TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PLG

Gene summary

Basic gene information	Gene symbol	PLG
	Gene name	plasminogen
	Synonyms	-
	Cytomap	UCSC genome browser: 6q26
	Type of gene	protein-coding
	RefGenes	NM_000301.3, NM_001168338.1,
	Description	plasmin
	Modification date	20141222
dbXrefs	MIM : 173350
	HGNC : HGNC
	Ensembl : ENSG00000122194
	HPRD : 01417
	Vega : OTTHUMG00000015957
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PLG
	BioGPS: 5340
Pathway	NCI Pathway Interaction Database: PLG
	KEGG: PLG
	REACTOME: PLG
	Pathway Commons: PLG
Context	iHOP: PLG
	ligand binding site mutation search in PubMed: PLG
	UCL Cancer Institute: PLG
Assigned class in TissGDB*	B
Included tissue-specific gene expression resources	HPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	KidneyLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	KIRC,KIRP,KICHLIHC
Reference showing the relevant tissue of PLG
Description by TissGene annotations	Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0010812	negative regulation of cell-substrate adhesion	14699093
GO:0022617	extracellular matrix disassembly	14699093
GO:0051918	negative regulation of fibrinolysis	14726399
GO:0051919	positive regulation of fibrinolysis	6438154
GO:0010812	negative regulation of cell-substrate adhesion	14699093
GO:0022617	extracellular matrix disassembly	14699093
GO:0051918	negative regulation of fibrinolysis	14726399
GO:0051919	positive regulation of fibrinolysis	6438154

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TissGeneExp for PLG

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
KIRP	-0.505275721	8.636905529	-9.14218125	1.36E-16	5.26E-15
LIHC	12.33751153	14.63549753	-2.297986	7.21E-08	5.25E-07
KICH	-1.655160471	6.430707529	-8.085868	4.20E-11	3.57E-10
KIRC	2.556748584	7.294405529	-4.737656944	9.31E-11	3.32E-10

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TissGene-miRNA for PLG

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for PLG

TissGeneSNV for PLG

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.E5K	SKCM	3
p.P225S	SKCM	3
p.E651K	SKCM	3
p.E743K	SKCM	2
p.R731C	SKCM	2
p.S129F	SKCM	2
p.R284C	SKCM	2
p.E281K	SKCM	2
p.S358F	SKCM	2
p.V581A	UCEC	1
p.Q571H	SKCM	1
p.P356S	SKCM	1
p.E360K	SKCM	1
p.E57K	SKCM	1
p.Y233H	LUAD	1
p.A31V	STAD	1
p.K528*	OV	1
p.T742A	BLCA	1
p.G278E	SKCM	1
p.E615Q	HNSC	1
p.S292C	KIRC	1
p.S116P	SKCM	1
p.E58X	READ	1
p.P159S	SKCM	1
p.D177N	COAD	1
p.D328E	OV	1
p.V681L	LUAD	1
p.A419T	CESC	1
p.I84V	HNSC	1
p.G293E	SKCM	1
p.D158N	SKCM	1
p.P722T	LUAD	1
p.E205K	SKCM	1
p.P630H	LGG	1
p.P465S	SKCM	1
p.W209R	LUAD	1
p.R284H	PRAD	1
p.P548L	SKCM	1
p.E768D	STAD	1
p.E48G	GBM	1
p.G19R	SKCM	1
p.D553N	UCEC	1
p.E615K	SKCM	1
p.C164S	LUAD	1
p.S564L	SKCM	1
p.S211F	UCEC	1
p.R261C	PCPG	1
p.K104M	LUAD	1
p.P548S	SKCM	1
p.G491S	SKCM	1
p.T166S	KIRC	1
p.E47K	SKCM	1
p.A675V	LUAD	1
p.R242Q	COAD	1
p.V444I	STAD	1
p.W209L	LUAD	1
p.S45R	HNSC	1
p.G146R	SKCM	1
p.A419V	UCEC	1
p.G705R	SKCM	1
p.Q72L	LUAD	1
p.A719V	GBM	1
p.P522Q	LUAD	1
p.G395E	SKCM	1
p.E184K	SKCM	1
p.E70Q	HNSC	1
p.E646K	STAD	1
p.D249E	BRCA	1
p.D535N	LUAD	1
p.E474K	SKCM	1
p.S83F	SKCM	1
p.G329E	SKCM	1
p.Q775E	STAD	1
p.R663Q	COAD	1
p.P466L	SKCM	1
p.S631*	LUAD	1
p.P574T	LUAD	1
p.S129F	LUAD	1
p.G195C	STAD	1
p.A719S	ESCA	1
p.E447K	SKCM	1
p.D441N	SKCM	1
p.T114M	UCEC	1
p.H215Q	LUAD	1
p.P311A	STAD	1
p.P169T	LUAD	1
p.P589T	LUAD	1
p.S101L	SKCM	1
p.G747E	BRCA	1
p.R62_splice	UCEC	1
p.P350L	STAD	1
p.R663*	UCEC	1
p.P271S	SKCM	1
p.M423I	SKCM	1
p.S613F	STAD	1
p.L686V	BLCA	1
p.R242W	COAD	1
p.V444I	READ	1
p.G161K	HNSC	1
p.R696Q	BRCA	1
p.G161E	HNSC	1
p.P510H	KIRP	1
p.S269Y	ACC	1
p.T359M	ESCA	1
p.D432H	SKCM	1
p.D665H	BRCA	1
p.Y530C	KIRC	1
p.V357E	LUAD	1
p.G603E	SKCM	1
p.K104N	BLCA	1
p.A216S	STAD	1
p.D432N	SKCM	1
p.D759N	DLBC	1
p.T710N	UCEC	1
p.G293E	ESCA	1
p.P266Q	SARC	1
p.R242Q	UCEC	1
p.D210Y	LUAD	1
p.S213G	READ	1
p.Y530H	UCEC	1
p.G395V	HNSC	1
p.L671Q	LUAD	1
p.D158N	UCEC	1
p.P265L	SKCM	1
p.E58K	SKCM	1
p.E240G	STAD	1
p.K4E	SKCM	1
p.Q160H	LUAD	1
p.R239K	COAD	1
p.E646K	BLCA	1
p.A301S	LUSC	1
p.E2K	SKCM	1
p.D168H	HNSC	1
p.L774F	STAD	1
p.E54*	LUAD	1
p.V287L	LUSC	1
p.L721F	UCEC	1
p.E55K	SKCM	1
p.E55*	LUAD	1
p.W334*	OV	1
p.V676I	COAD	1
p.Y175N	LIHC	1
p.P304L	SKCM	1
p.Q410K	CESC	1
p.L470F	SKCM	1
p.T422S	LUAD	1
p.D249N	READ	1
p.Q29H	HNSC	1
p.E182D	STAD	1
p.P169A	LUAD	1
p.G161R	HNSC	1
p.R663Q	SKCM	1
p.R89T	LUAD	1
p.R629S	LUAD	1
p.G161W	LUAD	1
p.T141K	LUAD	1
p.E625D	CESC	1
p.L469P	KIRC	1
p.E725D	COAD	1
p.N154S	SKCM	1
p.Y25C	UCEC	1
p.E182K	COAD	1
p.E474Q	BLCA	1
p.P689T	PRAD	1
p.C543Y	HNSC	1
p.R795H	UCEC	1
p.E170V	COAD	1
p.R738K	LUAD	1
p.E743K	LGG	1
p.V692A	STAD	1
p.D665Y	LUAD	1
p.L721I	HNSC	1
p.A431V	KIRP	1
p.P315L	LGG	1
p.P687A	LUAD	1
p.A216T	LUAD	1

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TissGeneCNV for PLG

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for PLG

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	AW301153	UAP1L1-PLG		chr9:139978989	chr6:161138609

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TissGeneNet for PLG

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
PLG, HMGB1, SMAD3, PRDX4, RBBP6, LAMA5, PAPPA, SERPINE1, MAPK14, THBS1, MEP1A, HNF1A, C7, CYFIP2, KNG1, MMP9, IGFBP3, CXCL2, SERPINC1, LAMA1, MMP3 (tumor)	PLG, HRG, SMAD4, SERPINE1, ANXA2, HNF1A, RUVBL1, CPB2, F10, S100A10, KNG1, MMP9, IGFBP3, CXCL2, SERPINC1, SERPING1, APOH, SERPINF2, CHGA, CP, SERPINI1 (normal)

COAD (tumor)	COAD (normal)
PLG, PRDX4, FN1, HRG, LAMA5, PAPPA, MEP1A, PLAT, HNF1A, RUVBL1, SERPINB6, CPB2, SPARC, CLEC3B, PRNP, CXCL2, F2R, SERPINC1, APOH, SERPINF2, CDCP1 (tumor)	PLG, FN1, HRG, PAPPA, SERPINE1, PLAU, MEP1A, PCOLCE, SERPINB6, CPB2, SPARC, ENO1, PRNP, KNG1, MMP7, KLK3, MMP9, SERPINC1, SERPING1, APOH, CDCP1 (normal)

HNSC (tumor)	HNSC (normal)
PLG, AMOT, HRG, PAPPA, PLAU, MEP1A, F2RL1, RUVBL1, SERPINB6, CPB2, F10, CLEC3B, ATP5B, NGF, KNG1, MMP9, IGFBP3, IGF2, SERPINC1, APOH, SERPINF2 (tumor)	PLG, HMGB1, PRDX4, RAP2A, HRG, LAMA5, PLAU, MAPK14, EP300, C7, CPB2, F10, KNG1, KLK3, SERPINC1, LAMA1, APOH, YTHDC1, SERPINF2, CHGA, CDCP1 (normal)

KICH (tumor)	KICH (normal)
PLG, AMOT, RAP2A, FN1, LAMA5, F3, HNF1A, PRNP, S100A10, KLK3, LAMA3, IGFBP3, CXCL2, IGF2, SERPINC1, LAMA1, APOH, YTHDC1, SERPINF2, TFPI2, SERPINI1 (tumor)	PLG, SMAD3, RBBP6, HRG, PAPPA, SMAD4, MAPK14, PCOLCE, SERPINB6, C7, CYFIP2, CPB2, SPARC, ENO1, S100A10, IGF2, SERPINC1, APOH, SERPINF2, SERPINB13, CP (normal)

KIRC (tumor)	KIRC (normal)
PLG, AMOT, RAP2A, PLAU, ANXA2, F2RL1, HNF1A, SPARC, ENO1, PRNP, S100A10, KLK3, LAMA3, IGFBP3, SERPINC1, LAMA1, APOH, YTHDC1, SERPINF2, TFPI2, SERPINI1 (tumor)	PLG, AMOT, RAP2A, HRG, ANXA2, F2RL1, F3, PCOLCE, PLAT, HNF1A, CYFIP2, ENO1, CLEC3B, MMP7, LAMA3, MMP9, SERPINC1, YTHDC1, SERPINF2, MMP3, CDCP1 (normal)

KIRP (tumor)	KIRP (normal)
PLG, HMGB1, AMOT, PRDX4, RAP2A, PLAU, ANXA2, HNF1A, SPARC, ENO1, PRNP, S100A10, LAMA3, IGFBP3, F2R, SERPINC1, LAMA1, APOH, YTHDC1, SERPINF2, TFPI2 (tumor)	PLG, SMAD3, RAP2A, RBBP6, HRG, MEP1A, PCOLCE, PLAT, HNF1A, CYFIP2, ATP5B, S100A10, MMP7, KLK3, LAMA3, IGFBP3, SERPINC1, LAMA1, APOH, CDCP1, SERPINI1 (normal)

LIHC (tumor)	LIHC (normal)
PLG, AMOT, FN1, PLAU, MAPK14, ANXA2, EP300, F3, PLAT, SERPINB6, C7, CPB2, PRNP, S100A10, KNG1, MMP7, SERPINC1, LAMA1, APOH, CDCP1, CP (tumor)	PLG, FN1, HRG, LAMA5, PLAU, ANXA2, F3, HNF1A, SERPINB6, CPB2, F10, KNG1, MMP7, MMP9, SERPINC1, LAMA1, SERPING1, APOH, SERPINF2, CDCP1, CP (normal)

LUAD (tumor)	LUAD (normal)
PLG, PRDX4, FN1, HRG, ANXA2, EP300, F2RL1, HNF1A, RUVBL1, SERPINB6, ATP5B, NGF, KNG1, MMP7, LAMA3, MMP9, CHGA, TFPI2, SERPINB13, CP, SERPINI1 (tumor)	PLG, HRG, PAPPA, HNF1A, RUVBL1, C7, CYFIP2, CPB2, F10, ENO1, CLEC3B, PRNP, S100A10, KNG1, MMP7, SERPINC1, SERPING1, APOH, SERPINF2, CHGA, SERPINB13 (normal)

LUSC (tumor)	LUSC (normal)
PLG, HRG, PAPPA, MAPK14, ANXA2, MEP1A, F3, PLAT, HNF1A, RUVBL1, C7, PRNP, KNG1, KLK3, CXCL2, F2R, SERPINC1, MMP3, CHGA, SERPINB13, CP (tumor)	PLG, AMOT, SMAD3, PRDX4, RBBP6, HRG, PAPPA, EP300, MEP1A, PLAT, SERPINB6, CPB2, F10, CLEC3B, KNG1, CXCL2, SERPINC1, APOH, SERPINF2, CDCP1, CP (normal)

PRAD (tumor)	PRAD (normal)
PLG, AMOT, PRDX4, HRG, SERPINE1, THBS1, ANXA2, F2RL1, PCOLCE, RUVBL1, CPB2, F10, PRNP, KLK3, MMP9, SERPINC1, LAMA1, SERPINF2, CHGA, CDCP1, CP (tumor)	PLG, RAP2A, FN1, HRG, LAMA5, SERPINE1, F2RL1, F3, PCOLCE, HNF1A, SERPINB6, CPB2, SPARC, KNG1, KLK3, LAMA3, IGF2, SERPINC1, APOH, SERPINF2, MMP3 (normal)

STAD (tumor)	STAD (normal)
PLG, HMGB1, RBBP6, THBS1, MEP1A, F2RL1, HNF1A, SERPINB6, ATP5B, PRNP, LAMA3, IGFBP3, F2R, SERPINC1, LAMA1, APOH, YTHDC1, SERPINF2, MMP3, CHGA, CDCP1 (tumor)	PLG, RBBP6, FN1, HRG, MAPK14, MEP1A, CPB2, F10, S100A10, NGF, KNG1, IGF2, SERPINC1, LAMA1, APOH, YTHDC1, SERPINF2, CHGA, CDCP1, SERPINB13, CP (normal)

THCA (tumor)	THCA (normal)
PLG, HMGB1, FN1, HRG, SERPINE1, ANXA2, PCOLCE, PLAT, HNF1A, F10, SPARC, CLEC3B, S100A10, NGF, KNG1, CXCL2, LAMA1, SERPING1, SERPINB13, CP, SERPINI1 (tumor)	PLG, SMAD3, RBBP6, HRG, LAMA5, SMAD4, PCOLCE, HNF1A, SERPINB6, C7, CPB2, ATP5B, S100A10, KNG1, KLK3, SERPINC1, SERPING1, APOH, YTHDC1, SERPINF2, CP (normal)

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TissGeneProg for PLG

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for PLG

TissGeneDrug for PLG

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for PLG

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0027627	Neoplasm Metastasis	60	BeFree,LHGDN
umls:C0006142	Malignant neoplasm of breast	30	BeFree
umls:C0678222	Breast Carcinoma	30	BeFree
umls:C0003850	Arteriosclerosis	22	BeFree
umls:C0004153	Atherosclerosis	21	BeFree
umls:C0007222	Cardiovascular Diseases	15	BeFree
umls:C0027051	Myocardial Infarction	15	BeFree,LHGDN
umls:C0398623	Thrombophilia	14	BeFree
umls:C1968804	Plasminogen Deficiency, Type I	14	BeFree,CLINVAR,CTD_human,MGD,UNIPROT
umls:C2239176	Liver carcinoma	14	BeFree
umls:C0028754	Obesity	12	BeFree
umls:C0029925	Ovarian Carcinoma	12	BeFree
umls:C0398621	Hypoplasminogenemia	12	BeFree,ORPHANET
umls:C0600139	Prostate carcinoma	12	BeFree
umls:C0376358	Malignant neoplasm of prostate	11	BeFree
umls:C0699790	Colon Carcinoma	11	BeFree
umls:C1274789	Ligneous conjunctivitis	11	BeFree,ORPHANET
umls:C1956346	Coronary Artery Disease	11	BeFree,LHGDN
umls:C0010054	Coronary Arteriosclerosis	10	BeFree
umls:C0178874	Tumor Progression	10	BeFree
umls:C1140680	Malignant neoplasm of ovary	10	BeFree
umls:C0007102	Malignant tumor of colon	9	BeFree
umls:C0025202	melanoma	9	BeFree
umls:C0010068	Coronary heart disease	8	BeFree
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	8	BeFree
umls:C0007137	Squamous cell carcinoma	7	BeFree
umls:C0011847	Diabetes	7	BeFree
umls:C0011849	Diabetes Mellitus	7	BeFree
umls:C0016057	Fibrosarcoma	7	BeFree
umls:C0017638	Glioma	7	BeFree
umls:C0023903	Liver neoplasms	7	BeFree
umls:C0024623	Malignant neoplasm of stomach	7	BeFree
umls:C0038454	Cerebrovascular accident	7	BeFree
umls:C0040038	Thromboembolism	7	BeFree
umls:C0042373	Vascular Diseases	7	BeFree,GAD
umls:C0699791	Stomach Carcinoma	7	BeFree
umls:C0004096	Asthma	6	BeFree
umls:C0020538	Hypertensive disease	6	BeFree,CTD_human
umls:C0948008	Ischemic stroke	6	BeFree
umls:C1866423	Quebec platelet disorder	6	BeFree
umls:C0003873	Rheumatoid Arthritis	5	BeFree
umls:C0005779	Blood Coagulation Disorders	5	BeFree
umls:C0014175	Endometriosis	5	BeFree,GAD
umls:C0017636	Glioblastoma	5	BeFree
umls:C0021400	Influenza	5	BeFree
umls:C0524620	Metabolic Syndrome X	5	BeFree
umls:C0596263	Carcinogenesis	5	BeFree
umls:C1458155	Mammary Neoplasms	5	BeFree
umls:C1519670	Tumor Angiogenesis	5	BeFree
umls:C3272363	Ischemic Cerebrovascular Accident	5	BeFree
umls:C0001418	Adenocarcinoma	4	BeFree
umls:C0002395	Alzheimer's Disease	4	BeFree,GAD
umls:C0002940	Aneurysm	4	BeFree
umls:C0003486	Aortic Aneurysm	4	BeFree
umls:C0007124	Noninfiltrating Intraductal Carcinoma	4	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	4	BeFree
umls:C0009402	Colorectal Carcinoma	4	BeFree
umls:C0023487	Acute Promyelocytic Leukemia	4	BeFree
umls:C0029408	Degenerative polyarthritis	4	BeFree
umls:C0031099	Periodontitis	4	BeFree
umls:C0155626	Acute myocardial infarction	4	BeFree
umls:C0242379	Malignant neoplasm of lung	4	BeFree
umls:C0280100	Solid tumour	4	BeFree
umls:C0684249	Carcinoma of lung	4	BeFree
umls:C0004114	Astrocytoma	3	BeFree
umls:C0007103	Malignant neoplasm of endometrium	3	BeFree
umls:C0007134	Renal Cell Carcinoma	3	BeFree
umls:C0007138	Carcinoma, Transitional Cell	3	BeFree
umls:C0007785	Cerebral Infarction	3	BeFree
umls:C0019087	Hemorrhagic Disorders	3	BeFree
umls:C0019243	Angioedemas, Hereditary	3	BeFree
umls:C0024198	Lyme Disease	3	BeFree
umls:C0025286	Meningioma	3	BeFree
umls:C0027726	Nephrotic Syndrome	3	BeFree
umls:C0029463	Osteosarcoma	3	BeFree
umls:C0030809	Pemphigus Vulgaris	3	BeFree
umls:C0032460	Polycystic Ovary Syndrome	3	BeFree
umls:C0034069	Pulmonary Fibrosis	3	BeFree
umls:C0085278	Antiphospholipid Syndrome	3	BeFree
umls:C0085409	Polyendocrinopathies, Autoimmune	3	BeFree
umls:C0220650	Metastatic malignant neoplasm to brain	3	BeFree
umls:C0235974	Pancreatic carcinoma	3	BeFree
umls:C0243026	Sepsis	3	BeFree
umls:C0346647	Malignant neoplasm of pancreas	3	BeFree
umls:C0476089	Endometrial Carcinoma	3	BeFree
umls:C0584960	Factor V Leiden mutation	3	BeFree
umls:C0600433	Activated Protein C Resistance	3	BeFree
umls:C1260903	Dysfibrinogenemia	3	BeFree
umls:C1527249	Colorectal Cancer	3	BeFree
umls:C1883486	Uterine Corpus Cancer	3	BeFree
umls:C2717961	Thrombotic Microangiopathies	3	BeFree
umls:C3714619	Insulin resistance syndrome	3	BeFree
umls:C0000768	Congenital Abnormality	2	BeFree
umls:C0003864	Arthritis	2	BeFree
umls:C0005684	Malignant neoplasm of urinary bladder	2	BeFree
umls:C0007273	Carotid Artery Diseases	2	BeFree,GAD
umls:C0009375	Colonic Neoplasms	2	BeFree
umls:C0010346	Crohn Disease	2	BeFree
umls:C0011881	Diabetic Nephropathy	2	BeFree
umls:C0013537	Eclampsia	2	BeFree
umls:C0017658	Glomerulonephritis	2	BeFree
umls:C0020456	Hyperglycemia	2	BeFree
umls:C0020473	Hyperlipidemia	2	BeFree
umls:C0021390	Inflammatory Bowel Diseases	2	BeFree
umls:C0022548	Keloid	2	BeFree
umls:C0023223	Leg Ulcer	2	BeFree
umls:C0024121	Lung Neoplasms	2	BeFree,LHGDN
umls:C0024141	Lupus Erythematosus, Systemic	2	BeFree
umls:C0030567	Parkinson Disease	2	BeFree,GAD
umls:C0030805	Bullous pemphigoid	2	BeFree
umls:C0032285	Pneumonia	2	BeFree
umls:C0034065	Pulmonary Embolism	2	BeFree
umls:C0035412	Rhabdomyosarcoma	2	BeFree
umls:C0036690	Septicemia	2	BeFree
umls:C0043119	Werner Syndrome	2	BeFree
umls:C0085109	Corneal Neovascularization	2	BeFree
umls:C0085580	Essential Hypertension	2	BeFree
umls:C0149871	Deep Vein Thrombosis	2	BeFree,GAD
umls:C0149925	Small cell carcinoma of lung	2	BeFree
umls:C0151942	Arterial thrombosis	2	BeFree
umls:C0162871	Aortic Aneurysm, Abdominal	2	BeFree
umls:C0238463	Papillary thyroid carcinoma	2	BeFree
umls:C0242383	Age related macular degeneration	2	BeFree
umls:C0311370	Lupus anticoagulant disorder	2	BeFree
umls:C0333186	Restenosis	2	BeFree
umls:C0333463	Senile Plaques	2	BeFree
umls:C0374997	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site	2	BeFree
umls:C0398625	Protein C Deficiency	2	BeFree
umls:C0555198	Malignant Glioma	2	BeFree
umls:C0677886	Epithelial ovarian cancer	2	BeFree
umls:C0699885	Carcinoma of bladder	2	BeFree
umls:C0853879	Invasive breast carcinoma	2	BeFree
umls:C0948089	Acute Coronary Syndrome	2	BeFree
umls:C0948162	Bone marrow oedema	2	BeFree
umls:C0948441	Venoocclusive disease	2	BeFree
umls:C1260403	prothrombin gene mutation	2	BeFree
umls:C1397307	Cardiac fibrosis	2	BeFree
umls:C1762616	Meningioma, benign, no ICD-O subtype	2	BeFree
umls:C1861171	THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder)	2	BeFree
umls:C2752081	ALPHA-2-PLASMIN INHIBITOR DEFICIENCY	2	BeFree
umls:C2936349	Plaque, Amyloid	2	BeFree
umls:C0002895	Anemia, Sickle Cell	1	BeFree
umls:C0003175	Anthrax disease	1	BeFree
umls:C0004030	Aspergillosis	1	GAD,LHGDN
umls:C0004610	Bacteremia	1	BeFree
umls:C0004623	Bacterial Infections	1	BeFree
umls:C0006118	Brain Neoplasms	1	BeFree
umls:C0007113	Rectal Carcinoma	1	BeFree
umls:C0007193	Cardiomyopathy, Dilated	1	BeFree
umls:C0007847	Malignant tumor of cervix	1	BeFree
umls:C0008073	Developmental Disabilities	1	BeFree
umls:C0009404	Colorectal Neoplasms	1	BeFree
umls:C0009766	Allergic Conjunctivitis	1	BeFree
umls:C0010674	Cystic Fibrosis	1	BeFree
umls:C0011269	Dementia, Vascular	1	BeFree
umls:C0011570	Mental Depression	1	BeFree
umls:C0011581	Depressive disorder	1	BeFree
umls:C0011603	Dermatitis	1	BeFree
umls:C0011608	Dermatitis Herpetiformis	1	BeFree
umls:C0011875	Diabetic Angiopathies	1	BeFree
umls:C0011884	Diabetic Retinopathy	1	BeFree
umls:C0013146	Drug abuse	1	BeFree
umls:C0014121	Bacterial Endocarditis	1	BeFree
umls:C0014518	Toxic Epidermal Necrolysis	1	BeFree
umls:C0014859	Esophageal Neoplasms	1	BeFree
umls:C0017665	Membranous glomerulonephritis	1	RGD
umls:C0018802	Congestive heart failure	1	BeFree
umls:C0018817	Atrial Septal Defects	1	BeFree
umls:C0019163	Hepatitis B	1	BeFree
umls:C0021831	Intestinal Diseases	1	BeFree
umls:C0022116	Ischemia	1	BeFree
umls:C0022577	Keratoconjunctivitis, Vernal	1	BeFree
umls:C0022658	Kidney Diseases	1	BeFree
umls:C0022672	Acute Kidney Tubular Necrosis	1	BeFree
umls:C0023470	Myeloid Leukemia	1	BeFree
umls:C0023890	Liver Cirrhosis	1	GAD
umls:C0023893	Liver Cirrhosis, Experimental	1	CTD_human
umls:C0024116	Lung Diseases, Fungal	1	GAD
umls:C0024117	Chronic Obstructive Airway Disease	1	BeFree
umls:C0024302	Reticulosarcoma	1	BeFree
umls:C0025303	Meningococcal Infections	1	BeFree
umls:C0026267	Mitral Valve Prolapse Syndrome	1	BeFree
umls:C0026269	Mitral Valve Stenosis	1	BeFree
umls:C0026640	Mouth Neoplasms	1	BeFree
umls:C0026946	Mycoses	1	BeFree
umls:C0027765	nervous system disorder	1	BeFree
umls:C0029172	Oral Submucous Fibrosis	1	BeFree
umls:C0030297	Pancreatic Neoplasm	1	LHGDN
umls:C0031106	Periodontitis, Juvenile	1	BeFree
umls:C0031144	Chronic peritoneal effusion (disorder)	1	BeFree
umls:C0032227	Pleural effusion disorder	1	LHGDN
umls:C0032300	Lobar Pneumonia	1	BeFree
umls:C0032580	Adenomatous Polyposis Coli	1	BeFree
umls:C0032962	Pregnancy Complications	1	BeFree
umls:C0033300	Progeria	1	BeFree
umls:C0033578	Prostatic Neoplasms	1	LHGDN
umls:C0033860	Psoriasis	1	BeFree
umls:C0033975	Psychotic Disorders	1	BeFree
umls:C0034155	Purpura, Thrombotic Thrombocytopenic	1	BeFree
umls:C0035021	Relapsing Fever	1	BeFree
umls:C0036341	Schizophrenia	1	BeFree
umls:C0036572	Seizures	1	BeFree
umls:C0036631	Seminoma	1	BeFree
umls:C0037278	Skin Diseases, Infectious	1	BeFree
umls:C0038395	Streptococcal Infections	1	BeFree
umls:C0039103	Synovitis	1	BeFree
umls:C0041341	Tuberous Sclerosis	1	BeFree
umls:C0042487	Venous Thrombosis	1	CTD_human
umls:C0079744	Diffuse Large B-Cell Lymphoma	1	BeFree
umls:C0085110	Severe Combined Immunodeficiency	1	BeFree
umls:C0085207	Gestational Diabetes	1	BeFree
umls:C0086692	Benign Neoplasm	1	BeFree
umls:C0149530	Congenital heart block	1	BeFree
umls:C0149939	Obstructive nephropathy	1	BeFree
umls:C0151526	Premature Birth	1	GAD
umls:C0151650	Renal fibrosis	1	BeFree
umls:C0151744	Myocardial Ischemia	1	BeFree
umls:C0151779	Cutaneous Melanoma	1	BeFree
umls:C0152018	Esophageal carcinoma	1	BeFree
umls:C0152171	Idiopathic pulmonary hypertension	1	BeFree
umls:C0153676	Secondary malignant neoplasm of lung	1	BeFree
umls:C0153690	Secondary malignant neoplasm of bone	1	BeFree
umls:C0155765	Disease of capillaries	1	BeFree
umls:C0155862	Streptococcal pneumonia	1	BeFree
umls:C0156181	Peritoneal adhesion	1	BeFree
umls:C0162529	Colitis, Ischemic	1	BeFree
umls:C0162872	Aortic Aneurysm, Thoracic	1	BeFree
umls:C0178664	Glomerulosclerosis (disorder)	1	BeFree
umls:C0206677	Adenomatous Polyps	1	BeFree
umls:C0206682	Follicular thyroid carcinoma	1	BeFree
umls:C0220810	Congenital defects	1	BeFree
umls:C0231341	Premature aging syndrome	1	BeFree
umls:C0232197	Fibrillation	1	BeFree
umls:C0238013	invasive aspergillosis	1	BeFree
umls:C0240035	Interstitial fibrosis	1	BeFree
umls:C0242666	Protein S Deficiency	1	BeFree
umls:C0267941	Pancreatitis, Acute Necrotizing	1	BeFree
umls:C0272350	Dysfibrinogenemia, Congenital	1	BeFree
umls:C0272375	Antithrombin III Deficiency	1	BeFree
umls:C0277355	Flea Infestation	1	BeFree
umls:C0278883	Metastatic melanoma	1	BeFree
umls:C0279626	Squamous cell carcinoma of esophagus	1	BeFree
umls:C0281361	Adenocarcinoma of pancreas	1	BeFree
umls:C0302592	Cervix carcinoma	1	BeFree
umls:C0311343	Membranous conjunctivitis	1	BeFree
umls:C0333205	Mural thrombus	1	BeFree
umls:C0333209	Platelet thrombus	1	BeFree
umls:C0333516	Tumor necrosis	1	BeFree
umls:C0334663	Histiocytic sarcoma	1	BeFree
umls:C0340613	Arterial aneurysm	1	BeFree
umls:C0345958	Large cell carcinoma of lung	1	BeFree
umls:C0349204	Nonorganic psychosis	1	BeFree
umls:C0349649	Pulmonary lymphangioleiomyomatosis	1	BeFree
umls:C0375023	Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site	1	BeFree
umls:C0376618	Endotoxemia	1	LHGDN
umls:C0406097	Streptococcal impetigo	1	BeFree
umls:C0445118	Nephrotic range proteinuria	1	BeFree
umls:C0524688	Pneumonic Plague	1	BeFree
umls:C0524702	Pulmonary Thromboembolisms	1	BeFree
umls:C0546837	Malignant neoplasm of esophagus	1	BeFree
umls:C0549473	Thyroid carcinoma	1	BeFree
umls:C0574014	Axillary vein thrombosis	1	BeFree
umls:C0585442	Osteosarcoma of bone	1	BeFree
umls:C0598894	Monocytic leukemia	1	BeFree
umls:C0600452	Hepatopulmonary Syndrome	1	GAD
umls:C0699753	Cancer Relapse	1	BeFree
umls:C0728936	Disorder of circulatory system	1	BeFree
umls:C0730328	Central Serous Chorioretinopathy	1	BeFree
umls:C0740858	Substance abuse problem	1	BeFree
umls:C0751674	Lymphangioleiomyomatosis	1	BeFree
umls:C0854248	Pneumonia due to Gram negative bacteria	1	BeFree
umls:C0860207	Drug-Induced Liver Injury	1	CTD_human
umls:C0878500	Intraepithelial Neoplasia	1	BeFree
umls:C0917798	Cerebral Ischemia	1	BeFree
umls:C0920646	Renal ischaemia	1	BeFree
umls:C0947751	Vascular inflammations	1	BeFree
umls:C1257930	Mammary Carcinoma, Human	1	BeFree
umls:C1260883	Mural thrombus of heart	1	BeFree
umls:C1269683	Major Depressive Disorder	1	BeFree
umls:C1274355	Streptococcal infection of skin	1	BeFree
umls:C1285498	Vegetation	1	BeFree
umls:C1290807	Diarrheal disorder	1	BeFree
umls:C1302401	Adenoma of large intestine	1	BeFree
umls:C1318544	M5b Acute differentiated monocytic leukemia	1	BeFree
umls:C1334274	Invasive Carcinoma	1	BeFree
umls:C1402315	Vascular lesions	1	BeFree
umls:C1511291	Breast Cancer Model	1	BeFree
umls:C1519666	Tumor-Associated Vasculature	1	BeFree
umls:C1519678	Tumor Expansion	1	BeFree
umls:C1520166	Xenograft Model	1	BeFree
umls:C1541923	Infective endocarditis	1	BeFree
umls:C1800706	Idiopathic Pulmonary Fibrosis	1	BeFree
umls:C1842937	AURAL ATRESIA, CONGENITAL	1	BeFree
umls:C2363973	Chronic thromboembolic pulmonary hypertension	1	BeFree
umls:C2584620	Thrombophilia, hereditary	1	BeFree
umls:C2945759	aggressive cancer	1	BeFree
umls:C2973725	Pulmonary arterial hypertension	1	BeFree
umls:C3203102	Idiopathic pulmonary arterial hypertension	1	BeFree
umls:C3714636	Pneumonitis	1	BeFree
umls:C3714844	Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia	1	BeFree
umls:C3811653	Experimental Organism Basal Cell Carcinoma	1	BeFree