | 2.96E-15 |
LIHC | 2.573187068 | 4.169237068 | -1.59605 | 1.04E-14 | 2.96E-13 |
BLCA | 0.030257174 | -1.082942826 | 1.1132 | 0.000599 | 0.00467351 |
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TissGene-miRNA for PANK1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-653-5p | MIMAT0003328 | 0.025 | -0.29 | 60 |
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TissGeneMut for PANK1 |
TissGeneSNV for PANK1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E30Q | CESC | 1 |
p.C403S | PRAD | 1 |
p.D596Y | KIRC | 1 |
p.A98V | COAD | 1 |
p.V251L | LUAD | 1 |
p.G342R | HNSC | 1 |
p.E454Q | CESC | 1 |
p.P391H | ESCA | 1 |
p.K24E | COAD | 1 |
p.N547H | UCEC | 1 |
p.Y252C | STAD | 1 |
p.E263* | STAD | 1 |
p.A492V | ESCA | 1 |
p.K400R | KIRP | 1 |
p.S508C | STAD | 1 |
p.N103D | HNSC | 1 |
p.L8V | SARC | 1 |
p.Y581C | SARC | 1 |
p.S314I | LIHC | 1 |
p.D596Y | THYM | 1 |
p.M532I | BLCA | 1 |
p.G41V | STAD | 1 |
p.G80W | PRAD | 1 |
p.R274Q | UCEC | 1 |
p.S420I | THYM | 1 |
p.R130C | TGCT | 1 |
p.M501I | BRCA | 1 |
p.P176L | KIRP | 1 |
p.R432T | CESC | 1 |
p.G481E | BLCA | 1 |
p.V433L | LUAD | 1 |
p.G108E | SKCM | 1 |
p.A18V | STAD | 1 |
p.G85E | LUAD | 1 |
p.K431T | MESO | 1 |
p.E263X | STAD | 1 |
p.G490R | BLCA | 1 |
p.E266K | SKCM | 1 |
p.R303C | PRAD | 1 |
p.M501T | STAD | 1 |
p.N393S | SKCM | 1 |
p.P394S | SKCM | 1 |
p.G43R | SKCM | 1 |
p.E363* | SARC | 1 |
p.D482N | LUSC | 1 |
p.A338V | UCEC | 1 |
p.E457K | ESCA | 1 |
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TissGeneCNV for PANK1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PANK1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF825680 | TRDMT1-PANK1 | chr10:17186032 | chr10:91344093 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A1FD-01A | PANK1-C8orf34 | Out-of-frame | Chr10:91404357 | Chr8:69621229 |
TCGAfusionPortal | PRADA | PRAD | TCGA-EJ-7327-01A | PANK1-PDK3 | In-frame | Chr10:91404357 | ChrX:24523326 |
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TissGeneNet for PANK1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PANK1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PANK1 |
TissGeneDrug for PANK1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PANK1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0018523 | Hallervorden-Spatz Syndrome | 7 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 2 | BeFree |
umls:C2931845 | Neurodegeneration with brain iron accumulation (NBIA) | 2 | BeFree |
umls:C0038160 | Staphylococcal Infections | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0270724 | Infantile Neuroaxonal Dystrophy | 1 | BeFree |